Hong‐Jian Zhu
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Author Swipe
View article: Inadequacies and inaccuracies in grading non proliferative diabetic retinopathy without fluorescein fundus angiography in Chinese patients
Inadequacies and inaccuracies in grading non proliferative diabetic retinopathy without fluorescein fundus angiography in Chinese patients Open
The grading of NPDR in Chinese patients without FFA appears inadequate and inaccurate. Routine use of FFA is recommended for NPDR grading, screening, treatment guidance, and follow-up in China.
View article: Radiosensitization Effect of PARP Inhibitor Talazoparib Involves Decreasing Mitochondrial Membrane Potential and Induction of Cellular Senescence
Radiosensitization Effect of PARP Inhibitor Talazoparib Involves Decreasing Mitochondrial Membrane Potential and Induction of Cellular Senescence Open
Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPis) with radiation therapy can enhance the sensitivity of cancer cells by inhibiting DNA repair pathways. To determine the most suitable PARP inhibitor for radiosensitization in cancer ce…
View article: Tau drives cell specific functional isolation of the hippocampal formation
Tau drives cell specific functional isolation of the hippocampal formation Open
A major challenge in understanding Alzheimer’s disease is linking changes that occur across different biological scales. For example, how do changes in individual neurons build into widespread network disruptions? To address this, we used …
View article: Plasticity Analysis of Plate Anchor Keying Process Considering an Integrated Anchor-Chain System
Plasticity Analysis of Plate Anchor Keying Process Considering an Integrated Anchor-Chain System Open
As offshore wind energy expands into deeper waters, the demand for efficient and reliable anchoring systems for floating structures continues to grow. Plate anchors are widely used due to their high holding capacity and cost-effective inst…
View article: A brain-to-lung signal from GABAergic neurons to ADRB2+ interstitial macrophages promotes pulmonary inflammatory responses
A brain-to-lung signal from GABAergic neurons to ADRB2+ interstitial macrophages promotes pulmonary inflammatory responses Open
Severe pneumonia is predominantly caused by cytokine storms in the lung, but whether this process is controlled by the brain-lung axis remains unclear. Here, we found that GABAergic neurons in the central amygdala (CeA) were highly activat…
View article: The Survival Benefits of Chemotherapy for Undifferentiated Carcinoma With Osteoclast‐Like Giant Cells of Pancreas: A Retrospective Analysis and Individual Participant Data Meta‐Analysis
The Survival Benefits of Chemotherapy for Undifferentiated Carcinoma With Osteoclast‐Like Giant Cells of Pancreas: A Retrospective Analysis and Individual Participant Data Meta‐Analysis Open
Background and Aim Undifferentiated carcinoma with osteoclast‐like giant cells of pancreas (UCOGCP) is a rare type of pancreatic adenocarcinoma (PDAC). However, the efficacy of chemotherapy in UCOGCP has not been evaluated so far due to th…
View article: Extracellular Vesicles Secreted by Cancer‐Associated Fibroblasts Drive Non‐Invasive Cancer Cell Progression to Metastasis via TGF‐β Signalling Hyperactivation
Extracellular Vesicles Secreted by Cancer‐Associated Fibroblasts Drive Non‐Invasive Cancer Cell Progression to Metastasis via TGF‐β Signalling Hyperactivation Open
Metastasis is the leading cause of cancer‐related deaths. Cancer‐associated fibroblasts (CAFs) are abundant components within the tumour microenvironment, playing critical roles in metastasis. Although increasing evidence supports a role f…
View article: Reduced T and NK Cell Activity in Glioblastoma Patients Correlates with TIM-3 and BAT3 Dysregulation
Reduced T and NK Cell Activity in Glioblastoma Patients Correlates with TIM-3 and BAT3 Dysregulation Open
Inhibitory receptors are critical for regulating immune cell function. In cancer, these receptors are often over-expressed on the cell surface of T and NK cells, leading to reduced anti-tumor activity. Here, through the analysis of 11 comm…
View article: S100A8 knockdown activates the PI3K/AKT signaling pathway to inhibit microglial autophagy and improve cognitive impairment mediated by chronic sleep deprivation
S100A8 knockdown activates the PI3K/AKT signaling pathway to inhibit microglial autophagy and improve cognitive impairment mediated by chronic sleep deprivation Open
The S100A8/PI3K/AKT axis plays a crucial role in chronic sleep deprivation-mediated autophagy and apoptosis in microglia.
