Jiahua Lv
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View article: Real-world efficacy of PD-1 inhibitors in treating oesophageal squamous cell carcinoma (ESCAPE): protocol of a multicentre, real-world, observational, cohort study
Real-world efficacy of PD-1 inhibitors in treating oesophageal squamous cell carcinoma (ESCAPE): protocol of a multicentre, real-world, observational, cohort study Open
Introduction Oesophageal cancer (EC) presents a substantial global health challenge, ranking eighth in incidence and sixth in cancer-related mortality. Oesophageal squamous cell carcinoma (ESCC) is the primary subtype and accounts for appr…
View article: Adjuvant immunotherapy for esophageal squamous cell carcinoma after neoadjuvant chemoimmunotherapy: a multicenter real-world study
Adjuvant immunotherapy for esophageal squamous cell carcinoma after neoadjuvant chemoimmunotherapy: a multicenter real-world study Open
Background: Although adjuvant immunotherapy demonstrated an improvement in disease-free survival (DFS) within the chemoradiotherapy cohort of the CheckMate 577 trial, its efficacy and role following NCIT remain to be elucidated. This large…
View article: A <i>GABRB3</i> mutation (c.5G>A, p.Trp2*) in twins with generalized epilepsy with febrile seizures: A case report
A <i>GABRB3</i> mutation (c.5G>A, p.Trp2*) in twins with generalized epilepsy with febrile seizures: A case report Open
In children aged 3 months to 6 years, convulsions that occur when the body temperature reaches >38˚C are referred to as febrile seizures (FS), provided that central nervous system infections and other metabolic etiologies are excluded. Gen…
View article: Diagnosis and Subtyping of Autoimmune Encephalitis Using an Attention‐Based Multi‐Instance Learning Model: A Multi‐Center <scp><sup>18</sup>F</scp>‐<scp>FDG PET</scp> Study
Diagnosis and Subtyping of Autoimmune Encephalitis Using an Attention‐Based Multi‐Instance Learning Model: A Multi‐Center <span><sup>18</sup>F</span>‐<span>FDG PET</span> Study Open
Background The aim was to develop an attention‐based model using 18 F‐fluorodeoxyglucose ( 18 F‐FDG) PET imaging to differentiate autoimmune encephalitis (AE) patients from controls and to discriminate among different AE subtypes. Methods …
View article: Impact of first-line chemoimmunotherapy with or without radiotherapy on the prognosis of patients with locally advanced or metastatic esophageal squamous cell carcinoma: a multicenter, real-world, retrospective cohort study from China (NCT06478355)
Impact of first-line chemoimmunotherapy with or without radiotherapy on the prognosis of patients with locally advanced or metastatic esophageal squamous cell carcinoma: a multicenter, real-world, retrospective cohort study from China (NCT06478355) Open
Background Chemotherapy combined with immunotherapy has already become the standard first-line treatment for advanced or metastatic esophageal squamous cell carcinoma (ESCC), whereas there are no satisfying overall survival (OS) and progre…
View article: Intermediate filament IFFO1 negatively regulates the migration of lung cancer cells by inhibiting the IQGAP3-Cdc42 interaction
Intermediate filament IFFO1 negatively regulates the migration of lung cancer cells by inhibiting the IQGAP3-Cdc42 interaction Open
View article: Neoadjuvant chemotherapy or chemoradiotherapy plus sintilimab versus neoadjuvant chemoradiotherapy for locally advanced oesophageal squamous cell carcinoma: a study protocol of a multicentre, randomised, controlled, phase III trial (SCIENCE study)
Neoadjuvant chemotherapy or chemoradiotherapy plus sintilimab versus neoadjuvant chemoradiotherapy for locally advanced oesophageal squamous cell carcinoma: a study protocol of a multicentre, randomised, controlled, phase III trial (SCIENCE study) Open
Introduction Oesophageal squamous cell carcinoma (ESCC) is a globally challenging digestive tract malignancy with poor prognosis and limited treatment options. Early-stage ESCC is often asymptomatic, leading to a late-stage diagnosis in ma…
View article: Neoadjuvant Chemoradiotherapy vs Chemoimmunotherapy for Esophageal Squamous Cell Carcinoma
Neoadjuvant Chemoradiotherapy vs Chemoimmunotherapy for Esophageal Squamous Cell Carcinoma Open
Importance The association of neoadjuvant chemoimmunotherapy (NCIT) vs chemoradiotherapy (NCRT) with tumor downstaging and survival in locally advanced esophageal squamous cell carcinoma (ESCC) remains unclear because of limited evidence. …
View article: China Anti-Cancer Association (CACA) guidelines for treating cancer-related malnutrition
China Anti-Cancer Association (CACA) guidelines for treating cancer-related malnutrition Open
Malnutrition in cancer patients is the result of a variety of factors. Decreased intake, absorption disorders, metabolic disorders and increased REE are the main causes of malnutrition. The incidence of malnutrition in cancer patients is h…
View article: Long-term outcomes of smoker and drinker with oesophageal squamous cell carcinoma after oesophagectomy: a large-scale propensity score matching analysis
Long-term outcomes of smoker and drinker with oesophageal squamous cell carcinoma after oesophagectomy: a large-scale propensity score matching analysis Open
Background Oesophageal squamous cell carcinoma (OSCC) poses a considerable health burden, particularly in regions such as East Asia. This study aims to investigate the long-term outcomes of OSCC patients who are smokers and drinkers. Mater…
View article: Advances in the study of polydopamine nanotechnology in central nervous system disorders
Advances in the study of polydopamine nanotechnology in central nervous system disorders Open
Disorders of the central nervous system (CNS) constitute a significant global health concern at the moment. Most CNS disorders are characterized by severe neuronal damage with excessive production of reactive oxygen species, which induces …
