Eun Lee
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View article: Trends in non-pharmacological treatment for insomnia: A nationwide study
Trends in non-pharmacological treatment for insomnia: A nationwide study Open
Background As the prevalence of insomnia disorder in Korea is gradually increasing, understanding real-world treatment patterns is essential for designing appropriate clinical guidelines. Although non-pharmacological treatments are recomme…
View article: Adjunctive smart ring monitoring during digital cognitive behavioral therapy for insomnia
Adjunctive smart ring monitoring during digital cognitive behavioral therapy for insomnia Open
Digital cognitive behavioral therapy for insomnia (dCBT-I) has emerged as a treatment for chronic insomnia. Smart rings provide objective, wearable-derived sleep data that may complement subjective sleep diaries, but their role in monitori…
View article: Validating the Efficacy of a Mobile Digital Therapeutic for Insomnia (WELT-I): Randomized Controlled Decentralized Clinical Trial
Validating the Efficacy of a Mobile Digital Therapeutic for Insomnia (WELT-I): Randomized Controlled Decentralized Clinical Trial Open
Background Cognitive behavioral therapy for insomnia (CBT-I) has proven to be an effective treatment; however, its accessibility is limited. To address this issue, digital therapeutics for insomnia (DTx-Is), which are software-driven inter…
View article: Lifetime Age‐Stratified Associations of Comorbidities in Chronic Urticaria: A Claims‐Based Study of 35,907 Cases
Lifetime Age‐Stratified Associations of Comorbidities in Chronic Urticaria: A Claims‐Based Study of 35,907 Cases Open
View article: Childhood trauma is associated with perceived stress and hair cortisol levels characterized by the BDNF Val66Met genotype and sex
Childhood trauma is associated with perceived stress and hair cortisol levels characterized by the BDNF Val66Met genotype and sex Open
Introduction Childhood trauma increases the risk of mental disorders by affecting both psychological and physiological stress responses in adulthood, including perceived stress and long-term hypothalamic-pituitary-adrenal (HPA) axis activi…
View article: 0591 Application of Decentralized Clinical Trial to Validate the Efficacy of Digital Therapeutics for Insomnia
0591 Application of Decentralized Clinical Trial to Validate the Efficacy of Digital Therapeutics for Insomnia Open
Introduction Cognitive behavioral therapy for insomnia (CBT-I) has proven to be an effective treatment, however, its accessibility is limited. To address this issue, digital therapeutics for insomnia (DTx-I) have emerged as potential solut…
View article: Wearable Technology in Circadian Rhythm Research: From Monitoring to Clinical Insights
Wearable Technology in Circadian Rhythm Research: From Monitoring to Clinical Insights Open
This review article explores the role of wearable technology in circadian rhythm research, providing an in-depth examination of its applications, benefits, limitations, and future potential. Wearable devices continuously monitor physiologi…
View article: EFFICACY OF DIGITAL COGNITIVE BEHAVIORAL THERAPY APP ON INSOMNIA PATIENTS: POOLED ANALYSIS OF TWO RANDOMIZED, DOUBLE- BLIND, SHAM-CONTROLLED TRIALS
EFFICACY OF DIGITAL COGNITIVE BEHAVIORAL THERAPY APP ON INSOMNIA PATIENTS: POOLED ANALYSIS OF TWO RANDOMIZED, DOUBLE- BLIND, SHAM-CONTROLLED TRIALS Open
Background Cognitive behavioral therapy for insomnia (CBT-I) is an effective treatment for insomnia treatment, but access is limited. Digital CBT-I (dCBT-I) may help to address this access issue. Numerous studies worldwide have demonstrate…
View article: Eye tracking based clustering using the Korean version of the reading the mind in the eyes test
Eye tracking based clustering using the Korean version of the reading the mind in the eyes test Open
This study applies eye-tracking paradigms to cluster data based on participants' gaze patterns, while performing the Korean version of the Reading the Mind in Eyes Test, and to investigate whether there were differences in the neurocogniti…
View article: Epigenetic modulation of social cognition: exploring the impact of methylation in brain-derived neurotrophic factor and oxytocin receptor genes across sex
Epigenetic modulation of social cognition: exploring the impact of methylation in brain-derived neurotrophic factor and oxytocin receptor genes across sex Open
Social cognition, which ranges from recognizing social cues to intricate inferential reasoning, is influenced by environmental factors and epigenetic mechanisms. Notably, methylation variations in stress-related genes like brain-derived ne…
