Jiajun Fan
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View article: Targeting angiopoietin-like protein 3 and Interleukin-1β alleviated liver and kidney injury through attenuation of lipotoxicity and normalization of glycolipid metabolism in db/db mice
Targeting angiopoietin-like protein 3 and Interleukin-1β alleviated liver and kidney injury through attenuation of lipotoxicity and normalization of glycolipid metabolism in db/db mice Open
Objective Concomitant liver and kidney injury is a critical pathological feature of metabolic disorders, but current organ-specific therapies often fail to provide cross-protection. Lipotoxicity is a core mechanism linking damage in both o…
View article: Imidazole ionic liquid based ultra-broadband low-thickness metamaterial absorber from union-pyramid-like structure design
Imidazole ionic liquid based ultra-broadband low-thickness metamaterial absorber from union-pyramid-like structure design Open
In this work, a union-pyramid-like imidazole ionic liquid metamaterial absorber (UPL ILMMA) is developed. The UPL ILMMA achieves over 90% absorption across 7.08–50.00 GHz, with a relative absorption bandwidth of 150%. When the incidence an…
View article: Gut microbiota-derived queuine reprograms colon gene expression and alleviates colorectal cancer synergistically with Limosilactobacillus reuteri
Gut microbiota-derived queuine reprograms colon gene expression and alleviates colorectal cancer synergistically with Limosilactobacillus reuteri Open
Background Colorectal cancer (CRC) is a multifactorial disease of the colorectal epithelium that could be driven by gut microbiota dysregulation, while the molecular mechanisms of microbial metabolitesin regulating CRC remain unclear. Resu…
View article: Adaptive Divergence Regularized Policy Optimization for Fine-tuning Generative Models
Adaptive Divergence Regularized Policy Optimization for Fine-tuning Generative Models Open
Balancing exploration and exploitation during reinforcement learning fine-tuning of generative models presents a critical challenge, as existing approaches rely on fixed divergence regularization that creates an inherent dilemma: strong re…
View article: Fine-tuning Flow Matching Generative Models with Intermediate Feedback
Fine-tuning Flow Matching Generative Models with Intermediate Feedback Open
Flow-based generative models have shown remarkable success in text-to-image generation, yet fine-tuning them with intermediate feedback remains challenging, especially for continuous-time flow matching models. Most existing approaches sole…
View article: P08.03.A DOUBLE-PUNCH STRATEGY: MACROPHAGE MEMBRANE-ENVELOPED IMIPRAMINE AND ACD47 REPROGRAMS TUMOR MICROENVIRONMENT TO ENHANCE GLIOBLASTOMA IMMUNOTHERAPY
P08.03.A DOUBLE-PUNCH STRATEGY: MACROPHAGE MEMBRANE-ENVELOPED IMIPRAMINE AND ACD47 REPROGRAMS TUMOR MICROENVIRONMENT TO ENHANCE GLIOBLASTOMA IMMUNOTHERAPY Open
BACKGROUND The immune response rates of patients with glioblastoma (GBM) are relatively low for the complex immunosuppressive tumor microenvironment, which is mainly attributed to the presence of M2-type tumor-associated macrophages (TAMs)…
View article: GP-CMRH: An inner product free iterative method for block two-by-two nonsymmetric linear systems
GP-CMRH: An inner product free iterative method for block two-by-two nonsymmetric linear systems Open
We propose an inner product free iterative method called GP-CMRH for solving block two-by-two nonsymmetric linear systems. GP-CMRH relies on a new simultaneous Hessenberg process that reduces two rectangular matrices to upper Hessenberg fo…
View article: DDR1 Drives Collagen Remodeling and Immune Exclusion: Pan-Cancer Insights and Therapeutic Targeting in Pancreatic Ductal Adenocarcinoma
DDR1 Drives Collagen Remodeling and Immune Exclusion: Pan-Cancer Insights and Therapeutic Targeting in Pancreatic Ductal Adenocarcinoma Open
Discoidin domain receptor 1 (DDR1), a collagen-binding receptor tyrosine kinase, plays a key role in extracellular matrix remodeling, tumor progression, and immune evasion. However, DDR1’s comprehensive role across diverse cancers and its …
View article: PVC Inhibits Radish (Raphanus sativus L.) Seedling Growth by Interfering with Plant Hormone Signal Transduction and Phenylpropanoid Biosynthesis
PVC Inhibits Radish (Raphanus sativus L.) Seedling Growth by Interfering with Plant Hormone Signal Transduction and Phenylpropanoid Biosynthesis Open
