Jane C. Tan
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View article: Cost-effectiveness of transplanting older candidates with acceptable quality deceased donor kidneys
Cost-effectiveness of transplanting older candidates with acceptable quality deceased donor kidneys Open
Importance Many acceptable quality deceased donor kidneys go unused every year. Older transplant candidates are more vulnerable to rapid health decline. Objective To assess the cost-effectiveness of increasing the rate of kidney transplant…
View article: The Mirage of Model Editing: Revisiting Evaluation in the Wild
The Mirage of Model Editing: Revisiting Evaluation in the Wild Open
Despite near-perfect results reported in the literature, the effectiveness of model editing in real-world applications remains unclear. To bridge this gap, we introduce QAEdit, a new benchmark aligned with widely used question answering (Q…
View article: Estimating the Benefit of Transplant Over Dialysis in Candidates Over 55 Years
Estimating the Benefit of Transplant Over Dialysis in Candidates Over 55 Years Open
Key Points Older kidney transplant candidates experience a gain in life years from transplantation. More updated models using a contemporary cohort are needed to guide current clinical practice for older adults. The magnitude of gain in li…
View article: The Mirage of Model Editing: Revisiting Evaluation in the Wild
The Mirage of Model Editing: Revisiting Evaluation in the Wild Open
View article: Immunologic Benefits of 0-antigen Mismatched Transplants: No Added Boost for Racial and Ethnic Minorities
Immunologic Benefits of 0-antigen Mismatched Transplants: No Added Boost for Racial and Ethnic Minorities Open
Background. Systemic barriers to posttransplant care, including access to immunosuppressant medications, contribute to higher rates of kidney transplant failure in racial minorities. Matching donor and recipient HLA alleles reduce alloreco…
View article: The Medical Costs of Determining Eligibility and Waiting for a Kidney Transplantation
The Medical Costs of Determining Eligibility and Waiting for a Kidney Transplantation Open
Background: Recent efforts to increase access to kidney transplant (KTx) in the United States include increasing referrals to transplant programs, leading to more pretransplant services. Transplant programs reconcile the costs of these ser…
View article: Comparing and contrasting barriers in augmentative alternative communication use in nonspeaking autism and complex communication needs: multi-stakeholder perspectives
Comparing and contrasting barriers in augmentative alternative communication use in nonspeaking autism and complex communication needs: multi-stakeholder perspectives Open
Augmentative alternative communication (AAC) devices or systems are often prescribed to minimally verbal or nonspeaking autistic individuals and other individuals with complex communication needs to facilitate communication or as an altern…
View article: An 8‐week compassion and mindfulness–based exposure therapy program improves posttraumatic stress symptoms
An 8‐week compassion and mindfulness–based exposure therapy program improves posttraumatic stress symptoms Open
The persistence of posttraumatic stress symptoms (PTSS) can be debilitating. However, many people experiencing such symptoms may not qualify for or may not seek treatment. Potentially contributing to ongoing residual symptoms of PTSS is em…
View article: Validation of a Core Patient-Reported Outcome Measure for Life Participation in Kidney Transplant Recipients: the SONG Life Participation Instrument
Validation of a Core Patient-Reported Outcome Measure for Life Participation in Kidney Transplant Recipients: the SONG Life Participation Instrument Open
The SONG-LP instrument is a simple, internally consistent, reliable measure for kidney transplant recipients and correlates with similar measures. Routine incorporation in clinical trials will ensure consistent and appropriate assessment o…
View article: Deceased Donor Kidney Transplantation for Older Transplant Candidates: A New Microsimulation Model for Determining Risks and Benefits
