Jian Wu
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View article: HBx promotes tumorigenicity through RRM2-mediated autophagy in hepatocellular carcinoma
HBx promotes tumorigenicity through RRM2-mediated autophagy in hepatocellular carcinoma Open
View article: IDH1-mutant metabolite D-2-hydroxyglutarate inhibits proliferation and sensitizes glioma to temozolomide via down-regulating ITGB4/PI3K/AKT
IDH1-mutant metabolite D-2-hydroxyglutarate inhibits proliferation and sensitizes glioma to temozolomide via down-regulating ITGB4/PI3K/AKT Open
The heterogeneous molecular subtypes of gliomas demonstrate varied responses to chemotherapy and distinct prognostic outcomes. Gliomas with Isocitrate dehydrogenase 1 (IDH1) mutation are associated with better outcomes and are more respons…
View article: Tat-CIRP Peptide Facilitates Frozen Wound Healing by Ameliorating Inflammation and Promoting Angiogenesis
Tat-CIRP Peptide Facilitates Frozen Wound Healing by Ameliorating Inflammation and Promoting Angiogenesis Open
Tat-CIRP promotes frozen wound healing via inhibiting inflammation and promoting angiogenesis in frostbitten mice.
View article: Multi-scale Spatio-temporal Transformer-based Imbalanced Longitudinal Learning for Glaucoma Forecasting from Irregular Time Series Images
Multi-scale Spatio-temporal Transformer-based Imbalanced Longitudinal Learning for Glaucoma Forecasting from Irregular Time Series Images Open
Glaucoma is one of the major eye diseases that leads to progressive optic nerve fiber damage and irreversible blindness, afflicting millions of individuals. Glaucoma forecast is a good solution to early screening and intervention of potent…
View article: Joint Explicit and Implicit Cross-Modal Interaction Network for Anterior Chamber Inflammation Diagnosis
Joint Explicit and Implicit Cross-Modal Interaction Network for Anterior Chamber Inflammation Diagnosis Open
Uveitis demands the precise diagnosis of anterior chamber inflammation (ACI) for optimal treatment. However, current diagnostic methods only rely on a limited single-modal disease perspective, which leads to poor performance. In this paper…
View article: HBx promotes tumorigenicity through RRM2-mediated autophagy in hepatocellular carcinoma
HBx promotes tumorigenicity through RRM2-mediated autophagy in hepatocellular carcinoma Open
HBV infection can exacerbate liver disease progression through multiple mechanisms, eventually leading to hepatocellular carcinoma (HCC). HBV-encoded oncogene X protein (HBx), a key regulatory protein of HBV infection, serves as a positive…
View article: Esophageal Ulcer After Intravitreal Ranibizumab Injection in a Patient With Age-Related Macular Degeneration
Esophageal Ulcer After Intravitreal Ranibizumab Injection in a Patient With Age-Related Macular Degeneration Open
Ranibizumab is a monoclonal antibody fragment targeted against vascular endothelial growth factor (VEGF) A isoform (VEGF-A). This study aimed to report a case of esophageal ulcer that developed soon after intravitreal ranibizumab injection…
View article: Supplementary Tables from JCAD Promotes Progression of Nonalcoholic Steatohepatitis to Liver Cancer by Inhibiting LATS2 Kinase Activity
Supplementary Tables from JCAD Promotes Progression of Nonalcoholic Steatohepatitis to Liver Cancer by Inhibiting LATS2 Kinase Activity Open
table S1 showed all shRNA sequences used for lentiviral generation table S2 showed primer sequences for quantitative PCR assays table S3 showed all antibodies used for Western blot analysis and immunohistochemical staining
View article: Supplementary Tables from JCAD Promotes Progression of Nonalcoholic Steatohepatitis to Liver Cancer by Inhibiting LATS2 Kinase Activity
Supplementary Tables from JCAD Promotes Progression of Nonalcoholic Steatohepatitis to Liver Cancer by Inhibiting LATS2 Kinase Activity Open
table S1 showed all shRNA sequences used for lentiviral generation table S2 showed primer sequences for quantitative PCR assays table S3 showed all antibodies used for Western blot analysis and immunohistochemical staining
View article: supplementary methods from JCAD Promotes Progression of Nonalcoholic Steatohepatitis to Liver Cancer by Inhibiting LATS2 Kinase Activity
supplementary methods from JCAD Promotes Progression of Nonalcoholic Steatohepatitis to Liver Cancer by Inhibiting LATS2 Kinase Activity Open
supplementary methods include Plasmids Generation of lentiviruses for JCAD knockdown and overexpression Genechip microarray analysis Total RNA extraction and cDNA synthesis Quantitative reverse transcriptase polymerase chain reaction (qRT-…
View article: supplementary methods from JCAD Promotes Progression of Nonalcoholic Steatohepatitis to Liver Cancer by Inhibiting LATS2 Kinase Activity
supplementary methods from JCAD Promotes Progression of Nonalcoholic Steatohepatitis to Liver Cancer by Inhibiting LATS2 Kinase Activity Open
supplementary methods include Plasmids Generation of lentiviruses for JCAD knockdown and overexpression Genechip microarray analysis Total RNA extraction and cDNA synthesis Quantitative reverse transcriptase polymerase chain reaction (qRT-…
