Jianhai Chen
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View article: Integrative Mendelian randomization for detecting exposure-by-group interactions using group-specific and combined summary statistics
Integrative Mendelian randomization for detecting exposure-by-group interactions using group-specific and combined summary statistics Open
Interactions between risk factors and covariate-defined groups are commonly observed in complex diseases. Existing methods for detecting interactions typically require individual-level data. The data availability and the measurements of ri…
View article: The Role of Primate-Specific Genes and Network Dynamics in Cancer Evolution
The Role of Primate-Specific Genes and Network Dynamics in Cancer Evolution Open
The atavistic evolutionary theory of cancer evolution highlights the role of ancient and unicell-originated genes, and comprehensive research demonstrated the evolutionary inference. Comparably, very few reports linked young genes with can…
View article: Genomic insights into the demographic history and local adaptation of wild boars across Eurasia
Genomic insights into the demographic history and local adaptation of wild boars across Eurasia Open
Wild boars exhibit genetic and phenotypic diversity shaped by migrations and local adaptations. Their expansion across Eurasia, especially in Central Asia, remains underexplored. Here, we present newly sequenced whole-genome data of 47 wil…
View article: Positive selection on rare variants of IGF1R and BRD4 underlying the cold adaptation of wild boar
Positive selection on rare variants of IGF1R and BRD4 underlying the cold adaptation of wild boar Open
Background Domestic piglets often die of hypothermia, whereas Eurasian wild boar (Sus scrofa) thrives from tropical lowlands to subarctic forests. The thermoregulation of wild boar offers a natural experiment to uncover the genetic basis o…
View article: Towards blockchain interoperability: a comprehensive survey on cross-chain solutions
Towards blockchain interoperability: a comprehensive survey on cross-chain solutions Open
The rapid expansion of decentralized finance (DeFi) applications has catalyzed the emergence of new blockchain systems at an unprecedented pace. However, these systems are largely evolving in isolation, hindering the development of a cohes…
View article: Evolutionarily new genes in humans with disease phenotypes reveal functional enrichment patterns shaped by adaptive innovation and sexual selection
Evolutionarily new genes in humans with disease phenotypes reveal functional enrichment patterns shaped by adaptive innovation and sexual selection Open
New genes (or young genes) are genetic novelties pivotal in mammalian evolution. However, their phenotypic impacts and evolutionary patterns over time remain elusive in humans owing to the technical and ethical complexities of functional s…
View article: Genomic Insights into the Demographic History and Local Adaptation of Wild Boars Across Eurasia
Genomic Insights into the Demographic History and Local Adaptation of Wild Boars Across Eurasia Open
Wild boars exhibit genetic and phenotypic diversity shaped by migrations and local adaptations. Its expansion across Eurasia, especially in central Asia, remains underexplored. Here, we present newly sequenced whole-genome data of 47 wild …
View article: Integrative Mendelian Randomization for Detecting Exposure-by-group Interactions Using Group-Specific and Combined Summary Statistics
Integrative Mendelian Randomization for Detecting Exposure-by-group Interactions Using Group-Specific and Combined Summary Statistics Open
Interactions between risk factors and covariate-defined groups are commonly observed in complex diseases. Existing methods for detecting interactions typically require individual-level data. The data availability and the measurements of ri…
View article: The three-dimensional genome drives the evolution of asymmetric gene duplicates via enhancer capture-divergence
The three-dimensional genome drives the evolution of asymmetric gene duplicates via enhancer capture-divergence Open
Previous evolutionary models of duplicate gene evolution have overlooked the pivotal role of genome architecture. Here, we show that proximity-based regulatory recruitment by distally duplicated genes is an efficient mechanism for modulati…
View article: Museum specimens shedding light on the evolutionary history and cryptic diversity of the hedgehog family Erinaceidae
Museum specimens shedding light on the evolutionary history and cryptic diversity of the hedgehog family Erinaceidae Open
The family Erinaceidae encompasses 27 extant species in two subfamilies: Erinaceinae, which includes spiny hedgehogs, and Galericinae, which comprises silky‐furred gymnures and moonrats. Although they are commonly recognized by the general…
View article: Blockchain-based Federated Recommendation with Incentive Mechanism
Blockchain-based Federated Recommendation with Incentive Mechanism Open
Nowadays, federated recommendation technology is rapidly evolving to help multiple organisations share data and train models while meeting user privacy, data security and government regulatory requirements. However, federated recommendatio…
View article: Graphene-assisted improve electrochemical performance of manganese vanadium oxide for aqueous zinc-ion battery
Graphene-assisted improve electrochemical performance of manganese vanadium oxide for aqueous zinc-ion battery Open
Layer spacing of vanadium oxide can be effectively expanded by metal ion, however, its conductivity and electrochemical kinetics still require improvement. This work expands the layer spacing using manganese ion and help to improve conduct…
View article: Rapid evolution of fine-scale recombination during domestication: a perspective from population genomics
Rapid evolution of fine-scale recombination during domestication: a perspective from population genomics Open
Recombination serves as a pivotal force propelling the evolution of genomic diversity in sexually reproducing organisms. Despite its fundamental role, the evolutionary dynamics of recombination rates and their implications for genome evolu…
View article: Synthesis of chain‐end functionalized highly branched polyethylene waxes using sterically open α‐diimine Ni(<scp>II</scp>) catalysts
Synthesis of chain‐end functionalized highly branched polyethylene waxes using sterically open α‐diimine Ni(<span>II</span>) catalysts Open
