Explanipedia

Elucidation of Cortex Dictamni hepatotoxicity mechanism by integrated serum pharmacochemistry and metabolomics Open

Sujie Liu, Jianbin Ruan, Chen Wang, Xiaoyun Wang, Jie Yan , et al. · 2025

Unanchored ubiquitin chains promote the non-canonical inflammasome via UBXN1 2222 Open

Jason G. Cahoon, Duomeng Yang, Tingting Geng, Chengliang Wang, Andrew G. Harrison , et al. · 2025

Description Ubiquitination is a major posttranslational covalent modification that regulates numerous cellular processes including inflammasome signaling. Cells also contain unanchored ubiquitin chains (polyUb) that bind protein targets no…

From pores to rupture: Structural basis and regulation of lytic cell death by gasdermins and NINJ1 Open

Chengliang Wang, BE Dreyer, Evelyn Teran, Jianbin Ruan · 2025

Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens Open

Sonia Shivcharan, Doulathunnisa Ahamed Younis, Skylar S. Wright, Chengliang Wang, Bharat Behl , et al. · 2025

Host cell cytosol is monitored by inflammasomes. Cytosolic invasion of pathogens involves breaching endolysosomal membranes, which is sensed by galectins triggering endolysosomal damage response. Whether and how endomembrane damage surveil…

LPS binding caspase activation and recruitment domains (CARDs) are bipartite lipid binding modules Open

Anh Cao, Pascal Devant, Chengliang Wang, M. Sun, Stephanie N. Kennedy , et al. · 2025

Caspase-11 is an innate immune pattern recognition receptor (PRR) that detects cytosolic bacterial lipopolysaccharides (LPS) through its caspase activation and recruitment domain (CARD). Caspase-11 also detects eukaryotic (i.e., self) lipi…

Unanchored ubiquitin chains promote the non-canonical inflammasome via UBXN1 Open

Duomeng Yang, Jason G. Cahoon, Tingting Geng, Chengliang Wang, Andrew G. Harrison , et al. · 2024

Ubiquitination is a major posttranslational covalent modification that regulates numerous cellular processes including inflammasome signaling. Cells also contain unanchored ubiquitin chains (polyUb) that bind protein targets non-covalently…

LPS binding caspase activation and recruitment domains (CARDs) are bipartite lipid binding modules Open

Anh Cao, Pascal Devant, Chengliang Wang, Mengyu Sun, Stephanie N. Kennedy , et al. · 2024

Caspase-11 is an innate immune pattern recognition receptor (PRR) that detects cytosolic bacterial lipopolysaccharides (LPS) through its caspase activation and recruitment domain (CARD), triggering inflammatory cell death known as pyroptos…

NLRP inflammasomes in health and disease Open

Zhihao Xu, Arnaud John Kombe Kombe, Shasha Deng, Hongliang Zhang, Songquan Wu , et al. · 2024

A bacterial toxin co-opts caspase-3 to disable active gasdermin D and limit macrophage pyroptosis Open

Skylar S. Wright, Chengliang Wang, Atri Ta, Morena S. Havira, Jianbin Ruan , et al. · 2024

Unanchored Ubiquitin Chains Promote the Non-Canonical Inflammasome via UBXN1 Open

Duomeng Yang, Jason G. Cahoon, Tingting Geng, Chengliang Wang, Andrew G. Harrison , et al. · 2024

An ancient defense mechanism: Conservation of gasdermin-mediated pyroptosis Open

Chengliang Wang, Jianbin Ruan · 2023

The gasdermins are a family of pore-forming proteins involved in various cellular processes such as cell death and inflammation. A new study in PLOS Biology explores the evolutionary history of gasdermins across metazoans, highlighting the…

Regulating GSDMB pore formation: to ignite or inhibit? Open

Jianbin Ruan · 2023

Structural basis for GSDMB pore formation and its targeting by IpaH7.8 Open

Chengliang Wang, Sonia Shivcharan, Tian Tian, Skylar S. Wright, Danyang Ma , et al. · 2023

Nexinhib20 Inhibits Neutrophil Adhesion and β2 Integrin Activation by Antagonizing Rac-1–Guanosine 5′-Triphosphate Interaction Open

Wei Liu, Chunxia Cronin, Ziming Cao, Chengliang Wang, Jianbin Ruan , et al. · 2022

Neutrophils are critical for mediating inflammatory responses. Inhibiting neutrophil recruitment is an attractive approach for preventing inflammatory injuries, including myocardial ischemia-reperfusion (I/R) injury, which exacerbates card…

Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors Open

Xiaozhe Xiong, Songhai Tian, Pan Yang, François Lebreton, Huan Bao , et al. · 2022

Data for EMSL Project 51599 from January 2022 Open