Polyvinyl chloride (PVC) is commonly employed as mulch in agriculture to boost crop yields. However, its toxicity is often overlooked. Due to its chemical stability, resistance to degradation, and the inadequacy of the recycling system, PV…
View article: Ventricular volume adjustment of brain regions depicts brain changes associated with HIV infection and aging better than intracranial volume adjustment
Ventricular volume adjustment of brain regions depicts brain changes associated with HIV infection and aging better than intracranial volume adjustment Open
Introduction While the adjustment of intracranial volume (ICV) is reported to have a significant influence in the outcomes of the analyses of brain structural measures, our study offers a paradigm shift, positing that adjusting for lateral…
View article: $α$-Flow: A Unified Framework for Continuous-State Discrete Flow Matching Models
$α$-Flow: A Unified Framework for Continuous-State Discrete Flow Matching Models Open
Recent efforts have extended the flow-matching framework to discrete generative modeling. One strand of models directly works with the continuous probabilities instead of discrete tokens, which we colloquially refer to as Continuous-State …
View article: Analysis of the Quality of Typical Acidic Groundwater of the Guangwang Mining Area and Its Associated Human Health Risks
Analysis of the Quality of Typical Acidic Groundwater of the Guangwang Mining Area and Its Associated Human Health Risks Open
This study determined the hydro-chemical properties of groundwater in a typical mining area and its associated human health risks, focusing on the Guangwang mining area. Groundwater samples were analyzed for toxic metals, after which analy…
View article: Identifying Key Influencers using an Egocentric Network-based Randomized Design
Identifying Key Influencers using an Egocentric Network-based Randomized Design Open
Behavioral health interventions, such as trainings or incentives, are implemented in settings where individuals are interconnected, and the intervention assigned to some individuals may also affect others within their network. Evaluating s…
View article: Online Reward-Weighted Fine-Tuning of Flow Matching with Wasserstein Regularization
Online Reward-Weighted Fine-Tuning of Flow Matching with Wasserstein Regularization Open
Recent advancements in reinforcement learning (RL) have achieved great success in fine-tuning diffusion-based generative models. However, fine-tuning continuous flow-based generative models to align with arbitrary user-defined reward funct…
View article: Recombinant CD80 fusion protein combined with discoidin domain receptor 1 inhibitor for cancer treatment
Recombinant CD80 fusion protein combined with discoidin domain receptor 1 inhibitor for cancer treatment Open
Immune checkpoint inhibitors (ICIs) have significantly advanced the field of cancer immunotherapy. However, clinical data has shown that many patients have a low response rate or even resistance to immune checkpoint inhibitor alone. The un…
View article: Evaluating the effects of subsoiler type and spacing on tillage resistance and soil conservation with DEM simulation and field experiment
Evaluating the effects of subsoiler type and spacing on tillage resistance and soil conservation with DEM simulation and field experiment Open
View article: Multiaxial Flexible Strain Sensor with Zero Poisson's Ratio
Multiaxial Flexible Strain Sensor with Zero Poisson's Ratio Open
View article: Ultra-broadband and wide-incident-angle metamaterial absorber based on imidazole ionic liquid with a pyramid-like structure
Ultra-broadband and wide-incident-angle metamaterial absorber based on imidazole ionic liquid with a pyramid-like structure Open
View article: Sources and Evolution of Sulfate Under Different Hydrodynamic Conditions in Groundwater of a Typical Southwest China Karst Mining Area: Evidence from Geochemical and Isotopic Fingerprints
Sources and Evolution of Sulfate Under Different Hydrodynamic Conditions in Groundwater of a Typical Southwest China Karst Mining Area: Evidence from Geochemical and Isotopic Fingerprints Open
View article: Application of 3D-printed rehabilitation aids for hypertrophic scars
Application of 3D-printed rehabilitation aids for hypertrophic scars Open
Hypertrophic scars (HS) are fibrotic proliferative diseases that develop after deep skin injuries caused by trauma, burns, and surgery. Traditional treatment methods include both surgical and nonsurgical therapies. Early intervention and c…
