Jiagui Huang
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View article: Interplay between lipid metabolism and macrophage dynamics in ischemic stroke: From mechanistic insights to therapeutic strategies
Interplay between lipid metabolism and macrophage dynamics in ischemic stroke: From mechanistic insights to therapeutic strategies Open
Ischemic stroke (IS), a leading global cause of long-term disability, is treated with therapies (e.g., thrombolysis, mechanical thrombectomy) constrained by a narrow therapeutic window and ischemia-reperfusion injury risks. Neuroinflammati…
View article: Inhibition of CK2 Diminishes Fibrotic Scar Formation and Improves Outcomes After Ischemic Stroke via Reducing BRD4 Phosphorylation
Inhibition of CK2 Diminishes Fibrotic Scar Formation and Improves Outcomes After Ischemic Stroke via Reducing BRD4 Phosphorylation Open
Fibrotic scars play important roles in tissue reconstruction and functional recovery in the late stage of nervous system injury. However, the mechanisms underlying fibrotic scar formation and regulation remain unclear. Casein kinase II (CK…
View article: New insights into Sirt1: potential therapeutic targets for the treatment of cerebral ischemic stroke
New insights into Sirt1: potential therapeutic targets for the treatment of cerebral ischemic stroke Open
Ischemic stroke is one of the main causes of mortality and disability worldwide. However, the majority of patients are currently unable to benefit from intravenous thrombolysis or intravascular mechanical thrombectomy due to the limited tr…
View article: Vitamin B12, Folate, Homocysteine, Inflammatory Mediators (Interleukin-6, Tumor Necrosis Factor-α and C-Reactive Protein) Levels in Adolescents with Anxiety or Depressive Symptoms
Vitamin B12, Folate, Homocysteine, Inflammatory Mediators (Interleukin-6, Tumor Necrosis Factor-α and C-Reactive Protein) Levels in Adolescents with Anxiety or Depressive Symptoms Open
Lower vitamin B12 levels were correlated with a higher risk of severe anxiety or depressive symptoms. Weak correlations were observed between the severity of some symptoms of anxiety or depression and vitamin B12, folate, tHcy, IL-6, and C…
View article: Sirt1 regulates microglial activation and inflammation following oxygen-glucose deprivation/reoxygenation injury by targeting the Shh/Gli-1 signaling pathway
Sirt1 regulates microglial activation and inflammation following oxygen-glucose deprivation/reoxygenation injury by targeting the Shh/Gli-1 signaling pathway Open
Background Cerebral ischemic injury leads to over-activation of microglia, which release pro-inflammatory factors that deteriorate neurological function during the acute phase of stroke. Thus, inhibiting microglial over-activation is cruci…
View article: Resveratrol Inhibits Activation of Microglia after Stroke through Triggering Translocation of Smo to Primary Cilia
Resveratrol Inhibits Activation of Microglia after Stroke through Triggering Translocation of Smo to Primary Cilia Open
Activated microglia act as a double-edged sword for stroke. In the acute phase of stroke, activated microglia might deteriorate neurological function. Therefore, it is of great clinical transforming potential to explore drugs or methods th…
View article: M2 macrophages mediate fibrotic scar formation in the early stages after cerebral ischemia in rats
M2 macrophages mediate fibrotic scar formation in the early stages after cerebral ischemia in rats Open
In the central nervous system, the formation of fibrotic scar after injury inhibits axon regeneration and promotes repair. However, the mechanism underlying fibrotic scar formation and regulation remains poorly understood. M2 macrophages r…
View article: The role of mesenchymal stem cell transplantation for ischemic stroke and recent research developments
The role of mesenchymal stem cell transplantation for ischemic stroke and recent research developments Open
Ischemic stroke is a common cerebrovascular disease that seriously affects human health. However, most patients do not practice self-care and cannot rely on the current clinical treatment for guaranteed functional recovery. Stem cell trans…
View article: Sirt1 overexpression inhibits fibrous scar formation and improves outcome after cerebral ischemic injury by deacetylation of 14-3-3ζ
Sirt1 overexpression inhibits fibrous scar formation and improves outcome after cerebral ischemic injury by deacetylation of 14-3-3ζ Open
Fibrous scar is one of major factors for hindering synaptic regeneration after central neural system (CNS) injury. Silencing information regulator 2 related enzyme 1 (Sirt1) can regulate lung, liver, kidney and heart fibrosis. However, it …
View article: Sirt1 regulates microglial activation and inflammation following oxygen-glucose deprivation/reoxygenation injury by targeting the Shh/Gli-1 signaling pathway
Sirt1 regulates microglial activation and inflammation following oxygen-glucose deprivation/reoxygenation injury by targeting the Shh/Gli-1 signaling pathway Open
Background: Cerebral ischemic injury leads to over-activation of microglia, which release pro-inflammatory factors that deteriorate neurological function during the acute phase of stroke. Thus, inhibiting microglial over-activation is cruc…
View article: [Inhibition of Sonic Hedgehog signaling inhibits fibrous scar formation and adversely affects functional outcome after ischemic brain injury in rats].
[Inhibition of Sonic Hedgehog signaling inhibits fibrous scar formation and adversely affects functional outcome after ischemic brain injury in rats]. Open
Inhibition of Shh signaling may inhibit fibrous scar formation and functional recovery in rats after ischemic brain injury.
View article: Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke
Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke Open
Ischemic stroke is one of the major causes of death and disability in the world. Currently, most patients cannot choose intravenous thrombolysis or intravascular mechanical thrombectomy because of narrow therapeutic windows and severe comp…
View article: IL4-dependent M2 macrophage mediates fibrotic scar formation and functional restoration via Sonic Hedgehog/TGFβ1 axis in the early stage of cerebral ischemia in rats
IL4-dependent M2 macrophage mediates fibrotic scar formation and functional restoration via Sonic Hedgehog/TGFβ1 axis in the early stage of cerebral ischemia in rats Open
Background: Fibrotic scar of the central nervous system (CNS) has dual roles for inhibiting axon regeneration and promoting repair. However, it is poorly understood for formed and regulated mechanisms. M2 macrophages regulate fibrotic scar…
View article: [Transforming growth factor-β1 induces transformation of rat meningeal fibroblasts into myofibroblasts by upregulating Shh signaling].
[Transforming growth factor-β1 induces transformation of rat meningeal fibroblasts into myofibroblasts by upregulating Shh signaling]. Open
TGF-β1 can induce the transformation of meningeal fibroblasts into myofibroblasts by up-regulating Shh expression in Sonic Hedgehog signaling pathway.
View article: Resveratrol Treatment in Different Time-Attenuated Neuronal Apoptosis After Oxygen and Glucose Deprivation/Reoxygenation via Enhancing the Activation of Nrf-2 Signaling Pathway In Vitro
Resveratrol Treatment in Different Time-Attenuated Neuronal Apoptosis After Oxygen and Glucose Deprivation/Reoxygenation via Enhancing the Activation of Nrf-2 Signaling Pathway In Vitro Open
Recent studies have indicated that resveratrol has protective effects against cerebral ischemia/reperfusion injury. However, the best therapeutic time for resveratrol treatment after acute ischemic stroke remains unknown. We aim to investi…