Jianbin Guan
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View article: Ultrasonic osteotome versus high-speed burr in channel-assisted cervical key hole technology: a clinical retrospective study
Ultrasonic osteotome versus high-speed burr in channel-assisted cervical key hole technology: a clinical retrospective study Open
The ultrasonic osteotome enhances surgical efficiency, minimizes intraoperative bleeding, and accelerates postoperative recovery in cervical endoscopic keyhole procedures, with a favorable safety profile compared with the traditional high-…
View article: Sodium tanshinone IIA sulfonate promotes proliferation and differentiation of endogenous neural stem cells to repair rat spinal cord injury via the Notch pathway
Sodium tanshinone IIA sulfonate promotes proliferation and differentiation of endogenous neural stem cells to repair rat spinal cord injury via the Notch pathway Open
STS promotes the proliferation of ENSCs post-SCI in rats, induces their differentiation into neurons, and inhibits their differentiation into astrocytes, thereby improving the pathological morphology of the injured spinal cord and promotin…
View article: Mid-Term Outcomes of Screw Loosening in Lumbar Dynamic Stabilization with Polyetheretherketone Rods versus Titanium Rods: A Minimum 4-Year Follow-Up
Mid-Term Outcomes of Screw Loosening in Lumbar Dynamic Stabilization with Polyetheretherketone Rods versus Titanium Rods: A Minimum 4-Year Follow-Up Open
Following PEEK rod dynamic fixation surgery, a certain proportion of screw loosening may occur in the short term. With prolonged follow-up, screws gradually restabilize at the bone interface, with most loosened screws returning to a stable…
View article: The value of fixed segment mobility in posterior dynamic stabilization: a single-center retrospective study
The value of fixed segment mobility in posterior dynamic stabilization: a single-center retrospective study Open
Compared to the first-generation, less mobile Isobar TTL, the second-generation, more mobile Isobar EVO offers superior preservation of the surgical segment and slows the progression of degeneration in the upper adjacent segments. These fi…
View article: Is There a Positive or Negative Correlation Between Cervical Vertebral Bone Quality and Intervertebral Disc Degeneration by Pfirrmann Grading
Is There a Positive or Negative Correlation Between Cervical Vertebral Bone Quality and Intervertebral Disc Degeneration by Pfirrmann Grading Open
Objective Cervical degeneration involves many pathophysiological changes. Vertebral bone loss, sclerotic hyperplasia of the vertebral body and intervertebral disc degeneration (IDD) are most common degenerative factors. However, whether th…
View article: Deciphering SPP1-related macrophage signaling in the pathogenesis of intervertebral disc degeneration
Deciphering SPP1-related macrophage signaling in the pathogenesis of intervertebral disc degeneration Open
This study delved into the molecular mechanisms underlying mechanical stress-induced intervertebral disc degeneration (msi-IDD) through single-cell and high-throughput transcriptome sequencing in mouse models and patient samples. Results e…
View article: The efficacy and safety of ketorolac for postoperative pain management in lumbar spine surgery: a meta-analysis of randomized controlled trials
The efficacy and safety of ketorolac for postoperative pain management in lumbar spine surgery: a meta-analysis of randomized controlled trials Open
Ketorolac administration, either alone or in combination with other analgesics, effectively reduces postoperative pain and opioid consumption in adults following lumbar spinal surgery. And Ketorolac did not significantly increase the incid…
View article: Correlation of the single-segment dynamic stabilization with different segmental mobility and zygapophysial (facet) joint degeneration: a retrospective study in northern China
Correlation of the single-segment dynamic stabilization with different segmental mobility and zygapophysial (facet) joint degeneration: a retrospective study in northern China Open
The Isobar EVO system, with its enhanced mobility, may delay facet joint degeneration in the superior adjacent segment compared to the Isobar TTL system. However, both systems result in degeneration at the fixed segment, indicating a need …
View article: A novel spherical GelMA-HAMA hydrogel encapsulating APET×2 polypeptide and CFIm25-targeting sgRNA for immune microenvironment modulation and nucleus pulposus regeneration in intervertebral discs
A novel spherical GelMA-HAMA hydrogel encapsulating APET×2 polypeptide and CFIm25-targeting sgRNA for immune microenvironment modulation and nucleus pulposus regeneration in intervertebral discs Open
The study highlighted the crucial role of CFIm25 in IDD and introduced a promising therapeutic strategy using a porous spherical GelMA-HAMA hydrogel loaded with APET×2 polypeptide and sgRNA. This innovative approach offers new possibilitie…
View article: Cervical Vertebra Bone Quality Score Predicts Zero-Profile Anchored Spacer Interbody Fusion Cage Subsidence after Anterior Cervical Diskectomy and Fusion: A Retrospective Study
Cervical Vertebra Bone Quality Score Predicts Zero-Profile Anchored Spacer Interbody Fusion Cage Subsidence after Anterior Cervical Diskectomy and Fusion: A Retrospective Study Open
Study Design Retrospective study. Objective This retrospective study primary focus is to investigate the relationship between the C-VBQ score and the occurrence of postoperative zero-profile anchored spacer (ROI-C) interbody fusion cage su…
View article: Jintiange capsule may have a positive effect on pain relief and functional activity in OVCF patients with PVA: A meta-analysis of randomized control trials
