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View article: The Impact of Body Mass Index on the Outcomes of In Vitro Fertilization in Patients with Polycystic Ovary Syndrome
The Impact of Body Mass Index on the Outcomes of In Vitro Fertilization in Patients with Polycystic Ovary Syndrome Open
Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder, accounting for approximately 80%–95% of anovulatory infertility cases. Patients with PCOS face various challenges during in vitro fertilization and embryo trans…
View article: Hereditary spherocytosis concomitant with JAK2V617F-positive primary myelofibrosis: a case report
Hereditary spherocytosis concomitant with JAK2V617F-positive primary myelofibrosis: a case report Open
Hereditary spherocytosis (HS) is a genetic hemolytic disorder primarily characterized by hemolytic anemia, jaundice, splenomegaly, and frequent complications, including cholelithiasis, accompanied by the presence of spherocytes in the peri…
View article: Low-intensity focused ultrasound stimulation on the hippocampus improved CSDS-induced neuroinflammation through the Notch1 signaling pathway
Low-intensity focused ultrasound stimulation on the hippocampus improved CSDS-induced neuroinflammation through the Notch1 signaling pathway Open
Exploring compensations for the limitations of current depression treatments holds significant social and clinical value. Low-intensity focused ultrasound (LIFU) is a promising emerging non-invasive therapy for the treatment of depression.…
View article: Association Between Gut Microbiota and Chronic Kidney Disease: A Two-Sample Mendelian Randomization Study in a Chinese Population
Association Between Gut Microbiota and Chronic Kidney Disease: A Two-Sample Mendelian Randomization Study in a Chinese Population Open
Background: Population differences in gut microbiota composition and related metabolites may influence their potential causal relationship with chronic kidney disease (CKD); however, this relationship remains poorly understood in the Chine…
View article: Hypertranscription of <scp>rDNA</scp> Responsible for Nucleolar Remodelling is a Doorman for Acquiring Pluripotency
Hypertranscription of <span>rDNA</span> Responsible for Nucleolar Remodelling is a Doorman for Acquiring Pluripotency Open
Ribosome biogenesis occurs within the nucleolus, with the initial step being the transcription of ribosomal DNA (rDNA). Although rDNA transcription is limited in somatic cells, it is more active in stem cells. Nevertheless, the mechanisms …
View article: Intercellular Communication Network of CellChat Uncovers Mechanisms of Kidney Fibrosis Based on Single-Cell RNA Sequencing
Intercellular Communication Network of CellChat Uncovers Mechanisms of Kidney Fibrosis Based on Single-Cell RNA Sequencing Open
Background: Chronic kidney disease (CKD) is a global health concern, with renal fibrosis being a major pathological feature. Empagliflozin (Empa), a sodium-glucose co-transporter-2 inhibitor, has shown promise in protecting the kidney. Thi…
View article: Effects of Acorns on Subcutaneous Fat Deposition in Yuxi Black Pigs by Transcriptomic Analysis
Effects of Acorns on Subcutaneous Fat Deposition in Yuxi Black Pigs by Transcriptomic Analysis Open
Background/Objectives: The backfat thickness of pigs is closely related to dorsal subcutaneous fat deposition and meat quality, and appropriate reduction in backfat thickness is important for improving pork quality. The present study inves…
View article: Dynamics and Efficacy: A Comprehensive Evaluation of the Advanced Dengue Fever Surveillance and Early Warning System in Ningbo City, 2023
Dynamics and Efficacy: A Comprehensive Evaluation of the Advanced Dengue Fever Surveillance and Early Warning System in Ningbo City, 2023 Open
The study underscores the critical role of public health bodies in managing disease outbreaks and advocates for enhanced methodologies to refine epidemic control efforts. The findings contribute to the advancement of early warning mechanis…
View article: Lactate modulates zygotic genome activation through H3K18 lactylation rather than H3K27 acetylation
Lactate modulates zygotic genome activation through H3K18 lactylation rather than H3K27 acetylation Open
In spite of its essential role in culture media, the precise influence of lactate on early mouse embryonic development remains elusive. Previous studies have implicated lactate accumulation in medium affecting histone acetylation. Recent r…
View article: Development and Validation of a Necroptosis-Related Prognostic Model in Head and Neck Squamous Cell Carcinoma
Development and Validation of a Necroptosis-Related Prognostic Model in Head and Neck Squamous Cell Carcinoma Open
Necroptosis is a new regulated cell-death mechanism that plays a critical role in various cancers. However, few studies have considered necroptosis-related genes (NRGs) as prognostic indexes for cancer. As one of the most common cancers in…
View article: [Analysis of the efficacy and safety of plerixafor combined with G-CSF in plasma cell disease mobilization].
