Yingjiang Ye
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View article: Chinese expert consensus on diagnosis and treatment of small gastrointestinal stromal tumors (2025 edition)
Chinese expert consensus on diagnosis and treatment of small gastrointestinal stromal tumors (2025 edition) Open
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, with malignant potential ranging from very low risk to high risk. Small GISTs, defined as those with measuring <2 cm in greatest …
View article: Disparities in management guidelines for gastrointestinal stromal tumors: A comparison of recommendations from the Chinese Society of Clinical Oncology, National Comprehensive Cancer Network, and European Society for Medical Oncology
Disparities in management guidelines for gastrointestinal stromal tumors: A comparison of recommendations from the Chinese Society of Clinical Oncology, National Comprehensive Cancer Network, and European Society for Medical Oncology Open
Gastrointestinal stromal tumors (GISTs) are the most common soft tissue sarcomas of the gastrointestinal tract, with most cases harboring oncogenic driver mutations in the KIT proto‐oncogene receptor tyrosine kinase ( KIT ) or platelet‐der…
View article: Updates on research and management of gastrointestinal stromal tumors in China
Updates on research and management of gastrointestinal stromal tumors in China Open
This editorial summarizes recent developments in the diagnosis and management of gastrointestinal stromal tumors in China, and highlights differences from Western practices and the growing role of medical oncology in treatment.
View article: Mutational landscape of gastrointestinal stromal tumors using next-generation sequencing of a 73-gene panel
Mutational landscape of gastrointestinal stromal tumors using next-generation sequencing of a 73-gene panel Open
Using a 73-gene panel, we characterized the molecular characteristics of GISTs and revealed a correlation with their clinical features. Moreover, KIT/PDGFRA-dependent and KIT/PDGFRA-independent mechanisms underlying resistance to imatinib …
View article: Metabolite to Modifier: Lactate and Lactylation in the Evolution of Tumors
Metabolite to Modifier: Lactate and Lactylation in the Evolution of Tumors Open
Lactate, once dismissed as a mere by‐product of cancer metabolism, has emerged as a pivotal factor in tumor progression, exerting diverse effects on metabolic reprogramming and immune modulation. Lactate enhances tumor cell adaptability th…
View article: Liver metastasis of colorectal cancer: Mechanism and clinical therapy (Review)
Liver metastasis of colorectal cancer: Mechanism and clinical therapy (Review) Open
Liver metastasis is a common complication in colorectal cancer (CRC), with its presence and progression significantly shortening patient survival. Therefore, a deeper understanding of the underlying mechanisms driving liver metastasis in C…
View article: The prognostic value of immunoscore in the early-onset colorectal cancer
The prognostic value of immunoscore in the early-onset colorectal cancer Open
Immunoscore can serve as a possible indicator in predicting prognosis of patients with early-onset colorectal cancer, but still need large sample research validation.
View article: Effect of intestinal microbiota on the recovery of bowel function for patients undergoing colon surgery: a prospective cohort study
Effect of intestinal microbiota on the recovery of bowel function for patients undergoing colon surgery: a prospective cohort study Open
Purpose This study aimed to investigate the risk factors and gut microbiome characteristics influencing postoperative bowel functional recovery in patients undergoing colorectal surgery. Methods Patients who underwent colorectal surgery be…
View article: Hsa_circ_0000231 Accelerates Cell Autophagy and Promotes Cell Proliferation and Invasion of Colorectal Cancer via miR‐140‐3p/Bcl‐2 Axis
Hsa_circ_0000231 Accelerates Cell Autophagy and Promotes Cell Proliferation and Invasion of Colorectal Cancer via miR‐140‐3p/Bcl‐2 Axis Open
Accumulating evidence indicated that circular RNAs (circRNAs) directly sponge to microRNAs (miRNAs),(miRNAs), which in turn regulate the gene expression and affect the malignancy behavior at the posttranscriptional level. However, the expr…
View article: CXCR2P1 enhances the response of gastric cancer to PD-1 inhibitors through increasing the immune infiltration of tumors
CXCR2P1 enhances the response of gastric cancer to PD-1 inhibitors through increasing the immune infiltration of tumors Open
Background Recent years, immunotherapy has emerged as a pivotal approach in cancer treatment. However, the response of gastric cancer to immunotherapy exhibits significant heterogeneity. Therefore, the early identification of gastric cance…
View article: Prognosis conferred by molecular features of appendix-derived Pseudomyxoma Peritonei
Prognosis conferred by molecular features of appendix-derived Pseudomyxoma Peritonei Open
The study reveals that genomic profiling can serve as a robust tool for identifying prognostic markers in PMP. The identified genomic mutations and signaling pathway offer new avenues for targeted therapies.
View article: Prognostic factors in retroperitoneal liposarcoma after R0 resection: a study of age, histologic type, tumor stage, and differentiation grade
Prognostic factors in retroperitoneal liposarcoma after R0 resection: a study of age, histologic type, tumor stage, and differentiation grade Open
Advanced age, DDLPS, PLS, stage III-IV disease, and poor tumor differentiation were identified as independent predictors of shorter PFS in RPLS patients following R0 resection.
