Jiye Zhu
YOU?
Author Swipe
View article: Molecular Mechanisms of the Ubiquitin-Specific Proteases (USPs) Family in Biliary Tract Cancer and Targeted Intervention Strategies
Molecular Mechanisms of the Ubiquitin-Specific Proteases (USPs) Family in Biliary Tract Cancer and Targeted Intervention Strategies Open
Biliary tract carcinoma (BTC) is a group of highly heterogeneous malignancies arising from the biliary epithelium. Anatomically, BTC is categorized into gallbladder cancer (GBC) and cholangiocarcinoma (CCA), with the latter further subdivi…
View article: Liver transplantation for intrahepatic cholangiocarcinoma: Insights from a National Registry Study in China
Liver transplantation for intrahepatic cholangiocarcinoma: Insights from a National Registry Study in China Open
This study investigates the clinical efficacy of liver transplantation (LT) for intrahepatic cholangiocarcinoma (ICC), identifies clinicopathologic factors impacting prognosis, and provides evidence-based data to support LT indications for…
View article: Immune checkpoint inhibitors use in liver transplantation for hepatocellular carcinoma: a global cohort study
Immune checkpoint inhibitors use in liver transplantation for hepatocellular carcinoma: a global cohort study Open
With careful management, peri-LT ICIs may be considered for HCC patients. Optimizing washout periods and monitoring graft PD-L1 expression may improve transplant outcomes.
View article: Sensitive SERS Platform for the Detection of <i>Staphylococcus aureus</i> via Freezing SERS Tags and Core–Shell Aptamer-Au@Fe<sub>3</sub>O<sub>4</sub> Nanoparticles
Sensitive SERS Platform for the Detection of <i>Staphylococcus aureus</i> via Freezing SERS Tags and Core–Shell Aptamer-Au@Fe<sub>3</sub>O<sub>4</sub> Nanoparticles Open
The detection of Staphylococcus aureus is crucial for the diagnosis and treatment of infectious diseases. However, developing a simple and sensitive method for S. aureus detection remains challenging. Herein, we propose a sen…
View article: Synchronous double primary hepatocellular carcinoma and intrahepatic cholangiocarcinoma in a single patient with chronic hepatitis B: two case reports and literature review
Synchronous double primary hepatocellular carcinoma and intrahepatic cholangiocarcinoma in a single patient with chronic hepatitis B: two case reports and literature review Open
Simultaneous occurrence of primary hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) is rare. We report two cases of synchronous double primary HCC and ICC (sdpHCC-ICC), both associated with chronic hepatitis B. Case…
View article: Nomogram for predicting the 28-day mortality risk of patients with subendocardial infarction
Nomogram for predicting the 28-day mortality risk of patients with subendocardial infarction Open
Background Subendocardial myocardial infarction (SEMI) represents a more severe form of myocardial infarction. Currently, there lacks a comprehensive clinical index for predicting mortality in cases of subendocardial myocardial infarction.…
View article: The Emerging Role and Mechanism of E2/E3 Hybrid Enzyme UBE2O in Human Diseases
The Emerging Role and Mechanism of E2/E3 Hybrid Enzyme UBE2O in Human Diseases Open
The ubiquitin–proteasome system (UPS) plays a pivotal role in determining protein fate, regulating signal transduction, and maintaining cellular homeostasis. Protein ubiquitination, a key post-translational modification, is orchestrated by…
View article: The association of life’s essential 8 scores trajectory patterns with the risk of all cancer types
The association of life’s essential 8 scores trajectory patterns with the risk of all cancer types Open
The "Life's Essential 8" (LE8) is a comprehensive lifestyle assessment tool by the American Heart Association, designed to mitigate cardiovascular disease risk by optimizing lifestyle factors including diet, physical activity, and other he…
View article: Obstructive Jaundice Induced by Hilar Mucinous Cystic Neoplasm of the Liver: A Rare Case Report and Literature Review
Obstructive Jaundice Induced by Hilar Mucinous Cystic Neoplasm of the Liver: A Rare Case Report and Literature Review Open
Mucinous cystic neoplasm of the liver (MCN-L) is a rare benign tumor accounting for less than 5% of all liver cysts, with MCN-L in the hilar region being exceptionally uncommon and often misdiagnosed due to its complex presentation. A 48-y…
View article: The associations between irregular breakfast and late-night snacking with metabolic dysfunction-associated steatotic liver disease
The associations between irregular breakfast and late-night snacking with metabolic dysfunction-associated steatotic liver disease Open
Irregular or skipped breakfast and late-night snacking were associated with an increased risk of MASLD and MetALD.
