Jialin Zheng
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View article: Chromogranin A promotes the pathological conversion of α-synuclein at the synapse in Parkinson’s disease
Chromogranin A promotes the pathological conversion of α-synuclein at the synapse in Parkinson’s disease Open
α-Synuclein (αSyn) aggregation is a prominent hallmark of Parkinson's disease (PD), yet the initial cellular mechanisms are not well understood. In this study, we show that a single day of αSyn preformed fibril (PFF) administration leads t…
View article: <i>N</i> -Acetylcysteine-Capped TLQP21-Containing Au Nanocages Alleviate Depression in Mice
<i>N</i> -Acetylcysteine-Capped TLQP21-Containing Au Nanocages Alleviate Depression in Mice Open
Major depressive disorder (MDD) is the most prevalent neuropsychiatric disorder globally. Promising therapies for MDD are urgently needed due to the limited effectiveness, delayed efficacy, and non-negligible side effects of current treatm…
View article: Clinically Inspired Multimodal Treatment Using Induced Neural Stem Cells‐Derived Exosomes Promotes Recovery of Traumatic Brain Injury through Microglial Modulation
Clinically Inspired Multimodal Treatment Using Induced Neural Stem Cells‐Derived Exosomes Promotes Recovery of Traumatic Brain Injury through Microglial Modulation Open
Traumatic brain injury (TBI) poses serious physical, psychosocial, and economic threats to millions of patients globally each year. While current treatment options, primarily surgery and medication, vary with TBI severity, there is no univ…
View article: The genomic history of East Asian Middle Neolithic millet- and rice-agricultural populations
The genomic history of East Asian Middle Neolithic millet- and rice-agricultural populations Open
The Yellow and Yangtze river basins in China are among the world's oldest independent agricultural centers, known for the domestication of millet and rice, respectively, yet their genetic history is poorly understood. Here, we present geno…
View article: Genomic formation of lower Yellow River populations in the Han dynasty
Genomic formation of lower Yellow River populations in the Han dynasty Open
Our findings highlight the role of the lower Yellow River Basin as a nexus of genetic exchange between northern millet-farming and southern rice-farming cultures, with sustained genetic influences from the middle Yellow River shaping the d…
View article: Dynein‐Dependent Endo‐Lysosomal Degradation Drives Lewy Body Disorders Accompanied by Aβ Pathology
Dynein‐Dependent Endo‐Lysosomal Degradation Drives Lewy Body Disorders Accompanied by Aβ Pathology Open
Dementia with Lewy bodies (DLB) is a significant cause of dementia. However, the limited availability of animal and cellular models that accurately replicate early DLB pathogenesis hampers the understanding of how Aβ plaques influence α‐sy…
View article: Neural Substitute Solver for Efficient Edge Inference of Power Electronic Hybrid Dynamics
Neural Substitute Solver for Efficient Edge Inference of Power Electronic Hybrid Dynamics Open
Advancing the dynamics inference of power electronic systems (PES) to the real-time edge-side holds transform-ative potential for testing, control, and monitoring. How-ever, efficiently inferring the inherent hybrid continu-ous-discrete dy…
View article: Electroacupuncture Attenuates High‐Fat Diet‐Exacerbated Alzheimer's Pathology by Enhancing <scp>TFEB</scp>/<scp>TFE3</scp>‐Mediated Autophagic Clearance of Tau and <scp>NLRP3</scp> Inflammasome in <scp>3xTg</scp> Mice
Electroacupuncture Attenuates High‐Fat Diet‐Exacerbated Alzheimer's Pathology by Enhancing <span>TFEB</span>/<span>TFE3</span>‐Mediated Autophagic Clearance of Tau and <span>NLRP3</span> Inflammasome in <span>3xTg</span> Mice Open
Background Alzheimer's disease (AD) pathology is increasingly linked to metabolic disturbances induced by high‐fat diets (HFD), with both autophagy‐lysosomal pathway (ALP) dysfunction and activation of the NLRP3 inflammasome emerging as ke…
View article: Association between N-terminal pro-brain natriuretic peptide levels and outcomes of ischemic stroke: A systematic review and meta-analysis
