Jingguo Zhou
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View article: Whole body MondoA deletion protects against diet-induced obesity through uncontrolled multi-organ substrate utilization and futile cycling
Whole body MondoA deletion protects against diet-induced obesity through uncontrolled multi-organ substrate utilization and futile cycling Open
Objective Delineating the nodal control points that maintain whole-body energy homeostasis is critical for understanding potential treatments of obesity and cardiometabolic diseases. The nutrient-sensing transcription factor MondoA is a re…
View article: Apnea and hypopnea event detection using EEG, EMG, and sleep stage labels in a cohort of patients with suspected sleep apnea
Apnea and hypopnea event detection using EEG, EMG, and sleep stage labels in a cohort of patients with suspected sleep apnea Open
Automating the screening, diagnosis, and monitoring of sleep apnea (SA) is potentially clinically useful. We present machine-learning models which detect SA and hypopnea events from the overnight electroencephalogram (EEG) and electromyogr…
View article: Related Factors and Risk Prediction of Chronic Pain after Knee Replacement
Related Factors and Risk Prediction of Chronic Pain after Knee Replacement Open
AIM: This study aimed to explore potential risk factors associated with chronic pain after total knee arthroplasty (TKA) and to establish the risk prediction model of chronic postoperative pain (CPSP). METHODS: This study retrospectively a…
View article: Analysis of Risk Factors for Changes in The Doppler Echocardiographic Indexes of Patients With Gout
Analysis of Risk Factors for Changes in The Doppler Echocardiographic Indexes of Patients With Gout Open
Objective: The analysis of risk factors for changes in the Doppler echocardiographic indexes of patients with gout with different serum uric acid (SUA) levels were explored to provide clinical evidence for the early diagnosis and treatment…
View article: Doppler Ultrasound Study on the Effects of Different Blood Uric Acid Levels on the Carotid Artery Intima-media Thickness in Patients with Gout
Doppler Ultrasound Study on the Effects of Different Blood Uric Acid Levels on the Carotid Artery Intima-media Thickness in Patients with Gout Open
Objective : Doppler ultrasonography is used to study the effects of different serum uric acid (SUA) levels in primary gout (PG) on the carotid artery intima-media thickness (CIMT) and its risk factors and to provide clinical evidence for e…
View article: microRNA-223 Deficiency Exacerbates Acute Inflammatory Response to Monosodium Urate Crystals by Targeting NLRP3
microRNA-223 Deficiency Exacerbates Acute Inflammatory Response to Monosodium Urate Crystals by Targeting NLRP3 Open
MiR-223 was down-regulated in gout patients and miR-223 deficiency exacerbated inflammatory response in diverse murine models, suggesting that up-regulation of miR-223 could be a potential therapeutic strategy for alleviating gouty inflamm…
View article: Prevalence, genetic diversity and implications for public health of Enterocytozoon bieneusi in various rodents from Hainan Province, China
Prevalence, genetic diversity and implications for public health of Enterocytozoon bieneusi in various rodents from Hainan Province, China Open
Rodents, globally overpopulated, are important source for zoonotic disease transmission to humans, including Enterocytozoon bieneusi (one of the most prevalent zoonotic pathogen). Here, we studied the prevalence and performed genetic analy…
View article: Molecular detection of <i>Enterocytozoon bieneusi</i> in farm-raised pigs in Hainan Province, China: infection rates, genotype distributions, and zoonotic potential
Molecular detection of <i>Enterocytozoon bieneusi</i> in farm-raised pigs in Hainan Province, China: infection rates, genotype distributions, and zoonotic potential Open
Enterocytozoon bieneusi is a zoonotic fungal pathogen with a high degree of host diversity that can parasitize many animals, including humans. Pigs may play an important role in the epidemiology of E. bieneusi as reservoir hosts. Neverthel…
View article: Inhibition of Triggering Receptor Expressed on Myeloid Cell-1 Alleviates Acute Gouty Inflammation
Inhibition of Triggering Receptor Expressed on Myeloid Cell-1 Alleviates Acute Gouty Inflammation Open
Gout is a prevalent form of aseptic inflammation caused by the deposition of monosodium urate (MSU) crystals in joints or tissues. Triggering receptor expressed on myeloid cell-1 (TREM-1) is a superimmunoglobulin receptor expressed on inna…
View article: Aberrant expression of long non‑coding RNAs in peripheral blood mononuclear cells isolated from patients with gouty arthritis
Aberrant expression of long non‑coding RNAs in peripheral blood mononuclear cells isolated from patients with gouty arthritis Open
Gouty arthritis (GA) is the most common inflammatory and immune-associated disease, and its prevalence and incidence exhibit yearly increases. The aim of the present study was to analyse the expression profile variation of long non-coding …
View article: Downregulation of Transcription Factor T-Bet as a Protective Strategy in Monosodium Urate-Induced Gouty Inflammation
Downregulation of Transcription Factor T-Bet as a Protective Strategy in Monosodium Urate-Induced Gouty Inflammation Open
Gout is sterile joint inflammation triggered by the damaging effects of monosodium urate (MSU) crystals accumulation. Previous studies suggest transcription factor T-bet plays an important role in inflammatory arthritis. Notably, mice lack…
View article: Systemic lupus erythematosus complicated by noncirrhotic portal hypertension: A case report and review of literature
Systemic lupus erythematosus complicated by noncirrhotic portal hypertension: A case report and review of literature Open
A 48 year-old Chinese woman suffering from polyarthritis, irregular fever and trichomadesis was admitted to the hospital. A diagnosis of systemic lupus erythematosus (SLE) was made based on polyarthritis, pancytopenia, reduced complement 3…
View article: Glassy carbon electrode modified with G‑MoS2‑Nafion acts as an electrochemical biosensor to determine uric acid in human serum
Glassy carbon electrode modified with G‑MoS2‑Nafion acts as an electrochemical biosensor to determine uric acid in human serum Open
At present, the majority of methods used for uric acid (UA) detection are not able to meet the detection requirements with speed, accuracy, high sensitivity, high specificity, a wide linear range or a low cost. Compared with other methods,…
View article: Mice with miR-146a deficiency develop severe gouty arthritis via dysregulation of TRAF 6, IRAK 1 and NALP3 inflammasome
Mice with miR-146a deficiency develop severe gouty arthritis via dysregulation of TRAF 6, IRAK 1 and NALP3 inflammasome Open
Collectively, these observations suggest that miR-146a provides negative feedback regulation of gouty arthritis development and lack of miR-146a enhances gouty arthritis via upregulation of TRAK6, IRAK-1, and the NALP3 inflammasome functio…
View article: Invariant Natural Killer T Cells Ameliorate Monosodium Urate Crystal-Induced Gouty Inflammation in Mice
Invariant Natural Killer T Cells Ameliorate Monosodium Urate Crystal-Induced Gouty Inflammation in Mice Open
Gout is an inflammatory arthritis caused by deposition of intra-articular monosodium urate (MSU) crystal. Previous studies have focused on resident macrophage, infiltrating monocyte, and neutrophil responses to MSU crystal; yet the mechani…
View article: Association of DNA methyltransferase polymorphisms with susceptibility to primary gouty arthritis
Association of DNA methyltransferase polymorphisms with susceptibility to primary gouty arthritis Open
Gouty arthritis is the most common type of inflammatory and immune disease, and the prevalence and incidence of gout increases annually. Genetic variations in the DNA methyltransferases (DNMTs) gene have not, to the best of our knowledge, …