Jiaji Ding
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View article: Nutrient stress diverts RRN3 from rRNA transcription to alternative polyadenylation of autophagy mRNAs in ovarian cancer
Nutrient stress diverts RRN3 from rRNA transcription to alternative polyadenylation of autophagy mRNAs in ovarian cancer Open
Stress-induced alternative processing of mRNA is emerging as an essential mechanism to drive almost every hallmark of cancer. Through a genome-wide screening based on an abnormal transcriptional readthrough event favoring the malignant pro…
View article: Hyaluronan catabolism supports the peritoneal disseminated metastasis of cancer through the glucuronic acid pathway
Hyaluronan catabolism supports the peritoneal disseminated metastasis of cancer through the glucuronic acid pathway Open
When disseminated into the peritoneal cavity at the very early stage, cancer cells must adapt to the glucose- and oxygen-limited environment in peritoneal fluid. To investigate the molecular mechanisms enabling this adaptation, we conducte…
View article: Integrated application of subsoiling tillage and micro-ridge-furrow planting enhances maize yield, water productivity and economic benefit in drought-prone regions
Integrated application of subsoiling tillage and micro-ridge-furrow planting enhances maize yield, water productivity and economic benefit in drought-prone regions Open
View article: Sagittaria Sagittaria polysaccharide protects against retinal vascular damage in diabetic mice by suppressing TLR4 signaling pathway and microglial activation
Sagittaria Sagittaria polysaccharide protects against retinal vascular damage in diabetic mice by suppressing TLR4 signaling pathway and microglial activation Open
Sagittaria sagittifolia polysaccharide (SSP) exhibits anti-inflammatory, antioxidant, lipid-regulating, and hypoglycemic properties, demonstrating therapeutic potential against diabetic retinopathy (DR). This study aimed to investigate the…
View article: The allogenic non-proteinogenic amino acid BMAA-based vaccine breaks up the immune tolerance against colorectal cancer
The allogenic non-proteinogenic amino acid BMAA-based vaccine breaks up the immune tolerance against colorectal cancer Open
The fundamental issue in immunotherapy is the lack of tumor-specific antigens in most types of tumors, leading to immune tolerance. For approximately 85% of patients with microsatellite stable (MSS) colorectal cancer (CRC), the absence of …
View article: Insight into prostate cancer osteolytic metastasis by RelB coordination of IL‐8 and S100A4
Insight into prostate cancer osteolytic metastasis by RelB coordination of IL‐8 and S100A4 Open
Background Although RANK‐LRANK interaction is essential for osteoclastogenesis, the mechanisms by which cancer cells invade bone tissues and initiate osteolytic metastasis remain unclear. Here, we show that the hyperactivation of RelB fost…
View article: Ubiquitin receptor protein OsDSK2b plays a negative role in rice leaf blast resistance and osmotic stress tolerance
Ubiquitin receptor protein OsDSK2b plays a negative role in rice leaf blast resistance and osmotic stress tolerance Open
View article: MicroRNA‑16 sensitizes drug‑resistant breast cancer cells to Adriamycin by targeting Wip1 and Bcl‑2
MicroRNA‑16 sensitizes drug‑resistant breast cancer cells to Adriamycin by targeting Wip1 and Bcl‑2 Open
Clinical evidence indicates that drug resistance is a major obstacle in the treatment of breast cancer (BC). Drug resistance results in the disease being uncontrollable, and leads to high mortality rates. The aim of the present study was t…
View article: Discrimination and Geographical Origin Prediction of<i>Cynomorium songaricum</i>Rupr. from Different Growing Areas in China by an Electronic Tongue
Discrimination and Geographical Origin Prediction of<i>Cynomorium songaricum</i>Rupr. from Different Growing Areas in China by an Electronic Tongue Open
Cynomorium songaricum Rupr. is a well-known and widespread plant in China. It has very high medicinal values in many aspects. The study aimed at discriminating and predicting C. songaricum from major growing areas in China. An electronic t…
View article: miR-17-3p Downregulates Mitochondrial Antioxidant Enzymes and Enhances the Radiosensitivity of Prostate Cancer Cells
miR-17-3p Downregulates Mitochondrial Antioxidant Enzymes and Enhances the Radiosensitivity of Prostate Cancer Cells Open
Radioresistance remains to be a major obstacle in the management of patients with advanced prostate cancer (PCa). We have identified a mature miR-17-3p processed from the 3' arm of precursor miR-17, which appeared to be able to inhibit thr…
View article: HZ08 suppresses RelB-activated MnSOD expression and enhances Radiosensitivity of prostate Cancer cells
HZ08 suppresses RelB-activated MnSOD expression and enhances Radiosensitivity of prostate Cancer cells Open