Jiahui Yan
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View article: Cerebrospinal fluid-based clinical-radiomics model for predicting treatment prognosis of acute ischemic stroke
Cerebrospinal fluid-based clinical-radiomics model for predicting treatment prognosis of acute ischemic stroke Open
View article: SlWRKY42 positively promotes proline accumulation by regulating SlP5CS1 to enhance tomato salt stress tolerance
SlWRKY42 positively promotes proline accumulation by regulating SlP5CS1 to enhance tomato salt stress tolerance Open
View article: Inhibition of AKT or mTOR molecules mitigates obesity-associated metabolic disorders in Riz1 mice with obesity
Inhibition of AKT or mTOR molecules mitigates obesity-associated metabolic disorders in Riz1 mice with obesity Open
The deficiency of the tumor suppressor factor RIZ1 can lead to obesity with activation of the V-Akt murine thymoma viral oncogene homolog (PKB) (AKT)/mechanistic target of rapamycin (mTOR) pathway. The aim of this study was to elucidate th…
View article: Predictive Value of Combined CRP and INR for Intracranial Hypertension in Cerebral Venous Thrombosis
Predictive Value of Combined CRP and INR for Intracranial Hypertension in Cerebral Venous Thrombosis Open
Background Intracranial hypertension (IH) is a frequently observed clinical manifestation of cerebral venous thrombosis (CVT), which reflects the severity of the disease. The gold standard of intracranial pressure (ICP) is through invasive…
View article: Effect of heat-treatment on the microstructure and magnetic properties of Tb and Tb/Cu diffused Nd-Fe-B magnets
Effect of heat-treatment on the microstructure and magnetic properties of Tb and Tb/Cu diffused Nd-Fe-B magnets Open
View article: Comparative analysis of CDR3 length-dependent patterns in VHHs
Comparative analysis of CDR3 length-dependent patterns in VHHs Open
Introduction VHHs, or nanobodies, are distinguished by their compact size, high stability, and unique ability to selectively target specific epitopes. The CDR3 region in VHHs, which plays a crucial role in antigen binding, exhibits signifi…
View article: Transcriptomic and metabolomic response of Methodist line peppers to BBWV2 infection in Qinghai Province, China
Transcriptomic and metabolomic response of Methodist line peppers to BBWV2 infection in Qinghai Province, China Open
Background Pepper (Capsicum annuum L.) is an important economic crop in Qinghai Province, China. In recent years, Broad bean wilt virus 2 (BBWV2) has severely affected the production of the local Methodist line pepper, leading to significa…
View article: Effects of Simiao Pill on rheumatoid arthritis complicated with interstitial lung disease via the ATX/LPA/LPA1 and RhoA/ROCK2 signaling pathways
Effects of Simiao Pill on rheumatoid arthritis complicated with interstitial lung disease via the ATX/LPA/LPA1 and RhoA/ROCK2 signaling pathways Open
Background: In Traditional Chinese Medicine theory, Simiao Pill represents a traditional herbal formulation used for rheumatoid arthritis (RA) management. Initial research indicates that Simiao Pill might have therapeutic benefits for RA l…
View article: Amino Acid‐Decorated MOF Membranes Toward Facilitated CO<sub>2</sub> Separation Under Varying Humidities
Amino Acid‐Decorated MOF Membranes Toward Facilitated CO<sub>2</sub> Separation Under Varying Humidities Open
Although proven to be promising for CO 2 capture from flue gas, maintaining superior separation efficiency of CO 2 ‐philic membranes under widely differing humidities remains highly challenging to date. Targeting high‐efficiency and humidi…
View article: Bidirectional causal association between type 1 diabetes and autoimmune diseases: a Mendelian randomization study
Bidirectional causal association between type 1 diabetes and autoimmune diseases: a Mendelian randomization study Open
Introduction It has been reported that individuals with type 1 diabetes (T1D) are at a higher risk of concomitant occurrence of other autoimmune diseases (AIDs). Currently, there is a lack of research investigating the causal relationship …
View article: Identification of barley yellow dwarf virus strains and genetic analysis of GAV strains in Qinghai Province