Association between N-terminal pro-brain natriuretic peptide levels and outcomes of ischemic stroke: A systematic review and meta-analysis Open
Background N-terminal pro-brain natriuretic peptide (NT-proBNP) was identified as an important biomarker of cardiovascular disease, in ischemic stroke. This study intends to assess the association of NT-proBNP levels with clinical outcomes…
View article: Think Twice, Act Once: Token-Aware Compression and Action Reuse for Efficient Inference in Vision-Language-Action Models
Think Twice, Act Once: Token-Aware Compression and Action Reuse for Efficient Inference in Vision-Language-Action Models Open
Vision-Language-Action (VLA) models have emerged as a powerful paradigm for general-purpose robot control through natural language instructions. However, their high inference cost-stemming from large-scale token computation and autoregress…
View article: Corrigendum to “Prediction of BRAF and TERT status in PTCs by machine learning-based ultrasound radiomics methods: A multicenter study” [J. Clin. Translat. Endocrinol. 40 (2025) 100390]
Corrigendum to “Prediction of BRAF and TERT status in PTCs by machine learning-based ultrasound radiomics methods: A multicenter study” [J. Clin. Translat. Endocrinol. 40 (2025) 100390] Open
[This corrects the article DOI: 10.1016/j.jcte.2025.100390.].
View article: Plasma <scp>IL4</scp> Levels Linked to Pulmonary Hypertension Severity and Outcome
Plasma <span>IL4</span> Levels Linked to Pulmonary Hypertension Severity and Outcome Open
Background The anti‐inflammatory cytokine interleukin‐4 (IL4) has been recognised as a protective factor in various cardiovascular events, yet its prognostic value in patients with pulmonary hypertension (PH) remains unclear. The study aim…
View article: Prediction of BRAF and TERT status in PTCs by machine learning-based ultrasound radiomics methods: A multicenter study
Prediction of BRAF and TERT status in PTCs by machine learning-based ultrasound radiomics methods: A multicenter study Open
View article: Magea13 attenuates myocardial injury in acute myocardial infarction by inhibiting the cAMP-PKA signaling pathway
Magea13 attenuates myocardial injury in acute myocardial infarction by inhibiting the cAMP-PKA signaling pathway Open
View article: Specific cognitive impairment predicts the neuropsychiatric symptoms in patient with mild cognitive impairment
Specific cognitive impairment predicts the neuropsychiatric symptoms in patient with mild cognitive impairment Open
View article: The Inhibitory Effect of Peptide Hydrolysate of Type I Collagen Derived from Pig Skin on Melanogenesis in B16F10 Melanoma Cells
The Inhibitory Effect of Peptide Hydrolysate of Type I Collagen Derived from Pig Skin on Melanogenesis in B16F10 Melanoma Cells Open
Collagen peptides, as a natural source of peptides, possess multiple advantages such as anti-aging, anti-inflammatory properties, tissue repair, and the ability to inhibit melanin production. In this study, type I collagen extracted from p…
View article: A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement
A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement Open
Hearing is one of the most vital sensory functions in human beings and a crucial means of perceiving and acquiring information from the natural environment. The advancement of human society is closely linked to the development of language,…
View article: Catalytic Hydrolysis of Perfluorinated Compounds in a Yolk–Shell Micro‐Reactor
Catalytic Hydrolysis of Perfluorinated Compounds in a Yolk–Shell Micro‐Reactor Open
Perfluorinated compounds (PFCs) are emerging environmental pollutants characterized by their extreme stability and resistance to degradation. Among them, tetrafluoromethane (CF 4 ) is the simplest and most abundant PFC in the atmosphere. H…
View article: Ancient genomes reveal the genetic legacy of domestic goats on the Tibetan Plateau ~3,600 years ago
Ancient genomes reveal the genetic legacy of domestic goats on the Tibetan Plateau ~3,600 years ago Open
View article: miR-185-5p regulates the proliferation and differentiation of neural stem/progenitor cells
miR-185-5p regulates the proliferation and differentiation of neural stem/progenitor cells Open