[Analysis of the efficacy and safety of plerixafor combined with G-CSF in plasma cell disease mobilization]. Open
Objective: To analyze the effect and safety of plerixafor combined with G-CSF mobilization in plasma cell disease. Methods: The clinical baseline data, success rate of collection, and adverse reactions of consecutive cases of plasma cell d…
View article: Amount of maternal factor within the male pronucleus affects the reprogramming and developmental efficiency of androgenetic embryos
Amount of maternal factor within the male pronucleus affects the reprogramming and developmental efficiency of androgenetic embryos Open
Background Uniparental embryos have uniparental genomes and are very useful models for studying parental specific gene expression or for exploring the biological significance of genomic imprinting in mammals. However, the early development…
View article: Iron Homeostasis Determines Fate of Human Pluripotent Stem Cells Via Glycerophospholipids-Epigenetic Circuit
Iron Homeostasis Determines Fate of Human Pluripotent Stem Cells Via Glycerophospholipids-Epigenetic Circuit Open
Iron homeostasis is crucial for a variety of biological processes, but the biological role of iron homeostasis in pluripotent stem cells (PSCs) remains largely unknown. The present study aimed to determine whether iron homeostasis is invol…
View article: Rapamycin and FTY720 Alleviate Atherosclerosis by Cross Talk of Macrophage Polarization and Autophagy
Rapamycin and FTY720 Alleviate Atherosclerosis by Cross Talk of Macrophage Polarization and Autophagy Open
Foam cell formation and macrophage polarization are involved in the pathologic development of atherosclerosis, one of the most important human diseases affecting large and medium artery walls. This study was designed to assess the effects …
View article: RNAi-mediated knockdown of <i>Parp1</i> does not improve the development of female cloned mouse embryos
RNAi-mediated knockdown of <i>Parp1</i> does not improve the development of female cloned mouse embryos Open
Somatic cell nuclear transfer is an important technique for life science research, but its efficiency is still extremely low, and most genes that are important during early development, such as X chromosome-linked genes, are not appropriat…
View article: iTRAQ-based quantitative proteomic analysis of Yamanaka factors reprogrammed breast cancer cells
iTRAQ-based quantitative proteomic analysis of Yamanaka factors reprogrammed breast cancer cells Open
Cancer cells had been developed to be reprogrammed into embryonic stem like cells by induced pluripotent stem cells (iPSCs) technology, however, the tumor differentiation/dedifferentiation mechanisms had not yet been analyzed on a genome-w…
View article: CDX2 is essential for cell proliferation and polarity in porcine blastocysts
CDX2 is essential for cell proliferation and polarity in porcine blastocysts Open
The role of CDX2 in trophectoderm (TE) cells has been extensively studied, yet the results are contradictory and species specific. Here, CDX2 expression and function were explored in early porcine embryos. Notably, siRNA-mediated gene knoc…
View article: miRNA-223 inhibits epithelial-mesenchymal transition in gastric carcinoma cells via Sp1
miRNA-223 inhibits epithelial-mesenchymal transition in gastric carcinoma cells via Sp1 Open
Sp1 plays critical roles in epithelial-mesenchymal transition (EMT) of certain cancer. However, few studies have indicated whether Sp1 is involved in the EMT of gastric cancer, and whether abnormal expression of Sp1 in gastric cancer EMT i…
View article: Embryos aggregation improves development and imprinting gene expression in mouse parthenogenesis
Embryos aggregation improves development and imprinting gene expression in mouse parthenogenesis Open
Mouse parthenogenetic embryonic stem cells (Pg ESC s) could be applied to study imprinting genes and are used in cell therapy. Our previous study found that stem cells established by aggregation of two parthenogenetic embryos at 8‐cell sta…
View article: Exendin-4 enhances expression of Neurod1 and Glut2 in insulin-producing cells derived from mouse embryonic stem cells
Exendin-4 enhances expression of Neurod1 and Glut2 in insulin-producing cells derived from mouse embryonic stem cells Open
Exendin-4 remarkably facilitated Neurod1 and Glut2 gene transcription, and was able to induce differentiation of embryonic stem cells into endocrine and insulin-producing cells.