Jianbo Fu
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View article: Dynamic clinical trial success rates for drugs in the 21st century
Dynamic clinical trial success rates for drugs in the 21st century Open
View article: Deciphering cross-cohort metabolic signatures of immune responses and their implications for disease pathogenesis
Deciphering cross-cohort metabolic signatures of immune responses and their implications for disease pathogenesis Open
The complex interplay between circulating metabolites and immune responses, which is pivotal to disease pathophysiology, remains poorly understood and understudied in systematic research. Here, we performed a comprehensive analysis of the …
View article: A Multi-Omics Framework for Decoding Disease Mechanisms: Insights From Methylmalonic Aciduria
A Multi-Omics Framework for Decoding Disease Mechanisms: Insights From Methylmalonic Aciduria Open
View article: MultiOmicsAgent: Guided Extreme Gradient-Boosted Decision Trees-Based Approaches for Biomarker-Candidate Discovery in Multiomics Data
MultiOmicsAgent: Guided Extreme Gradient-Boosted Decision Trees-Based Approaches for Biomarker-Candidate Discovery in Multiomics Data Open
MultiOmicsAgent (MOAgent) is an innovative, Python-based open-source tool for biomarker discovery, utilizing machine learning techniques, specifically extreme gradient-boosted decision trees, to process multiomics data. With its cross-plat…
View article: Bibliometric and Visualization Analysis of DprE1 Inhibitors to Combat Tuberculosis
Bibliometric and Visualization Analysis of DprE1 Inhibitors to Combat Tuberculosis Open
A systematic bibliometric study indicates that DprE1 remains a focal point in the anti-TB domain. These results can serve as a data-driven reference for future research and offer precise insights into the development of anti-TB agents asso…
View article: Deciphering Cross-Cohort Metabolic Signatures of Immune Responses and Their Implications for Disease Pathogenesis
Deciphering Cross-Cohort Metabolic Signatures of Immune Responses and Their Implications for Disease Pathogenesis Open
The intricate interplay between circulating metabolites and immune responses, though crucial to disease pathophysiology, remains poorly understood and underexplored in systematic research. Here, we performed a comprehensive analysis of the…
View article: MultiOmicsAgent: Guided extreme gradient-boosted decision trees-based approaches for biomarker-candidate discovery in multi-omics data
MultiOmicsAgent: Guided extreme gradient-boosted decision trees-based approaches for biomarker-candidate discovery in multi-omics data Open
MultiOmicsAgent (MOAgent) is an innovative, Python based open-source tool for biomarker discovery, utilizing machine learning techniques specifically extreme gradient-boosted decision trees to process multi-omics data. With its cross-platf…
View article: Dynamic Clinical Success Rates for Drugs in the 21st Century
Dynamic Clinical Success Rates for Drugs in the 21st Century Open
In clinical drug development, two fundamental questions remain unanswered: what is the success rate of drugs in clinical trial? how does such rate change over time? Herein, a systematic analysis on the dynamic change of drugs’ clinical suc…
View article: Dynamic Clinical Success Rates for Drugs in the 21st Century
Dynamic Clinical Success Rates for Drugs in the 21st Century Open
In clinical drug development, two fundamental questions remain unanswered: what is the success rate of drugs in clinical trial? how does such rate change over time? Herein, a systematic analysis on the dynamic change of drugs’ clinical suc…
View article: A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity
A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity Open
Bacillus Calmette-Guérin (BCG) vaccination is a prototype model for the study of trained immunity (TI) in humans, and results in a more effective response of innate immune cells upon stimulation with heterologous stimuli. Here, we investig…
View article: Metabolomics meets systems immunology
Metabolomics meets systems immunology Open
View article: Functional characterization of disease/comorbidity‐associated lncRNA
Functional characterization of disease/comorbidity‐associated lncRNA Open
Background Functional characterization of the long noncoding RNAs (lncRNAs) in disease attracts great attention, which results in a limited number of experimentally characterized lncRNAs. The major problems underlying the lack of experimen…
View article: INTEDE: interactome of drug-metabolizing enzymes
INTEDE: interactome of drug-metabolizing enzymes Open
