Jian Xiao
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View article: Infrared thermography for assessing skin temperature characteristics of postoperative blanching erythema and stage 1 pressure injuries
Infrared thermography for assessing skin temperature characteristics of postoperative blanching erythema and stage 1 pressure injuries Open
Postoperative blanching erythema and Stage 1 pressure injuries exhibit either warmer or cooler skin temperatures compared to adjacent normal skin. Compared to blanching erythema, Stage 1 pressure injuries are more likely to present with hy…
View article: Recent Advances in Membrane-Coated Micro/Nanomotors in Biological Applications
Recent Advances in Membrane-Coated Micro/Nanomotors in Biological Applications Open
The integration of synthetic micro/nanomotors (MNMs) with natural biomaterials derived from cell membranes has emerged as a highly promising strategy for advancing biological applications. The membrane-coated MNM offers distinct advantages…
View article: Living Environment and Intrinsic Capacity among Chinese Older Adults: A cross-sectional study
Living Environment and Intrinsic Capacity among Chinese Older Adults: A cross-sectional study Open
Background With the global aging population, intrinsic capacity has become a significant topic of interest. However, research on the relationship between intrinsic capacity and the living environment is limited. Methods This cross-sectiona…
View article: Optimizing Poultry Growth and Meat Quality: Effects of Guanidinoacetic Acid Supplementation in Yellow-Feathered Broilers
Optimizing Poultry Growth and Meat Quality: Effects of Guanidinoacetic Acid Supplementation in Yellow-Feathered Broilers Open
This study investigated the effects of dietary guanidinoacetic acid (GAA) supplementation on growth performance, carcass traits, meat quality, intestinal morphology, and cecal microbiota composition in yellow-feathered broilers. A total of…
View article: A dynamically phase-adaptive regulating hydrogel promotes ultrafast anti-fibrotic wound healing
A dynamically phase-adaptive regulating hydrogel promotes ultrafast anti-fibrotic wound healing Open
View article: Natural, safety immunomodulatory derivatives of lactobacillus biofilms promote diabetic wound healing by metabolically regulating macrophage phenotype and alleviating local inflammation
Natural, safety immunomodulatory derivatives of lactobacillus biofilms promote diabetic wound healing by metabolically regulating macrophage phenotype and alleviating local inflammation Open
The LBDs retains most bioactive components of the LB. As a natural, safe and immunomodulatory agent, LBDs promote diabetic wound healing by metabolically reprogramming macrophage phenotypes and improving the local immune microenvironment, …
View article: 3,4‐Dimethoxychalcone alleviates limb ischemia/reperfusion injury by <scp>TFEB</scp> ‐mediated autophagy enhancement and antioxidative response
3,4‐Dimethoxychalcone alleviates limb ischemia/reperfusion injury by <span>TFEB</span> ‐mediated autophagy enhancement and antioxidative response Open
Caloric restriction mimetics (CRMs) replicate the positive effects of caloric restriction (CR) and have demonstrated therapeutic benefits in neuroinflammatory and cardiovascular diseases. However, it remains uncertain whether CRMs enhance …
View article: Macelignan Improves Functional Recovery After Spinal Cord Injury by Augmenting Autophagy via the <scp>AKT</scp>‐<scp>mTOR</scp>‐<scp>TFEB</scp> Signaling Pathway
Macelignan Improves Functional Recovery After Spinal Cord Injury by Augmenting Autophagy via the <span>AKT</span>‐<span>mTOR</span>‐<span>TFEB</span> Signaling Pathway Open
Spinal cord injury (SCI) presents considerable therapeutic challenges due to its complex pathophysiology, and effective treatments are currently lacking. Macelignan (Mace) has shown therapeutic effects in some neurological disorders, but i…
View article: Pectin-Zein-IPA nanoparticles promote functional recovery and alleviate neuroinflammation after spinal cord injury
Pectin-Zein-IPA nanoparticles promote functional recovery and alleviate neuroinflammation after spinal cord injury Open
Our findings provide a strategy for oral drug research in SCI. The results suggest that Pectin-Zein-IPA NPs have potential advantages for treatment and management of SCI. Reducing L-methionine intake may help reduce neuroinflammation after…
View article: A Comprehensive Review of the Phytochemistry, Pharmacology and Other Applications of Euphorbiae Humifusae Herba
A Comprehensive Review of the Phytochemistry, Pharmacology and Other Applications of Euphorbiae Humifusae Herba Open
