Jianglan Long
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View article: Gut-initiated mucosal and systemic immunity against SARS-CoV-2 via an oral hyaluronic acid/chitosan vaccine coacervate
Gut-initiated mucosal and systemic immunity against SARS-CoV-2 via an oral hyaluronic acid/chitosan vaccine coacervate Open
Conventional intramuscular vaccines are unable to elicit robust mucosal immunity which is essential for preventing respiratory pathogens like SARS-CoV-2. To overcome this limitation, we developed an oral delivery platform based on coacerva…
View article: Roseburia hominis enriched by baicalin reverses the non-response to metformin via upregulating linolenic acid metabolism
Roseburia hominis enriched by baicalin reverses the non-response to metformin via upregulating linolenic acid metabolism Open
Metformin is the most commonly used hypoglycemic drug for patients with type 2 diabetes (T2D), but about 30% of patients show non-response potentially linked to gut microbiota imbalance. Although baicalin exhibits potent gut microbiota-mod…
View article: Safety and Immunogenicity of aerosolized adenovirus-vectored COVID-19 vaccine and intramuscular mRNA vaccine bivalent boosters: a randomized open-label clinical trial
Safety and Immunogenicity of aerosolized adenovirus-vectored COVID-19 vaccine and intramuscular mRNA vaccine bivalent boosters: a randomized open-label clinical trial Open
Both SARS-CoV-2 mRNA and mucosal vaccines induce protective immunity against COVID-19 but showed different immune profiles. We conducted a longitudinal head-to-head analysis of the safety and immunogenicity of the aerosolized adenovirus-ve…
View article: MTA‐TST Axis‐Mediated Apoptosis Activation: A Multi‐Omics Insight Into High‐Protein Diet's Anti‐Adiposity Effect
MTA‐TST Axis‐Mediated Apoptosis Activation: A Multi‐Omics Insight Into High‐Protein Diet's Anti‐Adiposity Effect Open
To explore the mechanism of a high‐protein diet (named high protein and rich fat diet, HPRFD) with weight loss effect regulating visceral fat metabolism through endogenous metabolites. Non‐targeted metabonomics compared the spectrum of dif…
View article: Microbial succinate promotes the response to metformin by upregulating secretory immunoglobulin a in intestinal immunity
Microbial succinate promotes the response to metformin by upregulating secretory immunoglobulin a in intestinal immunity Open
Metformin is the first-line pharmacotherapy for type 2 diabetes mellitus; however, many patients respond poorly to this drug in clinical practice. The potential involvement of microbiota-mediated intestinal immunity and related signals in …
View article: Uncovering the key pharmacodynamic material basis and possible molecular mechanism of Xiaoke formulation improve insulin resistant through a comprehensive investigation
Uncovering the key pharmacodynamic material basis and possible molecular mechanism of Xiaoke formulation improve insulin resistant through a comprehensive investigation Open
The key pharmacodynamic material basis of XKF, such as berberine and its metabolites (berberrubine and demethyleneberberine), chlorogenic acid and its metabolites (3-O-feruloylquinic acid and 5-O-feruloylquinic acid), calycosin and swertia…
View article: Novel weight loss diet attenuates dietary-induced obesity in mice and might correlate with altered gut microbiota and metabolite profiles
Novel weight loss diet attenuates dietary-induced obesity in mice and might correlate with altered gut microbiota and metabolite profiles Open
Although many dietary patterns have been studied for weight loss, various limitations still exist. Therefore, we designed a novel weight loss diet (NWLD) with carbohydrate, protein, and fat (energy) contents of 45%, 20%, and 35%, respectiv…
View article: Polystyrene microplastic exposure induces insulin resistance in mice via dysbacteriosis and pro-inflammation
Polystyrene microplastic exposure induces insulin resistance in mice via dysbacteriosis and pro-inflammation Open
Microplastics (MPs) as emerging contaminants have become a global environmental problem. However, studies on the effects of MPs on metabolic diseases remain limited. Here, we evaluated the effects of polystyrene (PS), one of the most promi…
View article: Network pharmacology‐based dissection of the underlying mechanisms of dyspnoea induced by zedoary turmeric oil
Network pharmacology‐based dissection of the underlying mechanisms of dyspnoea induced by zedoary turmeric oil Open
Zedoary turmeric oil (ZTO) has been widely used in clinic. However, the unpleasant induced dyspnoea inevitably impedes its clinical application. Thus, it is urgent to elucidate the mechanism underlying the ZTO‐induced dyspnoea. In this stu…
View article: Metabolomics based plasma biomarkers for diagnosis of oral squamous cell carcinoma and oral erosive lichen planus
Metabolomics based plasma biomarkers for diagnosis of oral squamous cell carcinoma and oral erosive lichen planus Open
Backgrounds: To identify diagnostic biomarkers for differentiating oral squamous cell carcinoma (OSCC) from oral erosive lichen planus (OELP) and investigate potential biomarkers associated with malignant transformation. Methods: In this s…
View article: Lipophagy: A New Perspective of Natural Products in Type 2 Diabetes Mellitus Treatment
Lipophagy: A New Perspective of Natural Products in Type 2 Diabetes Mellitus Treatment Open
Autophagy has been reported to involve in the pathogenesis of type 2 diabetes mellitus (T2DM), which protects the insulin target tissues and pancreatic β-cells. However, autophagy is inhibited when the cells are lipid overload. That, in tu…
View article: Integrated biomarker profiling of the metabolome associated with impaired fasting glucose and type 2 diabetes mellitus in large‐scale Chinese patients
Integrated biomarker profiling of the metabolome associated with impaired fasting glucose and type 2 diabetes mellitus in large‐scale Chinese patients Open
Dear Editor, Type 2 diabetes mellitus (T2DM) is an important cause of diabetes complications and mortality.1 The prevalence of prediabetes including impaired fasting glucose (IFG) is approximately one-third of the population in China,2 but…
View article: Author response for "Integrated biomarker for type 2 ddiffereiabetes mellitus and impaired fasting glucose based on metabolomics analysis using UHPLC/Q‐Orbitrap‐HRMS"
Author response for "Integrated biomarker for type 2 ddiffereiabetes mellitus and impaired fasting glucose based on metabolomics analysis using UHPLC/Q‐Orbitrap‐HRMS" Open
Rationale The prevalence of type 2 diabetes mellitus (T2DM) is increasing but its early diagnosis in high risk populations remains challenging using only fasting blood glucose (FBG) or hemoglobin A1c measurements. It is, therefore, importa…