View article: In Vivo Detection of Extracellular Vesicles by Flexible Needle-Type Microbiosensor
In Vivo Detection of Extracellular Vesicles by Flexible Needle-Type Microbiosensor Open
View article: Therapeutic efficacy and prognostic indicators in re-resection for recurrent hepatocellular carcinoma: Insights from a retrospective study
Therapeutic efficacy and prognostic indicators in re-resection for recurrent hepatocellular carcinoma: Insights from a retrospective study Open
View article: Multi-omics-driven discovery of invasive patterns and treatment strategies in CA19-9 positive intrahepatic cholangiocarcinoma
Multi-omics-driven discovery of invasive patterns and treatment strategies in CA19-9 positive intrahepatic cholangiocarcinoma Open
View article: Integrative analysis reveals different feature of intrahepatic cholangiocarcinoma subtypes
Integrative analysis reveals different feature of intrahepatic cholangiocarcinoma subtypes Open
Background & Aims Intrahepatic cholangiocarcinoma (iCCA) has two main histological subtypes: large and small duct‐type iCCA, which are characterized by different clinicopathological features. This study was conducted with the purpose of ex…
View article: Integrating Multi-Omics Reveals the Invasive Mechanisms and Treatment Strategies of CA19-9 Positive Intrahepatic Cholangiocarcinoma
Integrating Multi-Omics Reveals the Invasive Mechanisms and Treatment Strategies of CA19-9 Positive Intrahepatic Cholangiocarcinoma Open
View article: Chinese expert consensus on the overall management of liver function in conversion therapy for liver cancer (2022 edition)
Chinese expert consensus on the overall management of liver function in conversion therapy for liver cancer (2022 edition) Open
Introduction Primary liver cancer is a significant health issue in China, where it ranks fourth in morbidity and second in mortality among all malignant tumors.[1–4] The 5-year overall survival rate of Chinese patients with liver cancer fr…
View article: International experts consensus guidelines on robotic liver resection in 2023
International experts consensus guidelines on robotic liver resection in 2023 Open
The robotic liver resection (RLR) has been increasingly applied in recent years and its benefits shown in some aspects owing to the technical advancement of robotic surgical system, however, controversies still exist. Based on the foundati…
View article: NDRG1 facilitates self-renewal of liver cancer stem cells by preventing EpCAM ubiquitination
NDRG1 facilitates self-renewal of liver cancer stem cells by preventing EpCAM ubiquitination Open
View article: Fucosyltransferase 5 Promotes the Proliferative and Migratory Properties of Intrahepatic Cholangiocarcinoma Cells via Regulating Protein Glycosylation Profiles
Fucosyltransferase 5 Promotes the Proliferative and Migratory Properties of Intrahepatic Cholangiocarcinoma Cells via Regulating Protein Glycosylation Profiles Open
Background: The incidence of intrahepatic cholangiocarcinoma (ICC) is increasing globally, and its prognosis has not improved substantially in recent years. Understanding the pathogenesis of ICC may provide a theoretical basis for its trea…
View article: Guidelines for the Diagnosis and Treatment of Primary Liver Cancer (2022 Edition)
Guidelines for the Diagnosis and Treatment of Primary Liver Cancer (2022 Edition) Open
Background: Primary liver cancer, of which around 75–85% is hepatocellular carcinoma in China, is the fourth most common malignancy and the second leading cause of tumor-related death, thereby posing a significant threat to the life and he…
View article: WWP1 upregulation predicts poor prognosis and promotes tumor progression by regulating ubiquitination of NDFIP1 in intrahepatic cholangiocarcinoma
WWP1 upregulation predicts poor prognosis and promotes tumor progression by regulating ubiquitination of NDFIP1 in intrahepatic cholangiocarcinoma Open
View article: PESV represses non-small cell lung cancer cell malignancy through circ_0016760 under hypoxia
