Explanipedia

Brain-wide Genome Editing via STEP-RNPs for Treatment of Angelman Syndrome Open

Xiaona Lu, Jiang Yu, Gretchen Long, Zewei Tu, Jie Tong , et al. · 2025

Brain-wide genome-editing remains a major hurdle for the treatment of neurogenetic disorders. Here, we report a non-viral, non-nanoparticle, chemical modification-based method, called Stimuli-Responsive Traceless Engineering Platform (STEP…

RCC2 and CD24 cooperate to modulate prostate cancer progression through vimentin ubiquitination and β-catenin activation Open

Xuelian Cui, Yicun Wang, Yong Zhang, Zhichao Liu, Haiyan Yu , et al. · 2025

CD24 promotes prostate cancer progression and metastasis by disrupting the ARF-NPM interaction and impairing p53 signaling. However, the mechanisms underlying CD24-driven metastasis remain unclear. This study identifies a novel interaction…

Spatial epigenomic niches underlie glioblastoma cell state plasticity Open

Sam Kint, Subhi Talal Younes, Shuozhen Bao, Gretchen Long, D. J. Wouters , et al. · 2025

SUMMARY IDH -wildtype glioblastoma (GBM) is an aggressive brain tumor with poor survival and few therapeutic options. Transcriptionally-defined cell states coexist in GBM and occupy defined regions of the tumor. Evidence indicates that GBM…

Nanotechnology approaches to drug delivery for the treatment of ischemic stroke Open

Bin Peng, Farrah S. Mohammed, Xiangjun Tang, Jia Liu, Kevin N. Sheth , et al. · 2024

Ischemic stroke is a major global public health concern that lacks effective treatment options. A significant challenge lies in delivering therapeutic agents to the brain due to the restrictive nature of the blood-brain barrier (BBB). The …

CRISPR-based dissection of microRNA-23a ~ 27a ~ 24-2 cluster functionality in hepatocellular carcinoma Open

Mengying Cui, Zhichao Liu, Shuaibin Wang, Sejong Bae, Hua Guo , et al. · 2024

The miR-23a ~ 27a ~ 24-2 cluster, commonly upregulated in diverse cancers, including hepatocellular carcinoma (HCC), raises questions about the specific functions of its three mature miRNAs and their integrated function. Utilizing CRISPR k…

Autocatalytic, Brain Tumor‐Targeting Delivery of Bardoxolone Methyl Self‐Assembled Nanoparticles for Glioblastoma Treatment Open

Zhang Ye, Wendy C. Sheu, Huan Qu, Bin Peng, Jia Liu , et al. · 2024

Glioblastoma Treatment In article number 2400081, Qianxue Chen, Xuan Xiao, Shenqi Zhang, and co-workers developed and validated a novel nanotechnology-based approach for glioblastoma treatment. They synthesized autocatalytic, brain tumor-t…

Cathepsin B Nuclear Flux in a DNA-Guided “Antinuclear Missile” Cancer Therapy Open

Fei Cao, Caroline Tang, Xiaoyong Chen, Zewei Tu, Ying Jin , et al. · 2024

Some antinuclear antibodies (ANAs) bind extracellular nucleic acids released into tumor environments and are pulled into the nuclei of live cancer cells through nucleoside salvage pathways, independent of tumor-specific surface antigens. H…

Autocatalytic, Brain Tumor‐Targeting Delivery of Bardoxolone Methyl Self‐Assembled Nanoparticles for Glioblastoma Treatment Open

Zhang Ye, Wendy C. Sheu, Huan Qu, Bin Peng, Jia Liu , et al. · 2024

Glioblastoma multiforme (GBM) is a formidable cancer to treat due to the lack of effective drugs that can also efficiently cross the blood–brain barrier (BBB). Herein, a novel strategy involving the synthesis of p28 peptide‐conjugated, lex…

VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model Open

Lígia Simões Braga Boisserand, Luiz Henrique Geraldo, Jean Bouchart, Marie-Renée El Kamouh, Seyoung Lee , et al. · 2024

Meningeal lymphatic vessels (MLVs) promote tissue clearance and immune surveillance in the central nervous system (CNS). Vascular endothelial growth factor-C (VEGF-C) regulates MLV development and maintenance and has therapeutic potential …

