Jingying Xu
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View article: Dynein‐Dependent Endo‐Lysosomal Degradation Drives Lewy Body Disorders Accompanied by Aβ Pathology
Dynein‐Dependent Endo‐Lysosomal Degradation Drives Lewy Body Disorders Accompanied by Aβ Pathology Open
Dementia with Lewy bodies (DLB) is a significant cause of dementia. However, the limited availability of animal and cellular models that accurately replicate early DLB pathogenesis hampers the understanding of how Aβ plaques influence α‐sy…
View article: Naphthalene Metabolites From Long‐Term Environmental Tobacco Smoke Induce the Aging of Retinal Pigment Epithelium
Naphthalene Metabolites From Long‐Term Environmental Tobacco Smoke Induce the Aging of Retinal Pigment Epithelium Open
Tobacco use is the main source of indoor air pollution and contains a variety of toxic components. The smoke from burning cigarettes is a key environmental risk factor that leads to accelerated aging and the occurrence of numerous diseases…
View article: PHOSPHO1 Suppresses Ferroptosis in Retinal Pigment Epithelial Cells by Reducing the Levels of Phosphatidylethanolamine Molecular Species
PHOSPHO1 Suppresses Ferroptosis in Retinal Pigment Epithelial Cells by Reducing the Levels of Phosphatidylethanolamine Molecular Species Open
Iron‐induced lipid peroxidation of phosphatidylethanolamine (PE) species is a key driver of ferroptosis in retinal pigment epithelial (RPE) cells, a process closely associated with age‐related macular degeneration (AMD). The previous studi…
View article: Impact of Atrazine on Sucrose Sensitivity in Honey Bees
Impact of Atrazine on Sucrose Sensitivity in Honey Bees Open
Honey bees (Apis mellifera) are essential pollinators, responsible for the pollination of over 80% of crops and flowering plants globally. However, there is concern that the extensive use of pesticides, particularly atrazine, can harm poll…
View article: Novel integrative models to predict the severity of inflammation and fibrosis in patients with drug-induced liver injury
Novel integrative models to predict the severity of inflammation and fibrosis in patients with drug-induced liver injury Open
Background and aims Drug-induced liver injury (DILI) is becoming a worldwide emerging problem. However, few studies focus on the diagnostic performance of non-invasive markers in DILI. This study aims to develop novel integrative models to…
View article: Unraveling the role of CRX as a potent intrinsic suppressor of epithelial-mesenchymal transition in retinal pigment epithelial cells
Unraveling the role of CRX as a potent intrinsic suppressor of epithelial-mesenchymal transition in retinal pigment epithelial cells Open
The epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells is one of the significant pathogenic mechanisms for the formation of subretinal fibrosis in age-related macular degeneration (AMD). Multiple signaling pa…
View article: DNA-Dependent Protein Kinase Catalytic Subunit Prevents Ferroptosis in Retinal Pigment Epithelial Cells
DNA-Dependent Protein Kinase Catalytic Subunit Prevents Ferroptosis in Retinal Pigment Epithelial Cells Open
The present study elucidates that the key DDR kinase DNA-PKcs is activated and plays protective role during ferroptosis in RPE cells in vitro, which will provide new research targets and strategies for inhibiting ferroptosis in RPE cells.
View article: Knockdown of HSPA13 Inhibits TGFβ1-Induced Epithelial-Mesenchymal Transition of RPE by Suppressing the PI3K/Akt Signaling Pathway
Knockdown of HSPA13 Inhibits TGFβ1-Induced Epithelial-Mesenchymal Transition of RPE by Suppressing the PI3K/Akt Signaling Pathway Open
Our study revealed the involvement of HSPA13 in PVR development, as well as in TGFβ1-induced EMT of RPE through the PI3K/Akt signaling pathway. Targeting HSPA13-related pathways involved in regulating EMT in RPE cells could serve as a nove…
View article: Correction to “Diminishing Ethylbenzene in Methylation of Benzene with Methanol: Disentanglement of Methanol to Olefin Reactions over MFI Gallium Silicate”
Correction to “Diminishing Ethylbenzene in Methylation of Benzene with Methanol: Disentanglement of Methanol to Olefin Reactions over MFI Gallium Silicate” Open
ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Diminishing Ethylbenzene in Methylation of Benzene with Methanol: Disentanglement of Methanol to Olefin Reactions over MFI Ga…
View article: Case Report: An Imported Case of Typhoid Fever Combined with Rhabdomyolysis and Multiple Organ Lesions in China
Case Report: An Imported Case of Typhoid Fever Combined with Rhabdomyolysis and Multiple Organ Lesions in China Open
Here, we report a case of blood culture-confirmed typhoid fever, rhabdomyolysis, and multiple organ damage that arrived in our country from overseas. A 23-year-old male patient presented at our hospital with fever and muscle pain; the cond…
View article: Correction: Wu et al. Tumor-Suppressor Gene Transmembrane Protein 98 Promotes Proliferation and Inhibits Apoptosis in Ovarian Cancer. Frontiers in Bioscience-Landmark. 2022; 27: 210.