PESV represses non-small cell lung cancer cell malignancy through circ_0016760 under hypoxia Open
View article: Multi-Modal Imaging Probe for Glypican-3 Overexpressed in Orthotopic Hepatocellular Carcinoma
Multi-Modal Imaging Probe for Glypican-3 Overexpressed in Orthotopic Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC) is rising steadily in incidence, and more effective methods are needed for early detection and image-guided surgery. Glypican-3 (GPC3) is a cell surface biomarker that is overexpressed in early-stage cancer b…
View article: <i>IDH</i> Mutation Subgroup Status Associates with Intratumor Heterogeneity and the Tumor Microenvironment in Intrahepatic Cholangiocarcinoma
<i>IDH</i> Mutation Subgroup Status Associates with Intratumor Heterogeneity and the Tumor Microenvironment in Intrahepatic Cholangiocarcinoma Open
Intrahepatic cholangiocarcinoma (ICC) is highly heterogeneous. Here, the authors perform exome sequencing and bulk RNA sequencing on 73 tumor regions from 14 ICC patients to portray the multi‐faceted intratumor heterogeneity (ITH) landscap…
View article: NKG2D Enhances Double-Negative T Cell Regulation of B Cells
NKG2D Enhances Double-Negative T Cell Regulation of B Cells Open
Numerous studies reported a small subpopulation of TCRαβ + CD4 - CD8 - (double-negative) T cells that exert regulatory functions in the peripheral lymphocyte population. However, the origin of these double-negative T (DNT) cells is controv…
View article: Up-Regulation of Donor Dendritic Cell PD-L1 Expression Reduced Recipient Lymphocyte Activation and Proliferation In Vitro
Up-Regulation of Donor Dendritic Cell PD-L1 Expression Reduced Recipient Lymphocyte Activation and Proliferation In Vitro Open
The recombinant adenovirus vector Ad-PD-L1 containing the mouse PD-L1 gene was successfully constructed. After transfection with dendritic cells of donor C57BL/6 mice, PD-1/PD-L1 inhibited lymphocytes proliferation and activation of recipi…
View article: Cyclooxygenase-2 expressed hepatocellular carcinoma induces cytotoxic T lymphocytes exhaustion through M2 macrophage polarization.
Cyclooxygenase-2 expressed hepatocellular carcinoma induces cytotoxic T lymphocytes exhaustion through M2 macrophage polarization. Open
Due to the tumor immune microenvironment (TIME) complexity and cancer heterogeneity, the clinical outcomes of hepatocellular carcinoma (HCC) are barely elicited from the conventional treatment options, even from the promising anti-cancer i…
View article: TIGIT Can Exert Immunosuppressive Effects on CD8+ T Cells by the CD155/TIGIT Signaling Pathway for Hepatocellular Carcinoma In Vitro
TIGIT Can Exert Immunosuppressive Effects on CD8+ T Cells by the CD155/TIGIT Signaling Pathway for Hepatocellular Carcinoma In Vitro Open
The efficacy of adoptive cellular immunotherapy against cancer cells is limited due to the presence of immunosuppressive cells within the solid tumor microenvironment. The upregulation of certain coinhibitory receptors may lead to exhausti…
View article: Therapeutic Efficacy of Sorafenib in Patients with Hepatocellular Carcinoma Recurrence After Liver Transplantation: A Systematic Review and Meta-Analysis
Therapeutic Efficacy of Sorafenib in Patients with Hepatocellular Carcinoma Recurrence After Liver Transplantation: A Systematic Review and Meta-Analysis Open
Based on the results of this meta-analysis, sorafenib therapy seems to be safe and feasible and exhibits survival benefit in patients with post-LT HCC recurrence. However, prospective randomized controlled trials with larger sample sizes a…
View article: <p>Efficacy of sorafenib after liver transplantation in patients with primary hepatic carcinoma exceeding the Milan criteria: a preliminary study [Expression of concern] [Erratum]</p>
Efficacy of sorafenib after liver transplantation in patients with primary hepatic carcinoma exceeding the Milan criteria: a preliminary study [Expression of concern] [Erratum] Open
[This corrects the article DOI: 10.2147/OTT.S31387.].