View article: Is chemotherapy beneficial? A retrospective study of chemotherapy in patients with invasive intraductal papillary-mucinous carcinoma
Is chemotherapy beneficial? A retrospective study of chemotherapy in patients with invasive intraductal papillary-mucinous carcinoma Open
Chemotherapy is an independent protective factor IPMC, especially reducing the risk of short-term death for IPMC patients with lymph node metastasis.
View article: A Novel Method for the Early Detection of Single Circulating, Metastatic and Self-Seeding Cancer Cells in Orthotopic Breast Cancer Mouse Models
A Novel Method for the Early Detection of Single Circulating, Metastatic and Self-Seeding Cancer Cells in Orthotopic Breast Cancer Mouse Models Open
Background: Metastasis is the main cause of cancer-related deaths, but efficient targeted therapies against metastasis are still missing. Major gaps exist in our understanding of the metastatic cascade, as existing methods cannot combine s…
View article: Signaling pathways underlying TGF-β mediated suppression of IL-12A gene expression in monocytes
Signaling pathways underlying TGF-β mediated suppression of IL-12A gene expression in monocytes Open
Transforming growth factor-β (TGF-β) is a pleiotropic cytokine essential for multiple biological processes, including the regulation of inflammatory and immune responses. One of the important functions of TGF-β is the suppression of the pr…
View article: A New Systemic Disease Mouse Model for Glioblastoma Capable of Single-Tumour-Cell Detection
A New Systemic Disease Mouse Model for Glioblastoma Capable of Single-Tumour-Cell Detection Open
Background: Glioblastoma is characterised by extensive infiltration into the brain parenchyma, leading to inevitable tumor recurrence and therapeutic failure. Future treatments will need to target the specific biology of tumour recurrence,…
View article: The Prognostic Value of Preoperative Inflammatory Markers for Pathological Grading of Glioma Patients
The Prognostic Value of Preoperative Inflammatory Markers for Pathological Grading of Glioma Patients Open
Introduction: The independent diagnostic value of inflammatory markers neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) and the diagnostic efficacy of NLR, derived neutrophil to lymphocyte ratio (dNLR), PLR, and …
View article: ISSUES WITH YOUTH LABOUR MARKET: UNEMPLOYMENT AND PRECARIOUS EMPLOYMENT
ISSUES WITH YOUTH LABOUR MARKET: UNEMPLOYMENT AND PRECARIOUS EMPLOYMENT Open
The youth unemployment has become a more and more serious problem over the past few years. The pandemic also raises the number of part-time workers to a huge number. As research shows that the increase in education does not necessarily res…
View article: A New Era of Integration between Multiomics and Spatio-Temporal Analysis for the Translation of EMT towards Clinical Applications in Cancer
A New Era of Integration between Multiomics and Spatio-Temporal Analysis for the Translation of EMT towards Clinical Applications in Cancer Open
Epithelial-mesenchymal transition (EMT) is crucial to metastasis by increasing cancer cell migration and invasion. At the cellular level, EMT-related morphological and functional changes are well established. At the molecular level, critic…
View article: Metanephric stromal tumor in an adult with PDGFRA mutation: a case report
Metanephric stromal tumor in an adult with PDGFRA mutation: a case report Open
Background Metanephric stromal tumors (MST) are rare benign renal tumors that mainly occur in infants and children. Approximately 72% of MST in children have the B-Raf proto-oncogene serine/threonine kinase (BRAF) V600E mutation. To date, …
View article: N-Terminomic Changes in Neurons During Excitotoxicity Reveal Proteolytic Events Associated With Synaptic Dysfunctions and Potential Targets for Neuroprotection
N-Terminomic Changes in Neurons During Excitotoxicity Reveal Proteolytic Events Associated With Synaptic Dysfunctions and Potential Targets for Neuroprotection Open
