Jiali Yu
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View article: STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity
STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity Open
View article: Palmitoylation prevents B7-H4 lysosomal degradation sustaining tumor immune evasion
Palmitoylation prevents B7-H4 lysosomal degradation sustaining tumor immune evasion Open
B7-H4 functions as an immune checkpoint in the tumor microenvironment (TME). However, the post-translational modification (PTM) of B7-H4 and its translational potential in cancer remains incompletely understood. We find that ZDHHC3, a zinc…
View article: D44. Two Nerves Are Better Than One: A Pilot Study on Dual Vs. Single Nerve Coaptation in DIEP Flap Reconstruction
D44. Two Nerves Are Better Than One: A Pilot Study on Dual Vs. Single Nerve Coaptation in DIEP Flap Reconstruction Open
View article: The association between oxidative balance score and gallstones in adults: a population-based study
The association between oxidative balance score and gallstones in adults: a population-based study Open
Purpose Oxidative stress is a significant contributor to the progression of gallstones. However, the combined or independent effects of dietary and lifestyle pro-antioxidants and antioxidants on gallstone formation remain unclear. Our stud…
View article: Association between hs-CRP/HDL with type 2 diabetes mellitus in middle-aged and elderly people: a cross-sectional study from CHARLS
Association between hs-CRP/HDL with type 2 diabetes mellitus in middle-aged and elderly people: a cross-sectional study from CHARLS Open
Background Research into the relationship between the ratio of high-sensitivity C-reactive protein (hs-CRP) and high-density lipoprotein cholesterol (HDL-C) concerning type 2 diabetes mellitus (T2DM) is still scarce. The hs-CRP/HDL ratio c…
View article: Supplementary Table S4 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade
Supplementary Table S4 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade Open
Supplementary Table S4. Sequences of primers used in RT-qPCR in this study.
View article: Supplementary Figure S1 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade
Supplementary Figure S1 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade Open
Supplementary Figure S1. High expression of UBA1 is associated with low levels of intratumoral CD8+ T cells and predictive of ICB resistance and poor survival in ICB cohorts.
View article: Supplementary Table S1 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade
Supplementary Table S1 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade Open
Supplementary Table S1. UBA1 protein expression and levels of intratumoral CD8+ T cells in tumor samples.
View article: Supplementary Table S5 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade
Supplementary Table S5 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade Open
Supplementary Table S5. Data from the CRISPR screen in Myc-CaP cells treated with TAK-243 + IFN-γ.
View article: Figure 6 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade
Figure 6 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade Open
Depletion of Stub1 upregulates JAK1. A, Top: immunoblot analysis assessing levels of the indicated proteins in Myc-CaP cells that received distinct siRNAs or sgRNAs targeting Stub1. Nontargeting siRNA or sgRNA was used…
View article: Supplementary Table S7 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade
Supplementary Table S7 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade Open
Supplementary Table S7. Data from the mass spectrometry in Myc-CaP cells treated with TAK-243.
View article: Data from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade
Data from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade Open
How cancer cells escape immune surveillance and resist immune checkpoint blockade (ICB) remains to be fully elucidated. By screening candidate genes frequently gained in cancer, we identified expression of ubiquitin-like modifier-activatin…
View article: Figure 5 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade
Figure 5 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade Open
UBA1 inactivation upregulates interferon signaling via stabilization of JAK1. A, Hallmark pathways enriched by bulk RNA-seq of tumors with Uba1 depletion (sgUba1) versus control from the B16-BL6 (left) or Myc-CaP (righ…
View article: Supplementary Table S6 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade
Supplementary Table S6 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade Open
Supplementary Table S6. Data from the CRISPR screen in Myc-CaP cells treated with TAK-243 + IFN-β.
View article: Supplementary Figure S8 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade
Supplementary Figure S8 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade Open
Supplementary Figure S8. UBA1 mediates JAK1 ubiquitination via STUB1.
View article: Supplementary Figure S9 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade
Supplementary Figure S9 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade Open
Supplementary Figure S9. UBA1 inactivation upregulates interferon signaling in vivo.
View article: Figure 3 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade
Figure 3 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade Open
UBA1 diminishes intratumoral functional CD8+ T cells. A, Left: UMAP of 8,862 cells and the indicated clusters identified among CD45+ cells enriched from the indicated Myc-CaP tumors subjected to scRNA-seq. Righ…
View article: Supplementary Table S2 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade
Supplementary Table S2 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade Open
Supplementary Table S2. Target sequences of the sgRNAs used in this study.
View article: Supplementary Figure S4 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade
Supplementary Figure S4 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade Open
Supplementary Figure S4. UBA1 inhibition synergizes with anti-PD-1 therapy to control tumor growth.
View article: Figure 1 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade
Figure 1 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade Open
High expression of UBA1 is associated with low levels of intratumoral CD8+ T cells and predictive of ICB resistance and poor survival in ICB cohorts. A, Left: Spearman correlation between mRNA expression of IFNG…
View article: Supplementary Figure S3 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade
Supplementary Figure S3 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade Open
Supplementary Figure S3. UBA1 diminishes intratumoral functional T cells.
View article: Figure 2 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade
Figure 2 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade Open
UBA1 promotes tumor growth by mediating immune escape. A, Immunoblot analysis assessing levels of the indicated proteins in the indicated cells transduced with empty vector or Uba1 overexpression (OE). B and C, …
View article: Supplementary Figure S2 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade
Supplementary Figure S2 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade Open
Supplementary Figure S2. UBA1 promotes tumor growth by mediating immune escape.
View article: Supplementary Figure S5 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade
Supplementary Figure S5 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade Open
Supplementary Figure S5. UBA1 inactivation upregulates interferon signaling.
View article: Supplementary Figure S6 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade
Supplementary Figure S6 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade Open
Supplementary Figure S6. UBA1 inactivation upregulates interferon signaling via stabilizing JAK1.
View article: Figure 4 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade
Figure 4 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade Open
UBA1 inhibition synergizes with anti–PD-1 therapy to control tumor growth. A, Change of volume over time of subcutaneous tumors derived from B16-F10 cells in C57BL/6 mice treated with the indicated agents (n = 5–6 mice, per g…
View article: Supplementary Figure S10 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade
Supplementary Figure S10 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade Open
Supplementary Figure S10. UBA1 inactivation upregulates interferon signaling in human cancer.
View article: Supplementary Table S3 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade
Supplementary Table S3 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade Open
Supplementary Table S3. Population characteristics of the MI-ONCOSEQ ICB cohort.
View article: Supplementary Figure S7 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade
Supplementary Figure S7 from The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade Open
Supplementary Figure S7. UBA1 inactivation upregulates interferon signaling via stabilizing JAK1.
View article: Integrating single-cell RNA-Seq and machine learning to dissect tryptophan metabolism in ulcerative colitis
Integrating single-cell RNA-Seq and machine learning to dissect tryptophan metabolism in ulcerative colitis Open