Jiane Liu
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View article: Crab shell polypeptides enhance calcium dynamics and osteogenic activity in osteoporosis
Crab shell polypeptides enhance calcium dynamics and osteogenic activity in osteoporosis Open
Background Osteoporosis (OP) is a chronic, systemic skeletal disorder characterized by progressive bone loss and microarchitectural deterioration, which increases fracture susceptibility and presents a challenging set of global healthcare …
View article: Activation of pyroptosis impairs basal cell differentiation in the nasal epithelium in chronic rhinosinusitis with nasal polyps
Activation of pyroptosis impairs basal cell differentiation in the nasal epithelium in chronic rhinosinusitis with nasal polyps Open
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory sinus disease, which is categorized into eosinophilic CRSwNP (ECRSwNP) and non‑ECRSwNP (nECRSwNP), affecting 2‑4% of the population. Pyroptosis is implicated in th…
View article: Glucosamine alleviates liver fibrosis through modulation of sinusoidal blood flow and hepatic immune responses
Glucosamine alleviates liver fibrosis through modulation of sinusoidal blood flow and hepatic immune responses Open
Liver fibrosis, a key precursor to cirrhosis, arises from chronic liver injury and is marked by excessive deposition of extracellular matrix proteins, primarily collagen. This fibrotic remodeling is driven by activation of hepatic stellate…
View article: Ferroptosis in Osteoarthritis: Towards Novel Therapeutic Strategy
Ferroptosis in Osteoarthritis: Towards Novel Therapeutic Strategy Open
Osteoarthritis (OA) is a chronic, degenerative joint disease primarily characterised by damage to the articular cartilage, synovitis and persistent pain, and has become one of the most common diseases worldwide. In OA cartilage, various fo…
View article: Glucosamine mitigates ischemia-reperfusion-induced acute kidney injury through anti-inflammatory mechanisms
Glucosamine mitigates ischemia-reperfusion-induced acute kidney injury through anti-inflammatory mechanisms Open
Objective Acute kidney injury (AKI), a syndrome with high morbidity and mortality worldwide, frequently arises from renal ischemia-reperfusion (I/R) injury, particularly in surgical contexts. Despite extensive research, effective therapies…
View article: Assessing vaginal microbiome through Vaginal Microecology Evaluation System as a predictor for in vitro fertilization outcomes: a retrospective study
Assessing vaginal microbiome through Vaginal Microecology Evaluation System as a predictor for in vitro fertilization outcomes: a retrospective study Open
Objective This study aims to evaluate the effectiveness of the Vaginal Microecology Evaluation System (VMES) in assessing the dynamics of the vaginal microbiome (VM) throughout the process of in vitro fertilization and embryo transfer (IVF…
View article: Meta‐analysis reveals that rheumatoid arthritis is associated with worse clinical outcomes among patients with COVID‐19
Meta‐analysis reveals that rheumatoid arthritis is associated with worse clinical outcomes among patients with COVID‐19 Open
Patients with rheumatoid arthritis (RA) are reported to be more vulnerable to coronavirus disease 2019 (COVID‐19), so clinical severity is a particular concern for them. This meta‐analysis was performed to evaluate the clinical outcomes in…
View article: N-Acetylglucosamine mitigates lung injury and pulmonary fibrosis induced by bleomycin
N-Acetylglucosamine mitigates lung injury and pulmonary fibrosis induced by bleomycin Open
Lung injury and pulmonary fibrosis contribute to morbidity and mortality, and, in particular, are characterized as leading cause on confirmed COVID-19 death. To date, efficient therapeutic approach for such lung diseases is lacking. N-Acet…
View article: Chitosan oligosaccharide attenuates acute kidney injury and renal interstitial fibrosis induced by ischemia-reperfusion
Chitosan oligosaccharide attenuates acute kidney injury and renal interstitial fibrosis induced by ischemia-reperfusion Open
Acute kidney injury (AKI) and renal interstitial fibrosis are global clinical syndromes associated with high morbidity and mortality. Renal ischemia-reperfusion (I/R) injury, which commonly occurs during surgery, is one of the major causes…
View article: Chitosan oligosaccharides attenuate programmed necrosis induced by oxidative stress in spermatogonia cells
Chitosan oligosaccharides attenuate programmed necrosis induced by oxidative stress in spermatogonia cells Open
Oxidative stress (OS) has been considered as the main mediator of male infertility by causing abnormal sperm production and function, and, therefore, exploration of natural antioxidant has attracted a great deal of attention in human repro…
View article: High level of thyroid peroxidase antibodies as a detrimental risk of pregnancy outcomes in euthyroid women undergoing ART: A meta‐analysis
High level of thyroid peroxidase antibodies as a detrimental risk of pregnancy outcomes in euthyroid women undergoing ART: A meta‐analysis Open
Thyroid autoimmunity (TAI) triggered by genetic and epigenetic variation occurs mostly in women of reproductive age. TAI is described mainly by positivity of anti‐thyroid peroxidase antibody (TPO‐Ab) and/or thyroglobulin antibody (TG‐Ab). …
View article: Decoding microRNAs in autism spectrum disorder
Decoding microRNAs in autism spectrum disorder Open
Autism spectrum disorder (ASD)-a congenital mental disorder accompanied by social dysfunction and stereotyped behaviors-has attracted a great deal of attention worldwide. A combination of genetic and environmental factors may determine the…
View article: The Dynamics of the Vaginal Micro-Ecology During in Vitro Fertilization and Embryo Transfer (IVF-ET) Cycles and its Impact on Pregnancy Outcomes
The Dynamics of the Vaginal Micro-Ecology During in Vitro Fertilization and Embryo Transfer (IVF-ET) Cycles and its Impact on Pregnancy Outcomes Open
Background Abnormal reproductive tract flora may cause infertility, and it may play a key role in the success of assisted reproductive technologies (ART). The obvious short-term changes in estrogen caused by clinical protocols with IVF-ET …
View article: Calcium-dependent PKA and PKC activation participate in KA induced MHC-I expression.
Calcium-dependent PKA and PKC activation participate in KA induced MHC-I expression. Open
(A) Two representative cells showed the increased concentration of intracellular calcium soon after adding 100μM KA. Scale bar: 50 μm. (B) Average normalized fluorescence intensity before and after KA (100μM) treatment. Each bar represents…
View article: Neuronal MHC Class I Expression Is Regulated by Activity Driven Calcium Signaling
Neuronal MHC Class I Expression Is Regulated by Activity Driven Calcium Signaling Open
MHC class I (MHC-I) molecules are important components of the immune system. Recently MHC-I have been reported to also play important roles in brain development and synaptic plasticity. In this study, we examine the molecular mechanism(s) …