Identification of barley yellow dwarf virus strains and genetic analysis of GAV strains in Qinghai Province Open
Barley yellow dwarf disease, caused by barley yellow dwarf virus (BYDVs), significantly affects global wheat crop production. It has reached epidemic proportions in the Qinghai Province, China. To explore the primary epidemic strains, gene…
View article: Eliminating lattice defects in UiO-66-NH2 membrane towards high-precision desalination
Eliminating lattice defects in UiO-66-NH2 membrane towards high-precision desalination Open
Zirconium-based MOF membranes exhibit significant potential in energy-efficient desalination. Nevertheless, framework defect elimination, which represents an effective protocol to enhance their molecular sieving capacity and operation stab…
View article: Enhanced anti-inflammatory activity of chlorogenic acid via folic acid-TPGS-modified liposomes encapsulation: characterization and In vivo evaluation on colitis mice
Enhanced anti-inflammatory activity of chlorogenic acid via folic acid-TPGS-modified liposomes encapsulation: characterization and In vivo evaluation on colitis mice Open
Introduction Chlorogenic acid (CGA) has been identified to possess salient anti-inflammatory, antioxidant, and anticancer attributes. However, its application is limited by its instability and low bioavailability. Liposomes have been consi…
View article: NH<sub>2</sub>-MIL-125 Nanosheets Prepared via Crystallization Kinetics Modulation for Ultrathin Membrane Fabrication
NH<sub>2</sub>-MIL-125 Nanosheets Prepared via Crystallization Kinetics Modulation for Ultrathin Membrane Fabrication Open
Regulating both crystallographic orientation and thickness of titanium metal-organic framework (Ti-MOF) membranes remains a significant challenge. In this study, we pioneered the fabrication of uniform 29 nm thick NH2-MIL-125 na…
View article: Unraveling the interplay between dyskinesia and overactive bladder symptoms in Parkinson’s disease: a comprehensive cohort study based on the long-term follow-up database of Parkinson’s disease
Unraveling the interplay between dyskinesia and overactive bladder symptoms in Parkinson’s disease: a comprehensive cohort study based on the long-term follow-up database of Parkinson’s disease Open
View article: miR-214-3p promotes the pathogenesis of Parkinson's disease by inhibiting autophagy
miR-214-3p promotes the pathogenesis of Parkinson's disease by inhibiting autophagy Open
Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by dopaminergic neuron death in the substantia nigra, leading to motor dysfunction. Autophagy dysregulation has been implicated in PD pathogenesis. This study…
View article: Nonlinearity association between hyperuricemia and all-cause mortality in patients with chronic kidney disease
Nonlinearity association between hyperuricemia and all-cause mortality in patients with chronic kidney disease Open
View article: Hierarchical Uio-66 Synthesized from Hard Templates Towards Enhanced Co2/N2 Separation
Hierarchical Uio-66 Synthesized from Hard Templates Towards Enhanced Co2/N2 Separation Open
View article: Marine biomaterials in biomedical nano/micro-systems
Marine biomaterials in biomedical nano/micro-systems Open
View article: Multifaceted oncostatin M: novel roles and therapeutic potential of the oncostatin M signaling in rheumatoid arthritis
Multifaceted oncostatin M: novel roles and therapeutic potential of the oncostatin M signaling in rheumatoid arthritis Open
Rheumatoid arthritis (RA) is a self-immune inflammatory disease characterized by joint damage. A series of cytokines are involved in the development of RA. Oncostatin M (OSM) is a pleiotropic cytokine that primarily activates the Janus kin…
View article: Dyslipidemia in rheumatoid arthritis: the possible mechanisms
Dyslipidemia in rheumatoid arthritis: the possible mechanisms Open
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease, of which the leading cause of death is cardiovascular disease (CVD). The levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), and high-density lipop…
