Zhu Zhang
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View article: Quantifying Manure’s Fertilizer Nitrogen Equivalence to Optimize Chemical Fertilizer Substitution in Potato Production
Quantifying Manure’s Fertilizer Nitrogen Equivalence to Optimize Chemical Fertilizer Substitution in Potato Production Open
Accurate quantification of the Fertilizer Nitrogen Equivalence (FNE) of manure is crucial for optimizing integrated nitrogen (N) management and reducing chemical fertilizer use in potato production. However, uncertainties persist regarding…
View article: Limosilactobacillus reuteri Urob-7 Alleviates Hyperuricemia by Modulating Uric Acid Metabolism Through Nucleoside Degradation and Xanthine Oxidase Inhibition
Limosilactobacillus reuteri Urob-7 Alleviates Hyperuricemia by Modulating Uric Acid Metabolism Through Nucleoside Degradation and Xanthine Oxidase Inhibition Open
Hyperuricemia (HUA), a metabolic disorder characterized by elevated serum uric acid resulting from imbalanced production and excretion, is associated with gout and other serious health issues. This study aimed to screen out the potential p…
View article: Multi-Metaomics Unveils the Development Process of Microbial Communities During the Fermentation of Baobaoqu
Multi-Metaomics Unveils the Development Process of Microbial Communities During the Fermentation of Baobaoqu Open
In order to understand the dynamic interaction process among species, enzymes, and metabolites during the fermentation process of Baobaoqu, which is a representative Daqu starter for Chinese baijiu, the intimate connection between the prog…
View article: Pharmacological Effect and Clinical Application of Panax Notoginseng in Cardiovascular and Cerebrovascular Diseases
Pharmacological Effect and Clinical Application of Panax Notoginseng in Cardiovascular and Cerebrovascular Diseases Open
With the change of lifestyle and the acceleration of an aging society, the incidence of cardiovascular and cerebrovascular diseases (CCVDs) is increasing, which has become one of the major challenges of global public health. Panax notogins…
View article: Clinical and computed tomography characteristics of high-risk periampullary diverticulum
Clinical and computed tomography characteristics of high-risk periampullary diverticulum Open
Patients with HRPAD and those with N-HRPAD exhibited different clinical and imaging characteristics. A thorough understanding of these differences may facilitate early identification of HRPAD and timely treatment interventions, which would…
View article: Quality Analysis of Raw Material and Products of Goat Bezoar (Houzao), a Mysterious Traditional Medicine
Quality Analysis of Raw Material and Products of Goat Bezoar (Houzao), a Mysterious Traditional Medicine Open
Background Goat bezoar (Houzao in Chinese, also called “monkey” bezoar or Caprae Calculus) is a valued traditional Chinese medicine (TCM) used in the treatment of pediatric cough for centuries. However, its undefined chemical composition h…
View article: From Adipose to Action: Reprogramming Stem Cells for Functional Neural Progenitors for Neural Regenerative Therapy
From Adipose to Action: Reprogramming Stem Cells for Functional Neural Progenitors for Neural Regenerative Therapy Open
Neural stem cells have shown great potential in the therapy of neurodegenerative diseases such as Parkinson’s disease (PD), because of their ability to differentiate into various types of neural cells and substitute for damaged neurons. Th…
View article: The Role of the Pulmonary Vascular Microenvironment in Chronic Thromboembolic Pulmonary Hypertension
The Role of the Pulmonary Vascular Microenvironment in Chronic Thromboembolic Pulmonary Hypertension Open
Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by persistent obstruction and vascular remodeling of the pulmonary arteries following pulmonary thromboembolism (PTE), diagnosed after a minimum of 3 months of therapeu…
View article: Study on the relationship with knowledge, attitudes, and practices for prevention control of hepatitis B among university students in Hubei Province, China
Study on the relationship with knowledge, attitudes, and practices for prevention control of hepatitis B among university students in Hubei Province, China Open
This study evaluated the current status of knowledge, attitudes, and practices (KAP) concerning hepatitis B prevention and control among university students in Hubei province while also identifying the factors associated with their practic…
View article: Performance of Bleeding Risk Scores for Major Bleeding in Anticoagulated Patients with Pulmonary Embolism: Insights from the CURES Registry-2
Performance of Bleeding Risk Scores for Major Bleeding in Anticoagulated Patients with Pulmonary Embolism: Insights from the CURES Registry-2 Open
Most bleeding risk scores for pulmonary embolism (PE) were developed in patients receiving traditional anticoagulants. Evidence in East Asian populations and its applicability to direct oral anticoagulants (DOACs) remain limited. This post…
View article: Paeoniflorin Improves Stroke by Modulating the ESR1 Pathway: Data Mining and Validation Based on Network Approaches
Paeoniflorin Improves Stroke by Modulating the ESR1 Pathway: Data Mining and Validation Based on Network Approaches Open
