Jian V. Zhang
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View article: Intestinal bacteria translocation promotes β-cell dysfunction in DIO mice
Intestinal bacteria translocation promotes β-cell dysfunction in DIO mice Open
View article: Identification of a Novel Gene ARNT2 for Osteogenic Differentiation of Mesenchymal Stem Cells
Identification of a Novel Gene ARNT2 for Osteogenic Differentiation of Mesenchymal Stem Cells Open
View article: Chemerin sustains the growth of spongiotrophoblast and sinusoidal trophoblast giant cells through fatty acid oxidation
Chemerin sustains the growth of spongiotrophoblast and sinusoidal trophoblast giant cells through fatty acid oxidation Open
View article: Subcutaneous injection of genetically engineered exosomes for androgenic alopecia treatment
Subcutaneous injection of genetically engineered exosomes for androgenic alopecia treatment Open
Androgenetic alopecia (AGA) is a common disorder that negatively impacts quality of life but remains challenging to treat effectively. The hair loss observed in AGA is the consequence of a gradual reduction in the duration of the anagen ph…
View article: TNFRSF11B-modified umbilical cord mesenchymal stem cells as a novel strategy for bone-related diseases by suppressing osteoclast activity
TNFRSF11B-modified umbilical cord mesenchymal stem cells as a novel strategy for bone-related diseases by suppressing osteoclast activity Open
View article: 3D-printed scaffolds with controlled-releasing compounds for ectopic activation of dormant ovarian follicles
3D-printed scaffolds with controlled-releasing compounds for ectopic activation of dormant ovarian follicles Open
Throughout a woman’s reproductive life, hundreds of functioning follicles are activated for development, while thousands of dormant follicles remain in the ovaries. Dormant follicle activation in vitro is an effective clinical strate…
View article: Novel Function of Osteocalcin in Chondrocyte Differentiation and Endochondral Ossification Revealed on a CRISPR/Cas9 bglap–bglap2 Deficiency Mouse Model
Novel Function of Osteocalcin in Chondrocyte Differentiation and Endochondral Ossification Revealed on a CRISPR/Cas9 bglap–bglap2 Deficiency Mouse Model Open
Endochondral ossification is the process by which cartilage is mineralized into bone, and is essential for the development of long bones. Osteocalcin (OCN), a protein abundant in bone matrix, also exhibits high expression in chondrocytes, …
View article: FBXO47 regulates centromere pairing as key component of centromeric SCF E3 ligase in mouse spermatocytes
FBXO47 regulates centromere pairing as key component of centromeric SCF E3 ligase in mouse spermatocytes Open
Centromere pairing is crucial for synapsis in meiosis. This study delves into the Skp1-Cullin1-F-box protein (SCF) E3 ubiquitin ligase complex, specifically focusing on F-box protein 47 (FBXO47), in mouse meiosis. Here, we revealed that FB…
View article: ST6GALNAC1-mediated sialylation in uterine endometrial epithelium facilitates the epithelium-embryo attachment
ST6GALNAC1-mediated sialylation in uterine endometrial epithelium facilitates the epithelium-embryo attachment Open
View article: P300 regulates histone crotonylation and preimplantation embryo development
P300 regulates histone crotonylation and preimplantation embryo development Open
Histone lysine crotonylation, an evolutionarily conserved modification differing from acetylation, exerts pivotal control over diverse biological processes. Among these are gene transcriptional regulation, spermatogenesis, and cell cycle p…
View article: mTOR hypoactivity leads to trophectoderm cell failure by enhancing lysosomal activation and disrupting the cytoskeleton in preimplantation embryo
mTOR hypoactivity leads to trophectoderm cell failure by enhancing lysosomal activation and disrupting the cytoskeleton in preimplantation embryo Open
Background Metabolic homeostasis is closely related to early impairment of cell fate determination and embryo development. The protein kinase mechanistic target of rapamycin (mTOR) is a key regulator of cellular metabolism in the body. Inh…
View article: ClpP/ClpX deficiency impairs mitochondrial functions and mTORC1 signaling during spermatogenesis
ClpP/ClpX deficiency impairs mitochondrial functions and mTORC1 signaling during spermatogenesis Open
View article: P300 Regulates Histone Crotonylation and Preimplantation Embryo Development
P300 Regulates Histone Crotonylation and Preimplantation Embryo Development Open
Histone lysine crotonylation, an evolutionarily conserved modification differing from acetylation, exerts pivotal control over diverse biological processes. Among these are gene transcriptional regulation, spermatogenesis, and cell cycle p…
View article: Single-cell communication patterns and their intracellular information flow in synovial fibroblastic osteoarthritis and rheumatoid arthritis
Single-cell communication patterns and their intracellular information flow in synovial fibroblastic osteoarthritis and rheumatoid arthritis Open
Synovial fibroblasts are critical for maintaining homeostasis in major autoimmune diseases involving joint inflammation, including osteoarthritis and rheumatoid arthritis. However, little is known about the interactions among different cel…
View article: Probing the communication patterns of different chondrocyte subtypes in osteoarthritis at the single cell level using pattern recognition and manifold learning
Probing the communication patterns of different chondrocyte subtypes in osteoarthritis at the single cell level using pattern recognition and manifold learning Open
The patterns of communication among different chondrocyte subtypes in human cartilage degeneration and regeneration help us understand the microenvironment of osteoarthritis and optimize cell-targeted therapies. Here, a single-cell transcr…
View article: Publisher Correction: Small intestinal microbiota composition altered in obesity-T2DM mice with high salt fed
Publisher Correction: Small intestinal microbiota composition altered in obesity-T2DM mice with high salt fed Open
