Jian Ji
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View article: An inhalable gallium-polyphenol nanoparticle blocks bacterial electron transport chain and signal transduction for anti-biofilm therapy
An inhalable gallium-polyphenol nanoparticle blocks bacterial electron transport chain and signal transduction for anti-biofilm therapy Open
Bacterial biofilms have become an escalating global health threat due to their persistent infections and antimicrobial resistance. Conventional antibacterial approaches often fail to eliminate biofilms due to biofilm complexity involving b…
View article: Investigation of region-of-interest-based functional connectivity within the default mode network among adolescents with depression complicated by obesity
Investigation of region-of-interest-based functional connectivity within the default mode network among adolescents with depression complicated by obesity Open
Background This study utilized resting-state functional magnetic resonance imaging (rs-fMRI) combined with default mode network (DMN) region-of-interest (ROI)-based functional connectivity (FC) analysis to examine adolescents with depressi…
View article: A versatile multimodal learning framework bridging multiscale knowledge for material design
A versatile multimodal learning framework bridging multiscale knowledge for material design Open
Artificial intelligence has achieved remarkable success in materials science, accelerating novel material design. However, real-world material systems exhibit multiscale complexity—spanning composition, processing, structure, and propertie…
View article: Homeostasis of Gut Microbiota Protects against Susceptibility to Fungal Pneumonia
Homeostasis of Gut Microbiota Protects against Susceptibility to Fungal Pneumonia Open
Fungal pneumonia is a serious disease with great harm and high prevalence, presenting significant challenges in diagnosis and treatment. The gut and respiratory microbiota play a critical role in protecting lung health against fungal pneum…
View article: Pressure-driven microinjection (PMI) of porous-coated balloon for ultrafast endoluminal drug delivery across biological barriers
Pressure-driven microinjection (PMI) of porous-coated balloon for ultrafast endoluminal drug delivery across biological barriers Open
Biological barriers play a crucial role in safeguarding the human body against pathogens yet pose severe challenges to efficient delivery of therapeutic drugs. Here, we introduce a pressure-driven microinjection (PMI) strategy for the robu…
View article: Exploring the genetic basis of Newcastle disease virus in chickens: a comprehensive review
Exploring the genetic basis of Newcastle disease virus in chickens: a comprehensive review Open
Newcastle disease (ND) is one of the most serious viral diseases affecting chickens and is caused by Newcastle disease virus (NDV), an avian paramyxovirus serotype-1. The virus contains five structural proteins and two nonstructural protei…
View article: Immunocompatible Elastomer With Enhanced Fibrous Capsule‐Resistance and Elasticity by Water‐Induced Surface Phase Reconfiguration.
Immunocompatible Elastomer With Enhanced Fibrous Capsule‐Resistance and Elasticity by Water‐Induced Surface Phase Reconfiguration. Open
Integrating surface and bulk heterogeneity enables synergistic optimization of implantable biomaterials, harmonizing surface‐tissue interactions with the mechanical integrity of the bulk. However, achieving this heterogeneity within a sing…
View article: A study of seed-point-based functional connectivity in the default network of patients with adolescent depression complicated by obesity
A study of seed-point-based functional connectivity in the default network of patients with adolescent depression complicated by obesity Open
BACKGROUD: This study utilized resting-state functional magnetic resonance imaging (rs-fMRI) combined with default mode network (DMN) seed-point-based functional connectivity (FC) analysis to examine adolescents with depression complicated…
View article: A Broad‐Spectrum Antiviral Phase‐Transformable Liposome with Membrane Fusion‐Mediated Virucidal Capability
A Broad‐Spectrum Antiviral Phase‐Transformable Liposome with Membrane Fusion‐Mediated Virucidal Capability Open
