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View article: To explore the association between the neutrophil percentage to albumin ratio and low bone mineral density/osteoporosis based on NHANES 2011–2018
To explore the association between the neutrophil percentage to albumin ratio and low bone mineral density/osteoporosis based on NHANES 2011–2018 Open
View article: Associations between dietary macronutrient quality and odds of hyperlipidemia: findings from the NEC-Biobank cohort
Associations between dietary macronutrient quality and odds of hyperlipidemia: findings from the NEC-Biobank cohort Open
Background Associations between the overall quality of dietary macronutrients and the odds of hyperlipidemia remain unknown. This study aimed to first investigate the aforementioned associations, applying a novel multidimensional macronutr…
View article: Helicobacter pylori Promoted miR-196a/b-5p Expression and Accelerated Tumorigenesis of the Gastric Mucosa by Targeting IGF2BP1 and Activating PI3K-Akt Signaling Pathway
Helicobacter pylori Promoted miR-196a/b-5p Expression and Accelerated Tumorigenesis of the Gastric Mucosa by Targeting IGF2BP1 and Activating PI3K-Akt Signaling Pathway Open
Background/Aims: The study focuses on examining the impact of Helicobacter pylori (H. pylori) on the modulation of the miRNA expression profiles while also unraveling the associated pathways that play a significant role in initiating and d…
View article: Unveiling the Therapeutic Potential of Baicalin in Intervertebral Disc Degeneration: Integrative Bulk and Single-Cell Transcriptome Analysis with Experimental Validation of PANoptosis Inhibition
Unveiling the Therapeutic Potential of Baicalin in Intervertebral Disc Degeneration: Integrative Bulk and Single-Cell Transcriptome Analysis with Experimental Validation of PANoptosis Inhibition Open
Our findings reveal a critical role of PANoptosis in IVDD progression and demonstrate that baicalin alleviates disc degeneration by inhibiting PANoptosis. This study provides novel insights into PANoptosis as a promising therapeutic target…
View article: Endoscopists and endoscopic assistants’ qualifications, but not their biopsy rates, improve gastric precancerous lesions detection rate
Endoscopists and endoscopic assistants’ qualifications, but not their biopsy rates, improve gastric precancerous lesions detection rate Open
BACKGROUND Detecting gastric precancerous lesions (GPLs) is critical for the early diagnosis and treatment of gastric cancer. Endoscopy combined with tissue examination is an important method for detecting GPLs. However, negative biopsy re…
View article: Analysis of Key Differential Metabolites in Intervertebral Disc Degeneration Based on Untargeted Metabolomics
Analysis of Key Differential Metabolites in Intervertebral Disc Degeneration Based on Untargeted Metabolomics Open
Background Intervertebral disc degeneration disease (IVDD) is a prevalent orthopedic condition that causes chronic lower back pain, imposing a substantial economic burden on patients and society. Despite its high incidence, the pathophysio…
View article: Seismic Response Analysis of Continuous Girder Bridges Crossing Faults with Assembled Rocking-Self-Centering Piers
Seismic Response Analysis of Continuous Girder Bridges Crossing Faults with Assembled Rocking-Self-Centering Piers Open
Under the action of cross-fault ground motion, bridge piers can experience significant residual displacements, which can irreversibly impact the integrity and reliability of the bridge structure. Traditional seismic mitigation measures str…
View article: Exploring the therapeutic potential of puerarin on intervertebral disc degeneration by regulating apoptosis of nucleus pulposus cells
Exploring the therapeutic potential of puerarin on intervertebral disc degeneration by regulating apoptosis of nucleus pulposus cells Open
Intervertebral disc degeneration (IVDD) stands as a prevalent chronic orthopedic ailment, profoundly impacting patients' well‐being due to incapacitating low back pain. Studies have highlighted a close correlation between IVDD and the prog…
View article: Identifying critical modules and biomarkers of intervertebral disc degeneration by using weighted gene co‐expression network
Identifying critical modules and biomarkers of intervertebral disc degeneration by using weighted gene co‐expression network Open
Background Intervertebral disc degeneration (IVDD) is an age‐related orthopedic degenerative disease characterized by recurrent episodes of lower back pain, the pathogenesis of which is not fully understood. This study aimed to identify ke…
View article: Seismic responses of isolated bridges subjected to near-fault ground motions: simple pulses vs. whole records
Seismic responses of isolated bridges subjected to near-fault ground motions: simple pulses vs. whole records Open
Velocity pulse with strong energy input is the significant feature of near-fault ground motions. Bridges close to or passing across seismic faults may suffer from higher failure risk, which is inseparable from the influence of velocity pul…
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Table of Contents Open