Jinke Gu
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View article: YTHDF1 differentiates the contributing roles of mTORC1 in aging
YTHDF1 differentiates the contributing roles of mTORC1 in aging Open
The mechanistic target of rapamycin (mTOR) serves as an essential hub in sensing metabolic stress and regulating aging, although the differential contributions of mTOR-regulated protein and cholesterol synthesis are unclear. Post-transcrip…
View article: Protocol for high-throughput screening of SIRT7 inhibitors using fluorescent peptide technology
Protocol for high-throughput screening of SIRT7 inhibitors using fluorescent peptide technology Open
Fluorescent peptides combine the polypeptides with fluorescent groups organically to facilitate the measurement of enzyme activity. Here, we present a protocol to evaluate Sirtuin 7 (SIRT7) enzymatic activity by analyzing changes in lumine…
View article: Optimization of Heat Transfer and Flow Performance of Microchannel Liquid-Cooled Plate Based on Orthogonal Test
Optimization of Heat Transfer and Flow Performance of Microchannel Liquid-Cooled Plate Based on Orthogonal Test Open
Microchannel liquid-cooled plates are widely used in high-performance electronic devices, but their heat transfer performance and pressure drop characteristics face complex challenges in the design process. In this paper, a counter-flow re…
View article: The Pivotal Role of LACTB in the Process of Cancer Development
The Pivotal Role of LACTB in the Process of Cancer Development Open
The mitochondrial serine β-lactamase-like protein LACTB has emerged as a critical regulator in cancer biology, distinguished by its unique structural and functional attributes. Defined by its conserved penicillin-binding proteins and β-lac…
View article: Structural basis for the regulatory mechanism of mammalian mitochondrial respiratory chain megacomplex-I2III2IV2
Structural basis for the regulatory mechanism of mammalian mitochondrial respiratory chain megacomplex-I2III2IV2 Open
Mammalian mitochondrial electron transport chain complexes are the most important and complicated protein machinery in mitochondria. Although this system has been studied for more than a century, its composition and molecular mechanism are…
View article: Structural basis for the regulatory mechanism of mammalian mitochondrial megacomplex-I2III2IV2
Structural basis for the regulatory mechanism of mammalian mitochondrial megacomplex-I2III2IV2 Open
Mammalian mitochondrial electron transport chain complexes are the most important and complicated protein machineries in mitochondria. Although this system has been studied for more than a century, its composition and molecular mechanism i…
View article: Research journey of respirasome
Research journey of respirasome Open
Respirasome, as a vital part of the oxidative phosphorylation system, undertakes the task of transferring electrons from the electron donors to oxygen and produces a proton concentration gradient across the inner mitochondrial membrane thr…
View article: Mechanical Behavior of Supporting Structure of Rectangular Deep Ventilation Shaft in Rail Transit
Mechanical Behavior of Supporting Structure of Rectangular Deep Ventilation Shaft in Rail Transit Open
In order to analyze the mechanical behavior of surrounding rock and initial support during shaft excavation and support process, reveal the law of stratum displacement, the stress characteristics of surrounding rock and the internal force …
View article: Functional and structural profiles of <scp>GST</scp> gene family from three <i>Populus</i> species reveal the sequence–function decoupling of orthologous genes
Functional and structural profiles of <span>GST</span> gene family from three <i>Populus</i> species reveal the sequence–function decoupling of orthologous genes Open
Summary A common assumption in comparative genomics is that orthologous genes are functionally more similar than paralogous genes. However, the validity of this assumption needs to be assessed using robust experimental data. We conducted t…
View article: PD-L1 Nanobody Competitively Inhibits the Formation of the PD-1/PD-L1 Complex: Comparative Molecular Dynamics Simulations
PD-L1 Nanobody Competitively Inhibits the Formation of the PD-1/PD-L1 Complex: Comparative Molecular Dynamics Simulations Open
The anti-PD-L1 monoclonal antibody (mAb) targeting PD-1/PD-L1 immune checkpoint has achieved outstanding results in clinical application and has become one of the most popular anti-cancer drugs. The mechanism of molecular recognition and i…
View article: Amazing structure of respirasome: unveiling the secrets of cell respiration
Amazing structure of respirasome: unveiling the secrets of cell respiration Open
Respirasome, a huge molecular machine that carries out cellular respiration, has gained growing attention since its discovery, because respiration is the most indispensable biological process in almost all living creatures. The concept of …
View article: Crystal structures of Bbp from Staphylococcus aureus reveal the ligand binding mechanism with Fibrinogen α
Crystal structures of Bbp from Staphylococcus aureus reveal the ligand binding mechanism with Fibrinogen α Open
Bone sialoprotein-binding protein (Bbp), a MSCRAMMs (Microbial Surface Components Recognizing Adhesive Matrix Molecules) family protein expressed on the surface of Staphylococcus aureus (S. aureus), mediates adherence to fibrinogen α (Fg α…