Junmin Li
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View article: 1α,25(OH)<sub>2</sub>D<sub>3</sub> prevents CD19 CAR-T cell exhaustion and differentiation via VDR-dependent transcriptional reprogramming
1α,25(OH)<sub>2</sub>D<sub>3</sub> prevents CD19 CAR-T cell exhaustion and differentiation via VDR-dependent transcriptional reprogramming Open
CD19-directed chimeric antigen receptor T (CAR-T) cell therapy is promising for treating relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL), yet its long-term efficacy remains limited by CAR-T-cell exhaustion. Given the broad im…
View article: A Novel Microfluidic Platform for Circulating Tumor Cell Identification in Non-Small-Cell Lung Cancer
A Novel Microfluidic Platform for Circulating Tumor Cell Identification in Non-Small-Cell Lung Cancer Open
Circulating tumor cells (CTCs) are crucial biomarkers for lung cancer metastasis and recurrence, garnering significant clinical attention. Despite this, efficient and cost-effective detection methods remain scarce. Consequently, there is a…
View article: Global and Chinese trends in acute myeloid leukemia burden (1990–2021): a comprehensive analysis based on the GBD study
Global and Chinese trends in acute myeloid leukemia burden (1990–2021): a comprehensive analysis based on the GBD study Open
Background Acute myeloid leukemia (AML) poses a significant global health burden. This study evaluates long-term trends in AML burden from 1990 to 2021, focusing on global and Chinese patterns using Global Burden of Disease (GBD) data. Met…
View article: Identification of Abandoned Cropland and Global–Local Driving Mechanism Analysis via Multi-Source Remote Sensing Data and Multi-Objective Optimization
Identification of Abandoned Cropland and Global–Local Driving Mechanism Analysis via Multi-Source Remote Sensing Data and Multi-Objective Optimization Open
The issue of abandoned cropland poses a significant threat to national food security and the sustainable use of land resources, highlighting the urgent need for an efficient and interpretable remote sensing identification framework. This s…
View article: SNORD93 suppresses colorectal cancer progression by inducing G0/G1 arrest and apoptosis
SNORD93 suppresses colorectal cancer progression by inducing G0/G1 arrest and apoptosis Open
Collectively, these results establish SNORD93 as a functionally significant tumor-suppressive snoRNA in CRC.
View article: Transcript isoform diversity defines molecular subtypes and prognosis in acute myeloid leukemia through long-read sequencing
Transcript isoform diversity defines molecular subtypes and prognosis in acute myeloid leukemia through long-read sequencing Open
Acute myeloid leukemia (AML) is a genetically complex and clinically heterogeneous hematopoietic malignancy. This study employs long-read transcriptome analysis using oxford nanopore technologies sequencing on 60 primary AML bone marrow sa…
View article: Harnessing the Rhizosphere Microbiome for Selenium Biofortification in Plants: Mechanisms, Applications and Future Perspectives
Harnessing the Rhizosphere Microbiome for Selenium Biofortification in Plants: Mechanisms, Applications and Future Perspectives Open
The rhizosphere microbiome plays a critical role in promoting crop health and productivity. Selenium (Se), a beneficial trace element for plants, not only enhances resistance to both abiotic and biotic stresses but also modulates soil micr…
View article: Comprehensive investigation of DNA damage repair genes in children with cancer identifies<i>SMARCAL1</i>as novel osteosarcoma predisposition gene
Comprehensive investigation of DNA damage repair genes in children with cancer identifies<i>SMARCAL1</i>as novel osteosarcoma predisposition gene Open
Background Recent large-scale genomic sequencing studies reveal that 5-18% of children with cancer harbor pathogenic variants (PV) in known cancer predisposing genes (CPG). However, DNA damage repair (DDR) genes, which are frequently somat…
View article: [Expressions of miR-27a-3p mRNA and <i>YAP1</i> mRNA in Breast Cancer and the Relationship With Clinicopathology and Survival Prognosis].
