Jianjiao Ni
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View article: QuYuShengXin formula reshapes bile-acid-mediated macrophage polarization in the treatment of ulcerative colitis
QuYuShengXin formula reshapes bile-acid-mediated macrophage polarization in the treatment of ulcerative colitis Open
By re-instating the physiologic fecal BA landscape, QYSX engages TGR5 to inhibit NF-κB signaling, thereby suppressing LPS- and TNF-α-driven M1 hyper-activation. This restoration of M2/M1 homeostasis curbs mucosal inflammation and maintains…
View article: Pattern of Lymph Node Metastases and Recurrence in Thoracic Small Cell Esophageal Carcinoma: A Single-Institution Experience
Pattern of Lymph Node Metastases and Recurrence in Thoracic Small Cell Esophageal Carcinoma: A Single-Institution Experience Open
Background To study the patterns of lymph node metastases (LNMs) and associated factors, prognostic factors and failure patterns in primary thoracic small cell esophageal carcinoma (SCEC) after curative esophagectomy. Methods We retrospect…
View article: Radiation‐induced extracellular vesicles from cancer‐associated fibroblasts drive oesophageal squamous cell carcinoma metastasis via the miR‐193a‐3p/PTEN/Akt pathway
Radiation‐induced extracellular vesicles from cancer‐associated fibroblasts drive oesophageal squamous cell carcinoma metastasis via the miR‐193a‐3p/PTEN/Akt pathway Open
Background The recurrence and metastasis of oesophageal squamous cell cancer (ESCC) following radiation therapy are major treatment challenges. Cancer‐associated fibroblasts (CAFs) are key in the ESCC microenvironment, yet their role in po…
View article: A promising novel material-light-cured wound closure adhesives promote wound healing after pilonidal sinus open surgery: a Case Report
A promising novel material-light-cured wound closure adhesives promote wound healing after pilonidal sinus open surgery: a Case Report Open
Background/objectives Pilonidal sinus disease (PSD), a common sacrococcygeal infectious disease, is characterized by sacrococcygeal swelling, pain, sacrococcygeal midline pits, sinus containing hair. Surgery is the main treatment for PSD. …
View article: Please Do Not Respond Asap: Impact of Workplace Telepressure on Employees’ Innovative Behavior in the Digital Era
Please Do Not Respond Asap: Impact of Workplace Telepressure on Employees’ Innovative Behavior in the Digital Era Open
This study investigates how workplace telepressure—the urge and preoccupation to respond quickly to work-related messages via ICT—affects R&D employees’ innovative behavior. While telepressure is widely recognized as a response to job dema…
View article: Prognostic factors, patterns of failure and re-irradiation in hypofractionated stereotactic radiotherapy-treated brain metastases from non-small cell lung cancer
Prognostic factors, patterns of failure and re-irradiation in hypofractionated stereotactic radiotherapy-treated brain metastases from non-small cell lung cancer Open
fSRT is a promising treatment for limited BMs from NSCLC and some patients may benefit from re-fSRT.
View article: Physics-Constrained Diffusion Reconstruction with Posterior Correction for Quantitative and Fast PET Imaging
Physics-Constrained Diffusion Reconstruction with Posterior Correction for Quantitative and Fast PET Imaging Open
Deep learning-based reconstruction of positron emission tomography(PET) data has gained increasing attention in recent years. While these methods achieve fast reconstruction,concerns remain regarding quantitative accuracy and the presence …
View article: Design strategies for high entropy materials in water electrolysis: Enhancing activity, stability, and reaction kinetics
Design strategies for high entropy materials in water electrolysis: Enhancing activity, stability, and reaction kinetics Open
This review aims to establish general guidelines for designing highly active high-entropy materials (HEMs) with respect to lattice choice, component selection, and samorphological design, leading to the optimization of reaction kinetics an…
View article: Consolidative stereotactic radiotherapy for oligo-residual non-small cell lung cancer after first-line chemoimmunotherapy: A single-arm, phase 2 trial from China
Consolidative stereotactic radiotherapy for oligo-residual non-small cell lung cancer after first-line chemoimmunotherapy: A single-arm, phase 2 trial from China Open
Background Retrospective evidence indicated potential survival benefit of consolidative stereotactic radiotherapy (SRT) in patients with metastatic driver mutation-negative non-small cell lung cancer (NSCLC) harboring oligo-residual diseas…