Drug-metabolizing enzymes (DMEs) are critical determinant of drug safety and efficacy, and the interactome of DMEs has attracted extensive attention. There are 3 major interaction types in an interactome: microbiome–DME interaction (MICBIO…
View article: Research on Wind Turbine Selection Based on Different Heavy Icing Data Processing Strategies
Research on Wind Turbine Selection Based on Different Heavy Icing Data Processing Strategies Open
The selection of wind turbine icing processing technology is related to the safe and stable operation of wind farms during icing. Based on the processing strategy of wind data, this paper studies the impact of different processing strategi…
View article: Computational advances of tumor marker selection and sample classification in cancer proteomics
Computational advances of tumor marker selection and sample classification in cancer proteomics Open
Cancer proteomics has become a powerful technique for characterizing the protein markers driving transformation of malignancy, tracing proteome variation triggered by therapeutics, and discovering the novel targets and drugs for the treatm…
View article: Simultaneous Improvement in the Precision, Accuracy, and Robustness of Label-free Proteome Quantification by Optimizing Data Manipulation Chains*
Simultaneous Improvement in the Precision, Accuracy, and Robustness of Label-free Proteome Quantification by Optimizing Data Manipulation Chains* Open
The label-free proteome quantification (LFQ) is multistep workflow collectively defined by quantification tools and subsequent data manipulation methods that has been extensively applied in current biomedical, agricultural, and environment…
View article: Biomarker Discovery for Immunotherapy of Pituitary Adenomas: Enhanced Robustness and Prediction Ability by Modern Computational Tools
Biomarker Discovery for Immunotherapy of Pituitary Adenomas: Enhanced Robustness and Prediction Ability by Modern Computational Tools Open
Pituitary adenoma (PA) is prevalent in the general population. Due to its severe complications and aggressive infiltration into the surrounding brain structure, the effective management of PA is required. Till now, no drug has been approve…
View article: Clinical trials, progression-speed differentiating features and swiftness rule of the innovative targets of first-in-class drugs
Clinical trials, progression-speed differentiating features and swiftness rule of the innovative targets of first-in-class drugs Open
Drugs produce their therapeutic effects by modulating specific targets, and there are 89 innovative targets of first-in-class drugs approved in 2004–17, each with information about drug clinical trial dated back to 1984. Analysis of the cl…
View article: ANPELA: analysis and performance assessment of the label-free quantification workflow for metaproteomic studies
ANPELA: analysis and performance assessment of the label-free quantification workflow for metaproteomic studies Open
Label-free quantification (LFQ) with a specific and sequentially integrated workflow of acquisition technique, quantification tool and processing method has emerged as the popular technique employed in metaproteomic research to provide a c…
View article: Discovery of the Consistently Well-Performed Analysis Chain for SWATH-MS Based Pharmacoproteomic Quantification
Discovery of the Consistently Well-Performed Analysis Chain for SWATH-MS Based Pharmacoproteomic Quantification Open
Sequential windowed acquisition of all theoretical fragment ion mass spectra (SWATH-MS) has emerged as one of the most popular techniques for label-free proteome quantification in current pharmacoproteomic research. It provides more compre…
View article: Systematic identification and characterization of long non-coding RNAs in mouse mature sperm
Systematic identification and characterization of long non-coding RNAs in mouse mature sperm Open
Increasing studies have shown that mature spermatozoa contain many transcripts including mRNAs and miRNAs. However, the expression profile of long non-coding RNAs (lncRNAs) in mammalian sperm has not been systematically investigated. Here,…
View article: Endoplasmic reticulum stress is involved in 2,4-dichlorophenol-induced hepatotoxicity
Endoplasmic reticulum stress is involved in 2,4-dichlorophenol-induced hepatotoxicity Open
2,4-Dichlorophenol (2,4-DCP) is an environmental pollutant exhibiting a wide spectrum of toxic effects. We investigated the toxic effects and potential mechanisms underlying 2,4-DCP-induced hepatotoxicity. In vitro, 2,4-DCP caused hepatoto…