Jie Pan
YOU?
Author Swipe
View article: Integrative bulk and single-cell transcriptome analyses reveal integrated stress response-related biomarkers in periodontitis with experimental validation
Integrative bulk and single-cell transcriptome analyses reveal integrated stress response-related biomarkers in periodontitis with experimental validation Open
Background This study aimed to investigate the role of integrated stress response (ISR)-related biomarkers in periodontitis (PD). Methods Transcriptomic data related to PD were obtained from public databases. A bioinformatics approach comb…
View article: Artificial intelligence–assisted endoscopic diagnosis system for diagnosing Helicobacter pylori infection: a multicenter study
Artificial intelligence–assisted endoscopic diagnosis system for diagnosing Helicobacter pylori infection: a multicenter study Open
Chinese Clinical Trial Registry: ChiCTR 2400091317, 2,400,091,720.
View article: Intra-tumor heterogeneity-resistant gene signature predicts prognosis and immune infiltration in breast cancer
Intra-tumor heterogeneity-resistant gene signature predicts prognosis and immune infiltration in breast cancer Open
Background Breast cancer (BC) remains a significant threat to human health, with substantial variations in prognosis and treatment responses. Intra-tumor heterogeneity (ITH) presents a critical challenge in developing reliable prognostic m…
View article: Targeting the LY6H-PI3K/AKT Autophagy Axis Suppresses HCC Malignancy and Reveals a Druggable Vulnerability
Targeting the LY6H-PI3K/AKT Autophagy Axis Suppresses HCC Malignancy and Reveals a Druggable Vulnerability Open
Hepatocellular carcinoma (HCC) is a highly lethal malignancy worldwide, with its initiation and progression closely tied to dysregulated autophagy. Lymphocyte antigen 6 family member H (LY6H), a glycosylphosphatidylinositol-anchored protei…
View article: Analysis of Traditional Chinese Medicine and Western Medicine in Ankle Sprain and Fracture Treatment
Analysis of Traditional Chinese Medicine and Western Medicine in Ankle Sprain and Fracture Treatment Open
Ankle joint injuries have become a major global health burden, affecting millions of people every year. This thorough analysis looks at the basic clinical procedures and philosophical distinctions between Western medicine and Traditional C…
View article: Exploring differential gene expression and biomarker potential in systemic lupus erythematosus: a retrospective study
Exploring differential gene expression and biomarker potential in systemic lupus erythematosus: a retrospective study Open
Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by inflammation and immune-mediated multi-organ system damage, accompanied by clinical manifestations such as fever, hair loss, skin rash, oral ulc…
View article: Relationship between neuron-specific enolase and swallowing dysfunction in patients with acute ischemic stroke: a single-center retrospective study
Relationship between neuron-specific enolase and swallowing dysfunction in patients with acute ischemic stroke: a single-center retrospective study Open
NSE measurement is a simple supplement to the WST. There existed a significant correlation between NSE and swallowing dysfunction, making NSE a potential preliminary screening indicator for evaluating in ischemic stroke patients. And early…
View article: The aspartate superpathway in gut microbiota-related metabolic pathways mediates immune cell protection against COPD and IPF: a Mendelian randomization analysis
The aspartate superpathway in gut microbiota-related metabolic pathways mediates immune cell protection against COPD and IPF: a Mendelian randomization analysis Open
There is a causal link between the gut microbiota-related metabolic pathway, the aspartate superpathway, and IPF and COPD, where the influence is partially mediated by monocytes and cDCs. In clinical practice, we increase the focus on gut …
View article: Screen of propionate-producing probiotic strains in attenuating murine colitis by modulating immune response and restoring the intestinal barrier
Screen of propionate-producing probiotic strains in attenuating murine colitis by modulating immune response and restoring the intestinal barrier Open
Intestinal dysbiosis is central to inflammatory bowel disease (IBD) development. Probiotics produce propionate, a short-chain fatty acid that restores intestinal balance and reduces inflammation.Comparative genomic analysis of propionate p…
View article: Prognostic Implications of the Number of Lymph Node Metastases in Oral Tongue Squamous Cell Carcinoma: A Population Study of the <scp>SEER</scp> Database and an Institutional Registry
Prognostic Implications of the Number of Lymph Node Metastases in Oral Tongue Squamous Cell Carcinoma: A Population Study of the <span>SEER</span> Database and an Institutional Registry Open
Background To investigate the impact of the number of positive lymph nodes (PLNs) on long‐term survival and pathological nodal stage in patients with oral tongue squamous cell carcinoma (OTSCC). Materials and Methods Newly diagnosed and no…
View article: "Observing Pulmonary Function Disparities in Diabetes Patients from Demographic and Hormonal Perspectives: A Study Based on NHANES Database"
"Observing Pulmonary Function Disparities in Diabetes Patients from Demographic and Hormonal Perspectives: A Study Based on NHANES Database" Open
Background Diabetes is a global public health issue commonly associated with various complications, including impaired lung function. Existing studies suggest that the relationship between diabetes and lung function varies significantly ac…
View article: Bitongqing Attenuates CIA Rats by Suppressing Macrophage Pyroptosis and Modulating the NLRP3/Caspase-1/GSDMD Pathway
Bitongqing Attenuates CIA Rats by Suppressing Macrophage Pyroptosis and Modulating the NLRP3/Caspase-1/GSDMD Pathway Open
The therapeutic potential of BTQ in CIA lies in its ability to inhibit NLRP3-mediated macrophage pyroptosis, thereby suggesting a promising strategy for the treatment of RA.
