Jiafei Xi
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View article: Research on Risk Identification and Regulation of Binance from a Global Regulatory Perspective
Research on Risk Identification and Regulation of Binance from a Global Regulatory Perspective Open
This study systematically analyzes the compliance, technical, market, and legal risks faced by the Binance exchange from a global regulatory perspective. By examining Binance's operational practices in multiple countries and incorporating …
View article: Sustained‐Release Sitagliptin Microneedles for Scar Prevention via Fibroblast‐to‐Adipocyte Conversion
Sustained‐Release Sitagliptin Microneedles for Scar Prevention via Fibroblast‐to‐Adipocyte Conversion Open
Pathological scar treatment remains a clinical challenge, and novel efficient and safe approaches are urgently needed. Regulation of cell fate transition has promising potential for disease treatment and tissue regeneration. Skin fibrosis …
View article: Chronic low-dose cadmium exposure induces neurodevelopmental impairment in hESC-derived retinal organoids
Chronic low-dose cadmium exposure induces neurodevelopmental impairment in hESC-derived retinal organoids Open
Cadmium, a heavy metal environmental toxin known for its neurotoxic effects on the central nervous system, is implicated in multiple eye diseases, including cataracts, glaucoma, and age-related macular degeneration. However, due to the lac…
View article: Association between night shift work and cardiovascular disease: a systematic review and dose-response meta-analysis
Association between night shift work and cardiovascular disease: a systematic review and dose-response meta-analysis Open
Background Shift work, particularly night shift work, has become increasingly prevalent on a global scale and is associated with multiple health issues including type 2 diabetes and cardiovascular diseases (CVD). This study aimed to assess…
View article: Single-cell analysis reveals the spatiotemporal effects of long-term electromagnetic field exposure on the liver
Single-cell analysis reveals the spatiotemporal effects of long-term electromagnetic field exposure on the liver Open
Introduction Artificial electromagnetic fields (EMFs) can impair the functions of several organs. The impact of long-term artificial EMF on the liver, the synthetic and metabolic center of the body, has become concerning. The aim of this s…
View article: DSUP modified mesenchymal stem cells exert significant radiation protective effect by enhancing the hematopoietic niche
DSUP modified mesenchymal stem cells exert significant radiation protective effect by enhancing the hematopoietic niche Open
View article: HSV-1 UL56 protein recruits cellular NEDD4-family ubiquitin ligases to suppress CD1d expression and NKT cell function
HSV-1 UL56 protein recruits cellular NEDD4-family ubiquitin ligases to suppress CD1d expression and NKT cell function Open
Herpesviruses, including α-herpesvirus and herpes simplex virus (HSV-1), are masters of immune evasion. Previously we demonstrated that CD1d-restricted NKT cells are required for optimal anti-HSV-1 immune responses and HSV-1 efficiently do…
View article: Mesenchymal stem cell treatment alleviates seawater drowning induced lung injury by inhibiting the TNFα/Snail/EMT pathway
Mesenchymal stem cell treatment alleviates seawater drowning induced lung injury by inhibiting the TNFα/Snail/EMT pathway Open
Our research revealed that SWD triggered severe ALI, followed by long-term pulmonary fibrosis. However, treatment with nebulized MSCs significantly mitigated the ALI and slowed the progression of fibrosis.