[Expressions of miR-27a-3p mRNA and <i>YAP1</i> mRNA in Breast Cancer and the Relationship With Clinicopathology and Survival Prognosis]. Open
A significant downregulation of miR-27a-3p mRNA and upregulation of YAP1 mRNA are observed in breast tumor tissues. The low expression of miR-27a-3p mRNA and the high expression of YAP1 mRNA are associated with adverse clinicopathological …
View article: Modeling fire‐related smoke inhalation injury using the human lung‐on‐a‐chip and organoid platform: Pathogenesis insights and therapeutic evaluation
Modeling fire‐related smoke inhalation injury using the human lung‐on‐a‐chip and organoid platform: Pathogenesis insights and therapeutic evaluation Open
Fire‐related smoke inhalation‐induced acute lung injury (SI‐ALI) is a prevalent condition in modern fires, characterized by high mortality and a lack of targeted therapeutic options. Previous research has been hindered by instability in sm…
View article: Mini liver organoid models emulating metabolic dysfunction-associated steatotic disease development: gradually emerging beneath the iceberg
Mini liver organoid models emulating metabolic dysfunction-associated steatotic disease development: gradually emerging beneath the iceberg Open
Tissue spatial interaction in the liver, including the interplay among immune cells, blood vessels, sinusoidal endothelial cells, bile ducts, stellate cells, hepatic progenitor cells, and hepatocytes, is crucial not only for normal organog…
View article: First-principles Investigation of Exceptional Coarsening-resistant V-Sc(Al2Cu)4 Nanoprecipitates in Al-Cu-Mg-Ag-Sc Alloys
First-principles Investigation of Exceptional Coarsening-resistant V-Sc(Al2Cu)4 Nanoprecipitates in Al-Cu-Mg-Ag-Sc Alloys Open
Aluminum-copper-magnesium-sliver (Al-Cu-Mg-Ag) alloys are extensively utilized in aerospace industries due to the formation of Omega nano-plates.However, the rapid coarsening of these nano-plates above 475 K restricts their application at …
View article: Driver mutation landscape of acute myeloid leukemia provides insights for neoantigen-based immunotherapy
Driver mutation landscape of acute myeloid leukemia provides insights for neoantigen-based immunotherapy Open
Acute myeloid leukemia (AML) has lagged in benefiting from immunotherapies, primarily due to the scarcity of actionable AML-specific antigens. Driver mutations represent promising immunogenic targets, but a comprehensive characterization o…
View article: Effect of therapeutic erythrocytapheresis on outcomes and renal benefit in patients with high-altitude polycythemia: a real-world study
Effect of therapeutic erythrocytapheresis on outcomes and renal benefit in patients with high-altitude polycythemia: a real-world study Open
Kidney injury from high-altitude polycythemia (HAPC) is common, yet few studies have explored effective treatments. This research assessed the renal benefits of therapeutic erythrocytapheresis (TE) in HAPC patients, analyzing the efficacy …
View article: Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus
Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus Open
The 1957 H2N2 influenza pandemic virus [A(H2N2)pdm1957] has disappeared from humans since 1968, while H2N2 avian influenza viruses (AIVs) are still circulating in birds. It is necessary to reveal the recurrence risk and potential cross-spe…
View article: Isolation, identification, and mechanism analysis of plant growth-promoting rhizobacteria in tobacco
Isolation, identification, and mechanism analysis of plant growth-promoting rhizobacteria in tobacco Open
Plant growth, crop yield, and pest and disease control are enhanced by PGPR (Plant growth promoting rhizobacteria), which are beneficial microorganisms found in a close symbiosis with plant roots. Phytohormones are secreted, nutrient uptak…
View article: A CD8+ T cell related immune score predicts survival and refines the risk assessment in acute myeloid leukemia
A CD8+ T cell related immune score predicts survival and refines the risk assessment in acute myeloid leukemia Open
Although advancements in genomic and epigenetic research have deepened our understanding of acute myeloid leukemia (AML), only one-third of patients can achieve durable remission. Growing evidence suggests that the immune microenvironment …
View article: Exploring therapeutic targets and molecular mechanisms for treating diabetes mellitus-associated heart failure with Qishen Yiqi dropping pills: A network pharmacology and bioinformatics approach
Exploring therapeutic targets and molecular mechanisms for treating diabetes mellitus-associated heart failure with Qishen Yiqi dropping pills: A network pharmacology and bioinformatics approach Open
Diabetes mellitus (DM) and heart failure frequently coexist, presenting significant public health challenges. QiShenYiQi Dropping Pills (QSDP) are widely employed in the treatment of diabetes mellitus concomitant with heart failure (DM-HF)…
View article: Association between metabolic dysfunction-associated steatotic liver disease and pulmonary function: a population-based and two-sample mendelian randomization study
Association between metabolic dysfunction-associated steatotic liver disease and pulmonary function: a population-based and two-sample mendelian randomization study Open
Background Hepatic steatosis and its related complications are risk factors for multiple respiratory diseases; however, the causal relationship between metabolic dysfunction-associated steatotic liver disease (MASLD) and pulmonary function…
View article: [Inhibitory effect of 5-hydroxy-6,7-dimethoxyflavone on H1N1 influenza virus-induced ferroptosis and inflammation in A549 cells and its possible mechanisms].