Correction: Wu et al. Tumor-Suppressor Gene Transmembrane Protein 98 Promotes Proliferation and Inhibits Apoptosis in Ovarian Cancer. Frontiers in Bioscience-Landmark. 2022; 27: 210. Open
The authors wish to make the following corrections to this paper [1]: 1. In the Materials and Methods, Cell Growth Assay section, ‘OD values were determined after 24, 48, 72, and 96 hours to evaluate cell growth’ should instead read ‘OD va…
View article: Subconjunctival injection of human umbilical cord mesenchymal stem cells alleviates experimental allergic conjunctivitis via regulating T cell response
Subconjunctival injection of human umbilical cord mesenchymal stem cells alleviates experimental allergic conjunctivitis via regulating T cell response Open
Background T helper 2 (Th2) cells are thought to play critical roles in allergic conjunctivitis (AC). They release inflammatory cytokines to promote an allergic response in AC. Due to individual heterogeneity and long-term chronic manageme…
View article: Surface morphology and action mechanism of macrophage immunostimulating activity of Rosa Setate x Rosa Rugosa polysaccharide WSRP-1b
Surface morphology and action mechanism of macrophage immunostimulating activity of Rosa Setate x Rosa Rugosa polysaccharide WSRP-1b Open
Our previous research demonstrated that the glucomannan WSRP-1b, which was obtained from waste biomass of Rosa Setate x Rosa Rugosa, had potent immunostimulatory activity. However, the specific mechanisms involved in the activation of RAW2…
View article: Glia maturation factor beta deficiency protects against diabetic osteoporosis by suppressing osteoclast hyperactivity
Glia maturation factor beta deficiency protects against diabetic osteoporosis by suppressing osteoclast hyperactivity Open
Excessive osteoclast activation, which depends on dramatic changes in actin dynamics, causes osteoporosis (OP). The molecular mechanism of osteoclast activation in OP related to type 1 diabetes (T1D) remains unclear. Glia maturation factor…
View article: Supplementary Methods, Tables 1 - 2 from <i>PID1</i> (<i>NYGGF4</i>), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas
Supplementary Methods, Tables 1 - 2 from <i>PID1</i> (<i>NYGGF4</i>), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas Open
PDF file - 440K, Supplemental Table 1: Characteristics of the CHLA Medulloblastoma Patients. Supplemental Table 2: Neural and Proneural GBM subgroups have higher PID1 mRNA compared to Classical and Mesenchymal.
View article: Supplementary Figure 5 from <i>PID1</i> (<i>NYGGF4</i>), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas
Supplementary Figure 5 from <i>PID1</i> (<i>NYGGF4</i>), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas Open
PDF file 92K, Supplemental Fig 5: Expression of PID1 protein in human brain tumors and cell lines
View article: Data from <i>PID1</i> (<i>NYGGF4</i>), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas
Data from <i>PID1</i> (<i>NYGGF4</i>), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas Open
Purpose: We present here the first report of PID1 (Phosphotyrosine Interaction Domain containing 1; NYGGF4) in cancer. PID1 was identified in 2006 as a gene that modulates insulin signaling and mitochondrial function in adipocytes and musc…
View article: Supplementary Figure 2 from <i>PID1</i> (<i>NYGGF4</i>), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas
Supplementary Figure 2 from <i>PID1</i> (<i>NYGGF4</i>), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas Open
PDF file - 190K, Supplemental Fig 2: Proneural and Neural GBMs have higher PID1 mRNA; higher PID1 mRNA correlates with higher OS in patients with gliomas.
View article: Supplementary Figure 4 from <i>PID1</i> (<i>NYGGF4</i>), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas
Supplementary Figure 4 from <i>PID1</i> (<i>NYGGF4</i>), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas Open
PDF file - 17K, Supplemental Fig 4: PID1 increases the proportion of cells in Sub G0/G1 in CHLA-259 medulloblastoma cells.
View article: Supplementary Figure 3 from <i>PID1</i> (<i>NYGGF4</i>), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas
Supplementary Figure 3 from <i>PID1</i> (<i>NYGGF4</i>), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas Open
PDF file - 42K, Supplemental Fig 3: PID1 also inhibits colony formation using two other plasmid expression vectors.
View article: Supplementary Figure 6 from <i>PID1</i> (<i>NYGGF4</i>), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas
Supplementary Figure 6 from <i>PID1</i> (<i>NYGGF4</i>), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas Open
PDF file - 25K, Supplemental Fig 6: PID1 diminishes phosphorylation of AKT and ERK in D283MED medulloblastoma cells grown in presence of serum.
View article: Supplementary Figure 4 from <i>PID1</i> (<i>NYGGF4</i>), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas
Supplementary Figure 4 from <i>PID1</i> (<i>NYGGF4</i>), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas Open
PDF file - 17K, Supplemental Fig 4: PID1 increases the proportion of cells in Sub G0/G1 in CHLA-259 medulloblastoma cells.
View article: Supplementary Figure 1 from <i>PID1</i> (<i>NYGGF4</i>), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas
Supplementary Figure 1 from <i>PID1</i> (<i>NYGGF4</i>), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas Open
PDF file - 159K, Supplemental Fig 1: PID1 mRNA is lower in less favorable medulloblastomas in two additional independent datasets; PID1 mRNA correlates with rf-PFS when analyzing CHLA medulloblastomas by tertiles.
View article: Supplementary Methods, Tables 1 - 2 from <i>PID1</i> (<i>NYGGF4</i>), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas
Supplementary Methods, Tables 1 - 2 from <i>PID1</i> (<i>NYGGF4</i>), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas Open
PDF file - 440K, Supplemental Table 1: Characteristics of the CHLA Medulloblastoma Patients. Supplemental Table 2: Neural and Proneural GBM subgroups have higher PID1 mRNA compared to Classical and Mesenchymal.
View article: Supplementary Figure 3 from <i>PID1</i> (<i>NYGGF4</i>), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas
Supplementary Figure 3 from <i>PID1</i> (<i>NYGGF4</i>), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas Open
PDF file - 42K, Supplemental Fig 3: PID1 also inhibits colony formation using two other plasmid expression vectors.