Jianghui Tang
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View article: Fibrosis Impairs cGAS-Mediated Responses to Immunotherapy in Advanced HCC
Fibrosis Impairs cGAS-Mediated Responses to Immunotherapy in Advanced HCC Open
Hepatocellular carcinoma (HCC) management is challenging due to its heterogeneous tumor microenvironment and poor treatment responses. To develop personalized approaches, we conducted a clinical trial of transarterial chemoembolization (TA…
View article: Protocol for isolating single cells from human pancreatic cancer tissues and analyzing major immune cell populations using flow cytometry
Protocol for isolating single cells from human pancreatic cancer tissues and analyzing major immune cell populations using flow cytometry Open
Here, we present a protocol for collecting, dissociating, isolating, staining, and analyzing immune cells from pancreatic cancer tissues for flow cytometry. The isolated cells can also be used for single-cell RNA sequencing and other relat…
View article: Effect of topographic comparison of electroencephalographic microstates on the diagnosis and prognosis prediction of patients with prolonged disorders of consciousness
Effect of topographic comparison of electroencephalographic microstates on the diagnosis and prognosis prediction of patients with prolonged disorders of consciousness Open
Aims The electroencephalography (EEG) microstates are indicative of fundamental information processing mechanisms, which are severely damaged in patients with prolonged disorders of consciousness (pDoC). We aimed to improve the topographic…
View article: Multi-omics analysis reveals the chemoresistance mechanism of proliferating tissue-resident macrophages in PDAC via metabolic adaptation
Multi-omics analysis reveals the chemoresistance mechanism of proliferating tissue-resident macrophages in PDAC via metabolic adaptation Open
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer that typically demonstrates resistance to chemotherapy. Tumor-associated macrophages (TAMs) are essential in tumor microenvironment (TME) regulation, including promoting che…
View article: Runx3-overexpression cooperates with ex vivo AKT inhibition to generate receptor-engineered T cells with better persistence, tumor-residency, and antitumor ability
Runx3-overexpression cooperates with ex vivo AKT inhibition to generate receptor-engineered T cells with better persistence, tumor-residency, and antitumor ability Open
Background Solid tumors pose unique roadblocks to treatment with chimeric antigen receptor (CAR) T cells, including limited T-cell persistence, inefficient tumor infiltration, and an immunosuppressive tumor microenvironment. To date, attem…
View article: Recent Advancements of Nanotechnology-Based Strategies for Overcoming Tumor Microenvironment Hypoxia
Recent Advancements of Nanotechnology-Based Strategies for Overcoming Tumor Microenvironment Hypoxia Open
Hypoxia is a typical characteristic of most solid malignancies, which has multiple effects on malignant phenotypes and biological behaviors of tumors including epithelial-mesenchymal-transition (EMT), invasion, migration, metastasis, autop…
View article: Human endogenous retrovirus activation contributes to biliary atresia pathogenesis through re-education of resident macrophages
Human endogenous retrovirus activation contributes to biliary atresia pathogenesis through re-education of resident macrophages Open
Biliary atresia (BA) is a life-threatening neonatal fibro-inflammatory disease characterized by hepatic fibrosis, cirrhosis, and end-stage liver failure. BA is also the most frequent indication of pediatric liver transplantation globally. …
View article: Selective oxidative protection leads to tissue topological changes orchestrated by macrophage during ulcerative colitis
Selective oxidative protection leads to tissue topological changes orchestrated by macrophage during ulcerative colitis Open
Background and Aims: Ulcerative colitis(UC) is a chronic inflammatory bowel disorder with highly cellular heterogeneity. Mass cytometry(Cy-TOF) and single-cell RNA sequencing (scRNA-seq) have revealed cellular heterogeneity of UC. However,…