Jie Xu
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View article: Concomitant medication use and clinical outcome in hepatocellular carcinoma treated with immune-based therapy: a multicenter analysis
Concomitant medication use and clinical outcome in hepatocellular carcinoma treated with immune-based therapy: a multicenter analysis Open
Introduction Immune checkpoint inhibitors (ICIs) have been increasingly used in hepatocellular carcinoma (HCC). Despite emerging evidence indicating that concomitant medications might impact clinical outcomes, their association with ICI ef…
View article: Evaluation of integration in WHO’s tuberculosis, HIV, and antimicrobial resistance policies through the social-ecological lens
Evaluation of integration in WHO’s tuberculosis, HIV, and antimicrobial resistance policies through the social-ecological lens Open
Background TB, HIV, and AMR are closely related global health challenges. In the context of limited global health funds and insufficient resources, an integrated tuberculosis, HIV and antimicrobial resistance prevention and control method …
View article: Protocol for isolating and characterizing extracellular vesicles by ultracentrifugation from bone marrow-derived macrophages
Protocol for isolating and characterizing extracellular vesicles by ultracentrifugation from bone marrow-derived macrophages Open
Extracellular vesicles (EVs) enable the transmission of crucial molecular components between the parental and recipient cells. Macrophages can polarize into two distinct macrophage phenotypes, thereby exerting diverse effects on recipient …
View article: Role of SLC16A10 in Psoriasis Through the Regulation of Arachidonic Acid Metabolism in Keratinocytes
Role of SLC16A10 in Psoriasis Through the Regulation of Arachidonic Acid Metabolism in Keratinocytes Open
Psoriasis is an inflammatory dermatological condition challenging to treat and prone to recurrence. The pathogenesis of psoriasis is closely associated with metabolic disorders, while therapies targeting the dysregulated metabolism in psor…
View article: Pharmacological Effects and Mechanisms of Tanshinone IIA in Bone Injury Repair
Pharmacological Effects and Mechanisms of Tanshinone IIA in Bone Injury Repair Open
Tanshinone IIA (T-IIA), a fat-soluble diterpene quinone extracted from Salvia miltiorrhiza, is widely recognized for its multiple pharmacological properties, including anti-inflammatory, antioxidant, anti-fibrotic, and anti-tumor effects. …
View article: Ultra-Short-Term Wind Power Prediction Based on Spatiotemporal Contrastive Learning
Ultra-Short-Term Wind Power Prediction Based on Spatiotemporal Contrastive Learning Open
With the accelerating global energy transition, wind power has become a core pillar of renewable energy systems. However, its inherent intermittency and volatility pose significant challenges to the safe, stable, and economical operation o…
View article: Immunophenotypic, cytogenetic, and mutational features of chronic lymphocytic leukemia/small lymphocytic lymphoma with atypical immunophenotype
Immunophenotypic, cytogenetic, and mutational features of chronic lymphocytic leukemia/small lymphocytic lymphoma with atypical immunophenotype Open
Flow cytometric analysis plays an important role in the diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). Most CLL cases show a typical immunophenotype characterized by the expression of CD5, CD23, CD43, ROR1,…
View article: GIN-CRC-Pareto: A graph-based Pareto-optimal multi-task learning framework to identify miRNA-target interactions in colorectal cancer
GIN-CRC-Pareto: A graph-based Pareto-optimal multi-task learning framework to identify miRNA-target interactions in colorectal cancer Open
Colorectal cancer (CRC) ranks as the third highest incidence among malignancies in humans and the second most common cause of cancer-related mortality in the United States. Accumulating evidence has established microRNAs (miRNAs) as critic…
View article: Research Progress on Icariin Promoting Bone Injury Repair and Regeneration
Research Progress on Icariin Promoting Bone Injury Repair and Regeneration Open
Icariin (ICA) is a bioactive flavonoid compound extracted from Epimedium plants. In recent years, it has attracted significant research interest in the field of bone tissue repair due to its pharmacological effects via multiple targets and…
View article: Epimedium-Derived Exosome-Loaded GelMA Hydrogel Enhances MC3T3-E1 Osteogenesis via PI3K/Akt Pathway
Epimedium-Derived Exosome-Loaded GelMA Hydrogel Enhances MC3T3-E1 Osteogenesis via PI3K/Akt Pathway Open
Healing large bone defects remains challenging. Gelatin scaffolds are biocompatible and biodegradable, but lack osteoinductive activity. Plant-derived exosomes carry miRNAs, growth factors, and proteins that modulate osteogenesis, but free…
View article: Enhanced management strategy of synchronous percutaneous biopsy and microwave ablation in patients with lung ground-glass opacities undergoing antithrombotic treatment: a clinical perspective on our experience
Enhanced management strategy of synchronous percutaneous biopsy and microwave ablation in patients with lung ground-glass opacities undergoing antithrombotic treatment: a clinical perspective on our experience Open
