Jiancong Chen
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View article: Developing a Student-Centred Curriculum: Insights from Anaesthetic Placement Experiences for Co-Designing in China’s Greater Bay Area
Developing a Student-Centred Curriculum: Insights from Anaesthetic Placement Experiences for Co-Designing in China’s Greater Bay Area Open
This study demonstrates the effective implementation of collaborative teaching and curriculum co-designed in anaesthesia education at a tertiary hospital in the "Greater Bay Innovative Zones of China". This curricular design model facilita…
View article: SafePLUG: Empowering Multimodal LLMs with Pixel-Level Insight and Temporal Grounding for Traffic Accident Understanding
SafePLUG: Empowering Multimodal LLMs with Pixel-Level Insight and Temporal Grounding for Traffic Accident Understanding Open
Multimodal large language models (MLLMs) have achieved remarkable progress across a range of vision-language tasks and demonstrate strong potential for traffic accident understanding. However, existing MLLMs in this domain primarily focus …
View article: <scp>SUR1</scp>‐<scp>TRPM4</scp> Regulates Aquaporin‐4 Subcellular Localization by Astrocytic Endfeet Calcium Signals Following Status Epilepticus
<span>SUR1</span>‐<span>TRPM4</span> Regulates Aquaporin‐4 Subcellular Localization by Astrocytic Endfeet Calcium Signals Following Status Epilepticus Open
Status epilepticus (SE) is a severe condition that results in uncontrollable cerebral edema and cognitive dysfunction. Recent studies suggest that the localization of aquaporin‐4 (AQP4) in astrocytic endfeet plays a crucial role in regulat…
View article: Integrated Analysis of Single‐Cell and Bulk <scp>RNA</scp>‐Sequencing Defines <scp>N7</scp>‐Methylguanosine (<scp>m7G</scp>)‐Mediated Modifications' Role in Prognosis and the Tumor Immune Microenvironment in Hepatocellular Carcinoma
Integrated Analysis of Single‐Cell and Bulk <span>RNA</span>‐Sequencing Defines <span>N7</span>‐Methylguanosine (<span>m7G</span>)‐Mediated Modifications' Role in Prognosis and the Tumor Immune Microenvironment in Hepatocellular Carcinoma Open
Background RNA 7‐Methylguanosine (m7G) modification is biologically important to tumorigenesis and progression. Knowledge regarding the effect of m7G modification on the clinical features of hepatocellular carcinoma and its prognosis, tumo…
View article: Association between hypoglycemia and poor clinical outcomes in hospitalized non-diabetic patients with liver cirrhosis:– a narrative review
Association between hypoglycemia and poor clinical outcomes in hospitalized non-diabetic patients with liver cirrhosis:– a narrative review Open
Hypoglycemia is rarely highlighted as a complication that requires close monitoring in patients with chronic liver disease, despite substantial evidence of its occurrence in cirrhotic patients. This narrative review aims to evaluate whethe…
View article: Sky-Drive: A Distributed Multi-Agent Simulation Platform for Human-AI Collaborative and Socially-Aware Future Transportation
Sky-Drive: A Distributed Multi-Agent Simulation Platform for Human-AI Collaborative and Socially-Aware Future Transportation Open
Recent advances in autonomous system simulation platforms have significantly enhanced the safe and scalable testing of driving policies. However, existing simulators do not yet fully meet the needs of future transportation research-particu…
View article: The application of high-intensity interval training in college physical education and the improvement of students’ physical and mental quality
The application of high-intensity interval training in college physical education and the improvement of students’ physical and mental quality Open
A BSTRACT Purpose: With the increase of employment pressure in modern society and the influence of the long-term static learning mode, the obesity problem of college students is becoming more and more serious, which has become an important…
View article: Synthetic Data Generation with LLM for Improved Depression Prediction
Synthetic Data Generation with LLM for Improved Depression Prediction Open
Automatic detection of depression is a rapidly growing field of research at the intersection of psychology and machine learning. However, with its exponential interest comes a growing concern for data privacy and scarcity due to the sensit…
View article: Collaborative Teaching and Curricular Integration in Pre-Intern Clinical Placements: Insights from the Greater Bay Area
Collaborative Teaching and Curricular Integration in Pre-Intern Clinical Placements: Insights from the Greater Bay Area Open
