Jian Li
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View article: The Molecular Mechanisms of Muscle–Adipose Crosstalk: Myokines, Adipokines, Lipokines and the Mediating Role of Exosomes
The Molecular Mechanisms of Muscle–Adipose Crosstalk: Myokines, Adipokines, Lipokines and the Mediating Role of Exosomes Open
Adipose tissue and skeletal muscle are the foremost energy depots and locomotor organs; they orchestrate metabolic homeostasis through the secretion of cytokines via autocrine, paracrine, and endocrine pathways. This intricate interplay is…
View article: Integrative Toxicology Profiling of <i>Thuja sutchuenensis</i> Essential Oil: From <scp>LD50</scp> Safety Assessment to Hepatic Apoptosis and Gut Microbiota Modulation
Integrative Toxicology Profiling of <i>Thuja sutchuenensis</i> Essential Oil: From <span>LD50</span> Safety Assessment to Hepatic Apoptosis and Gut Microbiota Modulation Open
In traditional Chinese medicine, the leaves and essential oil of Thuja sutchuenensis Franch. are documented in the Supplement to the Compendium of Materia Medica for their properties of “cooling blood, detoxifying, and healing wounds”. How…
View article: Non-WNT/non-SHH medulloblastoma in siblings: case report and literature review
Non-WNT/non-SHH medulloblastoma in siblings: case report and literature review Open
This first report of familial non-WNT/non-SHH MBs highlights novel somatic (NF1) and germline (KYAT3, SPATA31A6) variants, suggesting unexplored oncogenic mechanisms. The findings underscore the need for further research to elucidate drive…
View article: Closed Traction Of Impacted Anterior Teeth Using Auxiliary Arch Wire.
Closed Traction Of Impacted Anterior Teeth Using Auxiliary Arch Wire. Open
Introduction: Open and closed exposure-orthodontic traction are commonly referenced techniques for addressing impacted anterior teeth, but present challenges in aesthetics and hygiene. Closed traction combined with an auxiliary arch wire o…
View article: Reduced <i>OTUD6A</i> Impairs Spermatogonia Proliferation and Contributes to Spermatogenic Arrest in Cattleyak
Reduced <i>OTUD6A</i> Impairs Spermatogonia Proliferation and Contributes to Spermatogenic Arrest in Cattleyak Open
Cattleyak is a hybrid between cattle and yak; the underlying mechanism for its spermatogenic arrest is still unclear, and it's a typical male sterile mammal. In this work, we cloned the OTUD6A gene of cattleyak and analyzed it by bioinform…
View article: A framework of biomarkers for adipose tissue aging: a consensus statement by the Aging Biomarker Consortium
A framework of biomarkers for adipose tissue aging: a consensus statement by the Aging Biomarker Consortium Open
Adipose tissue serves as a crucial energy storage and metabolic organ in the human body. With the surging of elderly population in China comes significant challenges in preventing and managing age-associated diseases, while adipose tissue …
View article: Partial Response Achieved in a Case of Metastatic Triple-Negative Breast Cancer Based on the Patient-Derived Tumor Organoids
Partial Response Achieved in a Case of Metastatic Triple-Negative Breast Cancer Based on the Patient-Derived Tumor Organoids Open
In our case of TNBC, partial response is achieved in the liver metastatic lesions after treatment based on the PDTOs, unveiling that the PDTO, a potential companion tool for selection of treatment options, can facilitate the personalized t…
View article: Screening and Evaluation of tRF-Glu-CTC-013 as a Biomarker and Key Regulator in the Development of Cardiac Hypertrophy
Screening and Evaluation of tRF-Glu-CTC-013 as a Biomarker and Key Regulator in the Development of Cardiac Hypertrophy Open
tRNA-derived small RNAs (tsRNAs) are a newly recognized class of non-coding RNAs involved in regulating RNA processing and translational control. Pathological cardiac hypertrophy, characterized by left ventricular remodeling under chronic …
View article: CRISPR-MFH: A Lightweight Hybrid Deep Learning Framework with Multi-Feature Encoding for Improved CRISPR-Cas9 Off-Target Prediction
CRISPR-MFH: A Lightweight Hybrid Deep Learning Framework with Multi-Feature Encoding for Improved CRISPR-Cas9 Off-Target Prediction Open
Background: The CRISPR-Cas9 system has emerged as one of the most promising gene-editing technologies in biology. However, off-target effects remain a significant challenge. While recent advances in deep learning have led to the developmen…
