Jingyi Shi
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View article: A synergistic generative-ranking framework for tailored design of therapeutic single-domain antibodies
A synergistic generative-ranking framework for tailored design of therapeutic single-domain antibodies Open
View article: Systematic studies on strength evolution and life prediction of Ultrafine Mineral Powder Concrete subject to freeze-thaw cycles
Systematic studies on strength evolution and life prediction of Ultrafine Mineral Powder Concrete subject to freeze-thaw cycles Open
View article: A Generative Foundation Model for Antibody Design
A Generative Foundation Model for Antibody Design Open
Antibodies are indispensable components of the immune system, yet the design of high-affinity antibodies remains a time-consuming and experimentally intensive process. To address this challenge, we present IgGM, a novel generative foundati…
View article: Black Soldier Fly Larvae as a Novel Protein Feed Resource Promoting Circular Economy in Agriculture
Black Soldier Fly Larvae as a Novel Protein Feed Resource Promoting Circular Economy in Agriculture Open
This study is a systematic critical review aimed at rigorously evaluating the potential of Hermetia illucens larvae (black soldier fly larvae, BSFL) as a sustainable protein source for animal feed through a standardized methodological fram…
View article: Ablation behavior of tungsten alloys under high-energy electron irradiation
Ablation behavior of tungsten alloys under high-energy electron irradiation Open
In order to investigate ablation behavior caused by runaway electrons on plasma facing materials (PFMs), the high energy electron irradiation experiment with a pulse duration of 0.6 µ s at room temperature was performed. Specimens of ITER-…
View article: The SlymiR394-ZDS Module Enhances the Antioxidant Capacity of Tomato by Promoting Lycopene Synthesis
The SlymiR394-ZDS Module Enhances the Antioxidant Capacity of Tomato by Promoting Lycopene Synthesis Open
Lycopene, a natural pigment, is valuable for human health because of its strong antioxidant capacity. However, studies on the involvement of tomato miR394 in the regulation of lycopene have not been reported. The aim of this study was to r…
View article: Pan-Genomic Insights into Rumen Microbiome-Mediated Short-Chain Fatty Acid Production and Regulation in Ruminants
Pan-Genomic Insights into Rumen Microbiome-Mediated Short-Chain Fatty Acid Production and Regulation in Ruminants Open
The rumen microbiome represents a cornerstone of ruminant digestive physiology, orchestrating the anaerobic fermentation of plant biomass into short-chain fatty acids (SCFAs)—critical metabolites underpinning host energy metabolism, immune…
View article: Influence of Yttria Nanoclusters on the Void Nucleation in BCC Iron During Multi-Axial Tensile Deformation: A Molecular Dynamics Simulation
Influence of Yttria Nanoclusters on the Void Nucleation in BCC Iron During Multi-Axial Tensile Deformation: A Molecular Dynamics Simulation Open
Oxide dispersion-strengthened (ODS) steels are among the most promising candidate structural materials for fusion and Generation-IV (Gen-IV) fission reactors, but the ductility of ODS steels is inferior to its strength properties. Therefor…
View article: A synergistic generative-ranking framework for tailored design of therapeutic single-domain antibodies
A synergistic generative-ranking framework for tailored design of therapeutic single-domain antibodies Open
Single-domain antibodies (sdAbs) have emerged as powerful therapeutic agents due to their small size, high stability, and superior tissue penetration. However, unlike conventional monoclonal antibodies (mAbs), sdAbs lack an Fc domain, limi…
View article: Influence of Yttria Nanoclusters on the Void Nucleation in Bcc Iron During Multi-Axial Tensile Deformation: A Molecular Dynamics Simulation
Influence of Yttria Nanoclusters on the Void Nucleation in Bcc Iron During Multi-Axial Tensile Deformation: A Molecular Dynamics Simulation Open
