Ji Su Hwang
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View article: EnsemPred-ACP: Combining machine and deep learning to improve anticancer peptide prediction
EnsemPred-ACP: Combining machine and deep learning to improve anticancer peptide prediction Open
Anticancer peptide (ACP) has emerged as potent therapeutic agents owing to its ability to selectively target cancer cells while minimising toxicity to healthy cells. However, the accurate computational prediction of ACP remains challenging…
View article: CPPpred-En: Ensemble framework integrating a protein language model and conventional features for highly accurate cell-penetrating peptide prediction
CPPpred-En: Ensemble framework integrating a protein language model and conventional features for highly accurate cell-penetrating peptide prediction Open
Cell-penetrating peptides (CPPs) have gained significant attention for biomedical applications, including drug delivery and therapeutic development, due to their ability to penetrate cell membranes. The accurate prediction of CPPs is criti…
View article: Synphilin-1 regulates mechanotransduction in rigidity sensing through interaction with zyxin
Synphilin-1 regulates mechanotransduction in rigidity sensing through interaction with zyxin Open
These findings provide novel insights into the biophysical functions of synphilin-1, suggesting a potential protective role to the altered extracellular matrix, which may be relevant to neurodegenerative conditions such as Parkinson's dise…
View article: Integrative Analysis of Metabolome and Proteome in the Cerebrospinal Fluid of Patients with Multiple System Atrophy
Integrative Analysis of Metabolome and Proteome in the Cerebrospinal Fluid of Patients with Multiple System Atrophy Open
Multiple system atrophy (MSA) is a progressive neurodegenerative synucleinopathy. Differentiating MSA from other synucleinopathies, especially in the early stages, is challenging because of its overlapping symptoms with other forms of Park…
View article: Biological Function Analysis of MicroRNAs and Proteins in the Cerebrospinal Fluid of Patients with Parkinson’s Disease
Biological Function Analysis of MicroRNAs and Proteins in the Cerebrospinal Fluid of Patients with Parkinson’s Disease Open
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by alpha-synuclein aggregation into Lewy bodies in the neurons. Cerebrospinal fluid (CSF) is considered the most suited source for investigating PD pathogen…
View article: Apical‐out Tubuloids for Accurate Kidney Toxicity Studies
Apical‐out Tubuloids for Accurate Kidney Toxicity Studies Open
In kidney organoids, typically only the basal membrane is exposed, limiting toxicity assessments of apically transported drugs. Although the reversion of basal‐out organoids has successfully created apical‐out organoids of the intestine an…
View article: Integrative Metabolome and Proteome Analysis of Cerebrospinal Fluid in Parkinson’s Disease
Integrative Metabolome and Proteome Analysis of Cerebrospinal Fluid in Parkinson’s Disease Open
Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra. Recent studies have highlighted the significant role of cerebrospinal fluid (CSF) in reflecting path…
View article: Human Bone Marrow-Derived Mesenchymal Stem Cell Applications in Neurodegenerative Disease Treatment and Integrated Omics Analysis for Successful Stem Cell Therapy
Human Bone Marrow-Derived Mesenchymal Stem Cell Applications in Neurodegenerative Disease Treatment and Integrated Omics Analysis for Successful Stem Cell Therapy Open
Neurodegenerative diseases (NDDs), which are chronic and progressive diseases, are a growing health concern. Among the therapeutic methods, stem-cell-based therapy is an attractive approach to NDD treatment owing to stem cells’ characteris…
View article: Diesel-derived PM2.5 induces impairment of cardiac movement followed by mitochondria dysfunction in cardiomyocytes
Diesel-derived PM2.5 induces impairment of cardiac movement followed by mitochondria dysfunction in cardiomyocytes Open
Particulate matter (PM) in polluted air can be exposed to the human body through inhalation, ingestion, and skin contact, accumulating in various organs throughout the body. Organ accumulation of PM is a growing health concern, particularl…
View article: Reduction in the Migration Activity of Microglia Treated with Silica-Coated Magnetic Nanoparticles and their Recovery Using Citrate
Reduction in the Migration Activity of Microglia Treated with Silica-Coated Magnetic Nanoparticles and their Recovery Using Citrate Open
Nanoparticles have garnered significant interest in neurological research in recent years owing to their efficient penetration of the blood–brain barrier (BBB). However, significant concerns are associated with their harmful effects, inclu…
View article: Development of Anticancer Peptides Using Artificial Intelligence and Combinational Therapy for Cancer Therapeutics
Development of Anticancer Peptides Using Artificial Intelligence and Combinational Therapy for Cancer Therapeutics Open
Cancer is a group of diseases causing abnormal cell growth, altering the genome, and invading or spreading to other parts of the body. Among therapeutic peptide drugs, anticancer peptides (ACPs) have been considered to target and kill canc…
View article: Cerebrospinal Fluid Metabolome in Parkinson’s Disease and Multiple System Atrophy
Cerebrospinal Fluid Metabolome in Parkinson’s Disease and Multiple System Atrophy Open
Parkinson’s disease (PD) and multiple system atrophy (MSA) belong to the neurodegenerative group of synucleinopathies; differential diagnosis between PD and MSA is difficult, especially at early stages, owing to their clinical and biologic…
View article: Analysis of Nanotoxicity with Integrated Omics and Mechanobiology
Analysis of Nanotoxicity with Integrated Omics and Mechanobiology Open
Nanoparticles (NPs) in biomedical applications have benefits owing to their small size. However, their intricate and sensitive nature makes an evaluation of the adverse effects of NPs on health necessary and challenging. Since there are li…
View article: Strategies to Improve the Quality and Freshness of Human Bone Marrow-Derived Mesenchymal Stem Cells for Neurological Diseases
Strategies to Improve the Quality and Freshness of Human Bone Marrow-Derived Mesenchymal Stem Cells for Neurological Diseases Open
Human bone marrow-derived mesenchymal stem cells (hBM-MSCs) have been studied for their application to manage various neurological diseases, owing to their anti-inflammatory, immunomodulatory, paracrine, and antiapoptotic ability, as well …
View article: A Study on Problem Solution of Culture Tourism Festival Through Big Data Analysis
A Study on Problem Solution of Culture Tourism Festival Through Big Data Analysis Open
Background/Objectives: Accordingly, this study proposes the successful model of the culture tourism festival and suggest the direction to go in the future.For this, the author analyzed the culture tourism festival that is held in each regi…