View article: Multiaxial Flexible Strain Sensor with Zero Poisson's Ratio
Multiaxial Flexible Strain Sensor with Zero Poisson's Ratio Open
View article: Simultaneously blocking ANGPTL3 and CD47 prevents the progression of atherosclerosis through regulating lipid metabolism, macrophagic efferocytosis and lipid peroxidation
Simultaneously blocking ANGPTL3 and CD47 prevents the progression of atherosclerosis through regulating lipid metabolism, macrophagic efferocytosis and lipid peroxidation Open
Atherosclerosis (AS) ultimately cause major adverse cardiovascular events (MACEs). While traditional strategies by lipid-reducing have reduced MACEs, many patients continue to face significant risks. It might attribute to the upregulation …
View article: Performance Evaluation of Damaged T-Beam Bridges with External Prestressing Reinforcement Based on Natural Frequencies
Performance Evaluation of Damaged T-Beam Bridges with External Prestressing Reinforcement Based on Natural Frequencies Open
View article: Oxidative Catalytic Depolymerization of Lignin into Value-Added Monophenols by Carbon Nanotube-Supported Cu-Based Catalysts
Oxidative Catalytic Depolymerization of Lignin into Value-Added Monophenols by Carbon Nanotube-Supported Cu-Based Catalysts Open
Lignin valorisation into chemicals and fuels is of great importance in addressing energy challenges and advancing biorefining in a sustainable manner. In this study, on the basis of the high microwave absorption performance of carbon nanot…
View article: Microbiome-induced reprogramming in post-transcriptional landscape using nanopore direct RNA sequencing
Microbiome-induced reprogramming in post-transcriptional landscape using nanopore direct RNA sequencing Open
It has been widely recognized that the microbiota has the capacity to shape host gene expression and physiological functions. However, there remains a paucity of comprehensive study revealing the host transcriptional landscape regulated by…
View article: Dynamic Neural Dowker Network: Approximating Persistent Homology in Dynamic Directed Graphs
Dynamic Neural Dowker Network: Approximating Persistent Homology in Dynamic Directed Graphs Open
Persistent homology, a fundamental technique within Topological Data Analysis (TDA), captures structural and shape characteristics of graphs, yet encounters computational difficulties when applied to dynamic directed graphs. This paper int…
View article: Self-healing behaviour of fly ash/slag-based engineered geopolymer composites under external alkaline environments
Self-healing behaviour of fly ash/slag-based engineered geopolymer composites under external alkaline environments Open
This study reports on the self-healing behaviour of fly ash and slag engineered geopolymer composites (FA/S-EGC) under external alkaline environments. FA/S-EGC specimens with different pre-damaged strains were subjected to self-healing at …
View article: Study on the impact of COVID-19 pandemic on the mental health of Chinese college students: a cross-sectional analysis
Study on the impact of COVID-19 pandemic on the mental health of Chinese college students: a cross-sectional analysis Open
Background The COVID-19 pandemic has significantly impacted the mental health of college students, prompting the need for universities to implement measures to mitigate these adverse effects. This study aims to assess the mental health sta…
View article: Damage assessment of precast reinforced concrete beam-column connections using AE technology
Damage assessment of precast reinforced concrete beam-column connections using AE technology Open
The beam-column connection is both the critical area and the weak part for the prefabricated reinforced concrete (PC) frame structure. The ductile connection with a U-shaped shell has been well-developed for the PC cross-shaped connection.…
View article: Obtaining the pseudoinverse solution of singular range-symmetric linear systems with GMRES-type methods
Obtaining the pseudoinverse solution of singular range-symmetric linear systems with GMRES-type methods Open
It is well known that for singular inconsistent range-symmetric linear systems, the generalized minimal residual (GMRES) method determines a least squares solution without breakdown. The reached least squares solution may be or not be the …