Compartmentalized ocular lymphatic system mediates eye–brain immunity Open

Xiangyun Yin, Sophia Zhang, Ju-Hyun Lee, Huiping Dong, George Mourgkos , et al. · 2024

The eye, an anatomical extension of the central nervous system (CNS), exhibits many molecular and cellular parallels to the brain. Emerging research demonstrates that changes in the brain are often reflected in the eye, particularly in the…

CRISPR-Based Dissection of microRNA-23a~27a~24-2 Cluster Functionality in Hepatocellular Carcinoma Open

Lizhong Wang, Mengying Cui, Zhichao Liu, Shuaibin Wang, Sejong Bae , et al. · 2024

The miR-23a ~ 27a ~ 24 − 2 cluster, commonly upregulated in diverse cancers, including hepatocellular carcinoma (HCC), raises questions about the specific functions of its three mature miRNAs and their integrated function. Utilizing CRISPR…

Correction: pH-Responsive fluorescent graphene quantum dots for fluorescence-guided cancer surgery and diagnosis Open

Zetan Fan, Shixin Zhou, César A. Garcia, Louzhen Fan, Jiangbing Zhou · 2024

Correction for ‘pH-Responsive fluorescent graphene quantum dots for fluorescence-guided cancer surgery and diagnosis’ by Zetan Fan et al. , Nanoscale , 2017, 9 , 4928–4933, https://doi.org/10.1039/C7NR00888K.

<span>Self‐Assembled</span> nanoparticles of natural bioactive molecules enhance the delivery and efficacy of paclitaxel in glioblastoma Open

Yong Li, Qingyu Zhao, Xinyi Zhu, Long Zhou, Ping Song , et al. · 2023

Background Glioblastoma (GBM) is the most common primary malignant tumor in the central nervous system. Paclitaxel (PTX) is a well‐established and highly effective anti‐cancer drug for peripheral solid tumors. However, the application of P…

A PILOT STUDY: SPATIOTEMPORALLY-RESOLVED MOLECULAR MECHANISMS OF ACUTE IMMUNE AND NEUROMODULATORY RESPONSES TO TRAUMATIC BRAIN INJURY Open

Farrah S. Mohammed, Declan McGuone, Sacit Bulent Omay, Zeynep Erson Omay, Jiangbing Zhou · 2023

VEGF-C promotes brain-derived fluid drainage, confers neuroprotection, and improves stroke outcomes Open

Lígia Simões Braga Boisserand, Jean Bouchart, Luiz Henrique Geraldo, Seyoung Lee, Basavaraju G. Sanganahalli , et al. · 2023

Meningeal lymphatic vessels promote tissue clearance and immune surveillance in the central nervous system (CNS). Vascular endothelium growth factor-C (VEGF-C) is essential for meningeal lymphatic development and maintenance and has therap…

cGAS-activating lupus autoantibody for cancer immunotherapy Open

Xiaoyong Chen, Xiangjun Tang, Benedette J. Cuffari, Caroline Tang, Xingchun Gao , et al. · 2023

Cytoplasmic DNA triggers a cGAS-mediated signaling cascade that promotes an innate immune response and is potentially actionable in cancer immunotherapy. Here we show that a cytoplasmic-localizing lupus anti-DNA autoantibody activates cGAS…

Nanoparticle-based drug delivery for the treatment of traumatic brain injury Open

Farrah S. Mohammed, Sacit Bulent Omay, Kevin N. Sheth, Jiangbing Zhou · 2022

Nanoparticles are well suited to improve secondary outcomes as their multifunctionality and customizability enhance their potential for efficient targeted delivery, payload protection, increased brain penetration, low off-target toxicity, …

Targeted Delivery of Chemo‐Sonodynamic Therapy via Brain Targeting, Glutathione‐Consumable Polymeric Nanoparticles for Effective Brain Cancer Treatment Open

Haoan Wu, Xingchun Gao, Yuanyuan Luo, Jiang Yu, Gretchen Long , et al. · 2022

Glioblastoma (GBM) is the most aggressive tumor of the central nervous system and remains universally lethal due to lack of effective treatment options and their inefficient delivery to the brain. Here the development of multifunctional po…

Cross-platform analysis reveals cellular and molecular landscape of glioblastoma invasion Open