View article: The causal relationship between immune cells and Sjögren’s syndrome: a univariate, multivariate, bidirectional Mendelian randomized study
The causal relationship between immune cells and Sjögren’s syndrome: a univariate, multivariate, bidirectional Mendelian randomized study Open
Introduction Immune cells are involved in the onset and progression of Sjögren’s syndrome (SS). This study explored the causal relationship between immune signature cells and SS, which has not been fully elucidated. Methods We conducted un…
View article: Cross-sectional associations of low body mass index and being underweight with joint damage in Chinese patients with rheumatoid arthritis
Cross-sectional associations of low body mass index and being underweight with joint damage in Chinese patients with rheumatoid arthritis Open
Objective To characterize BMI in Chinese patients with RA vs US patients and examine its association with joint damage in Chinese patients. Methods Each of the 1318 patients from a real-world Chinese RA population was first stratified by g…
View article: Accelerating the speed of innovative anti-tumor drugs to first-in-human trials incorporating key de-risk strategies
Accelerating the speed of innovative anti-tumor drugs to first-in-human trials incorporating key de-risk strategies Open
Pharmaceutical companies have recently focused on accelerating the timeline for initiating first-in-human (FIH) trials to allow quick assessment of biologic drugs. For example, a stable cell pool can be used to produce materials for the to…
View article: Development and Evaluation of a Surveillance System for Follow-Up After Colorectal Polypectomy
Development and Evaluation of a Surveillance System for Follow-Up After Colorectal Polypectomy Open
Importance The adherence of physicians and patients to published colorectal postpolypectomy surveillance guidelines varies greatly, and patient follow-up is critical but time consuming. Objectives To evaluate the accuracy of an automatic s…
View article: Explainable artificial intelligence incorporated with domain knowledge diagnosing early gastric neoplasms under white light endoscopy
Explainable artificial intelligence incorporated with domain knowledge diagnosing early gastric neoplasms under white light endoscopy Open
White light endoscopy is the most pivotal tool for detecting early gastric neoplasms. Previous artificial intelligence (AI) systems were primarily unexplainable, affecting their clinical credibility and acceptability. We aimed to develop a…
View article: An explainable artificial intelligence system for diagnosing <i>Helicobacter Pylori</i> infection under endoscopy: a case–control study
An explainable artificial intelligence system for diagnosing <i>Helicobacter Pylori</i> infection under endoscopy: a case–control study Open
Background: Changes in gastric mucosa caused by Helicobacter pylori ( H. pylori) infection affect the observation of early gastric cancer under endoscopy. Although previous researches reported that computer-aided diagnosis (CAD) systems ha…
View article: Therapeutic Effect of Human Bone Marrow- and Adipose-Derived Stem Cells on Intervertebral Disc Degeneration: A Comparative Study on Rats
Therapeutic Effect of Human Bone Marrow- and Adipose-Derived Stem Cells on Intervertebral Disc Degeneration: A Comparative Study on Rats Open
In summary, both hADSCs and hBMSCs can attenuate the progression of IVD by delaying, rather than completely reversing the deterioration of disc degeneration, and there is no significant difference between hADSCs and hBMSCs on the therapeut…
View article: Diagnostic accuracy of linked colour imaging versus white light imaging for early gastric cancers: a prospective, multicentre, randomized controlled trial study
Diagnostic accuracy of linked colour imaging versus white light imaging for early gastric cancers: a prospective, multicentre, randomized controlled trial study Open
LCI has better accuracy and shorter examination time in diagnosing EGC than WLI (Clinical trial registration: NCT03092414).Key messagesCompared with white light imaging (WLI), the diagnostic accuracy, sensitivity and specificity increased …