Jhommara Bautista
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View article: Reprogramming prostate cancer through the microbiome
Reprogramming prostate cancer through the microbiome Open
Prostate cancer (PCa) is a major global public health challenge, driven by a multifactorial interplay of genetic, epigenetic, hormonal and environmental determinants. In recent years, the human microbiome has emerged as a critical and prev…
View article: Chronobiome medicine: circadian regulation of host–microbiota crosstalk in systemic physiology
Chronobiome medicine: circadian regulation of host–microbiota crosstalk in systemic physiology Open
Circadian rhythms, governed by central and peripheral clocks, orchestrate nearly all aspects of human physiology, including metabolism, endocrine function, neuroimmune activity, and behavior. Emerging evidence reveals that these oscillatio…
View article: The gut–brain–circadian axis in anxiety and depression: a critical review
The gut–brain–circadian axis in anxiety and depression: a critical review Open
Anxiety and depressive disorders rank among the most prevalent psychiatric conditions worldwide, yet remission rates remain unsatisfactory despite advances in pharmacological and psychotherapeutic interventions. The gut–brain axis has emer…
View article: Microbiome influence in gastric cancer progression and therapeutic strategies
Microbiome influence in gastric cancer progression and therapeutic strategies Open
Gastric cancer (GC) remains a major global health burden, ranking as the fifth most commonly diagnosed malignancy and the fourth leading cause of cancer-related death worldwide. While Helicobacter pylori is established as the primary micro…
View article: Microbial beginnings: determinants and disruptions of the neonatal microbiome
Microbial beginnings: determinants and disruptions of the neonatal microbiome Open
The perinatal period is a critical window in human development, during which the neonatal microbiome, shaped by maternal, environmental, and clinical factors, influences immune, metabolic, and neurodevelopmental processes. Early-life micro…
View article: Bidirectional interactions between circadian rhythms and the gut microbiome
Bidirectional interactions between circadian rhythms and the gut microbiome Open
View article: Deciphering organotropism reveals therapeutic targets in metastasis
Deciphering organotropism reveals therapeutic targets in metastasis Open
Metastasis remains the principal cause of cancer-related mortality, yet its distribution across organs is far from random. Instead, tumor cells exhibit organotropism , a consistent preference for colonizing specific distant tissues, a phen…
View article: The vaginal microbiome in HPV persistence and cervical cancer progression
The vaginal microbiome in HPV persistence and cervical cancer progression Open
Persistent infection with high-risk human papillomaviruses (HR-HPV) is the primary cause of cervical cancer, but its progression depends on host and environmental factors beyond viral presence. The vaginal microbiome, particularly the tran…
View article: Microbial signatures in metastatic cancer
Microbial signatures in metastatic cancer Open
Metastasis remains the leading cause of cancer-related death, yet the biological determinants that enable tumor cells to disseminate and colonize distant organs are incompletely understood. Emerging evidence identifies the microbiome, not …
View article: Neurodegeneration rewires the tumor microenvironment via the neuro–immune–cancer axis
Neurodegeneration rewires the tumor microenvironment via the neuro–immune–cancer axis Open
View article: The human microbiome in clinical translation: from bench to bedside
The human microbiome in clinical translation: from bench to bedside Open
The human microbiome, once regarded as a passive passenger, is now recognized as a dynamic and essential determinant of human physiology, shaping immunity, metabolism, neurodevelopment, and therapeutic responsiveness across the lifespan. A…
View article: The microbiome as a therapeutic co-driver in melanoma immuno-oncology
The microbiome as a therapeutic co-driver in melanoma immuno-oncology Open
Melanoma, one of the most aggressive skin cancers, remains a major clinical challenge due to its high metastatic potential, therapy resistance, and rising global incidence. Although immune checkpoint inhibitors have transformed management,…