View article: PROTAC-mediated vimentin degradation promotes terminal erythroid differentiation of pluripotent stem cells
PROTAC-mediated vimentin degradation promotes terminal erythroid differentiation of pluripotent stem cells Open
View article: Hydrogel Microneedle Patches Loaded with Stem Cell Mitochondria-Enriched Microvesicles Boost the Chronic Wound Healing
Hydrogel Microneedle Patches Loaded with Stem Cell Mitochondria-Enriched Microvesicles Boost the Chronic Wound Healing Open
Rescuing or compensating mitochondrial function represents a promising therapeutic avenue for radiation-induced chronic wounds. Adult stem cell efficacies are primarily dependent on the paracrine secretion of mitochondria-containing extrac…
View article: Enhancing terminal erythroid differentiation in human embryonic stem cells through TRIB3 overexpression
Enhancing terminal erythroid differentiation in human embryonic stem cells through TRIB3 overexpression Open
View article: Decoding human in vitro terminal erythropoiesis originating from umbilical cord blood mononuclear cells and pluripotent stem cells
Decoding human in vitro terminal erythropoiesis originating from umbilical cord blood mononuclear cells and pluripotent stem cells Open
Ex vivo red blood cell (RBC) production generates unsatisfactory erythroid cells. A deep exploration into terminally differentiated cells is required to understand the impairments for RBC generation and the underlying mechanisms. Here, we …
View article: Nanoengineered Red Blood Cells Loaded with TMPRSS2 and Cathepsin L Inhibitors Block SARS‐CoV‐2 Pseudovirus Entry into Lung ACE2<sup>+</sup> Cells
Nanoengineered Red Blood Cells Loaded with TMPRSS2 and Cathepsin L Inhibitors Block SARS‐CoV‐2 Pseudovirus Entry into Lung ACE2<sup>+</sup> Cells Open
The enzymatic activities of Furin, Transmembrane serine proteinase 2 (TMPRSS2), Cathepsin L (CTSL), and Angiotensin‐converting enzyme 2 (ACE2) receptor binding are necessary for the entry of coronaviruses into host cells. Precise inhibitio…
View article: Long-term outcomes of single-incision plus one-port laparoscopic surgery versus conventional laparoscopic surgery for rectosigmoid cancer: a randomized controlled trial
Long-term outcomes of single-incision plus one-port laparoscopic surgery versus conventional laparoscopic surgery for rectosigmoid cancer: a randomized controlled trial Open
View article: Influence of hypoxia on retinal progenitor and ganglion cells in human induced pluripotent stem cell-derived retinal organoids
Influence of hypoxia on retinal progenitor and ganglion cells in human induced pluripotent stem cell-derived retinal organoids Open
AIM: To observe the effect of low oxygen concentration on the neural retina in human induced pluripotent stem cell (hiPSC)-derived retinal organoids (ROs). METHODS: The hiPSC and a three-dimensional culture method were used for the experim…
View article: Decoding human<i>in vitro</i>terminal erythropoiesis originating from umbilical cord blood mononuclear cells and pluripotent stem cells
Decoding human<i>in vitro</i>terminal erythropoiesis originating from umbilical cord blood mononuclear cells and pluripotent stem cells Open
SUMMARY Ex vivo RBC production generates unsatisfactory expansion, β-globin expression, and maturation of erythroid cells. The underlying mechanisms behind these limitations and ex vivo terminal erythropoiesis from different origins are la…
View article: Protective effects of resveratrol on the ethanol‐induced disruption of retinogenesis in pluripotent stem cell‐derived organoids
Protective effects of resveratrol on the ethanol‐induced disruption of retinogenesis in pluripotent stem cell‐derived organoids Open
Prenatal alcohol exposure‐induced fetal alcohol syndrome (FAS) can lead to serious maldevelopment in many organ systems, including the eyes. In the present study, the effects of alcohol exposure on early development of the human retina and…
View article: A Functional Screening Identifies a New Organic Selenium Compound Targeting Cancer Stem Cells: Role of c‐Myc Transcription Activity Inhibition in Liver Cancer
A Functional Screening Identifies a New Organic Selenium Compound Targeting Cancer Stem Cells: Role of c‐Myc Transcription Activity Inhibition in Liver Cancer Open
Cancer stem cells (CSCs) are reported to play essential roles in chemoresistance and metastasis. Pathways regulating CSC self‐renewal and proliferation, such as Hedgehog, Notch, Wnt/ β ‐catenin, TGF‐ β , and Myc, may be potential therapeut…
View article: Development and Validation of a Novel Survival Model for Cutaneous Melanoma Based on Necroptosis-Related Genes
Development and Validation of a Novel Survival Model for Cutaneous Melanoma Based on Necroptosis-Related Genes Open
Background Necroptosis is crucial for organismal development and pathogenesis. To date, the role of necroptosis in skin cutaneous melanoma (SKCM) is yet unveiled. In addition, the part of melanin pigmentation was largely neglected in the b…