Excitotoxicity, a neuronal death process in neurological disorders such as stroke, is initiated by the overstimulation of ionotropic glutamate receptors. Although dysregulation of proteolytic signaling networks is critical for excitotoxici…
View article: Supplementary Figure S2 from Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis
Supplementary Figure S2 from Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis Open
Supplementary Figure S2. Related to Figure 3. A, The UCHL1 activities of MDA-MB-231 cell lines stably transfected with control vector and UCHL1 expression vector were validated by TAMRA ABP assay. Coomassie staining of proteins in SDS-PAGE…
View article: Supplementary Figure S2 from Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis
Supplementary Figure S2 from Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis Open
Supplementary Figure S2. Related to Figure 3. A, The UCHL1 activities of MDA-MB-231 cell lines stably transfected with control vector and UCHL1 expression vector were validated by TAMRA ABP assay. Coomassie staining of proteins in SDS-PAGE…
View article: Supplementary tables from Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis
Supplementary tables from Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis Open
Supplementary Table S1-S6.
View article: Supplementary Figure S3 from Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis
Supplementary Figure S3 from Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis Open
Supplementary Figure S3. Related to Figure 4. A, qPCR analysis of mesenchymal markers in UCHL1 shRNA knock down MDA-MB-436 cells versus NT and PLKO control infected cells. *, P < 0.05, two-way ANOVA. B, Western blot analysis of AKT and HIF…
View article: Supplementary Figure S1 from Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis
Supplementary Figure S1 from Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis Open
Supplementary Figure S1. Related to Figure 1. A, LC-MS/MS analysis of in-gel tryptic digestion of excised gel slice indicated in figure 1D. iBAQ values (log2), sequence coverage, spectral count and number of peptides identified, of protein…
View article: Supplementary information from Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis
Supplementary information from Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis Open
Supplementary methods, supplementary table legends, supplementary references.
View article: Supplementary Figure S3 from Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis
Supplementary Figure S3 from Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis Open
Supplementary Figure S3. Related to Figure 4. A, qPCR analysis of mesenchymal markers in UCHL1 shRNA knock down MDA-MB-436 cells versus NT and PLKO control infected cells. *, P < 0.05, two-way ANOVA. B, Western blot analysis of AKT and HIF…
View article: Supplementary Figure S6 from Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis
Supplementary Figure S6 from Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis Open
Supplementary Figure S6. Related to Figure 5 and 6. A, Mass spectrometry analysis reveals covalent binding of 6RK73 to UCHL1. B, Western blot of SMAD3 and pSMAD3 in MDA-MB-436 cells treated with or without 6RK73 and shUCHL1 cells. Same blo…
View article: Supplementary Figure S1 from Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis
Supplementary Figure S1 from Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis Open
Supplementary Figure S1. Related to Figure 1. A, LC-MS/MS analysis of in-gel tryptic digestion of excised gel slice indicated in figure 1D. iBAQ values (log2), sequence coverage, spectral count and number of peptides identified, of protein…
View article: Supplementary Figure S6 from Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis
Supplementary Figure S6 from Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis Open
Supplementary Figure S6. Related to Figure 5 and 6. A, Mass spectrometry analysis reveals covalent binding of 6RK73 to UCHL1. B, Western blot of SMAD3 and pSMAD3 in MDA-MB-436 cells treated with or without 6RK73 and shUCHL1 cells. Same blo…