View article: Peripheral T lymphocyte and immunocyte subset dynamics: markers of neoadjuvant therapy outcomes in esophageal squamous cell carcinoma
Peripheral T lymphocyte and immunocyte subset dynamics: markers of neoadjuvant therapy outcomes in esophageal squamous cell carcinoma Open
Purpose In patients with resectable esophageal squamous cell carcinoma (ESCC), neoadjuvant therapy increased the curative resection rate, disease-free survival, and overall survival for patients with resectable ESCC. However, the efficacy …
View article: Collaborative multidisciplinary management and expertise of cT2–3 locally advanced operable esophageal squamous cell carcinoma: a report of two cases
Collaborative multidisciplinary management and expertise of cT2–3 locally advanced operable esophageal squamous cell carcinoma: a report of two cases Open
The article concludes that the accurate staging of ESCC is a cornerstone in determining the most suitable treatment strategies. It underscores the vital role that MDTs play in both clinical staging and the decision-making process for treat…
View article: Pharmacogenomic Analysis of Medial Temporal Lobe Epilepsy with Hippocampal Sclerosis in Humans and Animal Models
Pharmacogenomic Analysis of Medial Temporal Lobe Epilepsy with Hippocampal Sclerosis in Humans and Animal Models Open
Background Epilepsy is a neurological disorder caused by abnormal brain discharges. In recent years, genome-wide expression studies (GES) have been conducted using human patient samples and experimental models of epilepsy. Numerous molecul…
View article: Seizure Outcome After Surgery for Refractory Epilepsy Diagnosed by 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET/MRI): A Systematic Review and Meta-Analysis
Seizure Outcome After Surgery for Refractory Epilepsy Diagnosed by 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET/MRI): A Systematic Review and Meta-Analysis Open
Seventy-one percent of patients with refractory epilepsy and 18F-FDG PET/MRI epileptogenic lesion features had a good outcome of epilepsy after surgery. Our findings can be incorporated into routine preoperative consultations an…
View article: Pretreatment Low Serum Sodium as a Prognostic Factor for Patients with Esophageal Cancer Treated with Radiotherapy or Chemoradiotherapy
Pretreatment Low Serum Sodium as a Prognostic Factor for Patients with Esophageal Cancer Treated with Radiotherapy or Chemoradiotherapy Open
Low serum sodium levels have been associated with poor prognoses for several cancers. However, the prognostic value of low serum sodium levels in esophageal carcinoma (EC) has not been well elucidated. We examined the prognostic value of l…
View article: 413 Toripalimab in combination with concurrent chemoradiation in patients with advanced/metastatic esophageal carcinoma: protocol for a single-arm, prospective, open-label, phase II clinical trial
413 Toripalimab in combination with concurrent chemoradiation in patients with advanced/metastatic esophageal carcinoma: protocol for a single-arm, prospective, open-label, phase II clinical trial Open
Background Esophageal carcinoma is a disease with high morbidity and mortality in China and, recently, Immune checkpoint inhibitors(ICIs) combined with chemotherapy have shown good efficacy and safety for treatment; however, some patients …
View article: A Meta-Analysis of 5-Hydroxytryptamine Receptor 1B Polymorphisms With Risk of Major Depressive Disorder and Suicidal Behavior
A Meta-Analysis of 5-Hydroxytryptamine Receptor 1B Polymorphisms With Risk of Major Depressive Disorder and Suicidal Behavior Open
Purpose: Previous association studies have investigated whether genetic polymorphisms in HTR1B influenced individuals' susceptibility to major depressive disorder (MDD), anti-depressant response (ADR) and suicidal behavior. However, equivo…
View article: Tumor Compactness based on CT to predict prognosis after multimodal treatment for esophageal squamous cell carcinoma
Tumor Compactness based on CT to predict prognosis after multimodal treatment for esophageal squamous cell carcinoma Open
View article: Downregulation of microRNA-21 inhibited radiation-resistance of esophageal squamous cell carcinoma
Downregulation of microRNA-21 inhibited radiation-resistance of esophageal squamous cell carcinoma Open
View article: Does cervical lymph node recurrence after oesophagectomy or definitive chemoradiotherapy for thoracic oesophageal squamous cell carcinoma benefit from salvage treatment?
Does cervical lymph node recurrence after oesophagectomy or definitive chemoradiotherapy for thoracic oesophageal squamous cell carcinoma benefit from salvage treatment? Open
A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was 'Does cervical lymph node recurrence after oesophagectomy or definitive chemoradiotherapy for thoracic oesophageal squamou…
View article: Safety and outcome of external beam radiationand neutron brachytherapy in elderly patientswith esophageal squamous cell cancer
Safety and outcome of external beam radiationand neutron brachytherapy in elderly patientswith esophageal squamous cell cancer Open
The clinical data indicated that NBT in combination with EBRT produced favorable local control and long-term survival rates for elderly patients with ESCC, and that the side effects were tolerable. Patient's age, clinical stage N status, a…
View article: External beam radiation and high-dose-rate brachytherapy for elderly patients with gastroesophageal junction adenocarcinoma
External beam radiation and high-dose-rate brachytherapy for elderly patients with gastroesophageal junction adenocarcinoma Open
The clinical data indicated that NBT in combination with EBRT produced favorable local control and long-term survival rates for elderly patients with GEJAC, and that the side effects were tolerable. The patient's age could be used to selec…