Deceased Donor Kidney Transplantation for Older Transplant Candidates: A New Microsimulation Model for Determining Risks and Benefits Open
Background Under the current US kidney allocation system, older candidates receive a disproportionately small share of deceased donor kidneys despite a reserve of potentially usable kidneys that could shorten their wait times. To consider …
View article: An 8-week Compassion and Mindfulness-based Exposure Therapy Program effectively improves Posttraumatic Stress Symptoms
An 8-week Compassion and Mindfulness-based Exposure Therapy Program effectively improves Posttraumatic Stress Symptoms Open
The persistence of posttraumatic stress symptoms (PTSS) can be debilitating. However, many people experiencing such symptoms may not qualify for, or may not seek, treatment. Potentially contributing to ongoing residual symptoms of PTSS is …
View article: Association of Pretransplant Coronary Heart Disease Testing With Early Kidney Transplant Outcomes
Association of Pretransplant Coronary Heart Disease Testing With Early Kidney Transplant Outcomes Open
Importance Testing for coronary heart disease (CHD) in asymptomatic kidney transplant candidates before transplant is widespread and endorsed by various professional societies, but its association with perioperative outcomes is unclear. Ob…
View article: Infection, Rejection, and the Connection
Infection, Rejection, and the Connection Open
Solid organ transplantation is a life-saving treatment for people with end-stage organ disease. Immune-mediated transplant rejection is a common complication that decreases allograft survival. Although immunosuppression is required to prev…
View article: The Dissemination of Problematic News on Facebook: A Large-Scale, Longitudinal Study
The Dissemination of Problematic News on Facebook: A Large-Scale, Longitudinal Study Open
Social media in general, and Facebook in particular, have been clearly identified as important platforms for the dissemination of mis- and disinformation and related problematic content. However, the patterns and processes of such dissemin…
View article: Trends in Cost Attributable to Kidney Transplantation Evaluation and Waiting List Management in the United States, 2012-2017
Trends in Cost Attributable to Kidney Transplantation Evaluation and Waiting List Management in the United States, 2012-2017 Open
In this study, OACC costs increased at 4% per year from 2012 to 2017 and were not solely attributable to the cost of organ procurement. Expanding the waiting list will likely contribute to further increases in the mean OACC costs per trans…
View article: Trends in Coronary Artery Disease Screening before Kidney Transplantation
Trends in Coronary Artery Disease Screening before Kidney Transplantation Open
Key Points Coronary artery disease testing before kidney transplant has remained constant since the mid-2000s, despite a shift away from preoperative testing. Overall post-transplant death and myocardial infarction rates have fallen steadi…
View article: Racial Disparities in Pediatric Kidney Transplantation under the New Kidney Allocation System in the United States
Racial Disparities in Pediatric Kidney Transplantation under the New Kidney Allocation System in the United States Open
Background and objectives In December 2014, the Kidney Allocation System (KAS) was implemented to improve equity in access to transplantation, but preliminary studies in children show mixed results. Thus, we aimed to assess how the 2014 KA…
View article: Functional Consequences of Memory Inflation after Solid Organ Transplantation
Functional Consequences of Memory Inflation after Solid Organ Transplantation Open
CMV is a major infectious complication following solid organ transplantation. Reactivation of CMV leads to memory inflation, a process in which CD8 T cells expand over time. Memory inflation is associated with specific changes in T cell fu…
View article: Karnofsky Performance Score—Failure to Thrive as a Frailty Proxy?