View article: Tea consumption and risk of kidney stones: a dose-response meta-analysis of prospective cohort studies
Tea consumption and risk of kidney stones: a dose-response meta-analysis of prospective cohort studies Open
Review question / Objective: This doseresponse meta-analysis aims to evaluate the association of tea consumption with the risk of kidney stones based on prospective cohort studies.Condition being studied: Kidney stones is a highly prevalen…
View article: Effects of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) targeted combined chemotherapy on immune function, tumor markers and oxidative stress in patients with stage IV lung adenocarcinoma
Effects of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) targeted combined chemotherapy on immune function, tumor markers and oxidative stress in patients with stage IV lung adenocarcinoma Open
Objective: To investigate the effects of EGFR-TKI combined chemotherapy on immune function, tumor markers and oxidative stress in patients with stage-IV lung adenocarcinoma.
Methods: This retrospective observational study included 116 pat…
View article: Evaluation of 3-dimensional rotational venography for the diagnosis of non-thrombotic iliac venous lesion
Evaluation of 3-dimensional rotational venography for the diagnosis of non-thrombotic iliac venous lesion Open
Background The purpose of this study was to determine the technical feasibility and safety of 3D rotational venography (3D-RV) in the diagnosis of non-thrombotic iliac vein lesions compared with traditional 2D-digital subtraction angiograp…
View article: Vulvovaginal candidiasis and vaginal microflora interaction: Microflora changes and probiotic therapy
Vulvovaginal candidiasis and vaginal microflora interaction: Microflora changes and probiotic therapy Open
Vaginal microbiome is mutually beneficial to the host and has a significant impact on health and disease. Candida species, including Candida albicans , are part of the mucosal flora of most healthy women. Under suitable conditions, they ca…
View article: Modified lumbar foraminoplasty using a power-aided reciprocating burr for percutaneous transforaminal endoscopic lumbar discectomy: A technical note and clinical report
Modified lumbar foraminoplasty using a power-aided reciprocating burr for percutaneous transforaminal endoscopic lumbar discectomy: A technical note and clinical report Open
Background One of the main difficulties in a transforaminal endoscopic lumbar discectomy (TELD), and simultaneously the most critical step, is performing an effective and safe foraminoplasty, which is especially difficult for beginners. To…
View article: CTT-Net: A Multi-view Cross-token Transformer for Cataract Postoperative Visual Acuity Prediction
CTT-Net: A Multi-view Cross-token Transformer for Cataract Postoperative Visual Acuity Prediction Open
Surgery is the only viable treatment for cataract patients with visual acuity (VA) impairment. Clinically, to assess the necessity of cataract surgery, accurately predicting postoperative VA before surgery by analyzing multi-view optical c…
View article: Significance of Identifying Key Genes Involved in HBV-Related Hepatocellular Carcinoma for Primary Care Surveillance of Patients with Cirrhosis
Significance of Identifying Key Genes Involved in HBV-Related Hepatocellular Carcinoma for Primary Care Surveillance of Patients with Cirrhosis Open
Cirrhosis is frequently the final stage of disease preceding the development of hepatocellular carcinoma (HCC) and is one of the risk factors for HCC. Preventive surveillance for early HCC in patients with cirrhosis is advantageous for ach…
View article: A pan-cancer analysis of the oncogenic role of ribonucleotide reductase subunit M2 in human tumors
A pan-cancer analysis of the oncogenic role of ribonucleotide reductase subunit M2 in human tumors Open
Background Recent studies have identified ribonucleotide reductase subunit M2 (RRM2) as a putative promoter of tumors. However, no systematic analysis of its carcinogenicity has been conducted. Methods The potential functions of RRM2 in va…
View article: Hydrogen sulfide against preeclampsia exposure-induced oxidative mitochondrial damage in HTR-8/SVneo cells
Hydrogen sulfide against preeclampsia exposure-induced oxidative mitochondrial damage in HTR-8/SVneo cells Open
Extravillous trophoblast invasion disorder caused by oxidative stress is involved in the pathogenesis of preeclampsia (PE). In order to identify whether hydrogen sulfide (H 2 S) can prevent oxidative stress injury in extravillous trophobla…
View article: Effectiveness and safety of combined use of tranexamic acid and Xiyu dressing in chloasma therapy, and its effect on recurrence in patients
Effectiveness and safety of combined use of tranexamic acid and Xiyu dressing in chloasma therapy, and its effect on recurrence in patients Open
Purpose: To determine the effectiveness and safety of combined use of tranexamic acid (TA) and Xiyu dressing in chloasma patients.