View article: Oligo-residual disease in metastatic ALK-positive NSCLC treated with alectinib
Oligo-residual disease in metastatic ALK-positive NSCLC treated with alectinib Open
Accumulating evidence suggests local consolidative therapy may delay resistance and benefit metastatic NSCLC patients with oligo-residual disease (ORD) after effective systemic therapy. However, the incidence and clinical features of ORD i…
View article: Early local therapy in combination with PD-1/PD-L1 inhibitors in oligometastatic non-small cell lung cancer: results from a prospective multicenter observational study
Early local therapy in combination with PD-1/PD-L1 inhibitors in oligometastatic non-small cell lung cancer: results from a prospective multicenter observational study Open
View article: Identification of cancer-associated fibroblast signature genes for prognostic prediction in colorectal cancer
Identification of cancer-associated fibroblast signature genes for prognostic prediction in colorectal cancer Open
Background Cancer-associated fibroblasts are an essential part of the tumor immunoenvironment, playing key roles in malignancy progression and treatment response. This study was to characterize cancer-associated fibroblasts-related genes (…
View article: <scp>NSE</scp> and <scp>ProGRP</scp> Are Promising Markers for Diagnosis, Efficacy Evaluation, Follow‐Up Monitoring, and Prognosis of Small Cell Esophageal Carcinoma
<span>NSE</span> and <span>ProGRP</span> Are Promising Markers for Diagnosis, Efficacy Evaluation, Follow‐Up Monitoring, and Prognosis of Small Cell Esophageal Carcinoma Open
Background To investigate the clinical implications of serum carcinoembryonic antigen (CEA), neuron specific enolase (NSE), and pro‐gastrin‐releasing peptide (ProGRP) in small cell esophageal carcinoma (SCEC). Methods Receiver operating ch…
View article: Preliminary study on the correlation between thyroid magnetic resonance parameters and radiation dose after radiotherapy for nasopharyngeal carcinoma
Preliminary study on the correlation between thyroid magnetic resonance parameters and radiation dose after radiotherapy for nasopharyngeal carcinoma Open
Background Hypothyroidism is a common sequela after radiotherapy for nasopharyngeal carcinoma (NPC). Magnetic resonance imaging (MRI) has gained prominence in thyroid imaging, leveraging its non-ionizing radiation, high spatial resolution,…
View article: Highly Efficient Stabilization of Arsenic in the Contaminated Sediments of Jiehe River by Schwertmannite to Inhibit Arsenic Release into River Water
Highly Efficient Stabilization of Arsenic in the Contaminated Sediments of Jiehe River by Schwertmannite to Inhibit Arsenic Release into River Water Open
View article: Cranial Stereotactic Radiotherapy for Third-Generation EGFR Tyrosine Kinase Inhibitor-Treated Non-Small Cell Lung Cancer with Baseline Limited Brain Metastasis
Cranial Stereotactic Radiotherapy for Third-Generation EGFR Tyrosine Kinase Inhibitor-Treated Non-Small Cell Lung Cancer with Baseline Limited Brain Metastasis Open
View article: Identification of a novel subtype of SPP1 + macrophages expressing SIRPα: implications for tumor immune evasion and treatment response prediction
Identification of a novel subtype of SPP1 + macrophages expressing SIRPα: implications for tumor immune evasion and treatment response prediction Open
View article: Prognostic significance of bone metastasis and clinical value of bone radiotherapy in metastatic non-small cell lung cancer receiving PD-1/PD-L1 inhibitors: results from a multicenter, prospective, observational study
Prognostic significance of bone metastasis and clinical value of bone radiotherapy in metastatic non-small cell lung cancer receiving PD-1/PD-L1 inhibitors: results from a multicenter, prospective, observational study Open
Baseline BoM correlated with worse prognosis and palliative bone radiation did not improve PFS in metastatic NSCLC patients receiving PD-1/PD-L1 inhibitors.
View article: Safety and efficacy of consolidative stereotactic radiotherapy for oligo-residual EGFR-mutant non-small cell lung cancer after first-line third-generation EGFR-tyrosine kinase inhibitors: a single-arm, phase 2 trial
Safety and efficacy of consolidative stereotactic radiotherapy for oligo-residual EGFR-mutant non-small cell lung cancer after first-line third-generation EGFR-tyrosine kinase inhibitors: a single-arm, phase 2 trial Open
Hui Lan Public Welfare and the Chinese Society of Clinical Oncology Foundation.