Ann T. Chen, Yang Xiao, Xiangjun Tang, Mehdi Baqri, Xingchun Gao , et al. · 2022

Background Improved treatment of glioblastoma (GBM) needs to address tumor invasion, a hallmark of the disease that remains poorly understood. In this study, we profiled GBM invasion through integrative analysis of histological and single-…

Inhibition of NETosis by a Nuclear-Penetrating Anti-DNA Autoantibody Open

Xiaoyong Chen, Benedette J. Cuffari, Valentina Dubljevic, Anupama Shirali, Jiangbing Zhou , et al. · 2022

Nuclear-penetrating anti-DNA autoantibodies have therapeutic potential as delivery agents and in targeting DNA and the DNA damage response (DDR). Derivatives of such Abs have advanced to human testing in genetic disease and are in preparat…

Topical Capsaicin in Poly(lactic-co-glycolic)acid (PLGA) Nanoparticles Decreases Acute Itch and Heat Pain Open

Nathalie M. Malewicz, Zahra Rattray, Sebastian Oeck, Sebastian Jung, Vicente Escamilla‐Rivera , et al. · 2022

Background: Capsaicin, the hot pepper agent, produces burning followed by desensitization. To treat localized itch or pain with minimal burning, low capsaicin concentrations can be repeatedly applied. We hypothesized that alternatively con…

The microRNA-3622 family at the 8p21 locus exerts oncogenic effects by regulating the p53-downstream gene network in prostate cancer progression Open

Yue Zhang, Zhifang Xu, Wen Wen, Zhichao Liu, Chao Zhang , et al. · 2022

ZNF117 regulates glioblastoma stem cell differentiation towards oligodendroglial lineage Open

Jun Liu, Xiaoying Wang, Ann T. Chen, Xingchun Gao, Benjamin Himes , et al. · 2022

Glioblastoma (GBM) is a deadly disease without effective treatment. Because glioblastoma stem cells (GSCs) contribute to tumor resistance and recurrence, improved treatment of GBM can be achieved by eliminating GSCs through inducing their …

Epigenetic regulation of EIF4A1 through DNA methylation and an oncogenic role of eIF4A1 through BRD2 signaling in prostate cancer Open

Chao Wang, Jonathan D. Leavenworth, Chao Zhang, Zhichao Liu, Katherine Y. Yuan , et al. · 2022

Brain Targeting, Antioxidant Polymeric Nanoparticles for Stroke Drug Delivery and Therapy Open

Haoan Wu, Bin Peng, Farrah S. Mohammed, Xingchun Gao, Zhenpeng Qin , et al. · 2022

Ischemic stroke is a leading cause of death and disability and remains without effective treatment options. Improved treatment of stroke requires efficient delivery of multimodal therapy to ischemic brain tissue with high specificity. Here…

Preclinical Models of Brain Metastases in Breast Cancer Open

Natasha N. Knier, Sierra Pellizzari, Jiangbing Zhou, Paula J. Foster, Armen Parsyan · 2022

Breast cancer remains a leading cause of mortality among women worldwide. Brain metastases confer extremely poor prognosis due to a lack of understanding of their specific biology, unique physiologic and anatomic features of the brain, and…

Brain-targeting, acid-responsive antioxidant nanoparticles for stroke treatment and drug delivery Open

Shenqi Zhang, Bin Peng, Zeming Chen, Jiang Yu, Gang Deng , et al. · 2022

Author Correction: Targeted tumour theranostics in mice via carbon quantum dots structurally mimicking large amino acids Open

Shuhua Li, Wen Su, Hao Wu, Ting Yuan, Chang Yuan , et al. · 2022

Betulinic acid self-assembled nanoparticles for effective treatment of glioblastoma Open

Yong Li, Yixuan Wang, Lun Gao, Yinqiu Tan, Jiayang Cai , et al. · 2022

Targeted disruption of tumor vasculature via polyphenol nanoparticles to improve brain cancer treatment Open

Fuyao Liu, Bin Peng, Miao Li, Junning Ma, Gang Deng , et al. · 2021

Despite being effective for many other solid tumors, traditional anti-angiogenic therapy has been shown to be insufficient for the treatment of malignant glioma. Here, we report the development of polyphenol nanoparticles (NPs), which not …

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