Jiaming Lv
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View article: Catalytic Asymmetric Aza‐[2+2] Cyclization Reaction of Simple Ketoimine
Catalytic Asymmetric Aza‐[2+2] Cyclization Reaction of Simple Ketoimine Open
Herein, we report the first catalytic enantioselective aza‐[2+2] cyclization of simple ketoimines, thereby addressing a persistent challenge in four‐membered aza‐ring construction. While the aza‐[2+2] cyclization represents the most straig…
View article: Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's Disease
Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's Disease Open
Epidemiological studies have linked uric acid (UA), the end product of purine metabolism in humans, with reduced Alzheimer's disease (AD) risk. Decreased serum UA levels are observed in AD patients versus age‐matched controls, while upstre…
View article: Restoration of tumor suppressor protein with enhanced activity using super-tRNAs to induce tumor regression
Restoration of tumor suppressor protein with enhanced activity using super-tRNAs to induce tumor regression Open
SUMMARY Cancer develops through a gradual accumulation of mutations including nonsense mutations in tumor suppressor genes (TSGs), which drive tumor proliferation and progression due to the impairment or complete loss of tumor suppressor p…
View article: Causal effects of plasma metabolites on autoimmune hepatitis (AIH): a bidirectional two-sample mendelian randomization study
Causal effects of plasma metabolites on autoimmune hepatitis (AIH): a bidirectional two-sample mendelian randomization study Open
View article: High Uric Acid Promotes Atherosclerotic Plaque Instability by Apoptosis Targeted Autophagy
High Uric Acid Promotes Atherosclerotic Plaque Instability by Apoptosis Targeted Autophagy Open
HUA promoted atherosclerosis and exacerbated plaque vulnerability, and HUA facilitates foam cell apoptosis by inhibiting autophagy.
View article: The Application of Nimotuzumab Combined With Definitive Chemoradiotherapy Toward the Treatment of Locally Advanced Cervical Esophageal Carcinoma: A Retrospective Study
The Application of Nimotuzumab Combined With Definitive Chemoradiotherapy Toward the Treatment of Locally Advanced Cervical Esophageal Carcinoma: A Retrospective Study Open
Objective To evaluate the safety and effectiveness of nimotuzumab in combination with chemoradiotherapy for locally advanced cervical esophageal squamous cell carcinoma. Methods Retrospective analysis was conducted from September 2012 to F…
View article: Joint Distribution Matters: Deep Brownian Distance Covariance for Few-Shot Classification
Joint Distribution Matters: Deep Brownian Distance Covariance for Few-Shot Classification Open
Few-shot classification is a challenging problem as only very few training examples are given for each new task. One of the effective research lines to address this challenge focuses on learning deep representations driven by a similarity …
View article: Prevalence, Genetics and Evolutionary Properties of Eurasian Avian-like H1N1 Swine Influenza Viruses in Liaoning
Prevalence, Genetics and Evolutionary Properties of Eurasian Avian-like H1N1 Swine Influenza Viruses in Liaoning Open
Swine influenza virus (SIV) is an important zoonosis pathogen. The 2009 pandemic of H1N1 influenza A virus (2009/H1N1) highlighted the importance of the role of pigs as intermediate hosts. Liaoning province, located in northeastern China, …
View article: Wasp venom from <i>Vespa magnifica</i> acts as a neuroprotective agent to alleviate neuronal damage after stroke in rats
Wasp venom from <i>Vespa magnifica</i> acts as a neuroprotective agent to alleviate neuronal damage after stroke in rats Open
Wasp venom exhibited a potential neuroprotective effect for AIS. In the future, we will focus on determining whether the observed actions were due to a single compound or the interaction of multiple components of the venom.
View article: Vespakinin-M, a natural peptide from Vespa magnifica, promotes functional recovery in stroke mice
Vespakinin-M, a natural peptide from Vespa magnifica, promotes functional recovery in stroke mice Open
View article: High Level of Uric Acid Promotes Atherosclerosis by Targeting NRF2‐Mediated Autophagy Dysfunction and Ferroptosis
High Level of Uric Acid Promotes Atherosclerosis by Targeting NRF2‐Mediated Autophagy Dysfunction and Ferroptosis Open
Atherosclerotic vascular disease (ASVD) is the leading cause of death worldwide. Hyperuricemia is the fourth risk factor for atherosclerosis after hypertension, diabetes, and hyperlipidemia. The mechanism of hyperuricemia affecting the occ…
View article: Long noncoding RNA HAGLR sponges miR‐338‐3p to promote 5‐Fu resistance in gastric cancer through targeting the LDHA‐glycolysis pathway
Long noncoding RNA HAGLR sponges miR‐338‐3p to promote 5‐Fu resistance in gastric cancer through targeting the LDHA‐glycolysis pathway Open
Gastric cancer (GC) is one of the most common human malignancies due to its invasiveness and metastasis. 5‐Fu is a widely applied chemotherapeutic agent against GC. Although 5‐Fu therapy has achieved improvements in GC treatment, a large f…
View article: The effect of combined TPF and intensity modulated radiotherapy after TPF induction chemotherapy on locally advanced nasopharyngeal carcinoma: a retrospective analysis
The effect of combined TPF and intensity modulated radiotherapy after TPF induction chemotherapy on locally advanced nasopharyngeal carcinoma: a retrospective analysis Open
Compared with concurrent cisplatin chemotherapy and radiotherapy, the concurrent TPF regimen and IMRT showed no significant improvement in OS and PFS in patients with advanced NPC, but exhibited more severe hematologic toxicity, oral mucos…
View article: Fiber optic Fabry–Perot sensor that can amplify ultrasonic wave for an enhanced partial discharge detection
Fiber optic Fabry–Perot sensor that can amplify ultrasonic wave for an enhanced partial discharge detection Open
View article: MEMS-on-fiber sensor combining silicon diaphragm and supporting beams for on-line partial discharges monitoring
MEMS-on-fiber sensor combining silicon diaphragm and supporting beams for on-line partial discharges monitoring Open
Fiber optic extrinsic Fabry-Perot interferometric (EFPI) sensors are ideal candidates for on-line partial discharges (PDs) monitoring due to their inherent advantages, such as immunity to electromagnetic interference (EMI), highly compact …
View article: MEMS-on-fiber ultrasonic sensor with two resonant frequencies for partial discharges detection
MEMS-on-fiber ultrasonic sensor with two resonant frequencies for partial discharges detection Open
A novel fiber optic extrinsic Fabry-Perot interferometric (EFPI) ultrasonic sensor with two resonant frequencies for detecting the partial discharges (PDs) in switchgear is demonstrated. The key sensing element consists of two 5-µm-thickne…
View article: Locating Ultrasonic Signals Employing MEMS-On-Fiber Sensors
Locating Ultrasonic Signals Employing MEMS-On-Fiber Sensors Open
Sound sensing finds wide applications in various fields, such as underwater detection, structural health monitoring, and medical diagnosis, to name just a few. Based on our previously developed MEMS-on-fiber sensors, showing the advantages…
View article: High HLA-F Expression Is a Poor Prognosis Factor in Patients with Nasopharyngeal Carcinoma
High HLA-F Expression Is a Poor Prognosis Factor in Patients with Nasopharyngeal Carcinoma Open
Background and Aims . In patients with nasopharyngeal carcinoma (NPC), local treatment failure and distant metastasis contribute largely to poor outcomes. The nasopharynx is an important lymphoid tissue, and NPC tumourigenesis and developm…