View article: Longitudinal Trajectories of Asthma and Allergic Comorbidities in the Korean Childhood Asthma Study
Longitudinal Trajectories of Asthma and Allergic Comorbidities in the Korean Childhood Asthma Study Open
The longitudinal trajectories of asthma and allergic comorbidities in Korean children can be classified into distinct clusters. Most phenotypes exhibited early-onset asthma with a varying prevalence of comorbidities. The persistence of AD,…
View article: Impact of Adherence to Digital Cognitive Behavioral Therapy for Insomnia Effectiveness
Impact of Adherence to Digital Cognitive Behavioral Therapy for Insomnia Effectiveness Open
This combined analysis demonstrates the efficacy of dCBT-I in improving sleep outcomes compared with a sham app and highlights the role of adherence to SRT in enhancing treatment efficacy. The two studies were registered with ClinicalTrial…
View article: Pet Ownership Increases the Exhaled Nitric Oxide and Asthma Severity in Children With Atopic Asthma
Pet Ownership Increases the Exhaled Nitric Oxide and Asthma Severity in Children With Atopic Asthma Open
Exposure to pets can trigger symptoms in asthmatic children sensitized to pets. However, little is known about the association between pet ownership and asthma morbidity in children who are not sensitized to pets. We aimed to investigate t…
View article: Validating the efficacy of a digital therapeutic for insomnia with a decentralized clinical trial (Preprint)
Validating the efficacy of a digital therapeutic for insomnia with a decentralized clinical trial (Preprint) Open
BACKGROUND Cognitive behavioral therapy for insomnia has proven to be an effective treatment; however, its accessibility is limited. To address this issue, digital therapeutics for insomnia (DTx-Is) have emerged as a potential solution to…
View article: Predicting sleep based on physical activity, light exposure, and Heart rate variability data using wearable devices
Predicting sleep based on physical activity, light exposure, and Heart rate variability data using wearable devices Open
The results show that the performance of the sleep prediction models improved by increasing the data amount and adding HRV data. Further studies targeting insomnia patients and applied researches on non-pharmacological insomnia treatment a…
View article: Uterine lymphangioleiomyomatosis in a premenopausal woman with tuberous sclerosis: A case report
Uterine lymphangioleiomyomatosis in a premenopausal woman with tuberous sclerosis: A case report Open
Lymphangioleiomyomatosis is a rare disease characterized by abnormal smooth muscle cell growth. It primarily occurs in the lungs but can also rarely occur in other organs, in which case it is classified as extrapulmonary lymphangioleiomyom…
View article: Pathogenesis of Cerebral Small Vessel Disease: Role of the Glymphatic System Dysfunction
Pathogenesis of Cerebral Small Vessel Disease: Role of the Glymphatic System Dysfunction Open
Cerebral small vessel disease (CSVD) is a group of pathologies that affect the cerebral blood vessels. CSVD accounts for 25% of strokes and contributes to 45% of dementia. However, the pathogenesis of CSVD remains unclear, involving a vari…
View article: Understanding patient perspectives on digital therapeutics and its platform for insomnia: insights from focused group interviews
Understanding patient perspectives on digital therapeutics and its platform for insomnia: insights from focused group interviews Open
Background Digital therapeutics (DTx) is a treatment option that uses computer software to provide evidence-based interventions for medical disorders. DTx platforms are digital services that facilitate interactions among stakeholders of DT…
View article: Sevelamer-Induced Ischemic Enteritis
Sevelamer-Induced Ischemic Enteritis Open
Sevelamer, a nonabsorbable dietary phosphate binder, is essential for patients with renal impairment since hyperphosphatemia is associated with an increase in all-cause mortality. Sevelamer is generally well tolerated; however, it is rarel…
View article: The prevalence and moderating factors of sleep disturbances in people living with HIV: a systematic review and meta-analysis
The prevalence and moderating factors of sleep disturbances in people living with HIV: a systematic review and meta-analysis Open
This systematic review and meta-analysis aimed to investigate the prevalence of self-reported sleep disturbances in people living with HIV considering the effects of age, depression, anxiety, CD4 cell counts, time since HIV diagnosis, stud…
View article: Subjective Cognitive Decline in Community-Dwelling Older Adults With Objectively Normal Cognition: Mediation by Depression and Instrumental Activities of Daily Living
