Jiabin Zhan
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View article: METTL3-mediated m6A modification of circCDKAL1 regulates macrophage M1 polarization and nasal epithelial cell barrier function in allergic rhinitis through IGF2BP2/JARID2/HMGB1 axis
METTL3-mediated m6A modification of circCDKAL1 regulates macrophage M1 polarization and nasal epithelial cell barrier function in allergic rhinitis through IGF2BP2/JARID2/HMGB1 axis Open
Allergic rhinitis (AR) is a chronic inflammatory disease that significantly impairs patients’ quality of life, with CircCDKAL1 showing abnormal upregulation in AR patients, though its functional mechanisms remain unclear. In this study, we…
View article: Assessment of clinical efficacy and safety of sublingual immunotherapy for house dust mite-induced allergic pharyngitis with rhinitis
Assessment of clinical efficacy and safety of sublingual immunotherapy for house dust mite-induced allergic pharyngitis with rhinitis Open
Three years of HDM-SLIT may alleviate both pharyngeal and nasal symptoms in patients with AP and AR, thereby expanding the application of SLIT in the treatment of airway allergic diseases.
View article: Sphk1 regulates HMGB1 via HDAC4 and mediates epithelial pyroptosis in allergic rhinitis
Sphk1 regulates HMGB1 via HDAC4 and mediates epithelial pyroptosis in allergic rhinitis Open
We identified that the expression levels of Sphk1, HMGB1, and inflammasome components, including IL-18, and IL-1β were elevated in AR patients and mouse models. Knockdown of Sphk1 inhibited hNEC pyroptosis induced by dust mite allergen. Ov…
View article: Serum exosomal miR-141-3p and miR-3679-5p levels associated with endotype and postoperative recurrence in chronic rhinosinusitis with nasal polyps
Serum exosomal miR-141-3p and miR-3679-5p levels associated with endotype and postoperative recurrence in chronic rhinosinusitis with nasal polyps Open
This study identified unique miRNA expression patterns in serum exosomes of CRSwNP patients. Circulating exosomal miR-141-3p and miR-3679-5p emerged as novel biomarkers for diagnosing CRSwNP, predicting the eosinophilic endotype, and forec…
View article: HDAC3‐mediated lncRNA ZFAS1 inhibited IL‐13‐induced secretion of proinflammatory cytokines in nasal epithelial cells by regulating the miR‐7‐5p/SIRT1 pathway
HDAC3‐mediated lncRNA ZFAS1 inhibited IL‐13‐induced secretion of proinflammatory cytokines in nasal epithelial cells by regulating the miR‐7‐5p/SIRT1 pathway Open
Allergic rhinitis (AR) is a disease that is difficult to cure and accompanies the patient's life. Proinflammatory cytokines (GM‑CSF and eotaxin) and MUC5AC are key mediators promoting AR progression. Herein, the function of lncRNA ZFAS1 in…
View article: Exploration of Predictive Biomarkers for Postoperative Recurrence in Chronic Rhinosinusitis with Nasal Polyps Based on Serum Multiple-Cytokine Profiling
Exploration of Predictive Biomarkers for Postoperative Recurrence in Chronic Rhinosinusitis with Nasal Polyps Based on Serum Multiple-Cytokine Profiling Open
Background. Functional nasal endoscopic surgery (FESS) is an effective treatment approach for chronic rhinosinusitis with nasal polyps (CRSwNP) patients, but some patients still suffer from postoperative recurrence. This study is aimed at …
View article: Role of CD5L and SRD5A2 as Prognostic Biomarkers for Hepatocellular Carcinoma
Role of CD5L and SRD5A2 as Prognostic Biomarkers for Hepatocellular Carcinoma Open
CD5L can facilitate individualized, targeted therapy for HCC patients.
View article: YAP1 expression in nasal polyps and its relationship with epithelial mesenchymal transition.
YAP1 expression in nasal polyps and its relationship with epithelial mesenchymal transition. Open
High expressions of YAP1 and EMT occur in nasal polyp tissues, and YAP1 is likely to be involved in the regulation of EMT and might be one of the mechanisms in nasal polyps.
View article: LncRNA GAS5 expression in non-small cell lung cancer tissues and its correlation with Ki67 and EGFR.
LncRNA GAS5 expression in non-small cell lung cancer tissues and its correlation with Ki67 and EGFR. Open
The decrease in LncRNA GAS5 expression and the over-express of Ki67/EGFR occur in NSCLC tissues, the expressions of LncRNA GAS5, Ki67 and EGFR are connected with the progression, metastasis and prognosis of tumor; and LncRNA GAS5 is relate…