Oxide dispersion strengthened (ODS) steels are among the most promising candidate structural materials for fusion and Generation-IV (Gen-IV) fission reactors, but the ductility of ODS steels is inferior to its strength properties. Therefor…
View article: Epigenetic regulation and maternal-to-zygotic transition in dwarf surf clam (<i>Mulinia lateralis</i>): Insights from chromatin state profiling and transcriptomics
Epigenetic regulation and maternal-to-zygotic transition in dwarf surf clam (<i>Mulinia lateralis</i>): Insights from chromatin state profiling and transcriptomics Open
Bivalve mollusks represent a taxonomically and economically significant clade within Mollusca. However, the regulatory mechanisms governing their embryonic development remain poorly characterized. The dwarf surf clam ( Mulinia lateralis…
View article: Atomistic Investigation on the Helium Effect on Intergranular Crack Propagation in Iron
Atomistic Investigation on the Helium Effect on Intergranular Crack Propagation in Iron Open
View article: Influence of Yttria Nanoclusters on the Void Nucleation in Bcc Iron During Multi-Axial Tensile Deformation: A Molecular Dynamics Simulation
Influence of Yttria Nanoclusters on the Void Nucleation in Bcc Iron During Multi-Axial Tensile Deformation: A Molecular Dynamics Simulation Open
View article: Evaluation of Tungsten as Diffusion Barrier for High-Density U-Mo Fuel Using Heavy-Ion Irradiation
Evaluation of Tungsten as Diffusion Barrier for High-Density U-Mo Fuel Using Heavy-Ion Irradiation Open
View article: Helium-to-Vacancy Ratio of Helium Bubbles in Rafm Steels Irradiated in Stip: A New Perspective Via Md Simulation
Helium-to-Vacancy Ratio of Helium Bubbles in Rafm Steels Irradiated in Stip: A New Perspective Via Md Simulation Open
View article: Atomistic investigation on the helium effect on intergranular crack propagation in iron
Atomistic investigation on the helium effect on intergranular crack propagation in iron Open
View article: Limited involvement of Ca<sup>2+</sup>/calmodulin-dependent kinase II α and β in mammalian sleep
Limited involvement of Ca<sup>2+</sup>/calmodulin-dependent kinase II α and β in mammalian sleep Open
While sleep is important, our understanding of its molecular mechanisms is limited. Over the last two decades, protein kinases have been implicated in sleep regulation, with a prominent role for Ca ++ /calmodulin-dependent kinase II (CaMKI…
View article: Swill and Pig Manure Substrates Differentially Affected Transcriptome and Metabolome of the Black Soldier Fly Larvae
Swill and Pig Manure Substrates Differentially Affected Transcriptome and Metabolome of the Black Soldier Fly Larvae Open
Black soldier fly larvae (Hermetia illucens) (BSFL) are insect larvae with significant ecological and economic value. This study aims to investigate whether swill and manure had any effects on the transcriptome and metabolome of BSFL. Thro…
View article: Study on heat transfer performance of spiral fin plate collector
Study on heat transfer performance of spiral fin plate collector Open
As an important equipment for solar thermal utilization, solar collector is the key to improve energy efficiency and reduce carbon emissions. However, in order to improve the heat transfer capacity of solar collectors, further optimization…
View article: The fully activated open state of KCNQ1 controls the cardiac “fight-or-flight” response
The fully activated open state of KCNQ1 controls the cardiac “fight-or-flight” response Open
The cardiac KCNQ1 + KCNE1 (IKs) channel regulates heart rhythm under both normal and stress conditions. Under stress, the β-adrenergic stimulation elevates the intracellular cyclic adenosine monophosphate (cAMP) level, leading to KCNQ1 pho…
View article: The Multi-Parameter Fusion Early Warning Method for Lithium Battery Thermal Runaway Based on Cloud Model and Dempster–Shafer Evidence Theory
The Multi-Parameter Fusion Early Warning Method for Lithium Battery Thermal Runaway Based on Cloud Model and Dempster–Shafer Evidence Theory Open