View article: Evaluating the performance of ChatGPT in patient consultation and image-based preliminary diagnosis in thyroid eye disease
Evaluating the performance of ChatGPT in patient consultation and image-based preliminary diagnosis in thyroid eye disease Open
Background The emergence of Large Language Model (LLM) chatbots, such as ChatGPT, has great promise for enhancing healthcare practice. Online consultation, accurate pre-diagnosis, and clinical efforts are of fundamental importance for the …
View article: Molecular simulation-aided self-adjuvanting nanoamplifier for cancer photoimmunotherapy
Molecular simulation-aided self-adjuvanting nanoamplifier for cancer photoimmunotherapy Open
Background: By leveraging the power of photodynamic therapy (PDT), photosensitizers eliminate cancer cells under specific laser irradiation and trigger systemic immune responses, a potent strategy in tumor immunotherapy. However, the accom…
View article: Insulin-induced severe thyrotoxic periodic paralysis: A case report
Insulin-induced severe thyrotoxic periodic paralysis: A case report Open
BACKGROUND Thyrotoxic periodic paralysis (TPP) is an endocrine emergency caused by thyrotoxicosis, manifesting mainly as periodic myasthenia and hypokalemia, and posing a serious threat to the patient's health. Fatigue, strenuous exercise,…
View article: Integrated Numerical Simulation of PPTs
Integrated Numerical Simulation of PPTs Open
Unsteady and strong transient behavior are important characteristics of the pulsed plasma thruster (PPT) pulse discharge process. During the discharge process, rapidly heating the propellant surface leads to the ablation and ionization of …
View article: Artificial intelligence diagnosis of patent foramen ovale in contrast transthoracic echocardiography
Artificial intelligence diagnosis of patent foramen ovale in contrast transthoracic echocardiography Open
Artificial intelligence (AI) is rarely directly used in patent foramen ovale (PFO) diagnosis. In this study, an AI model was developed to detect the presence of PFO automatically in both contrast transthoracic echocardiography (cTTE) image…
View article: Overcoming CRISPR-Cas9 off-target prediction hurdles: A novel approach with ESB rebalancing strategy and CRISPR-MCA model
Overcoming CRISPR-Cas9 off-target prediction hurdles: A novel approach with ESB rebalancing strategy and CRISPR-MCA model Open
The off-target activities within the CRISPR-Cas9 system remains a formidable barrier to its broader application and development. Recent advancements have highlighted the potential of deep learning models in predicting these off-target effe…
View article: Sunitinib-induced endocapillary proliferative glomerulonephritis with IgA2 deposit in addition to thrombotic microangiopathy: a case report
Sunitinib-induced endocapillary proliferative glomerulonephritis with IgA2 deposit in addition to thrombotic microangiopathy: a case report Open
This case highlights the complex interplay between the therapeutic effects of sunitinib and its potential renal and cardiovascular toxicities, emphasizing the need for close monitoring and effective management strategies to optimize patien…
View article: Krüppel-like factor 12 decreases progestin sensitivity in endometrial cancer by inhibiting the progesterone receptor signaling pathway
Krüppel-like factor 12 decreases progestin sensitivity in endometrial cancer by inhibiting the progesterone receptor signaling pathway Open
This study is the first to investigate the effect of KLF12 expression on EC cell resistance to progesterone. Our results offer important mechanistic insight into the direct regulation of the PGR promoter region, demonstrating that KLF12 ex…
View article: DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure
DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure Open
DEAD-box helicase 17 (DDX17) is a typical member of the DEAD-box family with transcriptional cofactor activity. Although DDX17 is abundantly expressed in the myocardium, its role in heart is not fully understood. We generated cardiomyocyte…
View article: Bone marrow adipocytes and lung cancer bone metastasis: unraveling the role of adipokines in the tumor microenvironment
Bone marrow adipocytes and lung cancer bone metastasis: unraveling the role of adipokines in the tumor microenvironment Open