View article: Sintilimab in combination with stereotactic body radiotherapy and granulocyte-macrophage colony-stimulating factor in metastatic non-small cell lung cancer: The multicenter SWORD phase 2 trial
Sintilimab in combination with stereotactic body radiotherapy and granulocyte-macrophage colony-stimulating factor in metastatic non-small cell lung cancer: The multicenter SWORD phase 2 trial Open
View article: Oligo-residual disease in PD-1/PD-L1 inhibitor-treated metastatic non-small cell lung cancer: incidence, pattern of failure, and clinical value of local consolidative therapy
Oligo-residual disease in PD-1/PD-L1 inhibitor-treated metastatic non-small cell lung cancer: incidence, pattern of failure, and clinical value of local consolidative therapy Open
Objectives To investigate the feasibility and potential clinical value of local consolidative therapy (LCT) in PD-1/PD-L1 inhibitor-treated metastatic non-small cell lung cancer (NSCLC). Materials and methods PD-1/PD-L1 inhibitor-treated m…
View article: Prognostic value of genomic mutation signature associated with immune microenvironment in southern Chinese patients with esophageal squamous cell carcinoma
Prognostic value of genomic mutation signature associated with immune microenvironment in southern Chinese patients with esophageal squamous cell carcinoma Open
View article: Pamiparib as consolidation treatment after concurrent chemoradiotherapy of limited-stage small cell lung cancer: a single-arm, open-label phase 2 trial
Pamiparib as consolidation treatment after concurrent chemoradiotherapy of limited-stage small cell lung cancer: a single-arm, open-label phase 2 trial Open
Background Small cell lung cancer (SCLC) is highly invasive with poor prognosis, and its treatment has historically been hindered due to the absence of targetable driver genomic alterations. However, the high genomic instability and replic…
View article: 14P Consolidative stereotactic radiotherapy in metastatic EGFR-mutant non-small cell lung cancer receiving first-line third-generation EGFR tyrosine kinase inhibitors: A prospective, multicenter, phase II trial
14P Consolidative stereotactic radiotherapy in metastatic EGFR-mutant non-small cell lung cancer receiving first-line third-generation EGFR tyrosine kinase inhibitors: A prospective, multicenter, phase II trial Open
The efficacy and safety of consolidative stereotactic body radiation therapy (SBRT) in patients with EGFR-mutant NSCLC who developed oligo-residual disease after first-line third-generation EGFR TKIs is unknown. A single-arm, multicenter, …
View article: NGS-based Tissue-Blood TMB Comparison and Blood-TMB Monitoring in Stage-III Non-Small Cell Lung Cancer Treated with Concurrent Chemoradiotherapy
NGS-based Tissue-Blood TMB Comparison and Blood-TMB Monitoring in Stage-III Non-Small Cell Lung Cancer Treated with Concurrent Chemoradiotherapy Open
In this study, we analyzed the blood-based TMB (b-TMB) and its dynamic changes in patients with locally advanced non-small cell lung cancer (LA-NSCLC) who received concurrent chemoradiotherapy. Baseline tissue and blood TMB from 15 patient…
View article: A PET/CT radiomics model for predicting distant metastasis in early-stage non–small cell lung cancer patients treated with stereotactic body radiotherapy: a multicentric study
A PET/CT radiomics model for predicting distant metastasis in early-stage non–small cell lung cancer patients treated with stereotactic body radiotherapy: a multicentric study Open
Objectives Stereotactic body radiotherapy ( SBRT) is a treatment option for patients with early-stage non-small cell lung cancer (NSCLC) who are unfit for surgery. Some patients may experience distant metastasis. This study aimed to develo…
View article: Postoperative Radiotherapy in Curatively Resected Esophageal Squamous Cell Carcinoma With Occult Recurrent Laryngeal Nerve Lymph Node Metastasis
Postoperative Radiotherapy in Curatively Resected Esophageal Squamous Cell Carcinoma With Occult Recurrent Laryngeal Nerve Lymph Node Metastasis Open
Objectives Surgery is the mainstream treatment for early-stage esophageal squamous cell carcinoma (ESCC) and occult recurrent laryngeal nerve lymph node metastasis (RLNM) is not uncommon among those with R0 resection. The clinical value of…
View article: Potential synergistic effects of cranial radiotherapy and atezolizumab in non-small cell lung cancer: an analysis of individual patient data from seven prospective trials
Potential synergistic effects of cranial radiotherapy and atezolizumab in non-small cell lung cancer: an analysis of individual patient data from seven prospective trials Open
These data suggest potential synergistic effects of cranial RT and anti-PD-(L)1 therapy in NSCLC patients, which warrants further validation.
View article: Association of previously irradiated stable brain metastases with outcomes of atezolizumab‐treated non‐small cell lung cancer: A pooled analysis of individual patient data from three randomized trials
Association of previously irradiated stable brain metastases with outcomes of atezolizumab‐treated non‐small cell lung cancer: A pooled analysis of individual patient data from three randomized trials Open
Brain metastasis (BM) has long been recognized as a prognostic factor associated with poor prognosis for non-small cell lung cancer (NSCLC) in the era of conventional chemotherapy and targeted therapy [1]. In the era of immunotherapy, cont…
View article: STING signaling activation modulates macrophage polarization via CCL2 in radiation-induced lung injury
STING signaling activation modulates macrophage polarization via CCL2 in radiation-induced lung injury Open