Our previous research showed that bis(benzocyclopentyl) α‐diimine Pd(II) complexes can facilitate chain transfer and polar monomer insertion in ethylene (co)polymerization. In this study, we synthesized two bis(benzocyclopentyl) α‐diimine …
View article: The Rapid Evolution of De Novo Proteins in Structure and Complex
The Rapid Evolution of De Novo Proteins in Structure and Complex Open
Recent studies in the rice genome-wide have established that de novo genes, evolving from noncoding sequences, enhance protein diversity through a stepwise process. However, the pattern and rate of their evolution in protein structure over…
View article: Novel mutation leading to splice donor loss in a conserved site of <i>DMD</i> gene causes Duchenne muscular dystrophy with cryptorchidism
Novel mutation leading to splice donor loss in a conserved site of <i>DMD</i> gene causes Duchenne muscular dystrophy with cryptorchidism Open
Background As one of the most common congenital abnormalities in male births, cryptorchidism has been found to have a polygenic aetiology according to previous studies of common variants. However, little is known about genetic predispositi…
View article: Positive Selection on Rare Variants Underlying the Cold Adaptation of Wild Boar
Positive Selection on Rare Variants Underlying the Cold Adaptation of Wild Boar Open
The wide geographical distribution of Eurasian wild boar ( Sus scrofa ) offers a natural experiment to study the thermoregulation. Here, we conducted whole-genome resequencing and chromatin profiling experiments on the local populations fr…
View article: Novel mutation leading to splice donor loss in a conserved site of<i>DMD</i>causes cryptorchidism
Novel mutation leading to splice donor loss in a conserved site of<i>DMD</i>causes cryptorchidism Open
Background As one of the most common congenital abnormalities in male births, cryptorchidism has been found to have a polygenic etiology according to previous studies of common variants. However, little is known about genetic predispositio…
View article: One million years of solitude: the rapid evolution of de novo protein structure and complex
One million years of solitude: the rapid evolution of de novo protein structure and complex Open
Recent studies have established that de novo genes, evolving from non-coding sequences, enhance protein diversity through a stepwise process. However, the pattern and rate of their structural evolution over time remain unclear. Here, we ad…
View article: Relief of tumor hypoxia using a nanoenzyme amplifies NIR-II photoacoustic-guided photothermal therapy
Relief of tumor hypoxia using a nanoenzyme amplifies NIR-II photoacoustic-guided photothermal therapy Open
Hypoxia is a critical tumor microenvironment (TME) component. It significantly impacts tumor growth and metastasis and is known to be a major obstacle for cancer therapy. Integrating hypoxia modulation with imaging-based monitoring represe…
View article: Evolutionarily new genes in humans with disease phenotypes reveal functional enrichment patterns shaped by adaptive innovation and sexual selection.
Evolutionarily new genes in humans with disease phenotypes reveal functional enrichment patterns shaped by adaptive innovation and sexual selection. Open
New genes (or young genes) are structural novelties pivotal in mammalian evolution. Their phenotypic impact on humans, however, remains elusive due to the technical and ethical complexities in functional studies. Through combining gene age…
View article: Evolutionarily new genes in humans with disease phenotypes reveal functional enrichment patterns shaped by adaptive innovation and sexual selection.
Evolutionarily new genes in humans with disease phenotypes reveal functional enrichment patterns shaped by adaptive innovation and sexual selection. Open
New genes (or young genes) are genetic novelties pivotal in mammalian evolution. However, their phenotypic impacts and evolutionary patterns over time remain elusive in humans due to the technical and ethical complexities of functional stu…
View article: Human Gene Age Dating Reveals an Early and Rapid Evolutionary Construction of the Adaptive Immune System
Human Gene Age Dating Reveals an Early and Rapid Evolutionary Construction of the Adaptive Immune System Open
T cells are a type of white blood cell that play a critical role in the immune response against foreign pathogens through a process called T cell adaptive immunity (TCAI). However, the evolution of the genes and nucleotide sequences involv…
View article: Comparison of Interobserver Agreement of Four Classification Systems for Lateral Clavicle Fractures between Two Groups of Surgeons: A Multicenter Study
Comparison of Interobserver Agreement of Four Classification Systems for Lateral Clavicle Fractures between Two Groups of Surgeons: A Multicenter Study Open
Objective Distal clavicle fracture classification directly affects the treatment decisions. It is unclear whether the classification systems implemented differ depending on surgeons' backgrounds. This study aimed to compare the interobserv…
View article: The novel compound heterozygous rare variants may impact positively selected regions of TUBGCP6, a microcephaly associated gene
The novel compound heterozygous rare variants may impact positively selected regions of TUBGCP6, a microcephaly associated gene Open
Introduction The microcephaly is a rare and severe disease probably under purifying selection due to the reduction of human brain-size. In contrast, the brain-size enlargement is most probably driven by positive selection, in light of this…
View article: Proteomic Landscape of Human Spermatozoa: Optimized Extraction Method and Application
Proteomic Landscape of Human Spermatozoa: Optimized Extraction Method and Application Open
Human spermatozoa proteomics exposed to some physical, biological or chemical stressors is being explored. However, there is a lack of optimized sample preparation methods to achieve in-depth protein coverage for sperm cells. Meanwhile, it…
View article: Tuberosity reconstruction baseplate for shoulder hemiarthroplasty: Morphological design and biomaterial application
Tuberosity reconstruction baseplate for shoulder hemiarthroplasty: Morphological design and biomaterial application Open
Background: Shoulder hemiarthroplasty is prone to tuberosity malposition and migration, reducing the rate of tuberosity healing. We proposed to design a tuberosity reconstruction baseplate to assist in tuberosity integration and to evaluat…