Aim of the study: Traditional Chinese herbs have a unique therapeutic effect on stroke and numerous successful clinical cases. However, these clinical cases are highly dispersed, creating challenges for translational research. This study e…
View article: Protection against lethal HAdV-4 challenge in STAT1 mice by novel human monoclonal antibodies
Protection against lethal HAdV-4 challenge in STAT1 mice by novel human monoclonal antibodies Open
Introduction Human adenovirus serotype 4 (HAdV-4) is an epidemic pathogen associated with severe acute respiratory disease (ARD) in both pediatric and adult populations. Currently, no available vaccine or therapeutic interventions specific…
View article: Exploring the patterns in traditional Chinese medicine for bipolar disorder: a data-driven network approach
Exploring the patterns in traditional Chinese medicine for bipolar disorder: a data-driven network approach Open
Aim of the study Traditional Chinese Medicine offers a holistic approach that could provide complementary benefits for bipolar disorder treatment. However, the clinical cases in Traditional Chinese Medicine are highly dispersed, creating c…
View article: Genomic characterization of Candida parapsilosis hospital isolates revealed the spread and persistence of a fluconazole-resistant cluster associated with increased erg11 copies
Genomic characterization of Candida parapsilosis hospital isolates revealed the spread and persistence of a fluconazole-resistant cluster associated with increased erg11 copies Open
Candida parapsilosis is one of the most common species associated with candidemia infections globally. Recently, the emergence of fluconazole-resistant C. parapsilosis has become a significant global public health concern. In this study, w…
View article: Adolescent exposure to micro/nanoplastics induces cognitive impairments in mice with neuronal morphological damage and multi-omic alterations
Adolescent exposure to micro/nanoplastics induces cognitive impairments in mice with neuronal morphological damage and multi-omic alterations Open
Polystyrene micro/nanoplastics (MPs/NPs) are globally recognized environmental concerns due to their widespread pollution and detrimental effects on physiological functions. However, the neurotoxic effects and underlying mechanisms of MPs/…
View article: P0835 AI-guided generation and development of HXN-1001, a highly potent and half-life extended anti-TL1A antibody
P0835 AI-guided generation and development of HXN-1001, a highly potent and half-life extended anti-TL1A antibody Open
Background TL1A, a member of the TNF family, is genetically associated with several human autoimmune diseases, including IBD, psoriasis, and RA. TL1A-blocking antibodies have demonstrated clinical efficacy in patients with UC and CD. HXN-1…
View article: P1114 Engineering and Development of a Novel Bispecific Antibody Targeting IL-23 and TL1A
P1114 Engineering and Development of a Novel Bispecific Antibody Targeting IL-23 and TL1A Open
Background Both IL23 and TL1A are clinically validated targets with genetical linkage to various human autoimmune diseases. Here we engineered and produced HXN-1003, a bispecific antibody (bsAb) simultaneously targeting both IL23 and TL1A,…
View article: Characterizing the Contribution of Strain Specificity to the Microbiota Structure and Metabolites of Muqu and Fresh High-Temperature Daqu
Characterizing the Contribution of Strain Specificity to the Microbiota Structure and Metabolites of Muqu and Fresh High-Temperature Daqu Open
In this study, the differences in physicochemical properties, microbial community structure, and metabolic characteristics between various fortified Muqu and their corresponding high-temperature Daqu (HTD) were investigated using multiphas…
View article: Laser-patterned Thin-film Electrodes: Imaging Ion Accumulation and Trapped Nanoparticles
Laser-patterned Thin-film Electrodes: Imaging Ion Accumulation and Trapped Nanoparticles Open
This study introduces a straightforward electrode design featuring sharp edges with a curvature of a few hundred nanometers in radius, with which both ion accumulation and nanoparticle deposition can be observed under an alternating electr…
View article: Evaluation of Stroke-Related Dysphagia using surface electromyographic biofeedback and their management by Related Exercise
Evaluation of Stroke-Related Dysphagia using surface electromyographic biofeedback and their management by Related Exercise Open
Introduction: Poststroke oropharyngeal dysphagia increases pneumonia risk and lowers life quality. Speech therapy uses unfamiliar tasks to change habits. The repeatability of tests limits the use of precise feedback for motor learning. Neu…
View article: A new integrative analysis of histopathology and single cell RNA-seq reveals the CCL5 mediated T and NK cell interaction with vascular cells in idiopathic pulmonary arterial hypertension
A new integrative analysis of histopathology and single cell RNA-seq reveals the CCL5 mediated T and NK cell interaction with vascular cells in idiopathic pulmonary arterial hypertension Open
Background Inflammation and dysregulated immunity play vital roles in idiopathic pulmonary arterial hypertension (IPAH), while the mechanisms that initiate and promote these processes are unclear. Methods Transcriptomic data of lung tissue…