Abstract Colorectal cancer (CRC) is among the most prevalent and deadly cancers worldwide. The Yes‐associated protein 1 (YAP1) is frequently dysregulated in cancers, contributing to cancer stemness, chemoresistance, and cancer‐related death. However, strategies directly targeting YAP1 have not yet been successful because of the lack of active binding pockets and unregulated toxicity. In this study, our Food and Drug Administration (FDA)‐approved drug screening reveals that abemaciclib, a cyclin‐dependent kinase 4/…

Background A marked increase in suicide rate has been detected among individuals diagnosed with leukemia. Our research aimed to develop a predictive model intended for assessing the suicide risk in leukemia patients. This novel tool aims to optimize the process of pinpointing individuals at high risk within clinical environments, thereby guaranteeing the timely provision of targeted intervention strategies. Methods Between 2000 and 2020, our study involved a cohort of 194584 leukemia patients, extracted from the S…

Background: White noise has attracted widespread attention due to its potential effects on psychological and physiological states, particularly in promoting relaxation. The prefrontal cortex, a critical region of the brain responsible for higher cognitive functions and emotional regulation, may influence an individual’s mental and physical health through its responses to external stimuli. Although previous research has investigated the calming effects of white noise, systematic studies on its specific impact on pr…

Abstract The von Hippel-Lindau (VHL) protein (pVHL) functions as a potent tumor suppressor by mediating the degradation or inactivation of various substrates, including HIFα and Akt. However, pVHL is frequently downregulated in numerous cancers harboring wild-type VHL , and underlying mechanisms remains elusive. Aberrant glucose metabolism is a hallmark of cancer, driving tumor progression and therapeutic resistance. Despite this, the connection between glucose homoeostasis and pVHL turnover and functions has yet …

ABSTRACT Single‐atom (SA) sites have garnered significant attention in electrochemical applications due to their ability to leverage the unique electronic properties of isolated metal atoms, thereby enhancing interfacial charge transfer and detection sensitivity. Despite the limited exploration of electrochemical sensors utilizing SA, their integration into sensing electrodes holds great promise for improving the sensitivity and selectivity of bioactive molecule detection. In this study, SA modified electrodes wer…