Jianan Wang
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View article: Renal insulin-like growth factor binding-protein 7 is a critical promoter of progressive diabetic kidney disease
Renal insulin-like growth factor binding-protein 7 is a critical promoter of progressive diabetic kidney disease Open
Renal tubulointerstitial abnormalities predict diabetic kidney disease (DKD) progression, and targeting them may prevent DKD. Insulin-like growth factor binding-protein 7 (IGFBP7) is expressed in renal tubular cells and is elevated in both…
View article: #2501 Mettl3-mediated m6A methylation of Ndrg1 promotes acute kidney injury sensitivity in diabetic kidney diseases
#2501 Mettl3-mediated m6A methylation of Ndrg1 promotes acute kidney injury sensitivity in diabetic kidney diseases Open
Background and Aims The incidence of acute kidney injury (AKI) in patients is associated with diabetic kidney. Nevertheless, the precise underlying mechanism remains unclear. We previously revealed that methyltransferase 3 (METTL3) mediate…
View article: Integrated multi-omics analysis of single-cell and spatial transcriptomics reveals distinct hpv-associated immune microenvironment features and prognostic signatures in cervical cancer
Integrated multi-omics analysis of single-cell and spatial transcriptomics reveals distinct hpv-associated immune microenvironment features and prognostic signatures in cervical cancer Open
Background Cervical cancer (CC) is a highly heterogeneous malignancy primarily driven by persistent infection with high-risk human papillomavirus (HPV). However, comprehensive analyses of heterogeneity in the immune microenvironment, parti…
View article: Relationships among the triglyceride-glucose index, its changes, and the development of metabolically obese normal weight are strengthened by increased visceral fat area
Relationships among the triglyceride-glucose index, its changes, and the development of metabolically obese normal weight are strengthened by increased visceral fat area Open
Background Metabolically obese normal weight (MONW), obesity with a normal body mass index, is often neglected due to the seemingly normal weight but has a high risk of metabolic diseases. This study aimed to assess associations among the …
View article: Firesorb bioresorbable scaffold for de novo coronary artery disease: 1-year clinical outcomes
Firesorb bioresorbable scaffold for de novo coronary artery disease: 1-year clinical outcomes Open
ClinicalTrials.gov Identifier: NCT02890160 and NCT03660202.
View article: Effects of Mavacamten on Cardiac Magnetic Resonance Features in Chinese Patients With Obstructive Hypertrophic Cardiomyopathy
Effects of Mavacamten on Cardiac Magnetic Resonance Features in Chinese Patients With Obstructive Hypertrophic Cardiomyopathy Open
At 30 weeks, improvements were observed in measures of cardiac structure and function, with reductions in indicators of myocardial fibrosis, in the mavacamten vs the placebo group. (A Study to Evaluate the Efficacy and Safety of Mavacamten…
View article: Feedback regulation between histone lactylation and ALKBH3-mediated glycolysis regulates age-related macular degeneration pathology
Feedback regulation between histone lactylation and ALKBH3-mediated glycolysis regulates age-related macular degeneration pathology Open
Age-related macular degeneration (AMD) is a leading cause of blindness among the elderly. It is characterized by degeneration of the retinal pigment epithelium (RPE), which can develop into choroidal neovascularization (CNV) to cause sever…
View article: A Concise Asymmetric Synthesis of Sex Pheromone of Euproctis pseudoconspersa (Strand) and Its Enantiomer
A Concise Asymmetric Synthesis of Sex Pheromone of Euproctis pseudoconspersa (Strand) and Its Enantiomer Open
The tea tussock moth, Euproctis pseudoconspersa (Strand), is a serious pest, and its sex pheromone is (R)-10,14-dimethylpentadecyl isobutyrate. A new and concise asymmetric synthesis of the sex pheromone and its enantiomer was accomplished…
View article: Knockdown of PARM1 Alleviates Aortic Valve Calcification via the PRKCH-MAPK Signaling Pathway
Knockdown of PARM1 Alleviates Aortic Valve Calcification via the PRKCH-MAPK Signaling Pathway Open
With the aging of the population, the prevalence of calcific aortic valve disease (CAVD) has increased yearly. However, effective means to delay or even reverse the progression of CAVD are still lacking. This study revealed that prostate a…
View article: Safety and Efficacy of Tafamidis in Chinese Patients with Transthyretin Amyloid Cardiomyopathy
Safety and Efficacy of Tafamidis in Chinese Patients with Transthyretin Amyloid Cardiomyopathy Open
NCT04814186.