Karnofsky Performance Score—Failure to Thrive as a Frailty Proxy? Open
Background. Among patients listed for kidney transplantation, the Karnofsky Performance Status (KPS) Scale has been used as a proxy for frailty and proposed as a predictor of long-term posttransplant outcomes. The KPS is required by the Or…
View article: The organ procurement costs of expanding deceased donor organ acceptance criteria: Evidence from a cost function model
The organ procurement costs of expanding deceased donor organ acceptance criteria: Evidence from a cost function model Open
View article: Immunosuppression Considerations for Older Kidney Transplant Recipients
Immunosuppression Considerations for Older Kidney Transplant Recipients Open
Purpose of Review While kidney transplantation improves the long-term survival of the majority of patients with end-stage kidney disease (ESKD), age-related immune dysfunction and associated comorbidities make older transplant recipients m…
View article: Sex Disparity in Deceased-Donor Kidney Transplant Access by Cause of Kidney Disease
Sex Disparity in Deceased-Donor Kidney Transplant Access by Cause of Kidney Disease Open
Background and objectives Women with kidney failure have lower access to kidney transplantation compared with men, but the magnitude of this disparity may not be uniform across all kidney diseases. We hypothesized that the attributed cause…
View article: And Then There Were Three: Effects of Pretransplant Dialysis on Multiorgan Transplantation
And Then There Were Three: Effects of Pretransplant Dialysis on Multiorgan Transplantation Open
Background. Simultaneous liver-kidney (SLK) and simultaneous heart-kidney (SHK) transplantation currently utilize 6% of deceased donor kidneys in the United States. To what extent residual kidney function accounts for apparent kidney allog…
View article: Supplementary Material for: Performance versus Risk Factor-Based Approaches to Coronary Artery Disease Screening in Waitlisted Kidney Transplant Candidates
Supplementary Material for: Performance versus Risk Factor-Based Approaches to Coronary Artery Disease Screening in Waitlisted Kidney Transplant Candidates Open
Introduction: Current screening algorithms for coronary artery disease (CAD) before kidney transplantation result in many tests but few interventions. Objective: The aim of this study was to study the utility of…
View article: Performance versus Risk Factor-Based Approaches to Coronary Artery Disease Screening in Waitlisted Kidney Transplant Candidates
Performance versus Risk Factor-Based Approaches to Coronary Artery Disease Screening in Waitlisted Kidney Transplant Candidates Open
Introduction: Current screening algorithms for coronary artery disease (CAD) before kidney transplantation result in many tests but few interventions. Objective: The aim of this study was to study the utility of…
View article: Coronary Computed Tomography Angiography in Diagnosing Obstructive Coronary Artery Disease in Patients with Advanced Chronic Kidney Disease: A Systematic Review and Meta-Analysis
Coronary Computed Tomography Angiography in Diagnosing Obstructive Coronary Artery Disease in Patients with Advanced Chronic Kidney Disease: A Systematic Review and Meta-Analysis Open
Introduction: Coronary computed tomography angiography (CCTA) is emerging as an important noninvasive testing modality for coronary angiography. The performance characteristic of CCTA in patients with advanced kidney disease …
View article: Toward telemedicine‐compatible physical functioning assessments in kidney transplant candidates
Toward telemedicine‐compatible physical functioning assessments in kidney transplant candidates Open
Frailty is associated with adverse kidney transplant outcomes and can be assessed by subjective and objective metrics. There is increasing recognition of the value of metrics obtainable remotely. We compared the self‐reported SF‐36 physica…
View article: Impact of Functional Status on Outcomes of Simultaneous Pancreas-kidney Transplantation: Risks and Opportunities for Patient Benefit
Impact of Functional Status on Outcomes of Simultaneous Pancreas-kidney Transplantation: Risks and Opportunities for Patient Benefit Open
Background. The impact of functional status on survival among simultaneous pancreas-kidney transplant (SPKT) candidates and recipients is not well described. Methods. We examined national Scientific Registry of Transplant Recipients (SRTR)…
View article: Physical Performance Testing in Kidney Transplant Candidates at the Top of the Waitlist
Physical Performance Testing in Kidney Transplant Candidates at the Top of the Waitlist Open
Among waitlisted kidney transplant candidates with high kidney allocation scores, standardized and easily performed physical performance test results are associated with waitlist outcomes and contain information beyond what is currently ro…
View article: An overview of frailty in kidney transplantation: measurement, management and future considerations
An overview of frailty in kidney transplantation: measurement, management and future considerations Open
The construct of frailty was first developed in gerontology to help identify older adults with increased vulnerability when confronted with a health stressor. This article is a review of studies in which frailty has been applied to pre- an…