Justine Jia Wen Seow
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View article: Antigen reactivity defines tissue-resident memory and exhausted T cells in tumours
Antigen reactivity defines tissue-resident memory and exhausted T cells in tumours Open
CD8 + T cells are a key weapon in the therapeutic armamentarium against cancer. While CD8 + CD103 + T cells with a tissue-resident memory T (T RM ) cell phenotype have been favourably correlated with patient prognoses 1–6 , the tumour micr…
View article: CAN-Scan: A multi-omic phenotype-driven precision oncology platform identifies prognostic biomarkers of therapy response for colorectal cancer
CAN-Scan: A multi-omic phenotype-driven precision oncology platform identifies prognostic biomarkers of therapy response for colorectal cancer Open
Application of machine learning (ML) on cancer-specific pharmacogenomic datasets shows immense promise for identifying predictive response biomarkers to enable personalized treatment. We introduce CAN-Scan, a precision oncology platform, w…
View article: Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression
Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression Open
Stem-like T cells are attractive immunotherapeutic targets in patients with cancer given their ability to proliferate and differentiate into effector progeny. Thus, identifying T cells with enhanced stemness and understanding their develop…
View article: An <scp>AI</scp> ‐assisted integrated, scalable, single‐cell phenomic‐transcriptomic platform to elucidate intratumor heterogeneity against immune response
An <span>AI</span> ‐assisted integrated, scalable, single‐cell phenomic‐transcriptomic platform to elucidate intratumor heterogeneity against immune response Open
We present a novel framework combining single‐cell phenotypic data with single‐cell transcriptomic analysis to identify factors underpinning heterogeneity in antitumor immune response. We developed a pairwise, tumor‐immune discretized inte…
View article: CD38 marks the exhausted CD8+ tissue-resident memory T cells in hepatocellular carcinoma
CD38 marks the exhausted CD8+ tissue-resident memory T cells in hepatocellular carcinoma Open
Introduction Despite recent advances in immunotherapy for hepatocellular carcinoma (HCC), the overall modest response rate underscores the need for a better understanding of the tumor microenvironment (TME) of HCC. We have previously shown…
View article: Trajectory of immune evasion and cancer progression in hepatocellular carcinoma
Trajectory of immune evasion and cancer progression in hepatocellular carcinoma Open
View article: Single-Cell RNA-seq Reveals Angiotensin-Converting Enzyme 2 and Transmembrane Serine Protease 2 Expression in TROP2+ Liver Progenitor Cells: Implications in Coronavirus Disease 2019-Associated Liver Dysfunction
Single-Cell RNA-seq Reveals Angiotensin-Converting Enzyme 2 and Transmembrane Serine Protease 2 Expression in TROP2+ Liver Progenitor Cells: Implications in Coronavirus Disease 2019-Associated Liver Dysfunction Open
The recent coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2. COVID-19 was first reported in China (December 2019) and is now prevalent across the globe. Entry of severe acute respira…
View article: Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma
Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma Open
View article: Single‐Cell RNA Sequencing for Precision Oncology: Current State-of-Art
Single‐Cell RNA Sequencing for Precision Oncology: Current State-of-Art Open
View article: scRNA-seq reveals ACE2 and TMPRSS2 expression in TROP2<sup>+</sup>Liver Progenitor Cells: Implications in COVID-19 associated Liver Dysfunction
scRNA-seq reveals ACE2 and TMPRSS2 expression in TROP2<sup>+</sup>Liver Progenitor Cells: Implications in COVID-19 associated Liver Dysfunction Open
Summary The recent pandemic of coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 was first reported in China (December 2019) and now prevalent in ∼170 countries across t…
View article: ChronQC: a quality control monitoring system for clinical next generation sequencing
ChronQC: a quality control monitoring system for clinical next generation sequencing Open
Summary ChronQC is a quality control (QC) tracking system for clinical implementation of next-generation sequencing (NGS). ChronQC generates time series plots for various QC metrics to allow comparison of current runs to historical runs. C…