Jintiange capsule may have a positive effect on pain relief and functional activity in OVCF patients with PVA: A meta-analysis of randomized control trials Open
Background: This study aims to systematically evaluate the clinical efficacy and adverse reactions associated with Jintiange capsule (JTG capsule)-assisted percutaneous vertebral augmentation (PVA) in the treatment of osteoporotic vertebra…
View article: Association of type 2 Diabetes Mellitus and bone mineral density: a two-sample Mendelian randomization study
Association of type 2 Diabetes Mellitus and bone mineral density: a two-sample Mendelian randomization study Open
Background Observational studies have suggested that type 2 Diabetes Mellitus (DM2) is a potentially modifiable risk factor for lower BMD, but the causal relationship is unclear. This study aimed to examine whether the association of DM2 w…
View article: Animal Models of Internal Endplate Injury-Induced Intervertebral Disc Degeneration: A Systematic Review
Animal Models of Internal Endplate Injury-Induced Intervertebral Disc Degeneration: A Systematic Review Open
The damage to the direct injury model is more immediate and controllable in extent and can effectively lead to disk degeneration. The indirect injury models do not directly damage the endplate structure, making it easier to observe the phy…
View article: Animal models of internal endplate injury-induced intervertebral disc degeneration：a systematic review
Animal models of internal endplate injury-induced intervertebral disc degeneration：a systematic review Open
OBJECTIVE: To systematically review relevant animal models of disc degeneration induced through the endplate injury pathway,and to provide suitable animal models for exploring the intrinsic mechanisms and treatment of disc degeneration. DE…
View article: Biomechanical and clinical research of Isobar semi-rigid stabilization devices for lumbar degenerative diseases: a systematic review
Biomechanical and clinical research of Isobar semi-rigid stabilization devices for lumbar degenerative diseases: a systematic review Open
While lumbar spinal fusion using rigid rods is a prevalent surgical technique, it can lead to complications such as adjacent segment disease (ASDis). Dynamic stabilization devices serve to maintain physiological spinal motion and alleviate…
View article: Comparison of Robot-Assisted Versus Fluoroscopy-Guided Transforaminal Lumbar Interbody Fusion(TLIF) for Lumbar Degenerative Diseases: A Systematic Review Meta-Analysis of Trails and Observational Studies
Comparison of Robot-Assisted Versus Fluoroscopy-Guided Transforaminal Lumbar Interbody Fusion(TLIF) for Lumbar Degenerative Diseases: A Systematic Review Meta-Analysis of Trails and Observational Studies Open
Background As an emerging robot-assisted (RA) technology, whether its application in transforaminal lumbar interbody fusion (TLIF) is more worthwhile has not been supported by relevant evidence thus far. Moreover, utilizing RA procedures f…
View article: Polyetheretherketone (PEEK) rods versus titanium rods for posterior lumbar fusion surgery: a systematic review and meta-analysis
Polyetheretherketone (PEEK) rods versus titanium rods for posterior lumbar fusion surgery: a systematic review and meta-analysis Open
Background Rigid fixation, represented by titanium rods, is a widely used fixation technique for lumbar fusion. However, this technique carries the risk of degeneration of adjacent segments. In recent years, the semi-rigid fixation techniq…
View article: Isobar hybrid dynamic stabilization with posterolateral fusion in mild and moderate lumbar degenerative disease
Isobar hybrid dynamic stabilization with posterolateral fusion in mild and moderate lumbar degenerative disease Open
Objective The aim of this study was to investigate the feasibility of using the Isobar TTL system and posterolateral fusion in a two-segment hybrid fixation approach, combined with spinal decompression, for treating mild and moderate lumba…
View article: Correlation between surgical segment mobility and paravertebral muscle fatty infiltration of upper adjacent segment in single-segment LDD patients: retrospective study at a minimum 2 years’ follow-up
Correlation between surgical segment mobility and paravertebral muscle fatty infiltration of upper adjacent segment in single-segment LDD patients: retrospective study at a minimum 2 years’ follow-up Open
Objective The purpose of this study was to investigate the relationship between surgical segment mobility and fatty infiltration of the adjacent segment paravertebral muscles in patients with single-segment lumbar degenerative disease (LDD…
View article: Jintiange Capsule May Have a Positive Effect in OVCF Patients with percutaneous vertebral augmentation: A Meta-Analysis of Randomized Trials
Jintiange Capsule May Have a Positive Effect in OVCF Patients with percutaneous vertebral augmentation: A Meta-Analysis of Randomized Trials Open
Review question / Objective: We aimed to conduct a meta-analysis of the effects of JTG capsules on patients with OVCF underwent PVA surgery, focusing on clinical outcomes and drug safety. Condition being studied: This meta-analysis aims to…
View article: Evaluation of the Efficacy of Stem Cell Therapy in Animal Models of Intervertebral Disc Degeneration Based on Imaging Indicators: A Systematic Review and Meta-Analysis
Evaluation of the Efficacy of Stem Cell Therapy in Animal Models of Intervertebral Disc Degeneration Based on Imaging Indicators: A Systematic Review and Meta-Analysis Open
Objective. The purpose of this study is to make a systematic review of the therapeutic effect of stem cells in animal models of disc degeneration from an imaging point of view. Methods. Data were extracted by searching electronic databases…