View article: Large‐scale generation of megakaryocytes from human embryonic stem cells using transgene‐free and stepwise defined suspension culture conditions
Large‐scale generation of megakaryocytes from human embryonic stem cells using transgene‐free and stepwise defined suspension culture conditions Open
Objectives Ex vivo engineered production of megakaryocytes (MKs) and platelets (PLTs) from human pluripotent stem cells is an alternative approach to solve shortage of donor‐donated PLTs in clinics and to provide induced PLTs for transfusi…
View article: Integrative single-cell transcriptome analysis reveals a subpopulation of fibroblasts associated with favorable prognosis of liver cancer patients
Integrative single-cell transcriptome analysis reveals a subpopulation of fibroblasts associated with favorable prognosis of liver cancer patients Open
Single-cell transcriptome analysis has provided detailed insights into the ecosystem of liver cancer. However, the changes of the cellular and molecular components of liver tumors in comparison with normal livers have not been described at…
View article: The splicing regulatory factor hnRNPU is a novel transcriptional target of c‐Myc in hepatocellular carcinoma
The splicing regulatory factor hnRNPU is a novel transcriptional target of c‐Myc in hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) is the most common liver cancer with high mortality. Here, we found that hnRNPU is overexpressed in HCC tissues and is correlated with the poor prognosis of HCC patients. Besides, hnRNPU is of high significan…
View article: A new protocol for long‐term culture of a specific subpopulation of liver cancer stem cells enriched by cell surface markers
A new protocol for long‐term culture of a specific subpopulation of liver cancer stem cells enriched by cell surface markers Open
Liver cancer stem cells (L‐CSCs) are considered to be an important therapeutic target for hepatocellular carcinoma (HCC). This study provides a new in vitro long‐term culture model for a specific subpopulation of L‐CSCs enriched by cell su…
View article: HGF Mediates Clinical‐Grade Human Umbilical Cord‐Derived Mesenchymal Stem Cells Improved Functional Recovery in a Senescence‐Accelerated Mouse Model of Alzheimer's Disease
HGF Mediates Clinical‐Grade Human Umbilical Cord‐Derived Mesenchymal Stem Cells Improved Functional Recovery in a Senescence‐Accelerated Mouse Model of Alzheimer's Disease Open
Stem cells have emerged as a potential therapy for a range of neural insults, but their application in Alzheimer's disease (AD) is still limited and the mechanisms underlying the cognitive benefits of stem cells remain to be elucidated. He…
View article: Single-cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinoma
Single-cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinoma Open
Intrahepatic cholangiocarcinoma is an aggressive and chemoresistant malignancy. Better understanding the complex transcriptional architecture and intercellular crosstalk of these tumors will help in the development of more effective therap…
View article: Arsenic trioxide inhibits liver cancer stem cells and metastasis by targeting SRF/MCM7 complex
Arsenic trioxide inhibits liver cancer stem cells and metastasis by targeting SRF/MCM7 complex Open
View article: MicroRNA‑486‑5p functions as a tumor suppressor of proliferation and cancer stem‑like cell properties by targeting Sirt1 in liver cancer
MicroRNA‑486‑5p functions as a tumor suppressor of proliferation and cancer stem‑like cell properties by targeting Sirt1 in liver cancer Open
Cancer stem‑like cells (CSCs) are critical for the initiation, progression, chemoresistance and postsurgical recurrence of liver cancer. They are thought to be novel targets for the treatment of liver cancer, however, efficient agents that…
View article: Prostaglandin E2 Is Required for BMP4-Induced Mesoderm Differentiation of Human Embryonic Stem Cells
Prostaglandin E2 Is Required for BMP4-Induced Mesoderm Differentiation of Human Embryonic Stem Cells Open
View article: [The role of poloxamer 188 for cord blood mononuclear cells into megakaryocytes cultivation and induction in three-dimensional WAVE Bioreactor].
[The role of poloxamer 188 for cord blood mononuclear cells into megakaryocytes cultivation and induction in three-dimensional WAVE Bioreactor]. Open
Objective: To observe the effect of poloxamer 188 (P188) on megakaryocyte cultivation and induction from cord blood mononuclear cells in order to obtain more megakaryocyte progenitor cells (MPC). Methods: The cord blood monon…
View article: Clinical-grade human umbilical cord-derived mesenchymal stem cells reverse cognitive aging via improving synaptic plasticity and endogenous neurogenesis
Clinical-grade human umbilical cord-derived mesenchymal stem cells reverse cognitive aging via improving synaptic plasticity and endogenous neurogenesis Open