View article: Small intestinal microbiota composition altered in obesity-T2DM mice with high salt fed
Small intestinal microbiota composition altered in obesity-T2DM mice with high salt fed Open
View article: Adipokine chemerin overexpression in trophoblasts leads to dyslipidemia in pregnant mice: implications for preeclampsia
Adipokine chemerin overexpression in trophoblasts leads to dyslipidemia in pregnant mice: implications for preeclampsia Open
Background The adipokine chemerin regulates adipogenesis and the metabolic function of both adipocytes and liver. Chemerin is elevated in preeclamptic women, and overexpression of chemerin in placental trophoblasts induces preeclampsia-lik…
View article: ST6GALNAC1-Mediated Sialylation in Uterine Endometrial Epithelium Facilitates the Epithelium-Embryo Attachment
ST6GALNAC1-Mediated Sialylation in Uterine Endometrial Epithelium Facilitates the Epithelium-Embryo Attachment Open
View article: ClpP/ClpX deficiency impairs mitochondrial functions and mTORC1 signaling during spermatogenesis and meiosis
ClpP/ClpX deficiency impairs mitochondrial functions and mTORC1 signaling during spermatogenesis and meiosis Open
Caseinolytic protease proteolytic subunit (ClpP) and caseinolytic protease X (ClpX) are mitochondrial matrix peptidases that activate mitochondrial unfolded protein response to maintain protein homeostasis in the mitochondria. However, the…
View article: Targeting the chemerin/CMKLR1 axis by small molecule antagonist α-NETA mitigates endometriosis progression
Targeting the chemerin/CMKLR1 axis by small molecule antagonist α-NETA mitigates endometriosis progression Open
Endometriosis is a common gynecological disease, characterized by the presence of endometrial-like lesions outside the uterus. This debilitating disease causes chronic pelvic pain and infertility with limited therapeutics. Chemerin is a se…
View article: Orphan receptor <scp>GPR50</scp> attenuates inflammation and insulin signaling in <scp>3T3‐L1</scp> preadipocytes
Orphan receptor <span>GPR50</span> attenuates inflammation and insulin signaling in <span>3T3‐L1</span> preadipocytes Open
Type 2 diabetes (T2DM) is characterized by insulin secretion deficiencies and systemic insulin resistance (IR) in adipose tissue, skeletal muscle, and the liver. Although the mechanism of T2DM is not yet fully known, inflammation and insul…
View article: Chondroitin Sulfate Targeting Nanodrug Achieves Near-Infrared Fluorescence-Guided Chemotherapy Against Triple-Negative Breast Primary and Lung Metastatic Cancer
Chondroitin Sulfate Targeting Nanodrug Achieves Near-Infrared Fluorescence-Guided Chemotherapy Against Triple-Negative Breast Primary and Lung Metastatic Cancer Open
In conclusion, we provide solid evidence for chondroitin sulfate targeting peptide plCSA guided nanodrug, exhibit good targeting efficiency and therapeutic effect against TNBC primary and lung metastatic tumor growth.
View article: Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental development and preeclampsia
Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental development and preeclampsia Open
Preeclampsia, a clinical syndrome mainly characterized by hypertension and proteinuria, with a worldwide incidence of 3–8% and high maternal mortality, is a risk factor highly associated with maternal and offspring cardiovascular disease. …
View article: Extended endocrine therapy in breast cancer: A basket of length-constraint feature selection metaheuristics to balance Type I against Type II errors
Extended endocrine therapy in breast cancer: A basket of length-constraint feature selection metaheuristics to balance Type I against Type II errors Open
Extended endocrine therapy beyond 5 years is of major concern to ER + breast cancer survivors. However, it might be unsuitable to apply routinely used genomic tests designed for early recurrence risks to distant recurrence within 10 years …
View article: The Regulatory Roles of Chemerin-Chemokine-Like Receptor 1 Axis in Placental Development and Vascular Remodeling During Early Pregnancy
The Regulatory Roles of Chemerin-Chemokine-Like Receptor 1 Axis in Placental Development and Vascular Remodeling During Early Pregnancy Open
Chemerin is an adipokine that regulates metabolism in pregnancy. An elevation of serum chemerin level is associated with pregnancy complications. Consistently, we demonstrated that the chemerin expression was increased in placenta of preec…
View article: MFN2 Deficiency Impairs Mitochondrial Functions and PPAR Pathway During Spermatogenesis and Meiosis in Mice
MFN2 Deficiency Impairs Mitochondrial Functions and PPAR Pathway During Spermatogenesis and Meiosis in Mice Open
Mitochondria are highly dynamic organelles and their activity is known to be regulated by changes in morphology via fusion and fission events. However, the role of mitochondrial dynamics on cellular differentiation remains largely unknown.…
View article: Influences of gestational diabetes mellitus on the oral microbiota in offspring from birth to 1 month old
Influences of gestational diabetes mellitus on the oral microbiota in offspring from birth to 1 month old Open
Background Maternal gestational diabetes mellitus (GDM) had long-term influences on the health of their children. However, the influences of GDM on the oral microbiota, which was closely related to oral and systemic health in offspring, we…
View article: Simulated Microgravity Potentiates Hematopoietic Differentiation of Human Pluripotent Stem Cells and Supports Formation of 3D Hematopoietic Cluster
Simulated Microgravity Potentiates Hematopoietic Differentiation of Human Pluripotent Stem Cells and Supports Formation of 3D Hematopoietic Cluster Open
Microgravity has been shown to induces many changes in proliferation, differentiation and growth behavior of stem cells. Little is known about the effect of microgravity on hematopoietic differentiation of pluripotent stem cells (PSCs). In…
View article: Inhibition of Chemerin/CMKLR1 Axis Mitigates the Endometriosis Progression
Inhibition of Chemerin/CMKLR1 Axis Mitigates the Endometriosis Progression Open