Ji Kon Ryu
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View article: Serum gamma-glutamyl transferase level is associated with the risk of pancreatic cystic neoplasms: A nationwide retrospective cohort study
Serum gamma-glutamyl transferase level is associated with the risk of pancreatic cystic neoplasms: A nationwide retrospective cohort study Open
BACKGROUND Gamma-glutamyl transferase (GGT) is a known surrogate marker of hepatic dysfunction and oxidative stress. It has recently been reported to be associated with metabolic diseases, cardiovascular diseases, and malignancies includin…
View article: Comparison of 5‐Fluorouracil/Leucovorin and Capecitabine as Adjuvant Therapies in Biliary Tract Cancer
Comparison of 5‐Fluorouracil/Leucovorin and Capecitabine as Adjuvant Therapies in Biliary Tract Cancer Open
Background The prognosis of biliary tract cancer (BTC) is poor, and recurrence rates remain high even after curative resection. This study aimed to compare the efficacy and safety of capecitabine and 5‐fluorouracil/leucovorin (FL) as adjuv…
View article: Efficacy of Fully Covered Self-Expanding Metal Stents Removal versus Stent- in-Stent Techniques in Recurrent Malignant Distal Biliary Obstruction
Efficacy of Fully Covered Self-Expanding Metal Stents Removal versus Stent- in-Stent Techniques in Recurrent Malignant Distal Biliary Obstruction Open
Fully covered self-expandable metal stents (FCSEMSs) are widely used in managing malignant distal biliary obstruction (MDBO). However, recurrent biliary obstruction (RBO) has become a significant challenge due to improved patient survival …
View article: Eosinophilic Cholangitis Diagnosed in a Patient with Abnormal Liver Enzymes: A Case Report
Eosinophilic Cholangitis Diagnosed in a Patient with Abnormal Liver Enzymes: A Case Report Open
It is difficult to determine a cause of bile duct stricture and dilatation. Eosinophilic cholangitis, a rare benign condition, may be one cause of bile duct stricture and dilatation. It can be evaluated using various methods of histopathol…
View article: A Novel Digital Method for Accurate Endoscopic Size Measurement of Gastric Lesions: A Comparative Study With Visual and Forceps-Assisted Estimation
A Novel Digital Method for Accurate Endoscopic Size Measurement of Gastric Lesions: A Comparative Study With Visual and Forceps-Assisted Estimation Open
Given the observed error patterns in VE, endoscopists should exercise caution when evaluating polyp-shaped lesions and those located in the proximal stomach and greater curvature. The DEA outperformed conventional methods, especially for n…
View article: ATR inhibition promotes synergistic antitumor effect in platinum-resistant pancreatic cancer
ATR inhibition promotes synergistic antitumor effect in platinum-resistant pancreatic cancer Open
ATR inhibition enhanced the anticancer effect of oxaliplatin, suggesting that this combination treatment could be an effective therapeutic strategy for overcoming platinum resistance in PC.
View article: Factors affecting peripheral neuropathy induced by nanoparticle albumin‐bound paclitaxel in patients with pancreatic cancer
Factors affecting peripheral neuropathy induced by nanoparticle albumin‐bound paclitaxel in patients with pancreatic cancer Open
Aim Chemotherapy‐induced peripheral neuropathy (CIPN) is a major toxicity limiting the use of nab‐paclitaxel (Nab‐P) in treating patients with pancreatic cancer. The aim of this study was to identify the factors affecting CIPN using patien…
View article: Predictive biomarkers for metachronous gastric cancer development after endoscopic resection of early gastric cancer
Predictive biomarkers for metachronous gastric cancer development after endoscopic resection of early gastric cancer Open
Objectives We aimed to identify predictive markers for metachronous gastric cancer (MGC) in early gastric cancer (EGC) patients curatively treated with endoscopic submucosal dissection (ESD). Materials and Methods From EGC patients who und…
View article: Machine Learning-Based Prediction of Pulmonary Embolism to Reduce Unnecessary Computed Tomography Scans in Gastrointestinal Cancer Patients: A Retrospective Multicenter Study
Machine Learning-Based Prediction of Pulmonary Embolism to Reduce Unnecessary Computed Tomography Scans in Gastrointestinal Cancer Patients: A Retrospective Multicenter Study Open
Background Pulmonary embolism (PE) is one of the most important complications in cancer patients. Gastrointestinal cancers entail an increased risk of PE. However, there were few researches on predicting pulmonary embolism using machine le…
View article: Pancreatic Cancer Treatment Targeting the HGF/c-MET Pathway: The MEK Inhibitor Trametinib
Pancreatic Cancer Treatment Targeting the HGF/c-MET Pathway: The MEK Inhibitor Trametinib Open
Pancreatic cancer is characterized by fibrosis/desmoplasia in the tumor microenvironment, which is primarily mediated by pancreatic stellate cells and cancer-associated fibroblasts. HGF/c-MET signaling, which is instrumental in embryonic d…
View article: Antiproliferative Activity of Piceamycin by Regulating <i>Alpha-Actinin-4</i> in Gemcitabine-Resistant Pancreatic Cancer Cells
Antiproliferative Activity of Piceamycin by Regulating <i>Alpha-Actinin-4</i> in Gemcitabine-Resistant Pancreatic Cancer Cells Open
Although gemcitabine-based regimens are widely used as an effective treatment for pancreatic cancer, acquired resistance to gemcitabine has become an increasingly common problem. Therefore, a novel therapeutic strategy to treat gemcitabine…
View article: Two Cases of Life-Threatening Hemobilia Following Removal of Biliary Stents Treated with Covered Self-Expandable Metal Stents
Two Cases of Life-Threatening Hemobilia Following Removal of Biliary Stents Treated with Covered Self-Expandable Metal Stents Open
This corrects the article "Two Cases of Life-Threatening Hemobilia Following Removal of Biliary Stents Treated with Covered Self-Expandable Metal Stents" in Volume 28 on page 81.