This study demonstrates the successful delivery of collaborative teaching and learning through medical curricular integration in China's "Global-Innovation-Hub" zones. This integration enables the development of a consistent and student-pr…
View article: Fatty acid metabolism affects hepatocellular carcinoma progression via the PPAR-γ signaling pathway and fatty acid β-oxidation
Fatty acid metabolism affects hepatocellular carcinoma progression via the PPAR-γ signaling pathway and fatty acid β-oxidation Open
The risk characteristics based on FAMGs could serve as independent prognostic indicators for predicting HCC prognosis and could also serve as evaluation criteria for gene mutations, immunity, and chemotherapy drug therapy in HCC patients. …
View article: β-Hydroxybutyrate inhibits FOXO3a by histone H3K9 β-Hydroxybutyrylation to ameliorate stroke-related sarcopenia
β-Hydroxybutyrate inhibits FOXO3a by histone H3K9 β-Hydroxybutyrylation to ameliorate stroke-related sarcopenia Open
Stroke-related sarcopenia (SRS) is characterized by progressive systemic muscle loss and decreased function and is thought to be primarily affected by catabolic-anabolic imbalance, but there is a lack of specific treatment. Our study evalu…
View article: A Structured Light 3D Reconstruction Method Based on Neural Network
A Structured Light 3D Reconstruction Method Based on Neural Network Open
The monocular structured light measurement system has low cost, simple algorithms, and a wide measurement range, making it widely applicable in multiple fields. However, in practical applications, the system may be affected by various fact…
View article: Covalent organic framework based cytoprotective therapy after ischemic stroke
Covalent organic framework based cytoprotective therapy after ischemic stroke Open
Cytoprotection has emerged as an effective therapeutic strategy for mitigating brain injury following acute ischemic stroke (AIS). The sulfonylurea receptor 1-transient receptor potential M4 (SUR1-TRPM4) channel plays a pivotal role in bra…
View article: Flufenamic acid improves survival and neurologic outcome after successful cardiopulmonary resuscitation in mice
Flufenamic acid improves survival and neurologic outcome after successful cardiopulmonary resuscitation in mice Open
Background Brain injury is the main cause of high mortality and disability after successful cardiopulmonary resuscitation (CPR) from sudden cardiac arrest (CA). Transient receptor potential M4 (TRPM4) channel is a novel target for ameliora…
View article: High bile titer and high bile to serum ratio of CYFRA 21-1 reliably discriminate malignant biliary obstruction caused by cholangiocarcinoma
High bile titer and high bile to serum ratio of CYFRA 21-1 reliably discriminate malignant biliary obstruction caused by cholangiocarcinoma Open
Introduction Previously we demonstrated that elevated serum CYFRA 21 − 1 is a reliable diagnostic and prognostic biomarker for biliary tract cancers. This study aims to explore the diagnostic performance of bile CYFRA 21 − 1 (bCYFRA 21 − 1…
View article: DAGLβ is the principal synthesizing enzyme of 2-AG and promotes aggressive phenotype of intrahepatic cholangiocarcinoma via AP-1/DAGLβ/miR4516 feedforward circuitry
DAGLβ is the principal synthesizing enzyme of 2-AG and promotes aggressive phenotype of intrahepatic cholangiocarcinoma via AP-1/DAGLβ/miR4516 feedforward circuitry Open
Dysregulated endocannabinoid system (ECS) had been confirmed in various liver diseases. However, regulation and function of 2-arachidonoyl glycerol (2-AG) and diacylglycerol lipase β (DAGLβ) in intrahepatic cholangiocarcinoma (ICC) remain …
View article: Inflammatory responses involved in post-cardiac arrest brain injury: mechanisms, regulation, and therapeutic potential
Inflammatory responses involved in post-cardiac arrest brain injury: mechanisms, regulation, and therapeutic potential Open
Neuroinflammation plays a key role in the pathogenesis of post-cardiac arrest (CA) brain injury. Innate immune cells sense a variety of danger signals through pattern-recognition receptors and evoke rapidly after ischemic challenge, trigge…
View article: Supplementary Figure from PIM2 Expression Induced by Proinflammatory Macrophages Suppresses Immunotherapy Efficacy in Hepatocellular Carcinoma
Supplementary Figure from PIM2 Expression Induced by Proinflammatory Macrophages Suppresses Immunotherapy Efficacy in Hepatocellular Carcinoma Open
Supplementary Figure from PIM2 Expression Induced by Proinflammatory Macrophages Suppresses Immunotherapy Efficacy in Hepatocellular Carcinoma
View article: Supplementary Data from PIM2 Expression Induced by Proinflammatory Macrophages Suppresses Immunotherapy Efficacy in Hepatocellular Carcinoma
