Jun Yu
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View article: Spatial and functional dissection of cancer-associated fibroblasts-mediated immune modulation in H. pylori-associated gastric cancer
Spatial and functional dissection of cancer-associated fibroblasts-mediated immune modulation in H. pylori-associated gastric cancer Open
Background Cancer-associated fibroblasts (CAFs) are key regulators of the tumor microenvironment, yet their spatial organization and immunomodulatory functions in H. pylori -associated gastric cancer (GC) remain incompletely understood. Me…
View article: Antibody–drug conjugates in cancer therapy: current landscape, challenges, and future directions
Antibody–drug conjugates in cancer therapy: current landscape, challenges, and future directions Open
Antibody-drug conjugates (ADCs) have emerged as a transformative modality in oncology by combining the target specificity of antibodies with the high potency of diverse cytotoxic payloads. This review provides an integrative overview of AD…
View article: High‐throughput generic single‐entity sequencing using droplet microfluidics
High‐throughput generic single‐entity sequencing using droplet microfluidics Open
Single‐cell sequencing has revolutionized our understanding of cellular heterogeneity by providing a micro‐level perspective in the past decade. While heterogeneity is fundamental to diverse biological communities, existing platforms are p…
View article: Energy Management and Power Distribution in Hybrid Vehicles
Energy Management and Power Distribution in Hybrid Vehicles Open
As new energy technologies continue to evolve, hybrid electric vehicles (HEV) have emerged as a key transitional choice from gasoline-powered vehicles to new energy vehicles, owing to their extended driving range and environmental benefits…
View article: The Gut Commensal Bacteria Veillonella parvula-Induced Neutrophil Activation Mediates Antitumor Activity
The Gut Commensal Bacteria Veillonella parvula-Induced Neutrophil Activation Mediates Antitumor Activity Open
Recent scientific efforts have focused on identifying commensal microbiota with antitumor activity, yet most cancer studies remain limited to taxonomic associations or treatment-induced microbial changes, with only a few addressing underly…
View article: RNA m<sup>1</sup>A methyltransferase TRMT61A promotes colorectal tumorigenesis by enhancing <i>ONECUT2</i> mRNA stability and is a potential therapeutic target
RNA m<sup>1</sup>A methyltransferase TRMT61A promotes colorectal tumorigenesis by enhancing <i>ONECUT2</i> mRNA stability and is a potential therapeutic target Open
Background The role of N1‐methyladenosine (m 1 A) in cancer is poorly understood. Here we explored the function of RNA methyltransferase TRNA methyltransferase 61A (TRMT61A) in colorectal cancer (CRC) and its potential as a therapeutic tar…
View article: Shaping the future of probiotics, live biotherapeutic products, and fecal microbiota transplantation: 30 scientific recommendations from the CHINAGUT Conference
Shaping the future of probiotics, live biotherapeutic products, and fecal microbiota transplantation: 30 scientific recommendations from the CHINAGUT Conference Open
The 2025 CHINAGUT Conference has assembled a panel of 63 experts (30 scientists, 26 physicians, and 7 corporate R&D personnel) collaborated in three groups to present 30 scientific recommendations to advance probiotics, live biotherapeutic…
View article: Supplementary Table 5 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations
Supplementary Table 5 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations Open
Fisher's exact test results comparing segmental duplication (SD) association frequencies between tumor suppressor genes (TSGs) and non-cancer genes, stratified by two evolutionary age groups.
View article: Supplementary Table 2 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations
Supplementary Table 2 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations Open
Properties of annotated human protein-coding genes (non-cancer genes, oncogenes, and TSGs).
View article: Supplementary Figure 13 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations
Supplementary Figure 13 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations Open
Higher somatic non-CNA SV frequency (translocations/inversions) in TSGs with SDs versus TSGs without SDs across cancers.
View article: Supplementary Figure 18 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations
Supplementary Figure 18 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations Open
Positive correlation between gene size and missense mutation frequency in oncogenes with SDs across 33 TCGA cancers.
View article: Supplementary Figure 15 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations
Supplementary Figure 15 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations Open
Somatic non-CNA SV frequency comparison for oncogenes with/without SDs.
View article: Supplementary Figure 19 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations
Supplementary Figure 19 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations Open
Chinese cohort meta-analysis of somatic alterations in TSGs with SDs before/after size-matching.
View article: Supplementary Table 7 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations
Supplementary Table 7 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations Open
Results of GISTIC scores for TSGs with SDs in all TCGA cancer types.
View article: Supplementary Table 9 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations
Supplementary Table 9 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations Open
Size-adjusted comparison of deletion, structural variation, and mutation frequencies in TSGs with SDs versus TSGs without SDs using multivariate linear regression.
View article: Supplementary Table 1 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations
Supplementary Table 1 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations Open
A table showing fusion annotation of human TSGs from chimerkb database.
View article: Supplementary Figure 3 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations
Supplementary Figure 3 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations Open
Boxplot showing the distance distribution of non-cancer genes, oncogenes, and TSGs to their nearest SDs, with individual genes represented as dots and significant differences marked (p < 0.05).
View article: Supplementary Figure 5 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations
Supplementary Figure 5 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations Open
Spearman's correlation between evolutionary distance from humans and concordance scores of SD-associated TSGs across 32 non-human species.
View article: Supplementary Table 3 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations
Supplementary Table 3 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations Open
Results of Fisher's exact tests comparing the number of SDs association with oncogenes and tumor suppressor genes (TSGs) against non-cancer genes across multiple species.
View article: Supplementary Figure 6 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations
Supplementary Figure 6 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations Open
Kendall rank correlation of retrotransposon-associated gene proportions across 26 gene age classes, comparing non-cancer genes (green) and TSGs (purple), with Fisher’s z-test for coefficient differences.
View article: Supplementary Figure 21 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations
Supplementary Figure 21 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations Open
No significant difference in ionizing radiation-induced SV between with SDs and without SDs genes across normal human cell colonies.
View article: Supplementary Table 6 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations
Supplementary Table 6 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations Open
Results from multivariate linear regression of GISTIC scores of TSGs with SDs versus TSGs without SDs.
View article: Supplementary Figure 10 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations
Supplementary Figure 10 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations Open
Deletion frequency (log2 copy-number) comparison for with SDs versus without SDs TSGs across TCGA dataset (Illumina HiSeq).
View article: Supplementary Figure 14 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations
Supplementary Figure 14 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations Open
Positive correlation between SD repeat number and somatic non-CNA SV frequency in TSGs with SDs across 37 TCGA cancers.
View article: Supplementary Figure 11 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations
Supplementary Figure 11 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations Open
Positive correlation between SD repeat number and homozygous deletion frequency in SD-containing TSGs across 33 TCGA cancers.
View article: Supplementary Figure 20 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations
Supplementary Figure 20 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations Open
Long-read sequencing meta-analysis of somatic alterations in TSGs with SDs before/after size-matching.
View article: Supplementary Figure 4 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations
Supplementary Figure 4 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations Open
Odds ratios comparing SD association between oncogenes (including orthologs in 32 species) and non-cancer genes.
View article: Supplementary Table 4 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations
Supplementary Table 4 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations Open
Proportions of TSGs with SDs and non-cancer gene with SDs across 26 age class.
View article: Supplementary Figure 2 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations
Supplementary Figure 2 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations Open
Visualization of genes with SDs in three species, along with inter/intrachromosomal SD pairs.
View article: Supplementary Table 8 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations
Supplementary Table 8 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations Open
Results from multivariate linear regression of somatic non-CNA SV mutation frequency of TSGs with SDs versus TSGs without SDs.