Methods: Ninety female patients with moderate-to-severe melasma who were admitted to the Affiliated Suzhou …
View article: Genome‐wide virus‐integration analysis reveals a common insertional mechanism of HPV, HBV and EBV
Genome‐wide virus‐integration analysis reveals a common insertional mechanism of HPV, HBV and EBV Open
Human papillomavirus (HPV), hepatitis B virus (HBV) and Epstein–Barr virus (EBV) are the three most oncogenic DNA viruses, contributing to 15 different types of cancer.1 Although these viruses differ in many aspects, one common key step is…
View article: ME-GAN: Learning Panoptic Electrocardio Representations for Multi-view ECG Synthesis Conditioned on Heart Diseases
ME-GAN: Learning Panoptic Electrocardio Representations for Multi-view ECG Synthesis Conditioned on Heart Diseases Open
Electrocardiogram (ECG) is a widely used non-invasive diagnostic tool for heart diseases. Many studies have devised ECG analysis models (e.g., classifiers) to assist diagnosis. As an upstream task, researches have built generative models t…
View article: miR-4463 Regulates Hypoxia-Induced Autophagy and Apoptosis by Targeting ULK1 in Endothelial Cells
miR-4463 Regulates Hypoxia-Induced Autophagy and Apoptosis by Targeting ULK1 in Endothelial Cells Open
Background: Our previous study revealed aberrant miR-4463 expression in the vascular tissues of patients with arteriosclerosis obliterans of the lower extremities (ASO), but the role of miR-4463 was largely ambiguous. In the current study,…
View article: Outcome of primary intraosseous carcinoma: Case review of a single institution
Outcome of primary intraosseous carcinoma: Case review of a single institution Open
Objective The purpose of this study was to investigate the prognostic factors and treatment of primary intraosseous carcinoma (PIOC). Methods Patients diagnosed with POIC and received treatment in Sichuan Cancer Hospital from 2000 to 2019 …
View article: A One-Dimensional Serial ECG Diagnosis Approach Based on Ensemble Deep Learning
A One-Dimensional Serial ECG Diagnosis Approach Based on Ensemble Deep Learning Open
An electrocardiograph (ECG) reflects the health of the human heart and is used to help diagnose arrhythmia and myocardial infarction(MI) in clinical practice. Early diagnosis of arrhythmia helps implement preventive measures and plays a cr…
View article: Comparative Transcriptome and Lipidome Analyses Suggest a Lipid Droplet-Specific Response to Heat Exposure of Brown Adipose Tissue in Normal and Obese Mice
Comparative Transcriptome and Lipidome Analyses Suggest a Lipid Droplet-Specific Response to Heat Exposure of Brown Adipose Tissue in Normal and Obese Mice Open
View article: Epidemiological Investigation of Gallbladder Stone Disease in Shanghai China
Epidemiological Investigation of Gallbladder Stone Disease in Shanghai China Open
View article: Diagnostic Value of sIL-2R, TNF-α and PCT for Sepsis Infection in Patients with Closed Abdominal Injury Complicated with Severe Multiple Abdominal Injuries
Diagnostic Value of sIL-2R, TNF-α and PCT for Sepsis Infection in Patients with Closed Abdominal Injury Complicated with Severe Multiple Abdominal Injuries Open
Objective: To evaluate the diagnostic value of soluble interleukin-2 receptor (sIL-2R), tumor necrosis factor-α (TNF-α), procalcitonin (PCT) and combined detection for sepsis infection in patients with closed abdominal injury complicated w…
View article: Left-side vs. right-side hepatectomy for Hilar Cholangiocarcinoma: A meta-analysis
Left-side vs. right-side hepatectomy for Hilar Cholangiocarcinoma: A meta-analysis Open
Review question / Objective: Which side hepatectomy is better for patients.Patients with hilar cholangiocarcinoma.Patients undergone surgery.