Jiafen Hu
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View article: The effects of Co-exposure of tobacco smoke with Dibenzo[a,l]pyrene diol epoxide on molecular targets and immune cells in the mouse oral cavity
The effects of Co-exposure of tobacco smoke with Dibenzo[a,l]pyrene diol epoxide on molecular targets and immune cells in the mouse oral cavity Open
Tobacco smoking (TS) is an established etiological factor in the development of head and neck squamous cell carcinoma (HNSCC). We previously developed a mouse model using a select tobacco carcinogen, dibenzo[a,l]pyrene (DB[a,l]P, and its u…
View article: Current challenges and potential opportunities for interception and prevention of head and neck cancer
Current challenges and potential opportunities for interception and prevention of head and neck cancer Open
Globally, the incidence of head and neck squamous cell carcinoma (HNSCC) has increased over recent decades and is projected to continue to rise, largely driven by increases in oropharyngeal squamous cell carcinoma (OPSCC), which is linked …
View article: The full transcription map of cottontail rabbit papillomavirus in tumor tissues
The full transcription map of cottontail rabbit papillomavirus in tumor tissues Open
Cottontail rabbit papillomavirus (CRPV), the first papillomavirus associated with tumor development, has been used as a powerful model to study papillomavirus pathogenesis for more than 90 years. However, lack of a comprehensive analysis o…
View article: Monitoring mouse papillomavirus-associated cancer development using longitudinal Pap smear screening
Monitoring mouse papillomavirus-associated cancer development using longitudinal Pap smear screening Open
A substantial percentage of the population remains at risk for cervical cancer due to pre-existing human papillomavirus (HPV) infections, despite prophylactic vaccines. Early diagnosis and treatment are crucial for better disease outcomes.…
View article: Increased human papillomavirus viral load is correlated to higher severity of cervical disease and poorer clinical outcome: A systematic review
Increased human papillomavirus viral load is correlated to higher severity of cervical disease and poorer clinical outcome: A systematic review Open
Cervical cancer is the fourth most common cancer in women worldwide and is caused by persistent infection with high‐risk types of human papillomavirus (HPV). HPV viral load, the amount of HPV DNA in a sample, has been suggested to correlat…
View article: Gender Difference in DNA Damage Induced by the Environmental Carcinogen Dibenzo[<i>def,p</i>]chrysene Individually and in Combination with Mouse Papillomavirus Infection in the Mouse Oral Cavity
Gender Difference in DNA Damage Induced by the Environmental Carcinogen Dibenzo[<i>def,p</i>]chrysene Individually and in Combination with Mouse Papillomavirus Infection in the Mouse Oral Cavity Open
Tobacco smoking and human papillomavirus infection are established etiological agents in the development of head and neck squamous cell carcinoma (HNSCC). The incidence and mortality of HNSCC are higher in men than women. To provide bioche…
View article: DNA Vaccines: Their Formulations, Engineering and Delivery
DNA Vaccines: Their Formulations, Engineering and Delivery Open
The concept of DNA vaccination was introduced in the early 1990s. Since then, advancements in the augmentation of the immunogenicity of DNA vaccines have brought this technology to the market, especially in veterinary medicine, to prevent …
View article: Immune Responses in Oral Papillomavirus Clearance in the MmuPV1 Mouse Model
Immune Responses in Oral Papillomavirus Clearance in the MmuPV1 Mouse Model Open
Human papillomavirus (HPV)-induced oropharyngeal cancer now exceeds HPV-induced cervical cancer, with a noticeable sex bias. Although it is well established that women have a more proficient immune system, it remains unclear whether immune…
View article: The Integrated Consideration of Vaccine Platforms, Adjuvants, and Delivery Routes for Successful Vaccine Development
The Integrated Consideration of Vaccine Platforms, Adjuvants, and Delivery Routes for Successful Vaccine Development Open
Vaccines have proven to be the most cost-efficient and reasonable way to fight and exterminate virulent pathogens. Vaccines can be designed using a variety of platforms including inactivated/attenuated pathogen or subunits of it. The most …
View article: Papillomavirus can be transmitted through the blood and produce infections in blood recipients: Evidence from two animal models
Papillomavirus can be transmitted through the blood and produce infections in blood recipients: Evidence from two animal models Open
Human papillomaviruses (HPV) contribute to most cervical cancers and are considered to be sexually transmitted. However, papillomaviruses are often found in cancers of internal organs, including the stomach, raising the question as to how …
View article: Modeling HPV-Associated Disease and Cancer Using the Cottontail Rabbit Papillomavirus
Modeling HPV-Associated Disease and Cancer Using the Cottontail Rabbit Papillomavirus Open
Approximately 5% of all human cancers are attributable to human papillomavirus (HPV) infections. HPV-associated diseases and cancers remain a substantial public health and economic burden worldwide despite the availability of prophylactic …
View article: Passive Immunization with a Single Monoclonal Neutralizing Antibody Protects against Cutaneous and Mucosal Mouse Papillomavirus Infections
Passive Immunization with a Single Monoclonal Neutralizing Antibody Protects against Cutaneous and Mucosal Mouse Papillomavirus Infections Open
This is the first study testing a single monoclonal neutralizing antibody (MPV.A4) by passive immunization against papillomavirus infections at both cutaneous and mucosal sites in the same host in the mouse papillomavirus model. We demonst…
View article: RG2-VLP: a Vaccine Designed to Broadly Protect against Anogenital and Skin Human Papillomaviruses Causing Human Cancer
RG2-VLP: a Vaccine Designed to Broadly Protect against Anogenital and Skin Human Papillomaviruses Causing Human Cancer Open