[Inhibitory effect of 5-hydroxy-6,7-dimethoxyflavone on H1N1 influenza virus-induced ferroptosis and inflammation in A549 cells and its possible mechanisms]. Open
5-HDF offers protection against H1N1 influenza virus infection in mice possibly by suppressing H1N1-induced ferroptosis, inflammatory responses, and apoptosis via upregulating SLC7A11 and GPX4, inhibiting the activation of phospho-NF-κB p6…
View article: Supplementary Table S1-S20 from Mutant U2AF1-Induced Mis-Splicing of mRNA Translation Genes Confers Resistance to Chemotherapy in Acute Myeloid Leukemia
Supplementary Table S1-S20 from Mutant U2AF1-Induced Mis-Splicing of mRNA Translation Genes Confers Resistance to Chemotherapy in Acute Myeloid Leukemia Open
Supplementary Table S1-S20
View article: Data from Mutant U2AF1-Induced Mis-Splicing of mRNA Translation Genes Confers Resistance to Chemotherapy in Acute Myeloid Leukemia
Data from Mutant U2AF1-Induced Mis-Splicing of mRNA Translation Genes Confers Resistance to Chemotherapy in Acute Myeloid Leukemia Open
Patients with primary refractory acute myeloid leukemia (AML) have a dismal long-term prognosis. Elucidating the resistance mechanisms to induction chemotherapy could help identify strategies to improve AML patient outcomes. Herein, we ret…
View article: Supplementary Table S1-S20 from Mutant U2AF1-Induced Mis-Splicing of mRNA Translation Genes Confers Resistance to Chemotherapy in Acute Myeloid Leukemia
Supplementary Table S1-S20 from Mutant U2AF1-Induced Mis-Splicing of mRNA Translation Genes Confers Resistance to Chemotherapy in Acute Myeloid Leukemia Open
Supplementary Table S1-S20
View article: Data from Mutant U2AF1-Induced Mis-Splicing of mRNA Translation Genes Confers Resistance to Chemotherapy in Acute Myeloid Leukemia
Data from Mutant U2AF1-Induced Mis-Splicing of mRNA Translation Genes Confers Resistance to Chemotherapy in Acute Myeloid Leukemia Open
Patients with primary refractory acute myeloid leukemia (AML) have a dismal long-term prognosis. Elucidating the resistance mechanisms to induction chemotherapy could help identify strategies to improve AML patient outcomes. Herein, we ret…
View article: Supplementary methods and Figure S1-S12 from Mutant U2AF1-Induced Mis-Splicing of mRNA Translation Genes Confers Resistance to Chemotherapy in Acute Myeloid Leukemia
Supplementary methods and Figure S1-S12 from Mutant U2AF1-Induced Mis-Splicing of mRNA Translation Genes Confers Resistance to Chemotherapy in Acute Myeloid Leukemia Open
Supplementary methods and Figure S1-S12