Supplementary Data from PIM2 Expression Induced by Proinflammatory Macrophages Suppresses Immunotherapy Efficacy in Hepatocellular Carcinoma Open
Supplementary Data from PIM2 Expression Induced by Proinflammatory Macrophages Suppresses Immunotherapy Efficacy in Hepatocellular Carcinoma
View article: Data from PIM2 Expression Induced by Proinflammatory Macrophages Suppresses Immunotherapy Efficacy in Hepatocellular Carcinoma
Data from PIM2 Expression Induced by Proinflammatory Macrophages Suppresses Immunotherapy Efficacy in Hepatocellular Carcinoma Open
Cancer immunotherapy restores or enhances the effector function of T cells in the tumor microenvironment, but the efficacy of immunotherapy has been hindered by therapeutic resistance. Here, we identify the proto-oncogene serine/threonine …
View article: Data from PIM2 Expression Induced by Proinflammatory Macrophages Suppresses Immunotherapy Efficacy in Hepatocellular Carcinoma
Data from PIM2 Expression Induced by Proinflammatory Macrophages Suppresses Immunotherapy Efficacy in Hepatocellular Carcinoma Open
Cancer immunotherapy restores or enhances the effector function of T cells in the tumor microenvironment, but the efficacy of immunotherapy has been hindered by therapeutic resistance. Here, we identify the proto-oncogene serine/threonine …
View article: Supplementary Data from PIM2 Expression Induced by Proinflammatory Macrophages Suppresses Immunotherapy Efficacy in Hepatocellular Carcinoma
Supplementary Data from PIM2 Expression Induced by Proinflammatory Macrophages Suppresses Immunotherapy Efficacy in Hepatocellular Carcinoma Open
Supplementary Data from PIM2 Expression Induced by Proinflammatory Macrophages Suppresses Immunotherapy Efficacy in Hepatocellular Carcinoma
View article: Supplementary Figure from PIM2 Expression Induced by Proinflammatory Macrophages Suppresses Immunotherapy Efficacy in Hepatocellular Carcinoma
Supplementary Figure from PIM2 Expression Induced by Proinflammatory Macrophages Suppresses Immunotherapy Efficacy in Hepatocellular Carcinoma Open
Supplementary Figure from PIM2 Expression Induced by Proinflammatory Macrophages Suppresses Immunotherapy Efficacy in Hepatocellular Carcinoma
View article: Supplementary Data from PIM2 Expression Induced by Proinflammatory Macrophages Suppresses Immunotherapy Efficacy in Hepatocellular Carcinoma
Supplementary Data from PIM2 Expression Induced by Proinflammatory Macrophages Suppresses Immunotherapy Efficacy in Hepatocellular Carcinoma Open
Supplementary Data from PIM2 Expression Induced by Proinflammatory Macrophages Suppresses Immunotherapy Efficacy in Hepatocellular Carcinoma
View article: Supplementary Data from PIM2 Expression Induced by Proinflammatory Macrophages Suppresses Immunotherapy Efficacy in Hepatocellular Carcinoma
Supplementary Data from PIM2 Expression Induced by Proinflammatory Macrophages Suppresses Immunotherapy Efficacy in Hepatocellular Carcinoma Open
Supplementary Data from PIM2 Expression Induced by Proinflammatory Macrophages Suppresses Immunotherapy Efficacy in Hepatocellular Carcinoma
View article: Supplementary Material for: A Knowledge Map of the Relationship between Diabetes and Stroke: A Bibliometric Analysis Study
Supplementary Material for: A Knowledge Map of the Relationship between Diabetes and Stroke: A Bibliometric Analysis Study Open
Introduction: The correlation between diabetes and stroke has been studied extensively in epidemiological research. Here we used bibliometric software to visualize and analyze the literature related to diabetic stroke to provide an overvie…
View article: Supplementary Material for: A Knowledge Map of the Relationship between Diabetes and Stroke: A Bibliometric Analysis Study
Supplementary Material for: A Knowledge Map of the Relationship between Diabetes and Stroke: A Bibliometric Analysis Study Open
Introduction: The correlation between diabetes and stroke has been studied extensively in epidemiological research. Here we used bibliometric software to visualize and analyze the literature related to diabetic stroke to provide an overvie…
View article: Supplementary Material for: A Knowledge Map of the Relationship between Diabetes and Stroke: A Bibliometric Analysis Study
Supplementary Material for: A Knowledge Map of the Relationship between Diabetes and Stroke: A Bibliometric Analysis Study Open
Introduction: The correlation between diabetes and stroke has been studied extensively in epidemiological research. Here we used bibliometric software to visualize and analyze the literature related to diabetic stroke to provide an overvie…