Euphorbiae Humifusae Herba (EHH) is a globally distributed plant commonly utilized in traditional Chinese medicine (TCM) and health food within China. The dried aerial parts of EHH are well-recognized as health foods for the management of …
View article: Caveolae-Mediated Sensing of Nanoporous Cues in Fibroblasts Reprogramming During Wound Healing
Caveolae-Mediated Sensing of Nanoporous Cues in Fibroblasts Reprogramming During Wound Healing Open
Scaffolds with pores can influence cellular fate and tissue microenvironments by altering intracellular and intercellular signaling pathways, which are crucial for guiding tissue regeneration. Despite their significance, the cellular mecha…
View article: Multi-targeted nanogel drug delivery system alleviates neuroinflammation and promotes spinal cord injury repair
Multi-targeted nanogel drug delivery system alleviates neuroinflammation and promotes spinal cord injury repair Open
View article: A cryo-shocked M2 macrophages based treatment strategy promoting repair of spinal cord injury via immunomodulation and axonal regeneration effects
A cryo-shocked M2 macrophages based treatment strategy promoting repair of spinal cord injury via immunomodulation and axonal regeneration effects Open
View article: Mesoporous Prussian blue nanoparticle neuroconduit for the biological therapy targeting oxidative stress reduction, inflammation inhibition, and nerve regeneration
Mesoporous Prussian blue nanoparticle neuroconduit for the biological therapy targeting oxidative stress reduction, inflammation inhibition, and nerve regeneration Open
View article: Piezo1-Mediated Ferroptosis Delays Wound Healing in Aging Mice by Regulating the Transcriptional Activity of SLC7A11 through Activating Transcription Factor 3
Piezo1-Mediated Ferroptosis Delays Wound Healing in Aging Mice by Regulating the Transcriptional Activity of SLC7A11 through Activating Transcription Factor 3 Open
Ferroptosis plays a role in wound healing during the maturation of senescent endothelial cells. This study explores the modulation of ferroptosis in senescent human umbilical vein endothelial cells (HUVECs) and wound-healing processes by P…
View article: Photothermal-enhanced silver nanocluster bioactive glass hydrogels for synergistic antimicrobial and promote wound healing
Photothermal-enhanced silver nanocluster bioactive glass hydrogels for synergistic antimicrobial and promote wound healing Open
View article: IUPHAR review: Targeted therapies of signaling pathways based on the gut microbiome in autism spectrum disorders: Mechanistic and therapeutic applications
IUPHAR review: Targeted therapies of signaling pathways based on the gut microbiome in autism spectrum disorders: Mechanistic and therapeutic applications Open
Autism spectrum disorders (ASD) are complex neurodevelopmental disorders characterized by impairments in social interaction, communication and repetitive activities. Gut microbiota significantly influences behavior and neurodevelopment by …
View article: Cell-autonomous action of Slit2 in radial migration of cortical projection neurons
Cell-autonomous action of Slit2 in radial migration of cortical projection neurons Open
Neuronal radial migration is a fundamental process for cortical development, the disruption of which causes neurological and psychiatric dysfunctions. SLIT2 plays diverse functions in brain development and is a well-known axon guidance mol…
View article: Targeting Remyelination in Spinal Cord Injury: Insights and Emerging Therapeutic Strategies
Targeting Remyelination in Spinal Cord Injury: Insights and Emerging Therapeutic Strategies Open
Introduction Spinal cord injury (SCI) is a severe neurological disease characterized by significant motor, sensory, and autonomic dysfunctions. SCI is a major global disability cause, often resulting in long‐term neurological impairments d…
View article: Recent advances in the role of neuroregulation in skin wound healing
Recent advances in the role of neuroregulation in skin wound healing Open
Neuroregulation during skin wound healing involves complex interactions between the nervous system and intricate tissue repair processes. The skin, the largest organ, depends on a complex system of nerves to manage responses to injury. Rec…
View article: Engineering exosomes from fibroblast growth factor 1 pre-conditioned adipose-derived stem cells promote ischemic skin flaps survival by activating autophagy
Engineering exosomes from fibroblast growth factor 1 pre-conditioned adipose-derived stem cells promote ischemic skin flaps survival by activating autophagy Open
FEXO markedly improved the survivial rate of ischemic skin flaps through miR-183-5p/GPR137/Pi3k/Akt/mTOR axis, which would be a promising strategy to rescue ischemic skin flaps.