View article: SMOC2high myofibroblastic cancer-associated fibroblast drives primary cilia-associated tumor microenvironment remodeling and poor prognosis in gastric cancer
SMOC2high myofibroblastic cancer-associated fibroblast drives primary cilia-associated tumor microenvironment remodeling and poor prognosis in gastric cancer Open
PCS serves as a robust prognostic biomarker for gastric cancer patients. Additionally, targeting SMOC2 high mCAFs represents a potential therapeutic strategy for patients with high-PCS gastric cancer.
View article: <i>N‐</i>glycosylation Modification of CTSD Affects Liver Metastases in Colorectal Cancer
<i>N‐</i>glycosylation Modification of CTSD Affects Liver Metastases in Colorectal Cancer Open
Liver metastasis is the primary factor contributing to unfavorable prognosis in colorectal cancer (CRC). Although N ‐glycosylation is implicated in metastasis, there is a notable paucity of comprehensive studies addressing the N ‐glycosyla…
View article: A novel liquid-liquid phase separation-related gene signature for predicting prognosis in colon cancer
A novel liquid-liquid phase separation-related gene signature for predicting prognosis in colon cancer Open
Background An increasing body of evidence indicates that dysregulation of liquid-liquid phase separation (LLPS) in cellular processes is implicated in the development of diverse tumors. Nevertheless, the association between LLPS and the pr…
View article: Identification of cancer-associated fibrolast subtypes and distinctive role of MFAP5 in CT-detected extramural venous invasion in gastric cancer
Identification of cancer-associated fibrolast subtypes and distinctive role of MFAP5 in CT-detected extramural venous invasion in gastric cancer Open
Extramural venous invasion (EMVI) detected by computed tomography has been identified as an independent risk factor for distant metastasis in patients with advanced gastric cancer (GC). Cancer-associated fibroblasts (CAFs) are critical for…
View article: AFAP1L1 is indicative for a grim prognosis and immune microenvironment in gastric cancer
AFAP1L1 is indicative for a grim prognosis and immune microenvironment in gastric cancer Open
The biological role of the actin filament associated protein 1 like 1(AFAP1L1) has been investigated in human malignancies, but its function in gastric cancer (GC) is unclear. This research sought to elucidate more about AFAP1L1's biologic…
View article: LAMTOR1 ablation impedes cGAS degradation caused by chemotherapy and promotes antitumor immunity
LAMTOR1 ablation impedes cGAS degradation caused by chemotherapy and promotes antitumor immunity Open
Chemotherapy resistance remains a significant obstacle that limits the long-term efficacy of cancer therapy, necessitating further investigations into the underlying mechanisms. Here, we find that DNA fragments induced by chemotherapeutic …
View article: Overall survival prediction of gastric cancer using the gene signature of CT-detected extramural venous invasion combined with M2 macrophages infiltration
Overall survival prediction of gastric cancer using the gene signature of CT-detected extramural venous invasion combined with M2 macrophages infiltration Open
Our study demonstrated EMVI-M2 gene signature could effectively predict the prognosis of GC tissue, reflecting the relationship between EMVI and M2 macrophages.
View article: Unveiling the impact of glutathione (GSH) and p53 gene deletion on tumor cell metabolism by amino acid and proteomics analysis
Unveiling the impact of glutathione (GSH) and p53 gene deletion on tumor cell metabolism by amino acid and proteomics analysis Open
In conclusion, the concurrent administration of GSH treatment and p53 gene deletion triggers substantial modifications in the amino acid and protein metabolism of tumor cells, primarily characterized by down-regulation. This, in turn, comp…
View article: Therapeutic potentials of FexMoyS-PEG nanoparticles in colorectal cancer: a multimodal approach via ROS-ferroptosis-glycolysis regulation
Therapeutic potentials of FexMoyS-PEG nanoparticles in colorectal cancer: a multimodal approach via ROS-ferroptosis-glycolysis regulation Open
Improving cancer therapy by targeting the adverse tumor microenvironment (TME) rather than the cancer cells presents a novel and potentially effective strategy. In this study, we introduced Fe x Mo y S nanoparticles (NPs), which act as seq…
View article: Machine learning-based prediction models affecting the recovery of postoperative bowel function for patients undergoing colorectal surgeries
Machine learning-based prediction models affecting the recovery of postoperative bowel function for patients undergoing colorectal surgeries Open
Purpose The debate surrounding factors influencing postoperative flatus and defecation in patients undergoing colorectal resection prompted this study. Our objective was to identify independent risk factors and develop prediction models fo…
View article: Incidence, risk factors, and outcomes of the transition of HIPEC-induced acute kidney injury to acute kidney disease: a retrospective study
Incidence, risk factors, and outcomes of the transition of HIPEC-induced acute kidney injury to acute kidney disease: a retrospective study Open
Our study reveals a high incidence of AKI and AKI-to-AKD transition. Early identification of risk factors for HIPEC-induced AKD would assist clinicians in taking measures to mitigate the incidence.