Abstract B7-H4 functions as an immune checkpoint in the tumor microenvironment (TME). However, the post-translational modification (PTM) of B7-H4 and its translational potential in cancer remains incompletely understood. We find that ZDHHC3, a zinc finger DHHC-type palmitoyltransferase, palmitoylates B7-H4 at Cys130 in breast cancer cells, preventing its lysosomal degradation and sustaining B7-H4-mediated immunosuppression. Knockdown of ZDHHC3 in tumors results in robust anti-tumor immunity and reduces tumor progr…

Background Research into the relationship between the ratio of high-sensitivity C-reactive protein (hs-CRP) and high-density lipoprotein cholesterol (HDL-C) concerning type 2 diabetes mellitus (T2DM) is still scarce. The hs-CRP/HDL ratio could be an important biomarker for evaluating the risk of developing diabetes. This study primarily aims to investigate the association between hs-CRP/HDL ratios and the incidence of T2DM within a defined population. Methods This analysis was conducted using data from 9,381 parti…

<p>Supplementary Figure S10. UBA1 inactivation upregulates interferon signaling in human cancer.</p>

<p>Supplementary Figure S5. UBA1 inactivation upregulates interferon signaling.</p>