Viral infection is a significant threat to global public health. Available antiviral drugs are effective only for specific viruses. It is imperative to develop broad‐spectrum antiviral drugs. The heparin sulfate proteoglycan (HSPG) biomime…
View article: Ficolin‐3 Activates Complement and Triggers Necroptosis in Cholangiocarcinoma Cells via the <scp>RIPK1</scp> / <scp>RIPK3</scp> / <scp>MLKL</scp> Signaling Pathway
Ficolin‐3 Activates Complement and Triggers Necroptosis in Cholangiocarcinoma Cells via the <span>RIPK1</span> / <span>RIPK3</span> / <span>MLKL</span> Signaling Pathway Open
Ficolin 3 (FCN3) is a pattern recognition molecule that activates the complement system via the lectin pathway. While its immunological roles are known, the specific mechanisms by which FCN3 affects cholangiocarcinoma (CCA) pathogenesis re…
View article: Deep learning guided discovery of antibacterial polymeric nanoparticles
Deep learning guided discovery of antibacterial polymeric nanoparticles Open
Drug-resistant bacterial infections pose a serious threat to global health, driving the development of novel antibacterial strategies beyond classic antibiotics. Self-assembled polymeric nanoparticles (SANPs) have emerged as promising cand…
View article: MMG-Based Motion Segmentation and Recognition of Upper Limb Rehabilitation Using the YOLOv5s-SE
MMG-Based Motion Segmentation and Recognition of Upper Limb Rehabilitation Using the YOLOv5s-SE Open
Mechanomyography (MMG) is a non-invasive technique for assessing muscle activity by measuring mechanical signals, offering high sensitivity and real-time monitoring capabilities, and it has many applications in rehabilitation training. Tra…
View article: A Novel Prognostic Signature Integrating Immune and Glycolytic Pathways for Enhanced Prognosis and Immunotherapy Prediction in Hepatocellular Carcinoma
A Novel Prognostic Signature Integrating Immune and Glycolytic Pathways for Enhanced Prognosis and Immunotherapy Prediction in Hepatocellular Carcinoma Open
The IGRPS, based on immune- and glycolysis-related genes, effectively predicted prognosis and immunotherapy responses in HCC patients.
View article: Chain entanglement enhanced strong and tough wool keratin/albumin fibers for bioabsorbable and immunocompatible surgical sutures
Chain entanglement enhanced strong and tough wool keratin/albumin fibers for bioabsorbable and immunocompatible surgical sutures Open
High-performance fibers derived from non-silk proteins have garnered significant interest in biomedical applications because of their high accessibility and biocompatibility. Nonetheless, considerable challenges persist in addressing their…
View article: Clinical Outcomes of Hypertonic Saline vs Mannitol Treatment Among Children With Traumatic Brain Injury
Clinical Outcomes of Hypertonic Saline vs Mannitol Treatment Among Children With Traumatic Brain Injury Open
Importance The use of hypertonic saline (HTS) vs mannitol in the control of elevated intracranial pressure (ICP) secondary to neurotrauma is debated. Objective To compare mortality and functional outcomes of treatment with 3% HTS vs 20% ma…
View article: Engineering Multi‐Site Platinum Ensembles Synergistically Boosts Catalysis
Engineering Multi‐Site Platinum Ensembles Synergistically Boosts Catalysis Open
Engineering stable and efficient noble metal ensembles with multi‐type active sites while understanding the role of each site at the atomic level remains a significant challenge in heterogeneous catalysis. Herein, a sub‐nanometric Pt ensem…
View article: Strategy Optimization for a Combined Procedure in Patients With Atrial Fibrillation
Strategy Optimization for a Combined Procedure in Patients With Atrial Fibrillation Open
Importance The optimal strategy of combining left atrial appendage occlusion (LAAO) with catheter ablation (CA) in patients with atrial fibrillation (AF) during a single procedure remains unclear. Objective To determine the effects of abla…
View article: Synergistic wall digestion and cuproptosis against fungal infections using lywallzyme-induced self-assembly of metal-phenolic nanoflowers
Synergistic wall digestion and cuproptosis against fungal infections using lywallzyme-induced self-assembly of metal-phenolic nanoflowers Open
Fungi are very common infectious pathogens, which may cause invasive and potentially life-threatening infections. However, the efficacy of antifungal medications remains limited. Herein, a Cu2+-phenolic nanoflower is designed to combat fun…