View article: Influence of Foliar Application of Nanoparticles on Low Temperature Resistance of Rice Seedlings
Influence of Foliar Application of Nanoparticles on Low Temperature Resistance of Rice Seedlings Open
Chilling stress, a common abiotic factor, adversely affects the growth and biomass of rice seedlings during the early stages, ultimately reducing the yield. Effective strategies to mitigate these negative impacts are essential for improvin…
View article: Falcarindiol improves functional recovery and alleviates neuroinflammation after spinal cord injury by inhibiting STAT/MAPK signaling pathways
Falcarindiol improves functional recovery and alleviates neuroinflammation after spinal cord injury by inhibiting STAT/MAPK signaling pathways Open
Spinal cord injury (SCI) is a devastating trauma in the central nervous system (CNS), leading to motor and sensory impairment. Neuroinflammation is one of the critical contributors to the progression of secondary injury. Falcarindiol has b…
View article: Differences in Grain Yield and Nitrogen Uptake between Tetraploid and Diploid Rice: The Physiological Mechanisms under Field Conditions
Differences in Grain Yield and Nitrogen Uptake between Tetraploid and Diploid Rice: The Physiological Mechanisms under Field Conditions Open
Research indicates that, owing to the enhanced grain-filling rate of tetraploid rice, its yield has notably improved compared to previous levels. Studies conducted on diploid rice have revealed that optimal planting density and fertilizati…
View article: NAD+-boosting agent nicotinamide mononucleotide potently improves mitochondria stress response in Alzheimer’s disease via ATF4-dependent mitochondrial UPR
NAD+-boosting agent nicotinamide mononucleotide potently improves mitochondria stress response in Alzheimer’s disease via ATF4-dependent mitochondrial UPR Open
View article: NEMO‐Binding Domain/IKKγ Inhibitory Peptide Alleviates Neuronal Pyroptosis in Spinal Cord Injury by Inhibiting ASMase‐Induced Lysosome Membrane Permeabilization
NEMO‐Binding Domain/IKKγ Inhibitory Peptide Alleviates Neuronal Pyroptosis in Spinal Cord Injury by Inhibiting ASMase‐Induced Lysosome Membrane Permeabilization Open
A short peptide termed NEMO‐binding domain (NBD) peptide has an inhibitory effect on nuclear factor kappa‐B (NF‐κB). Despite its efficacy in inhibiting inflammatory responses, the precise neuroprotective mechanisms of NBD peptide in spinal…
View article: Microenvironment‐adaptive nanodecoy synergizes bacterial eradication, inflammation alleviation, and immunomodulation in promoting biofilm‐associated diabetic chronic wound healing cascade
Microenvironment‐adaptive nanodecoy synergizes bacterial eradication, inflammation alleviation, and immunomodulation in promoting biofilm‐associated diabetic chronic wound healing cascade Open
The presence of bacterial biofilms and the occurrence of excessive inflammatory response greatly imped the healing process of chronic wounds in diabetic patients. However, effective strategies to simultaneously address these issues are sti…
View article: Multifunctional Triamcinolone Acetonide Microneedle Patches for Atopic Dermatitis Treatment
Multifunctional Triamcinolone Acetonide Microneedle Patches for Atopic Dermatitis Treatment Open
Atopic dermatitis (AD), a chronic and inflammatory skin disease, has brought huge physiological and psychological burdens to patients, which causes wide concerns in society. Herein, a multifunctional microneedle (MN) patch is proposed inte…
View article: Thrombocytopenia in Severe Fever with Thrombocytopenia Syndrome Due to Platelets With Altered Function Undergoing Cell Death Pathways
Thrombocytopenia in Severe Fever with Thrombocytopenia Syndrome Due to Platelets With Altered Function Undergoing Cell Death Pathways Open
Background Thrombocytopenia is the major clinical feature of severe fever with thrombocytopenia syndrome (SFTS), but the mechanism by which it occurs remains unclear. Methods RNA transcriptome analyses were performed on platelets purified …
View article: Evaluating the pro-survival potential of apoptotic bodies derived from 2D- and 3D- cultured adipose stem cells in ischaemic flaps
Evaluating the pro-survival potential of apoptotic bodies derived from 2D- and 3D- cultured adipose stem cells in ischaemic flaps Open