Jiaming Zhuang
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View article: Conferring liver selectivity to a thyromimetic using a novel nanoparticle increases therapeutic efficacy in a diet-induced obesity animal model
Conferring liver selectivity to a thyromimetic using a novel nanoparticle increases therapeutic efficacy in a diet-induced obesity animal model Open
Optimization of metabolic regulation is a promising solution for many pathologies, including obesity, dyslipidemia, type 2 diabetes, and inflammatory liver disease. Synthetic thyroid hormone mimics–based regulation of metabolic balance in …
View article: Strategically constructed high-reflectivity multiple-stack distributed Bragg reflectors for efficient GaN-based flip-chip mini-LEDs
Strategically constructed high-reflectivity multiple-stack distributed Bragg reflectors for efficient GaN-based flip-chip mini-LEDs Open
Full-angle distributed Bragg reflectors (DBRs) consisting of numerous sub-DBRs with discrete central wavelengths have been developed to enhance performance of GaN-based flip-chip mini light-emitting diodes (FC mini-LEDs). However, relative…
View article: “Seminal testosterone”, rising viewpoint of local spermatogenesis in nonobstructive azoospermia: One center long-term bidirectional cohort study
“Seminal testosterone”, rising viewpoint of local spermatogenesis in nonobstructive azoospermia: One center long-term bidirectional cohort study Open
Objective Reproductive hormones are a traditional good method to evaluate spermatogenesis but might not accurately represent local spermatogenesis. To find a more accurate method, seminal reproductive hormones were studied. Methods A bidir…
View article: Stimuli Responsive Polymer Self-Assembly and Disassembly
Stimuli Responsive Polymer Self-Assembly and Disassembly Open
This dissertation consists of three chapters. The first two chapters focus on the Chinese hedge fund industry, and the third chapter focuses on American and offshore hedge funds. In the first chapter, I study the Chinese hedge fund industr…
View article: Cellular‐ and Subcellular‐Targeted Delivery Using a Simple All‐in‐One Polymeric Nanoassembly
Cellular‐ and Subcellular‐Targeted Delivery Using a Simple All‐in‐One Polymeric Nanoassembly Open
Nanocarrier‐mediated drug delivery is a promising strategy to maximize the power of chemotherapy and minimize side effects. However, current approaches show insufficient drug‐loading capacity and inefficient drug release, and require compl…
View article: Triblock–Diblock Composite Nanoassemblies with Sequentially Addressable Host–Guest Properties for Hydrophobics and Hydrophilics
Triblock–Diblock Composite Nanoassemblies with Sequentially Addressable Host–Guest Properties for Hydrophobics and Hydrophilics Open
Noncovalent encapsulation of multiple guest molecules with distinct physiochemical properties, especially hydrophilic and hydrophobic guests, into a single polymeric nanoassembly is challenging, but would be profoundly beneficial to combin…
View article: Covalent Labeling with an α,β-Unsaturated Carbonyl Scaffold for Studying Protein Structure and Interactions by Mass Spectrometry
Covalent Labeling with an α,β-Unsaturated Carbonyl Scaffold for Studying Protein Structure and Interactions by Mass Spectrometry Open
A new covalent labeling (CL) reagent based on an α,β-unsaturated carbonyl scaffold has been developed for studying protein structure and protein-protein interactions when coupled with mass spectrometry. We show that this new reagent scaffo…
View article: A programmable chemical switch based on triggerable Michael acceptors
A programmable chemical switch based on triggerable Michael acceptors Open
A triggerable Michael acceptor (TMAc) with programmable reactivity and reversibility for simultaneous coupling and decoupling has been developed for selective protein modification, self-immolative linker and orthogonally addressable hydrog…
View article: Tunable enzyme responses in amphiphilic nanoassemblies through alterations in the unimer–aggregate equilibrium
Tunable enzyme responses in amphiphilic nanoassemblies through alterations in the unimer–aggregate equilibrium Open
Developing design rules that offer tailorability in materials' response to enzymes is of great importance, as such materials are of interest in a variety of biomedical applications including sensing, diagnostics and drug delivery.
View article: Supramolecular Assemblies for Transporting Proteins Across an Immiscible Solvent Interface
Supramolecular Assemblies for Transporting Proteins Across an Immiscible Solvent Interface Open
Polymeric supramolecular assemblies that can effectively transport proteins across an incompatible solvent interface are described. We show that electrostatics and ligand-protein interactions can be used to selectively transport proteins f…
View article: Biodistribution Analysis of NIR-Labeled Nanogels Using<i>in Vivo</i>FMT Imaging in Triple Negative Human Mammary Carcinoma Models
Biodistribution Analysis of NIR-Labeled Nanogels Using<i>in Vivo</i>FMT Imaging in Triple Negative Human Mammary Carcinoma Models Open
The purpose of this study is to evaluate the biodistribution properties of random-copolymer-based core-cross-linked nanogels of various sizes and surface poly(ethylene glycol) composition. Systematic variations of near-IR labeled nanogels,…
View article: Self-assembly of random co-polymers for selective binding and detection of peptides
Self-assembly of random co-polymers for selective binding and detection of peptides Open
Amphiphilic random co-polymers, which form stable reverse micelle-type assemblies, have been shown to selectively extract and detect peptides.
View article: Templated Self-Assembly of a Covalent Polymer Network for Intracellular Protein Delivery and Traceless Release
Templated Self-Assembly of a Covalent Polymer Network for Intracellular Protein Delivery and Traceless Release Open
Trafficking proteins inside cells is an emerging field with potential utility in basic cell biology and biological therapeutics. A robust and sustainable delivery strategy demands not only good protection of the cargo but also reversibilit…
View article: Programmable Nanoassemblies from Non‐Assembling Homopolymers Using Ad Hoc Electrostatic Interactions
Programmable Nanoassemblies from Non‐Assembling Homopolymers Using Ad Hoc Electrostatic Interactions Open
Robust nanostructures were obtained from polymers that otherwise do not assemble by using a novel approach based on electrostatic self‐assembly. The essence of this strategy involves the use of divalent counterions to temporarily perturb t…
View article: Field Guide to Challenges and Opportunities in Antibody–Drug Conjugates for Chemists
Field Guide to Challenges and Opportunities in Antibody–Drug Conjugates for Chemists Open
Antibody-drug conjugates have attracted a great amount of attention as a therapeutic strategy for diseases where targeting specific tissues and cells are critical components, such as in cancer therapy. Although promising, the number of app…
View article: A supramolecular dissociation strategy for protein sensing
A supramolecular dissociation strategy for protein sensing Open
We report a simple, robust, and general strategy for protein detection based on supramolecular dissociation.