View article: Effect of magnetic field annealing on magnetic properties and corrosion resistance of MnBi alloy
Effect of magnetic field annealing on magnetic properties and corrosion resistance of MnBi alloy Open
Herein, MnBi alloys are prepared using melt spinning and magnetic-field annealing techniques, and the effects of magnetic-field annealing on the microstructure, magnetic properties, magnetisation behaviour, and corrosion resistance of MnBi…
View article: Oriented Ultrathin π‐complexation MOF Membrane for Ethylene/Ethane and Flue Gas Separations
Oriented Ultrathin π‐complexation MOF Membrane for Ethylene/Ethane and Flue Gas Separations Open
Rational design and engineering of high‐performance molecular sieve membranes towards C 2 H 4 /C 2 H 6 and flue gas separations remain a grand challenge to date. In this study, through combining pore micro‐environment engineering with meso…
View article: Triptolide attenuates pulmonary fibrosis by inhibiting fibrotic extracellular matrix remodeling mediated by MMPs/LOX/integrin
Triptolide attenuates pulmonary fibrosis by inhibiting fibrotic extracellular matrix remodeling mediated by MMPs/LOX/integrin Open
These findings show that triptolide prevents the key linkages of fibrotic ECM remodeling, including deposition, degradation, cross-linking, and pro-fibrotic feedback and, therefore, has potential therapeutic value for pulmonary fibrosis.
View article: Photoelectric characteristics of hydrogen-terminated polycrystalline diamond MESFETs
Photoelectric characteristics of hydrogen-terminated polycrystalline diamond MESFETs Open
In the field of diamond MESFETs, this work is what we believe to be the first to investigate the optoelectronic properties of hydrogen-terminated polycrystalline diamond MESFETs under visible and near-UV light irradiation. It is shown that…
View article: Distribution and identification of main viruses infecting pepper in Qinghai
Distribution and identification of main viruses infecting pepper in Qinghai Open
From 2019 to 2021, pepper viruses were investigated in pepper planting areas and collected a total of 333 samples were in Qinghai (The central district, Datong, Huangzhong in Xining; Ledu district, Pingan, Huzhu, Minhe in Haidong, and Jian…
View article: Issue Information
Issue Information Open
Cover image caption: The US healthcare system is primarily focused on care, and often only when disease is manifest.To make progress on health for all, a reconceptualization of health and the progression to disease is needed.Scientific adv…
View article: Nonlinearity Association between Hyperuricemia and All-cause Mortality of Patients with Chronic Kidney Disease
Nonlinearity Association between Hyperuricemia and All-cause Mortality of Patients with Chronic Kidney Disease Open
Background: Controversy surrounds the role of serum uric acid and whether treatment intervention is favorable in retarding the progress of chronic kidney disease (CKD). The association of serum uric acid levels and CKD patients’ mortality …
View article: Rapidly Inhibiting the Inflammatory Cytokine Storms and Restoring Cellular Homeostasis to Alleviate Sepsis by Blocking Pyroptosis and Mitochondrial Apoptosis Pathways
Rapidly Inhibiting the Inflammatory Cytokine Storms and Restoring Cellular Homeostasis to Alleviate Sepsis by Blocking Pyroptosis and Mitochondrial Apoptosis Pathways Open
Pyroptosis, systemic inflammation, and mitochondrial apoptosis are the three primary contributors to sepsis's multiple organ failure, the ultimate cause of high clinical mortality. Currently, the drugs under development only target a singl…
View article: Simiao pill attenuates collagen-induced arthritis and bleomycin-induced pulmonary fibrosis in mice by suppressing the JAK2/STAT3 and TGF-β/Smad2/3 signalling pathway
Simiao pill attenuates collagen-induced arthritis and bleomycin-induced pulmonary fibrosis in mice by suppressing the JAK2/STAT3 and TGF-β/Smad2/3 signalling pathway Open
SM can not only effectively improve joint inflammation by JAK2/STAT3 Pathway but also inhibit pulmonary fibrosis by TGF-β/SMAD2/3. The fibrosis induced by CIA-BLM model was more stable and obvious than that induced by CIA model alone.