Background MicroRNAs (miRNAs) have emerged as an essential regulator of the cell fate commitment of neural stem/progenitor cells (NPCs), although the impacts of certain miRNAs on NPCs remain vague. The aim of this study is to investigate t…
View article: Genetically modified E. Coli secreting melanin (E.melanin) activates the astrocytic PSAP-GPR37L1 pathway and mitigates the pathogenesis of Parkinson’s disease
Genetically modified E. Coli secreting melanin (E.melanin) activates the astrocytic PSAP-GPR37L1 pathway and mitigates the pathogenesis of Parkinson’s disease Open
The characteristic neuropathology of Parkinson’s disease (PD) involves the abnormal accumulation of phosphorylated α-synuclein (αSyn), as well as a significant decrease in neuromelanin (NM) levels within dopamine neurons (DaNs). Unlike αSy…
View article: Transcranial NIR Neuromodulation via Multifunctional Nano‐Optical Electrodes for Relieving Depressive Symptoms (Adv. Funct. Mater. 45/2024)
Transcranial NIR Neuromodulation via Multifunctional Nano‐Optical Electrodes for Relieving Depressive Symptoms (Adv. Funct. Mater. 45/2024) Open
View article: Evaluation of the McGill‐Tongji Blended Education Program for Teacher Leaders in General Practice: The importance of partnership and contextualization in International Primary Care Training Initiatives
Evaluation of the McGill‐Tongji Blended Education Program for Teacher Leaders in General Practice: The importance of partnership and contextualization in International Primary Care Training Initiatives Open
Purpose Strong primary health care (PHC) systems require well‐established PHC education systems to enhance the skills of general practitioners (GPs). However, the literature on the experiences of international collaboration in primary care…
View article: Preoperative pain sensitivity and its correlation with postoperative acute and chronic pain: a systematic review and meta-analysis
Preoperative pain sensitivity and its correlation with postoperative acute and chronic pain: a systematic review and meta-analysis Open
View article: DOS-3 mediates cell-non-autonomous DAF-16/FOXO activity in antagonizing age-related loss of C. elegans germline stem/progenitor cells
DOS-3 mediates cell-non-autonomous DAF-16/FOXO activity in antagonizing age-related loss of C. elegans germline stem/progenitor cells Open
Age-related depletion of stem cells causes tissue degeneration and failure to tissue regeneration, driving aging at the organismal level. Previously we reported a cell-non-autonomous DAF-16/FOXO activity in antagonizing the age-related los…
View article: Clinical applications of stem cell-derived exosomes
Clinical applications of stem cell-derived exosomes Open
View article: Microglial glutaminase 1 mediates chronic restraint stress-induced depression-like behaviors and synaptic damages
Microglial glutaminase 1 mediates chronic restraint stress-induced depression-like behaviors and synaptic damages Open
View article: 1004P Comparative efficacy of systemic sequential regorafenib after sorafenib or lenvatinib treatment failure for advanced hepatocellular carcinoma: A retrospective, multi-center, real-world study
1004P Comparative efficacy of systemic sequential regorafenib after sorafenib or lenvatinib treatment failure for advanced hepatocellular carcinoma: A retrospective, multi-center, real-world study Open
View article: Glutaminase 1 deficiency confined in forebrain neurons causes autism spectrum disorder-like behaviors
Glutaminase 1 deficiency confined in forebrain neurons causes autism spectrum disorder-like behaviors Open
An abnormal glutamate signaling pathway has been proposed in the mechanisms of autism spectrum disorder (ASD). However, less is known about the involvement of alterations of glutaminase 1 (GLS1) in the pathophysiology of ASD. We show that …
View article: Insulin‐incubated palladium clusters alleviate Alzheimer's disease‐like phenotypes in a preclinical mouse model
Insulin‐incubated palladium clusters alleviate Alzheimer's disease‐like phenotypes in a preclinical mouse model Open
Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly without a cure.1 Although the amyloid cascade hypothesis is the mainstream theory of AD pathogenesis for decades, it has been challenged due to unsatisfie…