Subjective Cognitive Decline in Community-Dwelling Older Adults With Objectively Normal Cognition: Mediation by Depression and Instrumental Activities of Daily Living Open
Objective Subjective cognitive decline (SCD) refers to self-reported memory loss despite normal cognitive function and is considered a preclinical stage of Alzheimer’s disease. This study aimed to examine the mediating effects of depressio…
View article: Epigenetic Modulation of Social Cognition: Exploring the Impact of Methylation in Brain-Derived Neurotrophic Factor and Oxytocin Receptor Genes Across Sex
Epigenetic Modulation of Social Cognition: Exploring the Impact of Methylation in Brain-Derived Neurotrophic Factor and Oxytocin Receptor Genes Across Sex Open
Background: Social cognition, which ranges from recognizing social cues to intricate inferential reasoning, is influenced by environmental factors and epigenetic mechanisms. Notably, methylation variations in stress-related genes like brai…
View article: The prevalence and moderating factors of sleep disturbances in people living with HIV: A systematic review and meta-analysis
The prevalence and moderating factors of sleep disturbances in people living with HIV: A systematic review and meta-analysis Open
This systematic review and meta-analysis aimed to investigate the prevalence of self-reported sleep disturbances in people living with HIV considering the effects of age, depression, anxiety, CD4 cell counts, time since HIV diagnosis, stud…
View article: Association of hair cortisol concentration with brain‐derived neurotrophic factor gene methylation: The role of sex as a moderator
Association of hair cortisol concentration with brain‐derived neurotrophic factor gene methylation: The role of sex as a moderator Open
Hair cortisol concentration (HCC) reflects the long‐term activity of the hypothalamus‐pituitary‐adrenal (HPA) axis in response to stress. Brain‐derived neurotrophic factor DNA methylation (BDNF DNA M ) may affect HCC, and sex and Val66Met …
View article: Unraveling the link between atopic dermatitis and autoimmune diseases in children: Insights from a large-scale cohort study with 15-year follow-up and shared gene ontology analysis
Unraveling the link between atopic dermatitis and autoimmune diseases in children: Insights from a large-scale cohort study with 15-year follow-up and shared gene ontology analysis Open
Atopic dermatitis was significantly associated with an increased risk of subsequent autoimmune disease. we identified the genetically associated disease in atopic dermatitis patients comorbid with autoimmune disease and demonstrated a gene…
View article: Association of Wheezing Requiring Hospitalization Before 2 Years of Age With Autoimmune Diseases During Childhood: A 15-Year Follow-up Study From Birth
Association of Wheezing Requiring Hospitalization Before 2 Years of Age With Autoimmune Diseases During Childhood: A 15-Year Follow-up Study From Birth Open
This research identifies associations between early-life wheeze and the development of autoimmune diseases in childhood. Understanding these relationships can aid in recognizing the underlying pathophysiology of early-life wheeze and child…
View article: Therapeutic effectiveness of probiotics for atopic dermatitis: A systematic review and meta-analysis of randomized controlled trials with subgroup analysis
Therapeutic effectiveness of probiotics for atopic dermatitis: A systematic review and meta-analysis of randomized controlled trials with subgroup analysis Open
Probiotics can be beneficial for the treatment of AD, and their therapeutic effect may be individually tailored to improve it based on the severity of AD, strain of probiotics, duration of supplementation, and geographic region.
View article: Table of Contents
Table of Contents Open
View article: Structural Gender Imbalances in Ballet Collaboration Networks
Structural Gender Imbalances in Ballet Collaboration Networks Open
Ballet, a mainstream performing art predominantly associated with women, exhibits significant gender imbalances in leading positions. However, the collaboration's structural composition on gender representation in the field remains unexplo…
View article: Digital cognitive behavioral therapy for insomnia on depression and anxiety: a systematic review and meta-analysis
Digital cognitive behavioral therapy for insomnia on depression and anxiety: a systematic review and meta-analysis Open
Despite research into the development of digital cognitive behavioral therapy for insomnia (dCBT-I), research into the outcomes of dCBT-I on insomnia and the associated clinical conditions of depression and anxiety have been limited. The P…