Bone is a common site of metastasis for lung cancer. The “seed and soil” hypothesis suggests that the bone marrow microenvironment (“soil”) may provide a conducive survival environment for metastasizing tumor cells (“seeds”). The bone marr…
View article: A biomarker framework for liver aging: the Aging Biomarker Consortium consensus statement
A biomarker framework for liver aging: the Aging Biomarker Consortium consensus statement Open
In human aging, liver aging per se not only increases susceptibility to liver diseases but also increases vulnerability of other organs given its central role in regulating metabolism. Total liver function tends to be well maintained in th…
View article: The dual functions of the pentacyclic triterpenoid madecassic acid in ameliorating doxorubicin-induced cardiotoxicity and enhancing the antitumor efficacy of doxorubicin
The dual functions of the pentacyclic triterpenoid madecassic acid in ameliorating doxorubicin-induced cardiotoxicity and enhancing the antitumor efficacy of doxorubicin Open
Doxorubicin (DOX) is an anthracycline that has excellent anticancer effects during tumor chemotherapy, but it can cause cardiotoxic effects and its clinical use has been limited. Therefore, finding new drugs or methods to prevent or revers…
View article: SNORA38B promotes proliferation, migration, invasion and epithelial-mesenchymal transition of gallbladder cancer cells <em>via</em> activating TGF-β/Smad2/3 signaling
SNORA38B promotes proliferation, migration, invasion and epithelial-mesenchymal transition of gallbladder cancer cells <em>via</em> activating TGF-β/Smad2/3 signaling Open
Evidence has shown that small nucleolar RNAs (snoRNAs) participate in the tumorigenesis in multiple cancers, including gallbladder cancer (GBC). Our results showed that SNORA38B level was increased in GBC tissues compared to adjacent norma…
View article: Doing housework and having regular daily routine standing out as factors associate with physical function in the older people
Doing housework and having regular daily routine standing out as factors associate with physical function in the older people Open
Background and objectives Nationwide data were used to explore factors associated with physical function in order to identify interventions that could improve and maintain physical function in the older people. Methods The physical functio…
View article: Effects of <scp>HMGB1</scp>/<scp>RAGE</scp>/cathespin B inhibitors on alleviating hippocampal injury by regulating microglial pyroptosis and caspase activation in neonatal hypoxic–ischemic brain damage
Effects of <span>HMGB1</span>/<span>RAGE</span>/cathespin B inhibitors on alleviating hippocampal injury by regulating microglial pyroptosis and caspase activation in neonatal hypoxic–ischemic brain damage Open
Microglia play a crucial role in regulating neuroinflammation in the pathogenesis of neonatal hypoxic–ischemic brain damage (HIBD). Pyroptosis, an inflammatory form of programmed cell death, has been implicated in HIBD; however, its underl…
View article: A biomarker framework for cardiac aging: the Aging Biomarker Consortium consensus statement
A biomarker framework for cardiac aging: the Aging Biomarker Consortium consensus statement Open
Cardiac aging constitutes a significant risk factor for cardiovascular diseases prevalent among the elderly population. Urgent attention is required to prioritize preventive and management strategies for age-related cardiovascular conditio…
View article: TRIM11 promotes cell proliferation of non‐small cell lung cancer through the inhibition of ferroptosis by AMPK
TRIM11 promotes cell proliferation of non‐small cell lung cancer through the inhibition of ferroptosis by AMPK Open
Lung cancer is one of the leading causes of cancer‐related deaths worldwide, with non‐small cell lung cancer (NSCLC) being the most prevalent type. This study investigates the role of TRIM11 gene in NSCLC and its underlying mechanism. NSCL…
View article: A framework of biomarkers for vascular aging: a consensus statement by the Aging Biomarker Consortium
A framework of biomarkers for vascular aging: a consensus statement by the Aging Biomarker Consortium Open
Aging of the vasculature, which is integral to the functioning of literally all human organs, serves as a fundamental physiological basis for age-related alterations as well as a shared etiological mechanism for various chronic diseases pr…