Objective This retrospective study was conducted to delineate our experience in managing perioperative antithrombotic agents in patients receiving antithrombotic therapy underwent percutaneous biopsy and microwave ablation (B+MWA) for lung…
View article: Application of Long Short-Term Memory Network Based on Deep Learning in Speech Emotion Recognition
Application of Long Short-Term Memory Network Based on Deep Learning in Speech Emotion Recognition Open
In this article, the authors present a long short-term memory (LSTM)-based approach for speech emotion recognition. First, they provide a detailed introduction to the LSTM model's fundamentals, along with information on how to calculate th…
View article: A Clinically-Grounded Two-Stage Framework for Renal CT Report Generation
A Clinically-Grounded Two-Stage Framework for Renal CT Report Generation Open
Objective Renal cancer is a common malignancy and a major cause of cancer-related deaths. Computed tomography (CT) is central to early detection, staging, and treatment planning. However, the growing CT workload increases radiologists' bur…
View article: A Retrospective Study on the Effect of STA Anesthesia Technique in the Extraction of Impacted Teeth in Dental Outpatients and Its Impact on Patient Anxiety Levels
A Retrospective Study on the Effect of STA Anesthesia Technique in the Extraction of Impacted Teeth in Dental Outpatients and Its Impact on Patient Anxiety Levels Open
Within the limitations of this retrospective study, the STA anesthesia technique showed advantages over traditional local injection anesthesia in reducing pain and anxiety, while improving compliance and tolerance during impacted tooth ext…
View article: Prostaglandin E2 receptor EP4 activation induces tolerogenic dendritic cells to mitigate ischemic acute kidney injury
Prostaglandin E2 receptor EP4 activation induces tolerogenic dendritic cells to mitigate ischemic acute kidney injury Open
The prevalence and mortality rates of acute kidney injury (AKI) remain high, with ischemia-reperfusion (I/R) being a major cause in clinical settings. Dendritic cells (DCs) play a crucial role in inducing the infiltration of inflammatory c…
View article: Prognostic Value of Blood Pressure Rhythmicity for Estimated Glomerular Filtration Rate in Male Hypertensive Patients Aged 55 and Older
Prognostic Value of Blood Pressure Rhythmicity for Estimated Glomerular Filtration Rate in Male Hypertensive Patients Aged 55 and Older Open
Background: Blood pressure (BP) exhibits a circadian rhythm characterized by higher levels during wakefulness and lower levels during sleep; however, the functional and structural impact of the rhythms of BP remains uncertain. Methods: Two…
View article: Fast, accurate parsing of antibody structures and antibody-antigen interactions enables a comprehensive structural antibody database
Fast, accurate parsing of antibody structures and antibody-antigen interactions enables a comprehensive structural antibody database Open
Antibody (Ab) structures and antibody-antigen interactions (AAIs) are essential for understanding immune recognition and designing Ab therapeutics. While existing structural Ab databases provide valuable insights, they still have notable l…
View article: Genome‐wide profiling of N6‐methyladenosine‐modified pseudogene‐derived long noncoding RNAs reveals the tumour‐promoting and innate immune‐restraining function of RPS15AP12 in ovarian cancer
Genome‐wide profiling of N6‐methyladenosine‐modified pseudogene‐derived long noncoding RNAs reveals the tumour‐promoting and innate immune‐restraining function of RPS15AP12 in ovarian cancer Open
Background Pseudogene‐derived lncRNAs are widely dysregulated in cancer. Technological advancements have facilitated the functional characterization of increasing pseudogenes in cancer progression. However, the association between pseudoge…
View article: Case report: Detection and treatment of a rare submucosal gland duct adenoma of the esophagus
Case report: Detection and treatment of a rare submucosal gland duct adenoma of the esophagus Open
This article reports a rare case of esophageal submucosal gland duct adenoma (ESGDA). The patient was found to have this tumor after undergoing endoscopy in an outpatient clinic due to occasional tingling while eating. White light endoscop…
View article: Genetic Susceptibility and Physical Activity Modified the Long‐Term Effect of Propylene Oxide Exposure on Lung Function: A Repeated‐Measurement Cohort Study
Genetic Susceptibility and Physical Activity Modified the Long‐Term Effect of Propylene Oxide Exposure on Lung Function: A Repeated‐Measurement Cohort Study Open
Background The gene–environment interaction between propylene oxide (PO) exposure and genetic susceptibility on lung function, as well as the potential influence of physical activity (PA) on lung function alteration related to PO exposure,…
View article: GPER-1 Rapid Regulation Influences p-Akt Expression to Resist Stress-Induced Injuries in a Sex-Specific Manner
GPER-1 Rapid Regulation Influences p-Akt Expression to Resist Stress-Induced Injuries in a Sex-Specific Manner Open
G protein-coupled estrogen receptor 1 (GPER-1) has gained recognition for its role in conferring cardioprotection. However, the extent to which GPER-1 exerts equally important effects in both sexes remains unclear. The study found similar …