Licensed preventive HPV vaccines are composed of VLPs derived by expression of major capsid protein L1. They confer protection generally restricted to infection by the αHPVs targeted by the up-to-9-valent vaccine, and their associated anog…
View article: Depo Medroxyprogesterone (DMPA) Promotes Papillomavirus Infections but Does Not Accelerate Disease Progression in the Anogenital Tract of a Mouse Model
Depo Medroxyprogesterone (DMPA) Promotes Papillomavirus Infections but Does Not Accelerate Disease Progression in the Anogenital Tract of a Mouse Model Open
Contraceptives such as Depo-medroxyprogesterone (DMPA) are used by an estimated 34 million women worldwide. DMPA has been associated with increased risk of several viral infections including Herpes simplex virus-2 (HSV-2) and Human immunod…
View article: A Comparative Study on Delivery of Externally Attached DNA by Papillomavirus VLPs and Pseudoviruses
A Comparative Study on Delivery of Externally Attached DNA by Papillomavirus VLPs and Pseudoviruses Open
Human papillomavirus (HPV) 16 capsids have been chosen as a DNA delivery vehicle in many studies. Our preliminary studies suggest that HPV58 capsids could be better vehicles than HPV16 capsids to deliver encapsidated DNA in vitro and in vi…
View article: Cryo EM Analysis Reveals Inherent Flexibility of Authentic Murine Papillomavirus Capsids
Cryo EM Analysis Reveals Inherent Flexibility of Authentic Murine Papillomavirus Capsids Open
Human papillomavirus (HPV) is a significant health burden and leading cause of virus-induced cancers. However, studies have been hampered due to restricted tropism that makes production and purification of high titer virus problematic. Thi…
View article: Mouse Papillomavirus L1 and L2 Are Dispensable for Viral Infection and Persistence at Both Cutaneous and Mucosal Tissues
Mouse Papillomavirus L1 and L2 Are Dispensable for Viral Infection and Persistence at Both Cutaneous and Mucosal Tissues Open
Papillomavirus L1 and L2, the major and minor capsid proteins, play significant roles in viral assembly, entry, and propagation. In the current study, we investigate the impact of L1 and L2 on viral life cycle and tumor growth with a newly…
View article: Gene Editing in Rabbits: Unique Opportunities for Translational Biomedical Research
Gene Editing in Rabbits: Unique Opportunities for Translational Biomedical Research Open
The rabbit is a classic animal model for biomedical research, but the production of gene targeted transgenic rabbits had been extremely challenging until the recent advent of gene editing tools. More than fifty gene knockout or knock-in ra…
View article: Papillomavirus can be transmitted through the blood and produce infections in blood recipients: Evidence from two animal models
Papillomavirus can be transmitted through the blood and produce infections in blood recipients: Evidence from two animal models Open
Human papillomaviruses (HPV) contribute to most cervical cancers and are considered to be sexually transmitted. However, papillomaviruses are often found in cancers of internal organs, including the stomach, raising the question as to how …
View article: Antibody-Mediated Immune Subset Depletion Modulates the Immune Response in a Rabbit (<i>Oryctolagus cuniculus</i>) Model of Epstein-Barr Virus Infection
Antibody-Mediated Immune Subset Depletion Modulates the Immune Response in a Rabbit (<i>Oryctolagus cuniculus</i>) Model of Epstein-Barr Virus Infection Open
Epstein-Barr Virus (EBV) is a γ-herpesvirus which infects over 90% of the adult human population. Most notably, this virus causes infectious mononucleosis but it is also associated with cancers such as Hodgkin and Burkitt lymphoma. EBV is …
View article: An Integrated Approach for Preventing Oral Cavity and Oropharyngeal Cancers: Two Etiologies with Distinct and Shared Mechanisms of Carcinogenesis
An Integrated Approach for Preventing Oral Cavity and Oropharyngeal Cancers: Two Etiologies with Distinct and Shared Mechanisms of Carcinogenesis Open
Head and neck squamous cell carcinoma (HNSCC) was the 7th most common malignancy worldwide in 2018 and despite therapeutic advances, the overall survival rate for oral squamous cell carcinoma (OSCC; ∼50%) has remained unchanged for decades…
View article: The rabbit papillomavirus model: a valuable tool to study viral–host interactions
The rabbit papillomavirus model: a valuable tool to study viral–host interactions Open
Cottontail rabbit papillomavirus (CRPV) was the first DNA virus shown to be tumorigenic. The virus has since been renamed and is officially known as Sylvilagus floridanus papillomavirus 1 (SfPV1). Since its inception as a surrogate preclin…
View article: Papillomavirus can be transmitted through the blood and produce infections in blood recipients: Evidence from two animal models
Papillomavirus can be transmitted through the blood and produce infections in blood recipients: Evidence from two animal models Open
Human papillomavirus (HPV) infections are commonly thought to be strictly sexually transmitted. However, studies have demonstrated the presence of HPV in cancers of many non-sexual internal organs, raising the question as to how the viruse…
View article: Papillomavirus can be transmitted through the blood and produce infections in blood recipients: Evidence from two animal models
Papillomavirus can be transmitted through the blood and produce infections in blood recipients: Evidence from two animal models Open
Human papillomaviruses (HPV) contribute to most cervical cancers and are considered to be sexually transmitted. However, papillomaviruses are often found in cancers of internal organs, including the stomach, raising the question as to how …
View article: Papillomavirus can be transmitted through the blood and produce infections in blood recipients: Evidence from two animal models
Papillomavirus can be transmitted through the blood and produce infections in blood recipients: Evidence from two animal models Open
Human papillomaviruses (HPV) contribute to most cervical cancers and are considered to be sexually transmitted. However, papillomaviruses are often found in cancers of internal organs, including the stomach, raising the question as to how …