View article: Reprogramming cancer immunity with next-generation combination therapies
Reprogramming cancer immunity with next-generation combination therapies Open
Cancer immunotherapy has fundamentally reshaped oncology by harnessing the immune system to eliminate malignant cells. Immune checkpoint inhibitors targeting CTLA-4 and PD-1/PD-L1 have achieved durable remissions in select cancers, yet mos…
View article: Oncolytic virotherapy and tumor microenvironment modulation
Oncolytic virotherapy and tumor microenvironment modulation Open
Oncolytic viruses (OVs) have emerged as a transformative approach in cancer therapy, offering tumor-specific lysis while sparing normal tissues. In addition to their direct cytolytic effects, OVs actively reshape the tumor microenvironment…
View article: Oncogenic viruses rewire the epigenome in human cancer
Oncogenic viruses rewire the epigenome in human cancer Open
Viruses contribute to approximately 15–20% of global cancer cases, yet the full spectrum of their oncogenic mechanisms continues to be uncovered. Beyond the classical roles of genome integration, chronic inflammation, and immune evasion, m…
View article: Peripheral clocks and systemic zeitgeber interactions: from molecular mechanisms to circadian precision medicine
Peripheral clocks and systemic zeitgeber interactions: from molecular mechanisms to circadian precision medicine Open
Circadian rhythms orchestrate nearly every aspect of human physiology through a hierarchical network of clocks. While the suprachiasmatic nucleus (SCN) serves as the central pacemaker, peripheral clocks within the brain, heart, liver, gut,…
View article: CardiOmics signatures reveal therapeutically actionable targets and drugs for cardiovascular diseases
CardiOmics signatures reveal therapeutically actionable targets and drugs for cardiovascular diseases Open
View article: The close interaction between hypoxia-related proteins and metastasis in pancarcinomas
The close interaction between hypoxia-related proteins and metastasis in pancarcinomas Open
View article: Pulmonary Inflammatory Response in Lethal COVID-19 Reveals Potential Therapeutic Targets and Drugs in Phases III/IV Clinical Trials
Pulmonary Inflammatory Response in Lethal COVID-19 Reveals Potential Therapeutic Targets and Drugs in Phases III/IV Clinical Trials Open
Background: It is imperative to identify drugs that allow treating symptoms of severe COVID-19. Respiratory failure is the main cause of death in severe COVID-19 patients, and the host inflammatory response at the lungs remains poorly unde…
View article: Estado de la bio�tica e investigaci�n cl�nica en Ecuador y otros pa�ses de Latinoam�rica
Estado de la bio�tica e investigaci�n cl�nica en Ecuador y otros pa�ses de Latinoam�rica Open
ResumenIntroducción: La educación bioética mejora las habilidades de razonamiento y toma de decisiones durante la interpretación del conocimiento científico.Objetivo: En esta revisión se analiza el estado de la bioética e investigación clí…
View article: Single-nucleus lung transcriptomics and inflammatory responses in lethal COVID-19 reveal potential drugs in advanced-stage clinical trials
Single-nucleus lung transcriptomics and inflammatory responses in lethal COVID-19 reveal potential drugs in advanced-stage clinical trials Open
There is pressing urgency to identify drugs that allow treating COVID-19 patients effectively. Respiratory failure is the leading cause of death in patients with severe COVID-19, and the host inflammatory response at the lungs remains poor…
View article: In silico Analyses of Immune System Protein Interactome Network, Single-Cell RNA Sequencing of Human Tissues, and Artificial Neural Networks Reveal Potential Therapeutic Targets for Drug Repurposing Against COVID-19
In silico Analyses of Immune System Protein Interactome Network, Single-Cell RNA Sequencing of Human Tissues, and Artificial Neural Networks Reveal Potential Therapeutic Targets for Drug Repurposing Against COVID-19 Open
Background: There is pressing urgency to identify therapeutic targets and drugs that allow treating COVID-19 patients effectively. Methods: We performed in silico analyses of immune system protein interactome network, single-cell RNA seque…