View article: Genetic susceptibility to post-endoscopic retrograde cholangiopancreatography pancreatitis identified in propensity score-matched analysis
Genetic susceptibility to post-endoscopic retrograde cholangiopancreatography pancreatitis identified in propensity score-matched analysis Open
Background/Aims: A previous history of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a risk factor for PEP, suggesting that there may be a genetic predisposition to PEP. However, nothing is known about th…
View article: Optimal Follow-up of Incidental Pancreatic Cystic Lesions without Worrisome Features: Clinical Outcome after Long-term Follow-up
Optimal Follow-up of Incidental Pancreatic Cystic Lesions without Worrisome Features: Clinical Outcome after Long-term Follow-up Open
: CLPs should be continuously monitored after 5 years because of the persistent potential for malignant transformation of CLPs. An interval of 24 months for initial follow-up might be enough for CLPs with initial size of less than 2 cm in …
View article: Savolitinib: A Promising Targeting Agent for Cancer
Savolitinib: A Promising Targeting Agent for Cancer Open
Savolitinib is a highly selective small molecule inhibitor of the mesenchymal epithelial transition factor (MET) tyrosine kinase, primarily developed for the treatment of non-small cell lung cancer (NSCLC) with MET mutations. It is also be…
View article: Hematocrit Determination using a Volumetric Absorptive Microsampling Technique in Patients with Pancreatic Cancer
Hematocrit Determination using a Volumetric Absorptive Microsampling Technique in Patients with Pancreatic Cancer Open
Hematocrit, the volume percentage of erythrocytes in whole blood, is an essential hematological parameter used for identifying various clinical conditions such as anemia and erythrocytosis, and monitoring the clinical effects of a drug the…
View article: Hypertriglyceridaemic waist phenotype and waist circumference triglyceride index are associated with higher incidence of acute pancreatitis: a nationwide population-based retrospective cohort study
Hypertriglyceridaemic waist phenotype and waist circumference triglyceride index are associated with higher incidence of acute pancreatitis: a nationwide population-based retrospective cohort study Open
Objectives The hypertriglyceridaemic waist (HTGW) phenotype, an indicator to assess metabolic syndrome, could be a useful predictive marker for the risk of acute pancreatitis. This study aimed to evaluate the association between the HTGW p…
View article: Two Cases of Life-Threatening Hemobilia Following Removal of Biliary Stents Treated with Covered Self-Expandable Metal Stents
Two Cases of Life-Threatening Hemobilia Following Removal of Biliary Stents Treated with Covered Self-Expandable Metal Stents Open
Biliary stent removal can cause hemobilia due to injury to the adjacent vessel, but it is rarely reported. If significant hemobilia occurs during stent removal, samesession covered self-expandable metal stent (CSEMS) insertion may be usefu…
View article: Safety and Efficacy of Neoadjuvant SABR in Pancreatic Cancer: Effect of Magnetic Resonance Imaging–Guided Respiratory-Gated Adaptive Radiation Therapy
Safety and Efficacy of Neoadjuvant SABR in Pancreatic Cancer: Effect of Magnetic Resonance Imaging–Guided Respiratory-Gated Adaptive Radiation Therapy Open
Neoadjuvant SABR with 50 Gy using MRgRg-ART delivered to pancreatic cancer resulted in a notable survival outcome with acceptable toxicities. Further studies are warranted to investigate the long-term effects of this method.
View article: Optimal timing of surgery after neoadjuvant treatment in borderline resectable pancreatic cancer
Optimal timing of surgery after neoadjuvant treatment in borderline resectable pancreatic cancer Open
Hye-Sol JUNG, Youngmin HAN, Won-Gun YUN, Young Jae CHO, Mirang LEE, Do-Youn OH, In Rae CHO, Woo Hyun PAIK, Sang Hyub LEE, Ji Kon RYU, Yong-Tae KIM, Kyungbun LEE, Haeryoung KIM, Eui Kyu CHIE, Wooil KWON, Jin-Young JANG*. Ann Hepatobiliary P…
View article: Antiproliferative Activity of Krukovine by Regulating Transmembrane Protein 139 (TMEM139) in Oxaliplatin-Resistant Pancreatic Cancer Cells
Antiproliferative Activity of Krukovine by Regulating Transmembrane Protein 139 (TMEM139) in Oxaliplatin-Resistant Pancreatic Cancer Cells Open
Krukovine (KV) is an alkaloid isolated from the bark of Abuta grandifolia (Mart.) Sandw. (Menispermaceae) with anticancer potential in some cancers with KRAS mutations. In this study, we explored the anticancer efficacy and mechanism of KV…
View article: Clinical Significance of Venous Thromboembolism in Patients with Advanced Cholangiocarcinoma
Clinical Significance of Venous Thromboembolism in Patients with Advanced Cholangiocarcinoma Open
Background/Aims: Patients with active cancer frequently develop venous thromboembolism (VTE). However, there is little data about VTE in patients with advanced cholangiocarcinoma (CCA). Therefore, we investigated the clinical significance …
View article: Development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model
Development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model Open
Background As of date, endoscopic biliary stenting with plastic stent (PS) and self-expandable metal stent (SEMS) have been widely used for the palliation of biliary tract strictures. However, these two stents have several limitations rega…