View article: Ethnobotanical Use, Phytochemistry, Pharmacology, and Toxicity of Canavalia gladiata
Ethnobotanical Use, Phytochemistry, Pharmacology, and Toxicity of Canavalia gladiata Open
Canavalia gladiata (C. gladiata) is a significant traditional Chinese medicine that has been used to treat hiccups, vomiting, nausea, amenorrhea, chronic dysentery, larynx arthralgia, lumbago, and inflammatory diseases in Asia for a long h…
View article: Cardiomyocyte‐Enriched USP20 Ameliorates Pathological Cardiac Hypertrophy by Targeting STAT3 Deubiquitination
Cardiomyocyte‐Enriched USP20 Ameliorates Pathological Cardiac Hypertrophy by Targeting STAT3 Deubiquitination Open
Although pathological cardiac hypertrophy is a key driver of heart failure, the underlying mechanisms remain incompletely elucidated. This study investigates the role and mechanism of deubiquitinating enzyme (DUB) ubiquitin‐specific protea…
View article: Establishing an Efficient Electron Transfer System for P450 Enzyme OleP to Improve the Biosynthesis of Murideoxycholic Acid by Redox Partner Engineering
Establishing an Efficient Electron Transfer System for P450 Enzyme OleP to Improve the Biosynthesis of Murideoxycholic Acid by Redox Partner Engineering Open
The electron transfer from NAD(P)H to heme is a rate‐limiting step in the redox partner‐mediated catalysis of P450 enzyme. However, due to the lack of efficient engineering strategies, it is difficult to improve the properties of redox par…
View article: Establishing an Efficient Electron Transfer System for P450 Enzyme OleP to Improve the Biosynthesis of Murideoxycholic Acid by Redox Partner Engineering
Establishing an Efficient Electron Transfer System for P450 Enzyme OleP to Improve the Biosynthesis of Murideoxycholic Acid by Redox Partner Engineering Open
The electron transfer from NAD(P)H to heme is a rate‐limiting step in the redox partner‐mediated catalysis of P450 enzyme. However, due to the lack of efficient engineering strategies, it is difficult to improve the properties of redox par…
View article: Evaluation of aortic arch calcification to predict prognosis after transcatheter aortic valve replacement
Evaluation of aortic arch calcification to predict prognosis after transcatheter aortic valve replacement Open
Few centers routinely report aortic arch calcification (AAC) due to the lack of an easy and effective evaluation method. The association between AAC and the clinical prognosis of patients who undergo transcatheter aortic valve replacement …
View article: A Membrane Modification Technique for Left Atrial Appendage Occlusion
A Membrane Modification Technique for Left Atrial Appendage Occlusion Open
This study suggests that transcatheter LAAO using the SMART technique may effectively and safely prevent stroke in patients with nonvalvular atrial fibrillation. Although further studies with larger sample sizes are needed, this novel tech…
View article: Assessment tools for transition readiness in adolescents with inflammatory bowel disease: A scoping review
Assessment tools for transition readiness in adolescents with inflammatory bowel disease: A scoping review Open
Background Assessing the level of transition readiness in adolescents with inflammatory bowel disease is crucial; however, standardized research tools are lacking. This study aimed to map transition readiness assessment tools for adolescen…
View article: Risk Factors and Prognostic Implications of New‐Onset Atrial Fibrillation Following Transcatheter Aortic Valve Replacement
Risk Factors and Prognostic Implications of New‐Onset Atrial Fibrillation Following Transcatheter Aortic Valve Replacement Open
Background: Transcatheter aortic valve replacement (TAVR) has become a standard treatment for severe aortic stenosis. New‐onset atrial fibrillation (NOAF) is a common complication after TAVR, with significant implications for patient outco…
View article: Diagnostic Accuracy of Computational Fluid Dynamics‐Based Fractional Flow Reserve Derived From Coronary Angiography: The ACCURATE Study
Diagnostic Accuracy of Computational Fluid Dynamics‐Based Fractional Flow Reserve Derived From Coronary Angiography: The ACCURATE Study Open
Background Although fractional flow reserve (FFR) is the contemporary standard to detect hemodynamically significant coronary stenosis, it remains underused for the need of pressure wire and hyperemic stimulus. Coronary angiography‐derived…