As the preferred technology in the current energy storage field, lithium-ion batteries cannot completely eliminate the occurrence of thermal runaway (TR) accidents. It is of significant importance to employ real-time monitoring and warning…
View article: The fully activated open state of KCNQ1 controls the cardiac “fight-or-flight” response
The fully activated open state of KCNQ1 controls the cardiac “fight-or-flight” response Open
The cardiac KCNQ1+KCNE1 (I Ks ) channel regulates heart rhythm in both normal and stress conditions. Under stress, the β-adrenergic stimulation elevates the intracellular cAMP level, leading to KCNQ1 phosphorylation by protein kinase A and…
View article: Irradiation Effects on Tensile Properties of Reduced Activation Ferritic/Martensitic Steel: A Micromechanical-Damage-Model-Based Numerical Investigation
Irradiation Effects on Tensile Properties of Reduced Activation Ferritic/Martensitic Steel: A Micromechanical-Damage-Model-Based Numerical Investigation Open
The tensile properties of reduced activation ferritic/martensitic (RAFM) steels are significantly influenced by neutron irradiation. Here, a mechanism-based model taking account of the typical ductile damage process of void nucleation, gro…
View article: The eighth SINQ Target Irradiation Program, STIP-VIII
The eighth SINQ Target Irradiation Program, STIP-VIII Open
The eighth experiment of the SINQ Target Irradiation Program (STIP-VIII) included a total of 941 specimens from 25 steels, 8 zircaloys, 6 tungsten based alloys (W-alloys) and 2 silicon carbide (SiC) composites. Specimens were prepared in 2…
View article: The Multi-Parameter Fusion Early Warning Method for Lithium Battery Thermal Runaway Based on Cloud Model and Dempster-Shafer Evidence Theory
The Multi-Parameter Fusion Early Warning Method for Lithium Battery Thermal Runaway Based on Cloud Model and Dempster-Shafer Evidence Theory Open
View article: Design and Thermal Performance Analysis of a Novel Dual-Layer Cascade Phase Change Battery Thermal Management System
Design and Thermal Performance Analysis of a Novel Dual-Layer Cascade Phase Change Battery Thermal Management System Open
View article: The datasets stored in TICCom
The datasets stored in TICCom Open
This database provided five datasets. The first dataset contained experimentally verified tumor-immune cell interactions which included interacting gene symbols, cell types, interaction types, cancer types, species and other detailed infor…
View article: Correction: Porous RuO<sub>2</sub>-Co<sub>3</sub>O<sub>4</sub>/C nanocubes as high-performance trifunctional electrocatalysts for zinc–air batteries and overall water splitting
Correction: Porous RuO<sub>2</sub>-Co<sub>3</sub>O<sub>4</sub>/C nanocubes as high-performance trifunctional electrocatalysts for zinc–air batteries and overall water splitting Open
Correction for ‘Porous RuO 2 -Co 3 O 4 /C nanocubes as high-performance trifunctional electrocatalysts for zinc–air batteries and overall water splitting’ by Jingyi Shi et al. , Mater. Chem. Front. , 2023, https://doi.org/10.1039/D3QM00507…
View article: A global database for modeling tumor-immune cell communication
A global database for modeling tumor-immune cell communication Open
Our database contained five CSV files. All the deposited data was processed and openly available. The CSV table ‘Experimentally verified TIC communication’ contained detailed information of experimentally verified TIC communications includ…
View article: Electro-mechanical coupling of KCNQ channels is a target of epilepsy-associated mutations and retigabine
Electro-mechanical coupling of KCNQ channels is a target of epilepsy-associated mutations and retigabine Open
KCNQ2 and KCNQ3 form the M-channels that are important in regulating neuronal excitability. Inherited mutations that alter voltage-dependent gating of M-channels are associated with neonatal epilepsy. In the homolog KCNQ1 channel, two step…